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Page 1
Dapagliflozin vs. metolazone in heart failure resistant to loop diuretics.
Yeoh SE, Osmanska J, Petrie MC, Brooksbank KJM, Clark AL, Docherty KF, Foley PWX, Guha K, Halliday CA, Jhund PS, Kalra PR, McKinley G, Lang NN, Lee MMY, McConnachie A, McDermott JJ, Platz E, Sartipy P, Seed A, Stanley B, Weir RAP, Welsh P, McMurray JJV, Campbell RT. Yeoh SE, et al. Eur Heart J. 2023 Aug 14;44(31):2966-2977. doi: 10.1093/eurheartj/ehad341. Eur Heart J. 2023. PMID: 37210742 Free PMC article. Clinical Trial.
Loop diuretic efficiency was less with dapagliflozin than with metolazone [mean 0.15 (0.12) vs. 0.25 (0.19); difference -0.08, 95% CI -0.17,0.01 kg; P = 0.10]. ...CONCLUSION: In patients with heart failure and loop diuretic resistance, dapagliflozin was not more effective …
Loop diuretic efficiency was less with dapagliflozin than with metolazone [mean 0.15 (0.12) vs. 0.25 (0.19); difference -0.08, 95% CI …
Diuretic Strategies for Loop Diuretic Resistance in Acute Heart Failure: The 3T Trial.
Cox ZL, Hung R, Lenihan DJ, Testani JM. Cox ZL, et al. JACC Heart Fail. 2020 Mar;8(3):157-168. doi: 10.1016/j.jchf.2019.09.012. Epub 2019 Dec 11. JACC Heart Fail. 2020. PMID: 31838029 Free PMC article. Clinical Trial.

Serum sodium decreased less with tolvaptan than with metolazone (+4 5 vs. -1 3 mEq/l; p = 0.001), but 48-h spot urine sodium was lower with tolvaptan (58 25 mmol/l) than with metolazone (104 16 mmol/l; p = 0.002) and with chlorothiazide (117 14 mmol/l; p < 0.001)

…
Serum sodium decreased less with tolvaptan than with metolazone (+4 5 vs. -1 3 mEq/l; p = 0.001), but 48-h spot urine sodium was lowe …
Pharmacokinetic study of single- and multiple-dosing with metolazone tablets in healthy Chinese population.
Li X, Wang R, Liu Y, Liu Y, Zheng H, Feng Y, Zhao N, Geng H, Zhang W, Wen A. Li X, et al. BMC Pharmacol Toxicol. 2017 Nov 16;18(1):73. doi: 10.1186/s40360-017-0178-x. BMC Pharmacol Toxicol. 2017. PMID: 29145890 Free PMC article. Clinical Trial.
Metolazone was well tolerated at the tested dose, and no adverse effects were observed. ...Gender factors did not appear to influence the pharmacokinetic parameter variation of metolazone. The t(max) of metolazone increased in the fed condition. ...
Metolazone was well tolerated at the tested dose, and no adverse effects were observed. ...Gender factors did not appear to influence …
Metolazone and spironolactone in cirrhosis and the nephrotic syndrome.
Lang GR, Westenfelder C, Nascimento L, Dhupelia VB, Arruda JA, Kane RE. Lang GR, et al. Clin Pharmacol Ther. 1977 Feb;21(2):234-43. doi: 10.1002/cpt1977212234. Clin Pharmacol Ther. 1977. PMID: 319937 Clinical Trial.
Metolazone alone produced a marked diuresis, natriuresis, and weight loss in 8 patients. ...The drugs were well tolerated; the administration of spironolactone with metolazone prevented decreases in serum potassium, which had occurred during treatment with metola …
Metolazone alone produced a marked diuresis, natriuresis, and weight loss in 8 patients. ...The drugs were well tolerated; the admini …
Pharmacokinetic and pharmacodynamic interaction between furosemide and metolazone in man.
Marone C, Muggli F, Lahn W, Frey FJ. Marone C, et al. Eur J Clin Invest. 1985 Oct;15(5):253-7. doi: 10.1111/j.1365-2362.1985.tb00179.x. Eur J Clin Invest. 1985. PMID: 3935455 Clinical Trial.
Total body clearance and renal clearance values of furosemide were similar before and after administration of metolazone. Our data confirm the additive diuretic effect of the combination treatment metolazone-furosemide and show for the first time a distinct hypocalc …
Total body clearance and renal clearance values of furosemide were similar before and after administration of metolazone. Our data co …
Metolazone and bendroflumethiazide in hypertension: physiologic and metabolic observations.
Winchester JF, Kellett RJ, Boddy K, Boyle P, Dargie HJ, Mahaffey ME, Ward DM, Kennedy AC. Winchester JF, et al. Clin Pharmacol Ther. 1980 Nov;28(5):611-8. doi: 10.1038/clpt.1980.211. Clin Pharmacol Ther. 1980. PMID: 7438679 Clinical Trial.
Metolazone induced a more sustained and greater blood pressure response than bendroflumethiazide. ...Total body potassium (TBK), measured by whole-body monitor, did not fall outside the normal range with either metolazone or bendroflumethiazide, although metolazo …
Metolazone induced a more sustained and greater blood pressure response than bendroflumethiazide. ...Total body potassium (TBK), meas …
Combination therapy with metolazone and loop diuretics in outpatients with refractory heart failure: an observational study and review of the literature.
Rosenberg J, Gustafsson F, Galatius S, Hildebrandt PR. Rosenberg J, et al. Cardiovasc Drugs Ther. 2005 Aug;19(4):301-6. doi: 10.1007/s10557-005-3350-2. Cardiovasc Drugs Ther. 2005. PMID: 16189620 Clinical Trial.
Absorption of metolazone seems to be reduced in HF. Metolazone produces a diuretic response despite a low glomerular filtration rate. ...RESULTS: We registered 42 episodes of treatment with metolazone. The maximal dose of metolazone was 5 mg. NYHA func …
Absorption of metolazone seems to be reduced in HF. Metolazone produces a diuretic response despite a low glomerular filtratio …
Comparing the sodium excreting efficacy of furosemide and indapamide combination against furosemide and metolazone combination in congestive heart failure patients: A randomized control trial.
Salahudin M, Shah H, Jan MU, Altaf A. Salahudin M, et al. J Pak Med Assoc. 2019 Dec;69(12):1794-1799. doi: 10.5455/JPMA.3401. J Pak Med Assoc. 2019. PMID: 31853105 Clinical Trial.
OBJECTIVE: To compare efficacy and safety of indapamide-furosemide combination against metolazone-furosemide combination in refractory heart failure patients. ...CONCLUSIONS: There was no significant differences between adverse events and efficacy between patients receivin …
OBJECTIVE: To compare efficacy and safety of indapamide-furosemide combination against metolazone-furosemide combination in refractor …
Combination antihypertensive therapy with terazosin and other antihypertensive agents: results of clinical trials.
Pool JL. Pool JL. Am Heart J. 1991 Sep;122(3 Pt 2):926-31. doi: 10.1016/0002-8703(91)90813-w. Am Heart J. 1991. PMID: 1678924 Review.
In several studies of the combination of terazosin plus a diuretic (hydrochlorothiazide, methyclothiazide, chlorthalidone, furosemide, amiloride, triamterene, metolazone, or spironolactone), significant decreases in one or more of the blood pressure variables studied were …
In several studies of the combination of terazosin plus a diuretic (hydrochlorothiazide, methyclothiazide, chlorthalidone, furosemide, amilo …
45 results