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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1979 1
1980 2
1981 14
1982 15
1983 48
1984 21
1985 22
1986 35
1987 52
1988 59
1989 59
1990 100
1991 98
1992 97
1993 116
1994 125
1995 111
1996 133
1997 132
1998 95
1999 139
2000 143
2001 131
2002 104
2003 118
2004 146
2005 128
2006 135
2007 146
2008 129
2009 144
2010 171
2011 155
2012 140
2013 147
2014 162
2015 133
2016 120
2017 128
2018 87
2019 105
2020 117
2021 91
2022 78
2023 83
2024 16

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4,199 results

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Page 1
Ketamine for Rapid Reduction of Suicidal Thoughts in Major Depression: A Midazolam-Controlled Randomized Clinical Trial.
Grunebaum MF, Galfalvy HC, Choo TH, Keilp JG, Moitra VK, Parris MS, Marver JE, Burke AK, Milak MS, Sublette ME, Oquendo MA, Mann JJ. Grunebaum MF, et al. Am J Psychiatry. 2018 Apr 1;175(4):327-335. doi: 10.1176/appi.ajp.2017.17060647. Epub 2017 Dec 5. Am J Psychiatry. 2018. PMID: 29202655 Free PMC article. Clinical Trial.
RESULTS: The reduction in SSI score at day 1 was 4.96 points greater for the ketamine group compared with the midazolam group (95% CI=2.33, 7.59; Cohen's d=0.75). The proportion of responders (defined as having a reduction 50% in SSI score) at day 1 was 55% for the ketamin …
RESULTS: The reduction in SSI score at day 1 was 4.96 points greater for the ketamine group compared with the midazolam group (95% CI …
Midazolam versus morphine in acute cardiogenic pulmonary oedema: results of a multicentre, open-label, randomized controlled trial.
Domínguez-Rodríguez A, Suero-Mendez C, Burillo-Putze G, Gil V, Calvo-Rodriguez R, Piñera-Salmeron P, Llorens P, Martín-Sánchez FJ, Abreu-Gonzalez P, Miró Ò; MIMO (MIdazolam versus MOrphine) Trial Investigators. Domínguez-Rodríguez A, et al. Eur J Heart Fail. 2022 Oct;24(10):1953-1962. doi: 10.1002/ejhf.2602. Epub 2022 Jul 16. Eur J Heart Fail. 2022. PMID: 35780488 Free article. Clinical Trial.
The trial was stopped early after a planned interim analysis by the safety monitoring committee. At that time, 111 patients had been randomized: 55 to midazolam and 56 to morphine. There were no significant differences in the primary endpoint (in-hospital mortality for …
The trial was stopped early after a planned interim analysis by the safety monitoring committee. At that time, 111 patients had been randomi …
Esketamine vs Midazolam in Boosting the Efficacy of Oral Antidepressants for Major Depressive Disorder: A Pilot Randomized Clinical Trial.
Xiao C, Zhou J, Li A, Zhang L, Zhu X, Zhou J, Hu Y, Zheng Y, Liu J, Deng Q, Wang H, Wang G. Xiao C, et al. JAMA Netw Open. 2023 Aug 1;6(8):e2328817. doi: 10.1001/jamanetworkopen.2023.28817. JAMA Netw Open. 2023. PMID: 37578792 Free PMC article. Clinical Trial.
INTERVENTIONS: All participants in the esketamine-treated group received intravenous esketamine at 0.2 mg/kg in 40 minutes. Participants in the midazolam control group received intravenous midazolam at 0.045 mg/kg in 40 minutes. ...Response rates at 2 weeks were sig …
INTERVENTIONS: All participants in the esketamine-treated group received intravenous esketamine at 0.2 mg/kg in 40 minutes. Participants in …
Pharmacokinetics and Safety of Letermovir and Midazolam Coadministration in Healthy Subjects.
Kropeit D, McCormick D, Erb-Zohar K, Stobernack HP, Zimmermann H, Rübsamen-Schaeff H. Kropeit D, et al. Clin Pharmacol Drug Dev. 2022 Jan;11(1):16-24. doi: 10.1002/cpdd.1027. Epub 2021 Oct 29. Clin Pharmacol Drug Dev. 2022. PMID: 34714967 Clinical Trial.
Thus, the effect of letermovir on the CYP3A isoenzyme-specific probe drug midazolam was investigated in a phase 1 trial. Healthy female subjects received single-dose intravenous (IV; 1 mg) and oral (2 mg) midazolam on days -4 and -2, respectively. Letermovir 240 mg …
Thus, the effect of letermovir on the CYP3A isoenzyme-specific probe drug midazolam was investigated in a phase 1 trial. Healthy fema …
Effect of Rectal Midazolam on Pain, Stress, and Cooperation of Patient during Urodynamic Test in Women: A Randomized Clinical Trial.
Saberi N, Hayrabedian A, Mazdak H, Hassannejad R, Zargham M, Mohammadi Sichani M, Mirzaei M. Saberi N, et al. Urol J. 2023 Feb 27;20(2):129-134. doi: 10.22037/uj.v19i.7261. Urol J. 2023. PMID: 36382431 Free article. Clinical Trial.
PURPOSE: The urodynamic study is an invasive test, and causes pain and stress in the patient. We have investigated the effect of rectal midazolam sedation on the pain, stress, and cooperation of women performing urodynamic study. ...While the stress and corporation scores …
PURPOSE: The urodynamic study is an invasive test, and causes pain and stress in the patient. We have investigated the effect of rectal m
A randomized clinical trial comparing oral, aerosolized intranasal, and aerosolized buccal midazolam.
Klein EJ, Brown JC, Kobayashi A, Osincup D, Seidel K. Klein EJ, et al. Ann Emerg Med. 2011 Oct;58(4):323-9. doi: 10.1016/j.annemergmed.2011.05.016. Ann Emerg Med. 2011. PMID: 21689865 Free PMC article. Clinical Trial.
STUDY OBJECTIVE: We determine whether aerosolized intranasal or buccal midazolam reduces the distress of pediatric laceration repair compared with oral midazolam. ...The intranasal route demonstrated a greater proportion of patients with optimal activity scores, gre …
STUDY OBJECTIVE: We determine whether aerosolized intranasal or buccal midazolam reduces the distress of pediatric laceration repair …
Safety, Pharmacokinetics, and Pharmacodynamics of Midazolam Gel After Rectal Administration in Healthy Chinese Subjects.
Zhou S, Zhu J, Sun X, Xie L, Zhao Y, Ding S, Wang L, Chen J, Zhu B, Zheng A, Li Y, Zhou C, Shao F. Zhou S, et al. Clin Drug Investig. 2023 Jun;43(6):421-433. doi: 10.1007/s40261-023-01276-5. Epub 2023 Jun 4. Clin Drug Investig. 2023. PMID: 37270744 Clinical Trial.
The objective of this study was to evaluate the safety, pharmacokinetics, pharmacodynamics, and absolute bioavailability of midazolam rectal gel in healthy Chinese subjects. METHODS: An open-label, single-dose, randomized, two-period, two-treatment, crossover clinical stud …
The objective of this study was to evaluate the safety, pharmacokinetics, pharmacodynamics, and absolute bioavailability of midazolam
Pharmacokinetics and pharmacodynamics of midazolam following intravenous and intramuscular administration to sheep.
Simon BT, Scallan EM, O O, Ebner LS, Cerullo MN, Follette C, Cox SK, Doherty TJ, Lizarraga I. Simon BT, et al. Am J Vet Res. 2017 May;78(5):539-549. doi: 10.2460/ajvr.78.5.539. Am J Vet Res. 2017. PMID: 28441044 Free article. Clinical Trial.
PROCEDURES Sheep were administered midazolam (0.5 mg/kg) by the IV route and then by the IM route 7 days later in a crossover study. Physiologic and behavioral variables were assessed and blood samples collected for determination of plasma midazolam and 1-hydroxymid …
PROCEDURES Sheep were administered midazolam (0.5 mg/kg) by the IV route and then by the IM route 7 days later in a crossover study. …
Midazolam versus morphine in acute cardiogenic pulmonary edema patients with and without atrial fibrillation: findings from the MIMO trial.
Domínguez-Rodríguez A, Hernandez-Vaquero D, Suero-Mendez C, Burillo-Putze G, Gil V, Calvo-Rodriguez R, Piñera-Salmeron P, Llorens P, Martín-Sánchez FJ, Abreu-Gonzalez P, Miró Ò; MIMO (MIdazolam versus MOrphine) Trial Investigators. Domínguez-Rodríguez A, et al. Eur J Emerg Med. 2023 Apr 1;30(2):78-84. doi: 10.1097/MEJ.0000000000001005. Epub 2023 Jan 20. Eur J Emerg Med. 2023. PMID: 36727880 Clinical Trial.
OBJECTIVE: The primary endpoint of this substudy is to know if AF modified the reduced risk of serious adverse events in the midazolam arm compared to morphine. The first secondary endpoint is to know if AF modified the reduced risk of serious adverse events or death at 30 …
OBJECTIVE: The primary endpoint of this substudy is to know if AF modified the reduced risk of serious adverse events in the midazolam
Pharmacokinetics and pharmacodynamics of midazolam after intravenous and intramuscular administration in alpacas.
Aarnes TK, Fry PR, Hubbell JA, Bednarski RM, Lerche P, Chen W, Bei D, Liu Z, Lakritz J. Aarnes TK, et al. Am J Vet Res. 2013 Feb;74(2):294-9. doi: 10.2460/ajvr.74.2.294. Am J Vet Res. 2013. PMID: 23363357 Free article. Clinical Trial.
PROCEDURES: Midazolam (0.5 mg/kg) was administered IV or IM in a randomized crossover design. ...Midazolam concentrations were determined by use of tandem liquid chromatography-mass spectrometry. ...
PROCEDURES: Midazolam (0.5 mg/kg) was administered IV or IM in a randomized crossover design. ...Midazolam concentrations were …
4,199 results