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417 results

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Cognitive enhancement effects of stimulants: a randomized controlled trial testing methylphenidate, modafinil, and caffeine.
Repantis D, Bovy L, Ohla K, Kühn S, Dresler M. Repantis D, et al. Psychopharmacology (Berl). 2021 Feb;238(2):441-451. doi: 10.1007/s00213-020-05691-w. Epub 2020 Nov 17. Psychopharmacology (Berl). 2021. PMID: 33201262 Free PMC article. Clinical Trial.
METHODS: We conducted a pilot study with three arms in which male participants received placebo and one of three stimulants (caffeine, methylphenidate, modafinil) and assessed cognitive performance with a test battery that captures various cognitive domains. ...Methylpheni …
METHODS: We conducted a pilot study with three arms in which male participants received placebo and one of three stimulants (caffeine, methy …
Safety and efficacy of amantadine, modafinil, and methylphenidate for fatigue in multiple sclerosis: a randomised, placebo-controlled, crossover, double-blind trial.
Nourbakhsh B, Revirajan N, Morris B, Cordano C, Creasman J, Manguinao M, Krysko K, Rutatangwa A, Auvray C, Aljarallah S, Jin C, Mowry E, McCulloch C, Waubant E. Nourbakhsh B, et al. Lancet Neurol. 2021 Jan;20(1):38-48. doi: 10.1016/S1474-4422(20)30354-9. Epub 2020 Nov 23. Lancet Neurol. 2021. PMID: 33242419 Free PMC article. Clinical Trial.
FINDINGS: Between Oct 4, 2017, and Feb 27, 2019, of 169 patients screened, 141 patients were enrolled and randomly assigned to one of four medication administration sequences: 35 (25%) patients to the amantadine, placebo, modafinil, and methylphenidate sequence; 34 (24%) p …
FINDINGS: Between Oct 4, 2017, and Feb 27, 2019, of 169 patients screened, 141 patients were enrolled and randomly assigned to one of four m …
Cognitive enhancement: Effects of methylphenidate, modafinil, and caffeine on latent memory and resting state functional connectivity in healthy adults.
Becker M, Repantis D, Dresler M, Kühn S. Becker M, et al. Hum Brain Mapp. 2022 Oct 1;43(14):4225-4238. doi: 10.1002/hbm.25949. Epub 2022 Jun 7. Hum Brain Mapp. 2022. PMID: 35670369 Free PMC article. Clinical Trial.
Stimulants like methylphenidate, modafinil, and caffeine have repeatedly shown to enhance cognitive processes such as attention and memory. ...Here, we utilized behavioral and resting-state fMRI data from a double-blind randomized placebocontrolled study of methylphenidate …
Stimulants like methylphenidate, modafinil, and caffeine have repeatedly shown to enhance cognitive processes such as attention and m …
Pitolisant versus placebo or modafinil in patients with narcolepsy: a double-blind, randomised trial.
Dauvilliers Y, Bassetti C, Lammers GJ, Arnulf I, Mayer G, Rodenbeck A, Lehert P, Ding CL, Lecomte JM, Schwartz JC; HARMONY I study group. Dauvilliers Y, et al. Lancet Neurol. 2013 Nov;12(11):1068-75. doi: 10.1016/S1474-4422(13)70225-4. Epub 2013 Oct 7. Lancet Neurol. 2013. PMID: 24107292 Clinical Trial.
Using a computer-generated randomisation sequence, we randomly allocated patients to receive pitolisant, modafinil, or placebo (1:1:1). Treatment lasted 8 weeks: 3 weeks of flexible dosing according to investigator's judgment (10 mg, 20 mg, or 40 mg a day of pitolisant; 10 …
Using a computer-generated randomisation sequence, we randomly allocated patients to receive pitolisant, modafinil, or placebo (1:1:1 …
A Randomized, Placebo-Controlled Clinical Trial of Efficacy and Safety: Modafinil in the Treatment of Fatigue in Patients With Primary Biliary Cirrhosis.
Silveira MG, Gossard AA, Stahler AC, Jorgensen RA, Petz JL, Ali AH, Lindor KD. Silveira MG, et al. Am J Ther. 2017 Mar/Apr;24(2):e167-e176. doi: 10.1097/MJT.0000000000000387. Am J Ther. 2017. PMID: 27148676 Clinical Trial.
STUDY QUESTION: No studies have assessed the use of modafinil in fatigue related to PBC in a controlled manner. STUDY DESIGN, MEASURES, AND OUTCOMES: A randomized, double-blind, placebo-controlled study was conducted to determine the safety and efficacy of modafinil
STUDY QUESTION: No studies have assessed the use of modafinil in fatigue related to PBC in a controlled manner. STUDY DESIGN, MEASURE …
Effects of modafinil and caffeine on night-time vigilance of air force crewmembers: A randomized controlled trial.
Wingelaar-Jagt YQ, Bottenheft C, Riedel WJ, Ramaekers JG. Wingelaar-Jagt YQ, et al. J Psychopharmacol. 2023 Feb;37(2):172-180. doi: 10.1177/02698811221142568. Epub 2022 Dec 14. J Psychopharmacol. 2023. PMID: 36515156 Free PMC article. Clinical Trial.
Stimulants may counteract fatigue's adverse effects, with modafinil as a promising alternative to caffeine. However, the effect of a single dose of modafinil after a limited period of sleep deprivation remains unknown. AIMS: This study aims to determine the effect o …
Stimulants may counteract fatigue's adverse effects, with modafinil as a promising alternative to caffeine. However, the effect of a …
Influence of modafinil on early ejaculation - Results from a double-blind randomized clinical trial.
Haghighi M, Jahangard L, Meybodi AM, Shayganfard M, Ahmadpanah M, Faryadres M, Dürsteler KM, Brühl AB, Sadeghi-Bahmani D, Brand S. Haghighi M, et al. J Psychiatr Res. 2022 Feb;146:264-271. doi: 10.1016/j.jpsychires.2021.11.015. Epub 2021 Nov 9. J Psychiatr Res. 2022. PMID: 34799125 Free article. Clinical Trial.
RESULTS: Dimensions of early ejaculation improved over time, but only so in the modafinil condition, while no improvements were observed in the placebo condition. CONCLUSIONS: Among male adults in stable marital relationships with regular weekly penile-vaginal intercourse …
RESULTS: Dimensions of early ejaculation improved over time, but only so in the modafinil condition, while no improvements were obser …
Equilibrium and Vestibular Safety of Modafinil in Healthy Volunteers.
Liu F, Zhang M, Chen T, Zhai L, Zhang Z, Xue J. Liu F, et al. Aerosp Med Hum Perform. 2022 Jun 1;93(6):487-492. doi: 10.3357/AMHP.6032.2022. Aerosp Med Hum Perform. 2022. PMID: 35729759 Clinical Trial.
BACKGROUND: Modafinil, as a wake-promoting agent, is commonly used to relieve fatigue during military operations. ...These findings preliminarily suggest that there is no hidden risk of vestibular dysfunction among aviation employees using modafinil.Liu F, Zhang M, …
BACKGROUND: Modafinil, as a wake-promoting agent, is commonly used to relieve fatigue during military operations. ...These findings p …
Treatment of fatigue with methylphenidate, modafinil and amantadine in multiple sclerosis (TRIUMPHANT-MS): Study design for a pragmatic, randomized, double-blind, crossover clinical trial.
Nourbakhsh B, Revirajan N, Waubant E. Nourbakhsh B, et al. Contemp Clin Trials. 2018 Jan;64:67-76. doi: 10.1016/j.cct.2017.11.005. Epub 2017 Nov 4. Contemp Clin Trials. 2018. PMID: 29113955 Clinical Trial.
BACKGROUND: Fatigue is the most common symptom of multiple sclerosis (MS). Amantadine, modafinil and amphetamine-like stimulants are commonly used in clinical practice for treatment of fatigue; however, the evidence supporting their effectiveness is sparse and conflicting. …
BACKGROUND: Fatigue is the most common symptom of multiple sclerosis (MS). Amantadine, modafinil and amphetamine-like stimulants are …
417 results