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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1989 2
1990 1
1991 1
1993 2
1994 2
1995 1
1996 1
1997 4
1998 5
1999 7
2000 6
2001 8
2002 13
2003 15
2004 24
2005 21
2006 26
2007 20
2008 25
2009 37
2010 43
2011 27
2012 27
2013 29
2014 30
2015 21
2016 18
2017 13
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2023 5
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2026 0

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424 results

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Page 1
Cognitive enhancement effects of stimulants: a randomized controlled trial testing methylphenidate, modafinil, and caffeine.
Repantis D, Bovy L, Ohla K, Kühn S, Dresler M. Repantis D, et al. Psychopharmacology (Berl). 2021 Feb;238(2):441-451. doi: 10.1007/s00213-020-05691-w. Epub 2020 Nov 17. Psychopharmacology (Berl). 2021. PMID: 33201262 Free PMC article. Clinical Trial.
METHODS: We conducted a pilot study with three arms in which male participants received placebo and one of three stimulants (caffeine, methylphenidate, modafinil) and assessed cognitive performance with a test battery that captures various cognitive domains. ...Methylpheni …
METHODS: We conducted a pilot study with three arms in which male participants received placebo and one of three stimulants (caffeine, methy …
Cognitive enhancement: Effects of methylphenidate, modafinil, and caffeine on latent memory and resting state functional connectivity in healthy adults.
Becker M, Repantis D, Dresler M, Kühn S. Becker M, et al. Hum Brain Mapp. 2022 Oct 1;43(14):4225-4238. doi: 10.1002/hbm.25949. Epub 2022 Jun 7. Hum Brain Mapp. 2022. PMID: 35670369 Free PMC article. Clinical Trial.
Stimulants like methylphenidate, modafinil, and caffeine have repeatedly shown to enhance cognitive processes such as attention and memory. ...Here, we utilized behavioral and resting-state fMRI data from a double-blind randomized placebocontrolled study of methylphenidate …
Stimulants like methylphenidate, modafinil, and caffeine have repeatedly shown to enhance cognitive processes such as attention and m …
Pitolisant versus placebo or modafinil in patients with narcolepsy: a double-blind, randomised trial.
Dauvilliers Y, Bassetti C, Lammers GJ, Arnulf I, Mayer G, Rodenbeck A, Lehert P, Ding CL, Lecomte JM, Schwartz JC; HARMONY I study group. Dauvilliers Y, et al. Lancet Neurol. 2013 Nov;12(11):1068-75. doi: 10.1016/S1474-4422(13)70225-4. Epub 2013 Oct 7. Lancet Neurol. 2013. PMID: 24107292 Clinical Trial.
Using a computer-generated randomisation sequence, we randomly allocated patients to receive pitolisant, modafinil, or placebo (1:1:1). Treatment lasted 8 weeks: 3 weeks of flexible dosing according to investigator's judgment (10 mg, 20 mg, or 40 mg a day of pitolisant; 10 …
Using a computer-generated randomisation sequence, we randomly allocated patients to receive pitolisant, modafinil, or placebo (1:1:1 …
Modafinil Versus Amphetamine-Dextroamphetamine For Idiopathic Hypersomnia and Narcolepsy Type 2: A Randomized, Blinded, Non-inferiority Trial.
Trotti LM, Blake T, Hoque R, Rye DB, Sharma S, Bliwise DL. Trotti LM, et al. CNS Drugs. 2024 Nov;38(11):909-920. doi: 10.1007/s40263-024-01122-y. Epub 2024 Sep 21. CNS Drugs. 2024. PMID: 39306601 Free PMC article. Clinical Trial.
We performed a randomized, fully blinded, noninferiority trial of modafinil versus amphetamine-dextroamphetamine in these disorders. METHODS: Forty-four adults were randomized to modafinil or amphetamine-dextroamphetamine, individually titrated to a maximum of mo …
We performed a randomized, fully blinded, noninferiority trial of modafinil versus amphetamine-dextroamphetamine in these disorders. …
Comparative effectiveness of cognitive behavioural therapy, modafinil, and their combination for treating fatigue in multiple sclerosis (COMBO-MS): a randomised, statistician-blinded, parallel-arm trial.
Braley TJ, Ehde DM, Alschuler KN, Little R, Ng YT, Zhai Y, von Geldern G, Chervin RD, Conroy D, Valentine TR, Romeo AR, LaRocca N, Hamade M, Jordan A, Singh M, Segal BM, Kratz AL. Braley TJ, et al. Lancet Neurol. 2024 Nov;23(11):1108-1118. doi: 10.1016/S1474-4422(24)00354-5. Lancet Neurol. 2024. PMID: 39424559 Clinical Trial.
Change in MFIS scores from baseline to 12 weeks did not differ between groups: relative to combination therapy, the adjusted total mean difference in MFIS change score was 1.88 (95% CI -2.21 to 5.96) for CBT and 1.20 (-2.83 to 5.23) for modafinil. Most common adverse event …
Change in MFIS scores from baseline to 12 weeks did not differ between groups: relative to combination therapy, the adjusted total mean diff …
Safety and efficacy of amantadine, modafinil, and methylphenidate for fatigue in multiple sclerosis: a randomised, placebo-controlled, crossover, double-blind trial.
Nourbakhsh B, Revirajan N, Morris B, Cordano C, Creasman J, Manguinao M, Krysko K, Rutatangwa A, Auvray C, Aljarallah S, Jin C, Mowry E, McCulloch C, Waubant E. Nourbakhsh B, et al. Lancet Neurol. 2021 Jan;20(1):38-48. doi: 10.1016/S1474-4422(20)30354-9. Epub 2020 Nov 23. Lancet Neurol. 2021. PMID: 33242419 Free PMC article. Clinical Trial.
FINDINGS: Between Oct 4, 2017, and Feb 27, 2019, of 169 patients screened, 141 patients were enrolled and randomly assigned to one of four medication administration sequences: 35 (25%) patients to the amantadine, placebo, modafinil, and methylphenidate sequence; 34 (24%) p …
FINDINGS: Between Oct 4, 2017, and Feb 27, 2019, of 169 patients screened, 141 patients were enrolled and randomly assigned to one of four m …
Orexin 2 receptor-selective agonist danavorexton (TAK-925) promotes wakefulness in non-human primates and healthy individuals.
Evans R, Kimura H, Nakashima M, Ishikawa T, Yukitake H, Suzuki M, Hazel J, Faessel H, Wu J, Hang Y, Alexander R, Rosen L, Hartman DS, Ratti E. Evans R, et al. J Sleep Res. 2023 Oct;32(5):e13878. doi: 10.1111/jsr.13878. Epub 2023 Mar 19. J Sleep Res. 2023. PMID: 36934366 Clinical Trial.
In a phase 1b crossover, randomized, double-blind, placebo-controlled and active-controlled study in sleep-deprived healthy participants (ClinicalTrials.gov identifier: NCT03522506), modafinil 300 mg (used to demonstrate assay sensitivity) and continuous infusion of danavo …
In a phase 1b crossover, randomized, double-blind, placebo-controlled and active-controlled study in sleep-deprived healthy participants (Cl …
Effects of modafinil and caffeine on night-time vigilance of air force crewmembers: A randomized controlled trial.
Wingelaar-Jagt YQ, Bottenheft C, Riedel WJ, Ramaekers JG. Wingelaar-Jagt YQ, et al. J Psychopharmacol. 2023 Feb;37(2):172-180. doi: 10.1177/02698811221142568. Epub 2022 Dec 14. J Psychopharmacol. 2023. PMID: 36515156 Free PMC article. Clinical Trial.
Stimulants may counteract fatigue's adverse effects, with modafinil as a promising alternative to caffeine. However, the effect of a single dose of modafinil after a limited period of sleep deprivation remains unknown. AIMS: This study aims to determine the effect o …
Stimulants may counteract fatigue's adverse effects, with modafinil as a promising alternative to caffeine. However, the effect of a …
Modulatory effects of modafinil on neural circuits regulating emotion and cognition.
Rasetti R, Mattay VS, Stankevich B, Skjei K, Blasi G, Sambataro F, Arrillaga-Romany IC, Goldberg TE, Callicott JH, Apud JA, Weinberger DR. Rasetti R, et al. Neuropsychopharmacology. 2010 Sep;35(10):2101-9. doi: 10.1038/npp.2010.83. Epub 2010 Jun 16. Neuropsychopharmacology. 2010. PMID: 20555311 Free PMC article. Clinical Trial.
Modafinil differs from other arousal-enhancing agents in chemical structure, neurochemical profile, and behavioral effects. ...BOLD fMRI revealed significantly decreased amygdala reactivity to fearful stimuli on modafinil compared with the placebo condition. During …
Modafinil differs from other arousal-enhancing agents in chemical structure, neurochemical profile, and behavioral effects. ...BOLD f …
Influence of modafinil on early ejaculation - Results from a double-blind randomized clinical trial.
Haghighi M, Jahangard L, Meybodi AM, Shayganfard M, Ahmadpanah M, Faryadres M, Dürsteler KM, Brühl AB, Sadeghi-Bahmani D, Brand S. Haghighi M, et al. J Psychiatr Res. 2022 Feb;146:264-271. doi: 10.1016/j.jpsychires.2021.11.015. Epub 2021 Nov 9. J Psychiatr Res. 2022. PMID: 34799125 Free article. Clinical Trial.
RESULTS: Dimensions of early ejaculation improved over time, but only so in the modafinil condition, while no improvements were observed in the placebo condition. CONCLUSIONS: Among male adults in stable marital relationships with regular weekly penile-vaginal intercourse …
RESULTS: Dimensions of early ejaculation improved over time, but only so in the modafinil condition, while no improvements were obser …
424 results