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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1989 2
1990 1
1991 1
1993 2
1994 2
1995 1
1996 1
1997 4
1998 5
1999 7
2000 6
2001 8
2002 13
2003 15
2004 24
2005 21
2006 26
2007 20
2008 25
2009 37
2010 43
2011 27
2012 27
2013 29
2014 30
2015 21
2016 18
2017 15
2018 9
2019 9
2020 5
2021 3
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391 results
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Safety and efficacy of amantadine, modafinil, and methylphenidate for fatigue in multiple sclerosis: a randomised, placebo-controlled, crossover, double-blind trial.
Nourbakhsh B, Revirajan N, Morris B, Cordano C, Creasman J, Manguinao M, Krysko K, Rutatangwa A, Auvray C, Aljarallah S, Jin C, Mowry E, McCulloch C, Waubant E. Nourbakhsh B, et al. Lancet Neurol. 2021 Jan;20(1):38-48. doi: 10.1016/S1474-4422(20)30354-9. Epub 2020 Nov 23. Lancet Neurol. 2021. PMID: 33242419 Free PMC article. Clinical Trial.
FINDINGS: Between Oct 4, 2017, and Feb 27, 2019, of 169 patients screened, 141 patients were enrolled and randomly assigned to one of four medication administration sequences: 35 (25%) patients to the amantadine, placebo, modafinil, and methylphenidate sequence; 34 (24%) p …
FINDINGS: Between Oct 4, 2017, and Feb 27, 2019, of 169 patients screened, 141 patients were enrolled and randomly assigned to one of four m …
Treatment of fatigue with methylphenidate, modafinil and amantadine in multiple sclerosis (TRIUMPHANT-MS): Study design for a pragmatic, randomized, double-blind, crossover clinical trial.
Nourbakhsh B, Revirajan N, Waubant E. Nourbakhsh B, et al. Contemp Clin Trials. 2018 Jan;64:67-76. doi: 10.1016/j.cct.2017.11.005. Epub 2017 Nov 4. Contemp Clin Trials. 2018. PMID: 29113955 Clinical Trial.
BACKGROUND: Fatigue is the most common symptom of multiple sclerosis (MS). Amantadine, modafinil and amphetamine-like stimulants are commonly used in clinical practice for treatment of fatigue; however, the evidence supporting their effectiveness is sparse and conflicting. …
BACKGROUND: Fatigue is the most common symptom of multiple sclerosis (MS). Amantadine, modafinil and amphetamine-like stimulants are …
Pitolisant versus placebo or modafinil in patients with narcolepsy: a double-blind, randomised trial.
Dauvilliers Y, Bassetti C, Lammers GJ, Arnulf I, Mayer G, Rodenbeck A, Lehert P, Ding CL, Lecomte JM, Schwartz JC; HARMONY I study group. Dauvilliers Y, et al. Lancet Neurol. 2013 Nov;12(11):1068-75. doi: 10.1016/S1474-4422(13)70225-4. Epub 2013 Oct 7. Lancet Neurol. 2013. PMID: 24107292 Clinical Trial.
Using a computer-generated randomisation sequence, we randomly allocated patients to receive pitolisant, modafinil, or placebo (1:1:1). Treatment lasted 8 weeks: 3 weeks of flexible dosing according to investigator's judgment (10 mg, 20 mg, or 40 mg a day of pitolis …
Using a computer-generated randomisation sequence, we randomly allocated patients to receive pitolisant, modafinil, or placebo (1:1:1 …
Methylphenidate, modafinil, and caffeine for cognitive enhancement in chess: A double-blind, randomised controlled trial.
Franke AG, Gränsmark P, Agricola A, Schühle K, Rommel T, Sebastian A, Balló HE, Gorbulev S, Gerdes C, Frank B, Ruckes C, Tüscher O, Lieb K. Franke AG, et al. Eur Neuropsychopharmacol. 2017 Mar;27(3):248-260. doi: 10.1016/j.euroneuro.2017.01.006. Epub 2017 Jan 22. Eur Neuropsychopharmacol. 2017. PMID: 28119083 Clinical Trial.
This study investigated whether performance in chess - a competitive mind game requiring highly complex cognitive skills - can be enhanced by methylphenidate, modafinil or caffeine. In a phase IV, randomized, double-blind, placebo-controlled trial, 39 male chess players re …
This study investigated whether performance in chess - a competitive mind game requiring highly complex cognitive skills - can be enhanced b …
Acute Effects of Methylphenidate, Modafinil, and MDMA on Negative Emotion Processing.
Schmidt A, Müller F, Dolder PC, Schmid Y, Zanchi D, Egloff L, Liechti ME, Borgwardt S. Schmidt A, et al. Int J Neuropsychopharmacol. 2018 Apr 1;21(4):345-354. doi: 10.1093/ijnp/pyx112. Int J Neuropsychopharmacol. 2018. PMID: 29206921 Free PMC article. Clinical Trial.
However, comparative data on the effects of methylphenidate and modafinil on negative emotions in healthy subjects have been partially missing. ...Modafinil but not methylphenidate also increased amygdala responses to fearful faces compared with 3,4-methylenedioxyme …
However, comparative data on the effects of methylphenidate and modafinil on negative emotions in healthy subjects have been partiall …
Cognitive enhancement effects of stimulants: a randomized controlled trial testing methylphenidate, modafinil, and caffeine.
Repantis D, Bovy L, Ohla K, Kühn S, Dresler M. Repantis D, et al. Psychopharmacology (Berl). 2021 Feb;238(2):441-451. doi: 10.1007/s00213-020-05691-w. Epub 2020 Nov 17. Psychopharmacology (Berl). 2021. PMID: 33201262 Free PMC article. Clinical Trial.
Widely available stimulants such as caffeine, but also prescription substances such as methylphenidate and modafinil, are being used by healthy individuals to enhance cognitive performance. ...METHODS: We conducted a pilot study with three arms in which male participants r …
Widely available stimulants such as caffeine, but also prescription substances such as methylphenidate and modafinil, are being used …
Direct comparison of the acute subjective, emotional, autonomic, and endocrine effects of MDMA, methylphenidate, and modafinil in healthy subjects.
Dolder PC, Müller F, Schmid Y, Borgwardt SJ, Liechti ME. Dolder PC, et al. Psychopharmacology (Berl). 2018 Feb;235(2):467-479. doi: 10.1007/s00213-017-4650-5. Epub 2017 May 27. Psychopharmacology (Berl). 2018. PMID: 28551715 Free PMC article. Clinical Trial.
In contrast to MDMA, methylphenidate increased subjective anxiety, and methylphenidate and modafinil increased misclassifications of emotions as angry on the FERT. Modafinil had no significant subjective drug effects but significant sympathomimetic and adverse effec …
In contrast to MDMA, methylphenidate increased subjective anxiety, and methylphenidate and modafinil increased misclassifications of …
A Randomized, Placebo-Controlled Clinical Trial of Efficacy and Safety: Modafinil in the Treatment of Fatigue in Patients With Primary Biliary Cirrhosis.
Silveira MG, Gossard AA, Stahler AC, Jorgensen RA, Petz JL, Ali AH, Lindor KD. Silveira MG, et al. Am J Ther. 2017 Mar/Apr;24(2):e167-e176. doi: 10.1097/MJT.0000000000000387. Am J Ther. 2017. PMID: 27148676 Clinical Trial.
Modafinil was administered at 100 mg by mouth once daily; a change by 50 mg every 2 weeks (maximum: 200 mg once daily) was allowed, depending on the subject's response to treatment. ...Modafinil was associated with minimal adverse events (headaches, diarrhea,
Modafinil was administered at 100 mg by mouth once daily; a change by 50 mg every 2 weeks (maximum: 200 mg once daily) was allowed, d
Safety and efficacy of methylphenidate for apathy in Alzheimer's disease: a randomized, placebo-controlled trial.
Rosenberg PB, Lanctôt KL, Drye LT, Herrmann N, Scherer RW, Bachman DL, Mintzer JE, ADMET Investigators. Rosenberg PB, et al. J Clin Psychiatry. 2013 Aug;74(8):810-6. doi: 10.4088/JCP.12m08099. J Clin Psychiatry. 2013. PMID: 24021498 Free PMC article. Clinical Trial.
Primary outcomes were change in Apathy Evaluation Scale (AES) score and modified Alzheimer's Disease Cooperative Study-Clinical Global Impression of Change (ADCS-CGI-C). ...CONCLUSIONS: Methylphenidate treatment of apathy in Alzheimer's disease was associated with s …
Primary outcomes were change in Apathy Evaluation Scale (AES) score and modified Alzheimer's Disease Cooperative Study-Clinical Globa …
Modafinil as a treatment for Attention-Deficit/Hyperactivity Disorder in children and adolescents: a double blind, randomized clinical trial.
Amiri S, Mohammadi MR, Mohammadi M, Nouroozinejad GH, Kahbazi M, Akhondzadeh S. Amiri S, et al. Prog Neuropsychopharmacol Biol Psychiatry. 2008 Jan 1;32(1):145-9. doi: 10.1016/j.pnpbp.2007.07.025. Epub 2007 Aug 8. Prog Neuropsychopharmacol Biol Psychiatry. 2008. PMID: 17765380 Clinical Trial.
The aim of the present study was to further evaluate, under double blind and controlled conditions, the efficacy of modafinil for ADHD in children and adolescents as compared to methylphenidate. ...Side effects of decreased appetite and difficulty falling asleep were obser …
The aim of the present study was to further evaluate, under double blind and controlled conditions, the efficacy of modafinil for ADH …
391 results
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