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Dimethyl Fumarate.
[No authors listed] [No authors listed] 2022 Sep 7. LiverTox: Clinical and Research Information on Drug-Induced Liver Injury [Internet]. Bethesda (MD): National Institute of Diabetes and Digestive and Kidney Diseases; 2012–. 2022 Sep 7. LiverTox: Clinical and Research Information on Drug-Induced Liver Injury [Internet]. Bethesda (MD): National Institute of Diabetes and Digestive and Kidney Diseases; 2012–. PMID: 31643803 Free Books & Documents. Review.
Dimethyl fumarate, monomethyl fumarate and diroximel fumarate are antiinflammatory and immunomodulatory agents that are used to treat relapsing multiple sclerosis and have similar beneficial as well as adverse effects. ...
Dimethyl fumarate, monomethyl fumarate and diroximel fumarate are antiinflammatory and immunomodulatory agents that are used t …
Dimethyl Fumarate.
[No authors listed] [No authors listed] 2024 Sep 15. Drugs and Lactation Database (LactMed®) [Internet]. Bethesda (MD): National Institute of Child Health and Human Development; 2006–. 2024 Sep 15. Drugs and Lactation Database (LactMed®) [Internet]. Bethesda (MD): National Institute of Child Health and Human Development; 2006–. PMID: 29999794 Free Books & Documents. Review.
The active form of both dimethyl fumarate and diroximel fumarate is monomethyl fumarate. Amounts of monomethyl fumarate in breastmilk appear to be low and would not be expected to cause any adverse effects in breastfed infants. ...
The active form of both dimethyl fumarate and diroximel fumarate is monomethyl fumarate. Amounts of monomethyl fumar …
Diroximel Fumarate.
[No authors listed] [No authors listed] 2024 May 15. Drugs and Lactation Database (LactMed®) [Internet]. Bethesda (MD): National Institute of Child Health and Human Development; 2006–. 2024 May 15. Drugs and Lactation Database (LactMed®) [Internet]. Bethesda (MD): National Institute of Child Health and Human Development; 2006–. PMID: 33886179 Free Books & Documents. Review.
However, amounts of the active metabolite of diroximel fumarate, monomethyl fumarate, in breastmilk appear to be low and would not be expected to cause any adverse effects in breastfed infants. ...
However, amounts of the active metabolite of diroximel fumarate, monomethyl fumarate, in breastmilk appear to be low and would …
Biased allosteric activation of ketone body receptor HCAR2 suppresses inflammation.
Zhao C, Wang H, Liu Y, Cheng L, Wang B, Tian X, Fu H, Wu C, Li Z, Shen C, Yu J, Yang S, Hu H, Fu P, Ma L, Wang C, Yan W, Shao Z. Zhao C, et al. Mol Cell. 2023 Sep 7;83(17):3171-3187.e7. doi: 10.1016/j.molcel.2023.07.030. Epub 2023 Aug 18. Mol Cell. 2023. PMID: 37597514 Free article.
Furthermore, four structures of HCAR2-G(i) complex bound to orthosteric agonists (niacin or monomethyl fumarate), compound 9n, and niacin together with compound 9n simultaneously reveal a common orthosteric site and a unique allosteric site. ...
Furthermore, four structures of HCAR2-G(i) complex bound to orthosteric agonists (niacin or monomethyl fumarate), compound 9n, …
Multiple Sclerosis Agents.
[No authors listed] [No authors listed] 2022 Sep 7. LiverTox: Clinical and Research Information on Drug-Induced Liver Injury [Internet]. Bethesda (MD): National Institute of Diabetes and Digestive and Kidney Diseases; 2012–. 2022 Sep 7. LiverTox: Clinical and Research Information on Drug-Induced Liver Injury [Internet]. Bethesda (MD): National Institute of Diabetes and Digestive and Kidney Diseases; 2012–. PMID: 31643690 Free Books & Documents. Review.
The disease modifying agents are largely immunomodulatory drugs including interferon beta-1a (Avonex, 1994 and Rebif, 2003), interferon beta-1b (Betaseron and Extavia, 1993), peginterferon beta-1a (Plegridy, 2014), glatiramer acetate (Copaxone and Glatopa 1996), alemtuzumab (Lemt …
The disease modifying agents are largely immunomodulatory drugs including interferon beta-1a (Avonex, 1994 and Rebif, 2003), interferon beta …
Monomethyl Fumarate (MMF, Bafiertam) for the Treatment of Relapsing Forms of Multiple Sclerosis (MS).
Berger AA, Sottosanti ER, Winnick A, Izygon J, Berardino K, Cornett EM, Kaye AD, Varrassi G, Viswanath O, Urits I. Berger AA, et al. Neurol Int. 2021 May 19;13(2):207-223. doi: 10.3390/neurolint13020022. Neurol Int. 2021. PMID: 34069538 Free PMC article. Review.
Recently, several modern therapies-including antibody therapy and oral agents-were approved as disease-modifying agents. Monomethyl fumarate (MMF, Bafiertam) is a recent addition to the arsenal available in the fight against MS and appears to be well-tolerated, safe …
Recently, several modern therapies-including antibody therapy and oral agents-were approved as disease-modifying agents. Monomethyl …
Intraarticular monomethyl fumarate as a perspective therapy for osteoarthritis by macrophage polarization.
de Souza DM, Malange KF, Nishijima CM, de Melo Lima BH, Capetini VC, de Oliveira ALR, Anhê GF, Tambeli CH, Parada CA. de Souza DM, et al. Inflammopharmacology. 2024 Apr;32(2):1239-1252. doi: 10.1007/s10787-024-01443-w. Epub 2024 Mar 13. Inflammopharmacology. 2024. PMID: 38472616
This study aimed to evaluate the analgesia and macrophage profile in the treatment of experimental osteoarthritis (EOA) with systemic dimethyl fumarate (DMF) or local intra-articular monomethyl fumarate (MMF). RESULTS: DMF via gavage or MMF via intra-articular in th …
This study aimed to evaluate the analgesia and macrophage profile in the treatment of experimental osteoarthritis (EOA) with systemic dimeth …
Monomethyl fumarate has better gastrointestinal tolerability profile compared with dimethyl fumarate.
Wynn D, Lategan TW, Sprague TN, Rousseau FS, Fox EJ. Wynn D, et al. Mult Scler Relat Disord. 2020 Oct;45:102335. doi: 10.1016/j.msard.2020.102335. Epub 2020 Jun 25. Mult Scler Relat Disord. 2020. PMID: 32629403 Free article. Clinical Trial.
BACKGROUND: Monomethyl fumarate (MMF) is the pharmacologically active metabolite of dimethyl fumarate (DMF). ...
BACKGROUND: Monomethyl fumarate (MMF) is the pharmacologically active metabolite of dimethyl fumarate (DMF). ...
Dimethyl Fumarate and Monomethyl Fumarate Promote Post-Ischemic Recovery in Mice.
Yao Y, Miao W, Liu Z, Han W, Shi K, Shen Y, Li H, Liu Q, Fu Y, Huang D, Shi FD. Yao Y, et al. Transl Stroke Res. 2016 Dec;7(6):535-547. doi: 10.1007/s12975-016-0496-0. Epub 2016 Sep 10. Transl Stroke Res. 2016. PMID: 27614618 Free PMC article.
Dimethyl fumarate (DMF) and its primary metabolite monomethyl fumarate (MMF) are antioxidant agents that can activate the nuclear factor erythroid-2-related factor 2 (Nrf2)/heme oxygenase-1 (HO-1) pathway and induce the expression of antioxidant proteins. ...
Dimethyl fumarate (DMF) and its primary metabolite monomethyl fumarate (MMF) are antioxidant agents that can activate the nucl …
150 results