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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1826 1
1829 2
1830 1
1850 1
1867 1
1869 1
1873 1
1875 1
1880 1
1882 1
1883 1
1885 1
1889 5
1890 4
1891 5
1893 2
1894 2
1896 3
1897 4
1898 1
1899 1
1900 1
1901 1
1903 1
1904 1
1905 3
1906 3
1907 1
1908 1
1909 2
1910 3
1911 5
1912 2
1913 7
1914 1
1915 4
1916 3
1917 5
1918 3
1919 2
1920 1
1921 4
1923 3
1924 2
1925 1
1926 2
1927 1
1928 1
1929 3
1930 2
1933 5
1934 1
1935 2
1938 1
1939 4
1940 6
1942 1
1943 2
1944 5
1945 23
1946 24
1947 63
1948 73
1949 64
1950 91
1951 104
1952 92
1953 110
1954 145
1955 183
1956 159
1957 145
1958 134
1959 139
1960 130
1961 135
1962 150
1963 295
1964 405
1965 306
1966 297
1967 342
1968 427
1969 428
1970 502
1971 574
1972 695
1973 768
1974 709
1975 806
1976 800
1977 795
1978 843
1979 881
1980 967
1981 1026
1982 1193
1983 1199
1984 1243
1985 1269
1986 1241
1987 1128
1988 1135
1989 1189
1990 1221
1991 1228
1992 1220
1993 1265
1994 1260
1995 1282
1996 1309
1997 1301
1998 1315
1999 1202
2000 1393
2001 1360
2002 1303
2003 1465
2004 1490
2005 1657
2006 1675
2007 1627
2008 1723
2009 1705
2010 1749
2011 1827
2012 1900
2013 1942
2014 2122
2015 2057
2016 2087
2017 2153
2018 2238
2019 2479
2020 2828
2021 2839
2022 2690
2023 278
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75,499 results
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Page 1
Morphine metabolites.
Christrup LL. Christrup LL. Acta Anaesthesiol Scand. 1997 Jan;41(1 Pt 2):116-22. doi: 10.1111/j.1399-6576.1997.tb04625.x. Acta Anaesthesiol Scand. 1997. PMID: 9061094 Review.
Morphine is a member of the morphinan-framed alkaloids, which are present in the poppy plant. The drug is soluble in water, but its solubility in lipids is poor. In man, morphine-3-glucuronide (M3G) and morphine-6-glucuronide (M6G) are the major metabolites o …
Morphine is a member of the morphinan-framed alkaloids, which are present in the poppy plant. The drug is soluble in water, but its s …
A review of morphine and morphine-6-glucuronide's pharmacokinetic-pharmacodynamic relationships in experimental and clinical pain.
Sverrisdóttir E, Lund TM, Olesen AE, Drewes AM, Christrup LL, Kreilgaard M. Sverrisdóttir E, et al. Eur J Pharm Sci. 2015 Jul 10;74:45-62. doi: 10.1016/j.ejps.2015.03.020. Epub 2015 Apr 7. Eur J Pharm Sci. 2015. PMID: 25861720 Review.
Morphine is a widely used opioid for treatment of moderate to severe pain, but large interindividual variability in patient response and no clear guidance on how to optimise morphine dosage regimen complicates treatment strategy for clinicians. ...This review provid …
Morphine is a widely used opioid for treatment of moderate to severe pain, but large interindividual variability in patient response …
Morphine-6-glucuronide: potency and safety compared with morphine.
van Dorp EL, Morariu A, Dahan A. van Dorp EL, et al. Expert Opin Pharmacother. 2008 Aug;9(11):1955-61. doi: 10.1517/14656566.9.11.1955. Expert Opin Pharmacother. 2008. PMID: 18627332 Review.
The search for opioid analgesics with a better side-effect profile than morphine has led to a morphine metabolites, morphine-6-glucuronide (M6G). ...M6G is an attractive alternative to morphine in the treatment of severe postoperative pain....
The search for opioid analgesics with a better side-effect profile than morphine has led to a morphine metabolites, morphin …
Morphine-6-glucuronide: morphine's successor for postoperative pain relief?
van Dorp EL, Romberg R, Sarton E, Bovill JG, Dahan A. van Dorp EL, et al. Anesth Analg. 2006 Jun;102(6):1789-97. doi: 10.1213/01.ane.0000217197.96784.c3. Anesth Analg. 2006. PMID: 16717327 Review.
In searching for an analgesic with fewer side effects than morphine, examination of morphine's active metabolite, morphine-6-glucuronide (M6G), suggests that M6G is possibly such a drug. ...M6G exhibits a delay in its analgesic effect (blood-effect sit …
In searching for an analgesic with fewer side effects than morphine, examination of morphine's active metabolite, mo …
Endogenous morphine and its metabolites in mammals: history, synthesis, localization and perspectives.
Laux-Biehlmann A, Mouheiche J, Vérièpe J, Goumon Y. Laux-Biehlmann A, et al. Neuroscience. 2013 Mar 13;233:95-117. doi: 10.1016/j.neuroscience.2012.12.013. Epub 2012 Dec 21. Neuroscience. 2013. PMID: 23266549 Review.
It is now accepted that endogenous morphine, structurally identical to vegetal morphine-alkaloid, is synthesized by mammalian cells from dopamine. Morphine binds mu opioid receptor and induces antinociceptive effects. ...
It is now accepted that endogenous morphine, structurally identical to vegetal morphine-alkaloid, is synthesized by mammalian …
Rethinking the opiate system? Morphine and morphine-6-glucuronide as new endocrine and neuroendocrine mediators.
Glattard E, Muller A, Aunis D, Metz-Boutigue MH, Stefano GB, Goumon Y. Glattard E, et al. Med Sci Monit. 2006 Jun;12(6):SR25-7. Epub 2006 May 29. Med Sci Monit. 2006. PMID: 16733499 Review.
Since the 80s, intrigued by presence of morphine precursors in some mammalian cells, different laboratories were able to characterize morphine and morphine precursors in animal tissues. ...Then, in the last three years a high rate of publications dealing with …
Since the 80s, intrigued by presence of morphine precursors in some mammalian cells, different laboratories were able to characterize …
The role of morphine glucuronides in cancer pain.
Mercadante S. Mercadante S. Palliat Med. 1999 Mar;13(2):95-104. doi: 10.1191/026921699678158579. Palliat Med. 1999. PMID: 10474692 Review.
Morphine metabolites are involved in various ways in determining the complex effects of morphine, both favourable and adverse, and may complicate the clinical use of morphine in the treatment of cancer pain. The production and effects of the principal morp …
Morphine metabolites are involved in various ways in determining the complex effects of morphine, both favourable and adverse, …
Stability of morphine, morphine-3-glucuronide, and morphine-6-glucuronide in fresh blood and plasma and postmortem blood samples.
Skopp G, Pötsch L, Klingmann A, Mattern R. Skopp G, et al. J Anal Toxicol. 2001 Jan-Feb;25(1):2-7. doi: 10.1093/jat/25.1.2. J Anal Toxicol. 2001. PMID: 11215995
Photodegradation of morphine-3-glucuronide in plasma was consistent with a second-order reaction. In postmortem samples the degradation pattern differed completely from that observed in fresh blood and plasma. The elevated morphine levels observed were primarily due …
Photodegradation of morphine-3-glucuronide in plasma was consistent with a second-order reaction. In postmortem samples the degradati …
Considerations in morphine therapy.
Laizure SC. Laizure SC. Am J Hosp Pharm. 1994 Aug 15;51(16):2042-3. Am J Hosp Pharm. 1994. PMID: 7977426 Review. No abstract available.
Role of morphine's metabolites in analgesia: concepts and controversies.
Wittwer E, Kern SE. Wittwer E, et al. AAPS J. 2006 May 26;8(2):E348-52. doi: 10.1007/BF02854905. AAPS J. 2006. PMID: 16796385 Free PMC article. Review.
The metabolites of morphine, morphine-6-glucuronide (M6G) and morphine-3-glucuronide (M3G), have been extensively studied for their contribution to clinical effects following administration of morphine. ...Much attention and effort have been directed a …
The metabolites of morphine, morphine-6-glucuronide (M6G) and morphine-3-glucuronide (M3G), have been extensively studi …
75,499 results
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