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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1964 1
1965 15
1966 24
1967 17
1968 31
1969 24
1970 29
1971 38
1972 25
1973 23
1974 41
1975 31
1976 45
1977 51
1978 35
1979 43
1980 39
1981 58
1982 62
1983 69
1984 74
1985 100
1986 93
1987 96
1988 109
1989 117
1990 111
1991 139
1992 168
1993 181
1994 210
1995 197
1996 238
1997 259
1998 235
1999 207
2000 228
2001 226
2002 251
2003 243
2004 265
2005 277
2006 278
2007 279
2008 299
2009 297
2010 302
2011 310
2012 313
2013 308
2014 341
2015 332
2016 348
2017 329
2018 289
2019 267
2020 305
2021 302
2022 289
2023 103

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9,234 results

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Page 1
Pharmacokinetics of Morphine and Morphine-6-Glucuronide During Postoperative Pain Therapy in Cardiac Surgery Patients.
Ihmsen H, Schüttler J, Jeleazcov C. Ihmsen H, et al. Eur J Drug Metab Pharmacokinet. 2021 Mar;46(2):249-263. doi: 10.1007/s13318-020-00663-z. Epub 2021 Feb 5. Eur J Drug Metab Pharmacokinet. 2021. PMID: 33547559 Clinical Trial.
BACKGROUND AND OBJECTIVE: Morphine is a standard analgesic drug for postoperative pain therapy. This study aimed to evaluate the pharmacokinetics of morphine and its active metabolite morphine-6-glucuronide (M6G) in cardiac surgery patients during postoperati …
BACKGROUND AND OBJECTIVE: Morphine is a standard analgesic drug for postoperative pain therapy. This study aimed to evaluate the phar …
Clinical pharmacokinetics of morphine and its metabolites during morphine dose titration for chronic cancer pain.
De Gregori S, Minella CE, De Gregori M, Tinelli C, Ranzani GN, Govoni S, Allegri M, Regazzi M. De Gregori S, et al. Ther Drug Monit. 2014 Jun;36(3):335-44. doi: 10.1097/FTD.0000000000000009. Ther Drug Monit. 2014. PMID: 24595069 Clinical Trial.
METHODS: The aim of this study was to evaluate the clinical pharmacokinetics of morphine (M) and their correlation with pharmacodynamic results (effective daily dose of M and side effects) during the M titration phase, in the management of chronic cancer pain. Fifty-two co …
METHODS: The aim of this study was to evaluate the clinical pharmacokinetics of morphine (M) and their correlation with pharmacodynam …
Population pharmacokinetics of morphine and morphine-6-glucuronide following rectal administration--a dose escalation study.
Brokjær A, Kreilgaard M, Olesen AE, Simonsson US, Christrup LL, Dahan A, Drewes AM. Brokjær A, et al. Eur J Pharm Sci. 2015 Feb 20;68:78-86. doi: 10.1016/j.ejps.2014.12.004. Epub 2014 Dec 5. Eur J Pharm Sci. 2015. PMID: 25486331 Clinical Trial.
The aims were: (1) to develop a population pharmacokinetic model of liquid rectal morphine and morphine-6-glucoronide (M6G), (2) to simulate clinically relevant rectal doses of morphine and (3) to assess the tolerability and safety. ...A 2mg morphine h …
The aims were: (1) to develop a population pharmacokinetic model of liquid rectal morphine and morphine-6-glucoronide (M6G), ( …
Morphine decreases clopidogrel concentrations and effects: a randomized, double-blind, placebo-controlled trial.
Hobl EL, Stimpfl T, Ebner J, Schoergenhofer C, Derhaschnig U, Sunder-Plassmann R, Jilma-Stohlawetz P, Mannhalter C, Posch M, Jilma B. Hobl EL, et al. J Am Coll Cardiol. 2014 Feb 25;63(7):630-635. doi: 10.1016/j.jacc.2013.10.068. Epub 2013 Dec 4. J Am Coll Cardiol. 2014. PMID: 24315907 Free article. Clinical Trial.
OBJECTIVES: This study sought to examine the possible drug-drug interactions between clopidogrel and morphine. BACKGROUND: Because morphine-the recommended treatment for pain of myocardial infarction-is associated with poor clinical outcome, we hypothesized that …
OBJECTIVES: This study sought to examine the possible drug-drug interactions between clopidogrel and morphine. BACKGROUND: Because …
Morphine and morphine-6-glucuronide in the plasma and cerebrospinal fluid of children.
Hain RD, Hardcastle A, Pinkerton CR, Aherne GW. Hain RD, et al. Br J Clin Pharmacol. 1999 Jul;48(1):37-42. doi: 10.1046/j.1365-2125.1999.00948.x. Br J Clin Pharmacol. 1999. PMID: 10383558 Free PMC article. Clinical Trial.
AIMS: To measure morphine and morphine-6-glucuronide in the plasma and cerebrospinal fluid of children following a single intravenous dose of morphine. ...Concentrations of morphine and morphine-6-glucuronide (M6G) were measured in each sample. …
AIMS: To measure morphine and morphine-6-glucuronide in the plasma and cerebrospinal fluid of children following a single intr …
Morphine and morphine-6-glucuronide plasma concentrations and effect in cancer pain.
Faura CC, Moore RA, Horga JF, Hand CW, McQuay HJ. Faura CC, et al. J Pain Symptom Manage. 1996 Feb;11(2):95-102. doi: 10.1016/0885-3924(95)00148-4. J Pain Symptom Manage. 1996. PMID: 8907140 Free article. Clinical Trial.
The relationships between plasma morphine and metabolite (M3G and M6G) concentrations and analgesic efficacy were investigated in an open study of 39 cancer pain patients receiving chronic oral morphine therapy with either morphine sulfate solution or control …
The relationships between plasma morphine and metabolite (M3G and M6G) concentrations and analgesic efficacy were investigated in an …
Quantifying the Pharmacodynamics of Morphine in the Treatment of Postoperative Pain in Preverbal Children.
Goulooze SC, de Kluis T, van Dijk M, Ceelie I, de Wildt SN, Tibboel D, Krekels EHJ, Knibbe CAJ. Goulooze SC, et al. J Clin Pharmacol. 2022 Jan;62(1):99-109. doi: 10.1002/jcph.1952. Epub 2021 Sep 17. J Clin Pharmacol. 2022. PMID: 34383975 Free PMC article. Clinical Trial.
While the pharmacokinetics of morphine in children have been studied extensively, little is known about the pharmacodynamics of morphine in this population. ...In responders to morphine up-titration, the COMFORT-B score slowly decreases with increasing mor …
While the pharmacokinetics of morphine in children have been studied extensively, little is known about the pharmacodynamics of mo …
Plasma morphine concentrations and clinical effects after thoracic extradural morphine or diamorphine.
Phillips DM, Moore RA, Bullingham RE, Allen MC, Baldwin D, Fisher A, Lloyd JW, McQuay HJ. Phillips DM, et al. Br J Anaesth. 1984 Aug;56(8):829-36. doi: 10.1093/bja/56.8.829. Br J Anaesth. 1984. PMID: 6743447 Free article. Clinical Trial.
The plasma morphine concentrations were significantly greater after extradural diamorphine than after extradural morphine in the first 30 min after injection. The maximum increase in plasma morphine concentration was significantly (P less than 0.02) greater a …
The plasma morphine concentrations were significantly greater after extradural diamorphine than after extradural morphine in t …
Morphine, morphine-6-glucuronide and morphine-3-glucuronide pharmacokinetics in newborn infants receiving diamorphine infusions.
Barrett DA, Barker DP, Rutter N, Pawula M, Shaw PN. Barrett DA, et al. Br J Clin Pharmacol. 1996 Jun;41(6):531-7. doi: 10.1046/j.1365-2125.1996.03539.x. Br J Clin Pharmacol. 1996. PMID: 8799518 Free PMC article. Clinical Trial.
1. The pharmacokinetics of morphine, morphine-6-glucuronide (M6G) and morphine-3-glucuronide (M3G) were studied in 19 ventilated newborn infants (24-41 weeks gestation) who were given a loading dose of 50 micrograms kg-1 or 200 micrograms kg-1 of diamorphine …
1. The pharmacokinetics of morphine, morphine-6-glucuronide (M6G) and morphine-3-glucuronide (M3G) were studied in 19 v …
Pharmacokinetics of morphine and plasma concentrations of morphine-6-glucuronide following morphine administration to dogs.
KuKanich B, Lascelles BD, Papich MG. KuKanich B, et al. J Vet Pharmacol Ther. 2005 Aug;28(4):371-6. doi: 10.1111/j.1365-2885.2005.00661.x. J Vet Pharmacol Ther. 2005. PMID: 16050817 Clinical Trial.
The purpose of this study was to evaluate the pharmacokinetics of morphine and morphine-6-glucuronide (M-6-G) following morphine administered intravenously and orally to dogs in a randomized crossover design. ...Oral morphine is poorly and erratically …
The purpose of this study was to evaluate the pharmacokinetics of morphine and morphine-6-glucuronide (M-6-G) following mor …
9,234 results