Nasal Iodophor Antiseptic vs Nasal Mupirocin Antibiotic in the Setting of Chlorhexidine Bathing to Prevent Infections in Adult ICUs: A Randomized Clinical Trial.
Huang SS, Septimus EJ, Kleinman K, Heim LT, Moody JA, Avery TR, McLean L, Rashid S, Haffenreffer K, Shimelman L, Staub-Juergens W, Spencer-Smith C, Sljivo S, Rosen E, Poland RE, Coady MH, Lee CH, Blanchard EJ, Reddish K, Hayden MK, Weinstein RA, Carver B, Smith K, Hickok J, Lolans K, Khan N, Sturdevant SG, Reddy SC, Jernigan JA, Sands KE, Perlin JB, Platt R.
Huang SS, et al.
JAMA. 2023 Oct 10;330(14):1337-1347. doi: 10.1001/jama.2023.17219.
JAMA. 2023.
PMID: 37815567
Free PMC article.
Clinical Trial.
Antibiotic resistance to mupirocin has raised questions about whether an antiseptic could be advantageous for ICU decolonization. ...For MRSA clinical cultures, HRs were 1.13 for iodophor-CHG (raw rate: 2.3 vs 2.1/1000 ICU-attributable days) and 0.99 for mupirocin-C …
Antibiotic resistance to mupirocin has raised questions about whether an antiseptic could be advantageous for ICU decolonization. ... …