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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1982 3
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1984 2
1987 20
1988 2
1989 3
1990 13
1991 1
1992 4
1993 5
1994 4
1995 5
1996 3
1997 4
1998 2
1999 8
2000 5
2001 7
2002 3
2003 3
2004 2
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2006 1
2007 2
2009 3
2012 1
2013 2
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2025 0

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112 results

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Page 1
Clinical efficacy and safety of nabumetone in rheumatoid arthritis and osteoarthritis.
Fleischmann RM. Fleischmann RM. J Rheumatol Suppl. 1992 Nov;36:32-40. J Rheumatol Suppl. 1992. PMID: 1474533 Clinical Trial.
The efficacy and safety of nabumetone were evaluated in short term (up to 6 months), double blind, comparative trials and a longterm (up to 8 years), open label, noncomparative trial. In the short term trials, nabumetone was determined to be significantly more effec …
The efficacy and safety of nabumetone were evaluated in short term (up to 6 months), double blind, comparative trials and a longterm …
Comparative clinical trial of S-adenosylmethionine versus nabumetone for the treatment of knee osteoarthritis: an 8-week, multicenter, randomized, double-blind, double-dummy, Phase IV study in Korean patients.
Kim J, Lee EY, Koh EM, Cha HS, Yoo B, Lee CK, Lee YJ, Ryu H, Lee KH, Song YW. Kim J, et al. Clin Ther. 2009 Dec;31(12):2860-72. doi: 10.1016/j.clinthera.2009.12.016. Clin Ther. 2009. PMID: 20110025 Clinical Trial.
Use of acetaminophen as rescue medication did not differ significantly between the groups during weeks 0 to 4 (SAMe, 88.5% [54/61]; nabumetone, 81.3% [52/64]) or weeks 4 to 8 (SAMe, 79.5% [35/44]; nabumetone, 68.5% [37/54]). No significant differences were observed …
Use of acetaminophen as rescue medication did not differ significantly between the groups during weeks 0 to 4 (SAMe, 88.5% [54/61]; nabum …
Nabumetone and 6-MNA Pharmacokinetics, Assessment of Intrasubject Variability and Gender Effect.
Světlík S, Štícha M, Matoušková O, Nespěšná L, Sklenář Z, Bartůněk A, Perlík F, Slanař O. Světlík S, et al. Am J Ther. 2016 Nov/Dec;23(6):e1498-e1503. doi: 10.1097/MJT.0000000000000158. Am J Ther. 2016. PMID: 25393072 Clinical Trial.
In this open-label, laboratory-blinded, 2-way single dose study in 24 volunteers of both sexes we found that (1) nabumetone reaches mean Cmax SD of 0.56 0.20 mg.L at mean tmax of 8.63 7.05 hours, and mean area under the curve (AUC)last of 18.07 7.19 h.mg.L; (2) there are n …
In this open-label, laboratory-blinded, 2-way single dose study in 24 volunteers of both sexes we found that (1) nabumetone reaches m …
Clinical efficacy and tolerance of nabumetone in articular and non-articular rheumatic disorders: personal experience during 12 weeks of treatment.
Coaccioli S, Allegra A, Di Cato L, Puxeddu A. Coaccioli S, et al. Panminerva Med. 1998 Jun;40(2):110-5. Panminerva Med. 1998. PMID: 9689831 Clinical Trial.
BACKGROUND: We evaluated the clinical efficacy and the tolerance of Nabumetone (N), in comparison with a pool of non-steroidal anti-inflammatory drugs (NSAIDs), in a cohort of patients affected by rheumatoid arthritis, osteoarthritis, non-articular rheumatisms and primary …
BACKGROUND: We evaluated the clinical efficacy and the tolerance of Nabumetone (N), in comparison with a pool of non-steroidal anti-i …
Tolerability and efficacy of nabumetone and naproxen in the treatment of rheumatoid arthritis.
Krug H, Broadwell LK, Berry M, DeLapp R, Palmer RH, Mahowald M. Krug H, et al. Clin Ther. 2000 Jan;22(1):40-52. doi: 10.1016/s0149-2918(00)87976-x. Clin Ther. 2000. PMID: 10688389 Clinical Trial.

The only significant difference between the 2 groups was a higher incidence of diarrhea (P < 0.01) in patients receiving nabumetone. CONCLUSIONS: Nabumetone 2000 mg/d was as effective as naproxen 1000 mg/d in relieving the signs and symptoms of RA. In this study,

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The only significant difference between the 2 groups was a higher incidence of diarrhea (P < 0.01) in patients receiving nabumetone

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The effects of aceclofenac and nabumetone in osteoarthritis.
Paul S, Das N, Ghosh S. Paul S, et al. JNMA J Nepal Med Assoc. 2009 Apr-Jun;48(174):121-5. JNMA J Nepal Med Assoc. 2009. PMID: 20387351 Clinical Trial.
While 108 (76.6%) participants could take the full course of treatment with aceclofenac, 118 (83.7%) of the nabumetone group completed the study. Drop outs were highest in the placebo group (33.9%) followed by the aceclofenac group (12.1%) and nabumetone group (8.5% …
While 108 (76.6%) participants could take the full course of treatment with aceclofenac, 118 (83.7%) of the nabumetone group complete …
Efficacy and safety of nabumetone versus diclofenac, naproxen, ibuprofen, and piroxicam in the elderly.
Morgan GJ, Poland M, DeLapp RE. Morgan GJ, et al. Am J Med. 1993 Aug 9;95(2A):19S-27S. doi: 10.1016/0002-9343(93)90392-3. Am J Med. 1993. PMID: 8356998 Clinical Trial.

Ibuprofen and diclofenac caused significantly (p < 0.05) more abdominal pain than nabumetone (8.5%, 13.1%, and 4.1%, respectively). The frequency of abdominal pain was dose related for all NSAIDs except nabumetone. ...With regard to withdrawals for adverse events

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Ibuprofen and diclofenac caused significantly (p < 0.05) more abdominal pain than nabumetone (8.5%, 13.1%, and 4.1%, respectively)

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Pain management in osteoarthritis: a focus on onset of efficacy--a comparison of rofecoxib, celecoxib, acetaminophen, and nabumetone across four clinical trials.
Battisti WP, Katz NP, Weaver AL, Matsumoto AK, Kivitz AJ, Polis AB, Geba GP. Battisti WP, et al. J Pain. 2004 Nov;5(9):511-20. doi: 10.1016/j.jpain.2004.09.004. J Pain. 2004. PMID: 15556830 Free article. Clinical Trial.
We compared onset of efficacy (during days 1 to 6) of 2 coxibs (rofecoxib, celecoxib) with acetaminophen and nabumetone by using a prespecified approach to data from 4 similarly designed 6-week randomized osteoarthritis trials. ...PERSPECTIVE: The efficacy of rofecoxib, ce …
We compared onset of efficacy (during days 1 to 6) of 2 coxibs (rofecoxib, celecoxib) with acetaminophen and nabumetone by using a pr …
Efficacy and safety of rofecoxib 12.5 mg versus nabumetone 1,000 mg in patients with osteoarthritis of the knee: a randomized controlled trial.
Kivitz AJ, Greenwald MW, Cohen SB, Polis AB, Najarian DK, Dixon ME, Moidel RA, Green JA, Baraf HS, Petruschke RA, Matsumoto AK, Geba GP; Protocol 085 Study Investigators. Kivitz AJ, et al. J Am Geriatr Soc. 2004 May;52(5):666-74. doi: 10.1111/j.1532-5415.2004.52201.x. J Am Geriatr Soc. 2004. PMID: 15086644 Clinical Trial.
RESULTS: The percentage of patients with a good or excellent response to therapy as assessed using PGART at Week 6 was significantly higher with rofecoxib (55.4%) than nabumetone (47.5%; P=.018) or placebo (26.7%; P<.001 vs rofecoxib or nabumetone). Median time t …
RESULTS: The percentage of patients with a good or excellent response to therapy as assessed using PGART at Week 6 was significantly higher …
Efficacy of nabumetone versus diclofenac, naproxen, ibuprofen, and piroxicam in osteoarthritis and rheumatoid arthritis.
Lister BJ, Poland M, DeLapp RE. Lister BJ, et al. Am J Med. 1993 Aug 9;95(2A):2S-9S. doi: 10.1016/0002-9343(93)90390-b. Am J Med. 1993. PMID: 8356999 Clinical Trial.
Eligible patients were assigned in a 3:1 ratio to receive nabumetone or a comparator NSAID for 12 weeks. Thus a total of 4,411 eligible patients were randomized to receive nabumetone (N = 3,315) or one of the comparator NSAIDs (N = 1,096). Initial daily doses were: …
Eligible patients were assigned in a 3:1 ratio to receive nabumetone or a comparator NSAID for 12 weeks. Thus a total of 4,411 eligib …
112 results