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352 results

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Page 1
Oral Nalbuphine in Idiopathic Pulmonary Fibrosis-Associated Cough: The CORAL Randomized Clinical Trial.
Molyneaux PL, Mogulkoc N, Gunen H, Doboszynska A, Kreuter M, Neustifter B, Mathur V, Cassella J; CORAL Study Group. Molyneaux PL, et al. JAMA. 2026 Mar 24;335(12):1050-1059. doi: 10.1001/jama.2025.26179. JAMA. 2026. PMID: 41569557 Free PMC article. Clinical Trial.
INTERVENTION: Patients were randomized 1:1:1:1 to receive nalbuphine ER at doses of 27 mg, 54 mg, or 108 mg or placebo twice daily for 6 weeks. MAIN OUTCOMES AND MEASURES: The primary outcome was the relative change from baseline in 24-hour cough frequency (coughs/h), meas …
INTERVENTION: Patients were randomized 1:1:1:1 to receive nalbuphine ER at doses of 27 mg, 54 mg, or 108 mg or placebo twice daily fo …
Comparison between butorphanol and nalbuphine for alleviation of catheter-related bladder discomfort and emergence agitation in patients undergoing open spinal surgery: a randomized clinical trial.
Wang W, Zhang C, Zhou Q, Dan J, Zhang K, Zheng T. Wang W, et al. Ann Med. 2025 Dec;57(1):2534853. doi: 10.1080/07853890.2025.2534853. Epub 2025 Jul 25. Ann Med. 2025. PMID: 40711580 Free PMC article. Clinical Trial.
PATIENTS AND METHODS: A total of 120 patients undergoing open spinal surgery were randomly assigned into three groups: saline group, butorphanol group, and nalbuphine group. All drugs were injected intravenously 30 min before the end of surgery. ...Butorphanol exhibits sup …
PATIENTS AND METHODS: A total of 120 patients undergoing open spinal surgery were randomly assigned into three groups: saline group, butorph …
Nalbuphine Tablets for Cough in Patients with Idiopathic Pulmonary Fibrosis.
Maher TM, Avram C, Bortey E, Hart SP, Hirani N, Molyneux PL, Porter JC, Smith JA, Sciascia T. Maher TM, et al. NEJM Evid. 2023 Aug;2(8):EVIDoa2300083. doi: 10.1056/EVIDoa2300083. Epub 2023 May 22. NEJM Evid. 2023. PMID: 38320144 Clinical Trial.
In this small crossover trial we administered nalbuphine extended-release tablets (NAL ER) as a potential cough therapy for such patients. ...
In this small crossover trial we administered nalbuphine extended-release tablets (NAL ER) as a potential cough therapy for such pati …
Comparison of nalbuphine and sufentanil for colonoscopy: A randomized controlled trial.
Deng C, Wang X, Zhu Q, Kang Y, Yang J, Wang H. Deng C, et al. PLoS One. 2017 Dec 12;12(12):e0188901. doi: 10.1371/journal.pone.0188901. eCollection 2017. PLoS One. 2017. PMID: 29232379 Free PMC article. Clinical Trial.
The aims of this study were to compare the efficacy and safety of nalbuphine with that of sufentanil in patients undergoing colonoscopy and to determine the optimal doses of nalbuphine in this indication. METHODS: Two hundred and forty consecutive eligible patients …
The aims of this study were to compare the efficacy and safety of nalbuphine with that of sufentanil in patients undergoing colonosco …
Comparison of nalbuphine, ondansetron and placebo for the prevention of shivering after spinal anaesthesia for urgent caesarean delivery: a randomised double-blind controlled clinical trial.
Liu J, Huang S, Sun S, Sun X, Wang T. Liu J, et al. Int J Obstet Anesth. 2020 May;42:39-46. doi: 10.1016/j.ijoa.2019.10.002. Epub 2019 Oct 24. Int J Obstet Anesth. 2020. PMID: 31734098 Clinical Trial.
We tested the hypothesis that prophylactic nalbuphine and ondansetron can prevent post-spinal anaesthesia shivering in parturients undergoing urgent caesarean delivery. ...After peripheral venous catheterisation, parturients were given intravenous nalbuphine 0.08 mg …
We tested the hypothesis that prophylactic nalbuphine and ondansetron can prevent post-spinal anaesthesia shivering in parturients un …
Nalbuphine for Analgesia After Orthognathic Surgery and Its Effect on Postoperative Inflammatory and Oxidative Stress: A Randomized Double-Blind Controlled Trial.
Xi MY, Li SS, Zhang C, Zhang L, Wang T, Yu C. Xi MY, et al. J Oral Maxillofac Surg. 2020 Apr;78(4):528-537. doi: 10.1016/j.joms.2019.10.017. Epub 2019 Nov 5. J Oral Maxillofac Surg. 2020. PMID: 31785250 Clinical Trial.
Furthermore, the VAS scores correlated positively with the plasma levels of TNF-alpha, IL-6, and MDA and correlated negatively with the SOD levels. CONCLUSIONS: Nalbuphine offers better postoperative analgesia and sedation after orthognathic surgery. Nalbuphine also …
Furthermore, the VAS scores correlated positively with the plasma levels of TNF-alpha, IL-6, and MDA and correlated negatively with the SOD …
A randomized clinical trial of continuous flow nitrous oxide and nalbuphine infusion for sedation of patients during radiofrequency atrial flutter ablation.
Laurent G, Bertaux G, Martel A, Fraison M, Fromentin S, Gonzalez S, Pierre FS, Wolf JE. Laurent G, et al. Pacing Clin Electrophysiol. 2006 Apr;29(4):351-7. doi: 10.1111/j.1540-8159.2006.00352.x. Pacing Clin Electrophysiol. 2006. PMID: 16650261 Clinical Trial.
METHODS AND RESULTS: In a prospective randomized study, the effect of Inhaled N2O was compared with that of intravenous sedation with Nalbuphine during CAF ablation in 76 patients (64 +/- 13 years, 56 men). We used a 24 pole mapping catheter around the tricuspid annulus an …
METHODS AND RESULTS: In a prospective randomized study, the effect of Inhaled N2O was compared with that of intravenous sedation with Nal
Safety and Efficacy of Oral Nalbuphine on Postoperative Pain in Hemorrhoidectomy Patients: A Randomized, Double-blind, Placebo-controlled, Pivotal Trial.
Jao SW, Hsiao KH, Lin HC, Lee CC, Lin TC, Chen WS, Lin CC, Lee TY, Jiang JK, Wu CC, Hu OY. Jao SW, et al. Clin J Pain. 2023 Dec 1;39(12):686-694. doi: 10.1097/AJP.0000000000001160. Clin J Pain. 2023. PMID: 37732966 Clinical Trial.
Nalbuphine was developed from the intravenous form into an oral form (PHN131) to alleviate moderate-to-severe pain. ...Eligible patients were randomly assigned to receive either PHN131 soft capsules containing nalbuphine hydrochloride 60 mg or placebo capsules. Intr
Nalbuphine was developed from the intravenous form into an oral form (PHN131) to alleviate moderate-to-severe pain. ...Eligible patie
Comparison of intra-cuff lidocaine vs alkalinized lidocaine effects for prevention of post-operative sore throat.
Hassan SU, Abbas N, Asghar A, Tariq S, Naqvi N, Rafique M. Hassan SU, et al. J Pak Med Assoc. 2022 Dec;72(12):2422-2426. doi: 10.47391/JPMA.4269. J Pak Med Assoc. 2022. PMID: 37246661 Free article. Clinical Trial.
General anaesthesia was given using induction dose of propofol 2-3mg/kg, nalbuphine 0.1mg/kg and atracurium 0.5mg/kg and female patients were intubated with 7.0mm size endotracheal tube and males patients with 8.0mm. ...
General anaesthesia was given using induction dose of propofol 2-3mg/kg, nalbuphine 0.1mg/kg and atracurium 0.5mg/kg and female patie …
352 results