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1974 3
1975 4
1976 1
1977 5
1978 3
1979 1
1980 4
1981 6
1982 9
1983 5
1984 7
1985 8
1986 8
1987 11
1988 19
1989 11
1990 7
1991 11
1992 15
1993 15
1994 19
1995 23
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1997 20
1998 16
1999 18
2000 20
2001 18
2002 10
2003 14
2004 10
2005 16
2006 10
2007 9
2008 13
2009 10
2010 13
2011 12
2012 9
2013 9
2014 12
2015 16
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624 results

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Page 1
Sugammadex for Reversal of Neuromuscular Blockade in Neonates and Infants Less than 2 Years Old: Results from a Phase IV Randomized Clinical Trial.
Mensah-Osman E, Mukai Y, Wang A, Matuszczak M, Saldien V, Leibensperger H, Speek M, Locco A, Wrishko R, Gee A, Herring WJ; New Collective Author. Mensah-Osman E, et al. Anesthesiology. 2025 Aug 1;143(2):300-312. doi: 10.1097/ALN.0000000000005535. Epub 2025 May 5. Anesthesiology. 2025. PMID: 40324166 Free PMC article. Clinical Trial.
Participants were randomized to (1) moderate NMB and reversal with 2 mg/kg sugammadex; (2) moderate NMB and reversal with neostigmine + glycopyrrolate or atropine (hereafter, called neostigmine); or (3) deep NMB and reversal with 4 mg/kg sugammadex. ...The primary e …
Participants were randomized to (1) moderate NMB and reversal with 2 mg/kg sugammadex; (2) moderate NMB and reversal with neostigmine …
Sugammadex Versus Neostigmine for Reversal of Neuromuscular Blockade in Patients With Severe Renal Impairment: A Randomized, Double-Blinded Study.
Oh MW, Mohapatra SG, Pak T, Hermawan A, Chen CA, Thota B, Chen J, Siu E, Park J, Moon TS. Oh MW, et al. Anesth Analg. 2024 May 1;138(5):1043-1051. doi: 10.1213/ANE.0000000000006807. Epub 2024 Jan 8. Anesth Analg. 2024. PMID: 38190344 Clinical Trial.
BACKGROUND: Sugammadex is not advised for patients with severe renal impairment, but has been shown in a variety of other populations to be superior to neostigmine for reversal of neuromuscular blockade. The objective of this study was to determine if reversal of rocuroniu …
BACKGROUND: Sugammadex is not advised for patients with severe renal impairment, but has been shown in a variety of other populations to be …
Irreversible curarization.
Baraka A. Baraka A. Anaesth Intensive Care. 1977 Aug;5(3):244-6. doi: 10.1177/0310057X7700500311. Anaesth Intensive Care. 1977. PMID: 332002 Clinical Trial.
The reversal effect of neostigmine following different doses of tubocurarine was investigated in 20 anesthetized adults. ...An overdose of tubocurarine predisposes to the so called "neostigmine-resistant curarization"....
The reversal effect of neostigmine following different doses of tubocurarine was investigated in 20 anesthetized adults. ...An overdo …
Postoperative residual neuromuscular blockade and hypoventilation after rocuronium and sugammadex or neostigmine for kidney transplantation: A randomized clinical trial.
Stewart E, Kaizer A, Fioravanti J, Russell N, Hendrickse A, Adams M, Pshak T, Fernandez-Bustamante A. Stewart E, et al. J Clin Anesth. 2026 Apr;111:112174. doi: 10.1016/j.jclinane.2026.112174. Epub 2026 Mar 14. J Clin Anesth. 2026. PMID: 41833179 Clinical Trial.
BACKGROUND: Inadequate neuromuscular blockade (NMB) reversal can cause residual NMB (RNMB) and hypoventilation, but the incidence after sugammadex or neostigmine for kidney transplantation is unknown. We compared hypoventilation for up to three days after neostigmine …
BACKGROUND: Inadequate neuromuscular blockade (NMB) reversal can cause residual NMB (RNMB) and hypoventilation, but the incidence after suga …
Effect of Neostigmine on Attenuation of Proinflammatory Cytokines When Given as an Adjuvant Therapy in Septic Shock: A Randomized Control Trial.
Bashni T M, Kothari N, Sharma A, Goyal S, Sankanagoudar S, Paliwal B, Bhatia PK. Bashni T M, et al. Crit Care Med. 2026 Apr 1;54(4):904-914. doi: 10.1097/CCM.0000000000007051. Epub 2026 Feb 12. Crit Care Med. 2026. PMID: 41677407 Clinical Trial.
The objective of this study was to evaluate whether neostigmine administration modulates the inflammatory response in sepsis by enhancing cholinergic anti-inflammatory activity. ...INTERVENTION: Patients were randomized to receive neostigmine at a fixed rate of 0.2 …
The objective of this study was to evaluate whether neostigmine administration modulates the inflammatory response in sepsis by enhan …
Comparing the Effect of Neostigmine and Metoclopramide on Gastric Residual Volume of Mechanically Ventilated Patients in Intensive Care Unit: A Double-Blind Randomized Clinical Trial.
Rahat-Dahmardeh A, Saneie-Moghadam S, Khosh-Fetrat M. Rahat-Dahmardeh A, et al. Biomed Res Int. 2021 Aug 16;2021:5550653. doi: 10.1155/2021/5550653. eCollection 2021. Biomed Res Int. 2021. PMID: 34447851 Free PMC article. Clinical Trial.
The purpose of this study was to compare the effect of neostigmine and metoclopramide on GRV among MV patients in the intensive care unit (ICU). ...Patients in groups A and B received intravenous infusion of neostigmine at a dose of 2.5 mg/100 ml normal saline and m …
The purpose of this study was to compare the effect of neostigmine and metoclopramide on GRV among MV patients in the intensive care …
Neuromuscular and Clinical Recovery in Thoracic Surgical Patients Reversed With Neostigmine or Sugammadex.
Murphy GS, Avram MJ, Greenberg SB, Bilimoria S, Benson J, Maher CE, Teister KJ, Szokol JW. Murphy GS, et al. Anesth Analg. 2021 Aug 1;133(2):435-444. doi: 10.1213/ANE.0000000000005294. Anesth Analg. 2021. PMID: 33323787 Clinical Trial.
The aim of this clinical investigation was to assess the incidence of postoperative residual neuromuscular blockade in adult thoracic surgical patients administered neostigmine or sugammadex when optimal dosing and reversal strategies for these agents were used. ...One hun …
The aim of this clinical investigation was to assess the incidence of postoperative residual neuromuscular blockade in adult thoracic surgic …
Neostigmine Administration after Spontaneous Recovery to a Train-of-Four Ratio of 0.9 to 1.0: A Randomized Controlled Trial of the Effect on Neuromuscular and Clinical Recovery.
Murphy GS, Szokol JW, Avram MJ, Greenberg SB, Shear TD, Deshur MA, Benson J, Newmark RL, Maher CE. Murphy GS, et al. Anesthesiology. 2018 Jan;128(1):27-37. doi: 10.1097/ALN.0000000000001893. Anesthesiology. 2018. PMID: 28953501 Clinical Trial.
Mean train-of-four ratios in the control and neostigmine groups before reversal (1.02 vs. 1.03), 5 min postreversal (1.05 vs. 1.07), and at postanesthesia care unit admission (1.06 vs. 1.08) did not differ. ...The number of patients with postoperative signs and symptoms of …
Mean train-of-four ratios in the control and neostigmine groups before reversal (1.02 vs. 1.03), 5 min postreversal (1.05 vs. 1.07), …
Comparative effects of glycopyrrolate vs. atropine combined with neostigmine on heart rate dynamics and safety outcomes in pediatric patients: a prospective randomized controlled trial.
Zou T, Yang X, Ren L, Wei S, Wang G, Wei R, Yu S. Zou T, et al. BMC Pediatr. 2025 Oct 2;25(1):714. doi: 10.1186/s12887-025-06092-8. BMC Pediatr. 2025. PMID: 41039299 Free PMC article. Clinical Trial.
BACKGROUND: Neostigmine is a widely used muscle relaxant antagonist that requires combination with anticholinergic agents like atropine to mitigate its muscarinic effects. ...Postoperatively, patients in Group G received glycopyrrolate (8 g/kg) and neostigmine (40 …
BACKGROUND: Neostigmine is a widely used muscle relaxant antagonist that requires combination with anticholinergic agents like atropi …
Randomized controlled trial: neostigmine for intra-abdominal hypertension in acute pancreatitis.
He W, Chen P, Lei Y, Xia L, Liu P, Zhu Y, Zeng H, Wu Y, Ke H, Huang X, Cai W, Sun X, Huang W, Sutton R, Zhu Y, Lu N. He W, et al. Crit Care. 2022 Mar 3;26(1):52. doi: 10.1186/s13054-022-03922-4. Crit Care. 2022. PMID: 35241135 Free PMC article. Clinical Trial.
RESULTS: A total of 80 patients were recruited to neostigmine (n = 40) or conventional treatment (n = 40). There was no significant difference in baseline parameters. ...Stool volume was consistently higher in the neostigmine group during the 7-day observational per …
RESULTS: A total of 80 patients were recruited to neostigmine (n = 40) or conventional treatment (n = 40). There was no significant d …
624 results