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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1967 4
1968 2
1971 5
1972 2
1973 4
1974 5
1975 3
1976 4
1977 4
1978 4
1979 3
1980 4
1981 3
1982 13
1983 8
1984 30
1985 18
1986 29
1987 24
1988 33
1989 40
1990 25
1991 39
1992 45
1993 44
1994 67
1995 73
1996 70
1997 65
1998 77
1999 93
2000 82
2001 86
2002 96
2003 129
2004 129
2005 122
2006 154
2007 169
2008 183
2009 163
2010 190
2011 224
2012 215
2013 253
2014 240
2015 216
2016 215
2017 168
2018 174
2019 168
2020 206
2021 173
2022 183
2023 158
2024 160
2025 179
2026 21

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4,644 results

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Page 1
Nicotine-mecamylamine interactions.
Zevin S, Jacob P 3rd, Benowitz NL. Zevin S, et al. Clin Pharmacol Ther. 2000 Jul;68(1):58-66. doi: 10.1067/mcp.2000.108066. Clin Pharmacol Ther. 2000. PMID: 10945316 Clinical Trial.
On the fifth day of patch use, subjects received a combined infusion of deuterium-labeled nicotine and cotinine, with measurement of disposition kinetics of nicotine and cotinine, and cardiovascular and plasma catecholamine responses to nicotine. ...CONCLUSIO …
On the fifth day of patch use, subjects received a combined infusion of deuterium-labeled nicotine and cotinine, with measurement of …
Antismoking products.
Gourlay SG, McNeil JJ. Gourlay SG, et al. Med J Aust. 1990 Dec 3-17;153(11-12):699-707. doi: 10.5694/j.1326-5377.1990.tb126327.x. Med J Aust. 1990. PMID: 2246997 Review.
Its efficacy is greatest when prescribed for those who are motivated and highly nicotine-dependent. It is probably not indicated for smokers with a low degree of nicotine dependence. ...Currently available over-the-counter products, apart from nicotine chewin …
Its efficacy is greatest when prescribed for those who are motivated and highly nicotine-dependent. It is probably not indicated for …
Randomized Trial of Low-Nicotine Cigarettes and Transdermal Nicotine.
Smith TT, Koopmeiners JS, Tessier KM, Davis EM, Conklin CA, Denlinger-Apte RL, Lane T, Murphy SE, Tidey JW, Hatsukami DK, Donny EC. Smith TT, et al. Am J Prev Med. 2019 Oct;57(4):515-524. doi: 10.1016/j.amepre.2019.05.010. Am J Prev Med. 2019. PMID: 31542129 Free PMC article. Clinical Trial.
The present study tested the impact of smoking cigarettes with very low nicotine content and concurrent use of a transdermal nicotine patch. STUDY DESIGN: A balanced 2 2 factorial randomized clinical trial investigating the impact of cigarette nicotine conten …
The present study tested the impact of smoking cigarettes with very low nicotine content and concurrent use of a transdermal nicot …
Reduced nicotine content cigarettes and use of alternative nicotine products: exploratory trial.
Hatsukami DK, Luo X, Dick L, Kangkum M, Allen SS, Murphy SE, Hecht SS, Shields PG, al'Absi M. Hatsukami DK, et al. Addiction. 2017 Jan;112(1):156-167. doi: 10.1111/add.13603. Epub 2016 Nov 2. Addiction. 2017. PMID: 27614097 Free PMC article. Clinical Trial.
AIMS: To compare the use of alternative nicotine products, smoking behavior and tobacco biomarker exposure in smokers unwilling to quit who were assigned randomly to normal nicotine content (NNC) cigarettes or very low nicotine content (VLNC) cigarettes. ...C …
AIMS: To compare the use of alternative nicotine products, smoking behavior and tobacco biomarker exposure in smokers unwilling to qu …
Randomized clinical studies assessing the pharmacokinetics and subjective effects of vuse alto electronic nicotine delivery systems.
Prevette K, Jordan KG, Keyser BM, Kanobe MN, Jin T, Ayoku S, Darnell J, Makena P, Baxter SA. Prevette K, et al. Sci Rep. 2025 Jul 1;15(1):21711. doi: 10.1038/s41598-025-06716-0. Sci Rep. 2025. PMID: 40593024 Free PMC article. Clinical Trial.
Study 1 included high (usual brand [UB] cigarettes) and low abuse liability (nicotine gum) comparators. Nicotine PK of Vuse Alto products were generally similar across the three nicotine concentrations and four flavors tested in these studies. ...These result …
Study 1 included high (usual brand [UB] cigarettes) and low abuse liability (nicotine gum) comparators. Nicotine PK of Vuse Al …
Pharmacokinetics and Pharmacodynamics of Inhaled Nicotine Salt and Free-Base Using an E-cigarette: A Randomized Crossover Study.
Christen SE, Hermann L, Bekka E, Vonwyl C, Hammann F, van der Velpen V, Eap CB, Benowitz NL, Haschke M, Liakoni E. Christen SE, et al. Nicotine Tob Res. 2024 Sep 23;26(10):1313-1321. doi: 10.1093/ntr/ntae074. Nicotine Tob Res. 2024. PMID: 38597729 Free PMC article. Clinical Trial.
INTRODUCTION: Popular "pod-style" e-cigarettes commonly use nicotine salt-based e-liquids that cause less irritation when inhaled and can deliver higher nicotine concentrations than free-base nicotine. ...CONCLUSIONS: Free-base 20 mg/mL formulations achieved …
INTRODUCTION: Popular "pod-style" e-cigarettes commonly use nicotine salt-based e-liquids that cause less irritation when inhaled and …
Effect of e-cigarette flavors on nicotine delivery and puffing topography: results from a randomized clinical trial of daily smokers.
Voos N, Smith D, Kaiser L, Mahoney MC, Bradizza CM, Kozlowski LT, Benowitz NL, O'Connor RJ, Goniewicz ML. Voos N, et al. Psychopharmacology (Berl). 2020 Feb;237(2):491-502. doi: 10.1007/s00213-019-05386-x. Epub 2019 Nov 26. Psychopharmacology (Berl). 2020. PMID: 31773209 Free PMC article. Clinical Trial.
Assessments at each visit included puffing topography, blood samples for nicotine analysis, and subjective reports of nicotine effects and flavor satisfaction. RESULTS: Vaping different flavors resulted in different levels of plasma nicotine. The flavor produ …
Assessments at each visit included puffing topography, blood samples for nicotine analysis, and subjective reports of nicotine …
Combination Nicotine Metered Dose Inhaler and Nicotine Patch for Smoking Cessation: A Randomized Controlled Trial.
Caldwell BO, Crane J. Caldwell BO, et al. Nicotine Tob Res. 2016 Oct;18(10):1944-1951. doi: 10.1093/ntr/ntw093. Epub 2016 May 16. Nicotine Tob Res. 2016. PMID: 27185903 Clinical Trial.
INTRODUCTION: In order to replicate the rewarding effects of smoking, nicotine replacement therapies must deliver nicotine via the pulmonary route. We aimed to measure the efficacy of a simple pressurized metered dose inhaler containing nicotine combined with …
INTRODUCTION: In order to replicate the rewarding effects of smoking, nicotine replacement therapies must deliver nicotine via …
Experience with reduced-nicotine cigarettes and whether this decreases smoking and substitution for full-nicotine cigarettes.
Naudé GP, Strickland JC, Berry MS, Dolan SB, Cox DJ, Johnson MW. Naudé GP, et al. J Exp Anal Behav. 2024 Nov;122(3):282-296. doi: 10.1002/jeab.4223. Epub 2024 Nov 4. J Exp Anal Behav. 2024. PMID: 39495162 Clinical Trial.
Studies suggest that reduced-nicotine cigarettes decrease nicotine intake and dependence. However, questions remain about reduced-nicotine cigarette abuse liability, whether reduced-nicotine cigarette exposure lowers reduced- and full-nicotine c …
Studies suggest that reduced-nicotine cigarettes decrease nicotine intake and dependence. However, questions remain about redu …
A randomised, open-label, cross-over clinical study to evaluate the pharmacokinetic, pharmacodynamic and safety and tolerability profiles of tobacco-free oral nicotine pouches relative to cigarettes.
Chapman F, McDermott S, Rudd K, Taverner V, Stevenson M, Chaudhary N, Reichmann K, Thompson J, Nahde T, O'Connell G. Chapman F, et al. Psychopharmacology (Berl). 2022 Sep;239(9):2931-2943. doi: 10.1007/s00213-022-06178-6. Epub 2022 Jun 23. Psychopharmacology (Berl). 2022. PMID: 35732751 Free PMC article. Clinical Trial.
The most recent THR innovation is tobacco-free oral nicotine pouches. OBJECTIVES: This study aimed to compare pharmacokinetic, pharmacodynamic and safety and tolerability profiles of two nicotine pouch variants (ZoneX #2 (5.8 mg nicotine/pouch); ZoneX #3 (10. …
The most recent THR innovation is tobacco-free oral nicotine pouches. OBJECTIVES: This study aimed to compare pharmacokinetic, pharma …
4,644 results