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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1967 4
1968 2
1971 5
1972 2
1973 4
1974 5
1975 3
1976 4
1977 4
1978 4
1979 3
1980 4
1981 3
1982 13
1983 8
1984 30
1985 18
1986 29
1987 24
1988 33
1989 40
1990 25
1991 39
1992 45
1993 44
1994 67
1995 73
1996 70
1997 65
1998 77
1999 93
2000 82
2001 86
2002 96
2003 129
2004 129
2005 122
2006 154
2007 169
2008 183
2009 163
2010 190
2011 224
2012 215
2013 254
2014 242
2015 217
2016 215
2017 169
2018 184
2019 172
2020 208
2021 123
2022 1
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4,017 results
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Page 1
Pharmacokinetic Comparison of a Novel Non-tobacco-Based Nicotine Pouch (ZYN) With Conventional, Tobacco-Based Swedish Snus and American Moist Snuff.
Lunell E, Fagerström K, Hughes J, Pendrill R. Lunell E, et al. Nicotine Tob Res. 2020 Oct 8;22(10):1757-1763. doi: 10.1093/ntr/ntaa068. Nicotine Tob Res. 2020. PMID: 32319528 Clinical Trial.
The extracted fractions of nicotine for both ZYN products (56% and 59%) were significantly larger than for 8 mg General (32%). ...The extracted amount of nicotine from ZYN 8 mg (3.8 mg) was larger than the amount extracted from Longhorn Natural 18 mg (3.0 mg), but s …
The extracted fractions of nicotine for both ZYN products (56% and 59%) were significantly larger than for 8 mg General (32%). ...The …
Effect of Exposure to e-Cigarettes With Salt vs Free-Base Nicotine on the Appeal and Sensory Experience of Vaping: A Randomized Clinical Trial.
Leventhal AM, Madden DR, Peraza N, Schiff SJ, Lebovitz L, Whitted L, Barrington-Trimis J, Mason TB, Anderson MK, Tackett AP. Leventhal AM, et al. JAMA Netw Open. 2021 Jan 4;4(1):e2032757. doi: 10.1001/jamanetworkopen.2020.32757. JAMA Netw Open. 2021. PMID: 33433597 Free PMC article. Clinical Trial.
IMPORTANCE: Alkaline free-base nicotine is bitter and a respiratory irritant. High-nicotine electronic cigarette (e-cigarette) products contain acid additives that change nicotine from a free-base to a protonated salt chemical form, which could improve the se …
IMPORTANCE: Alkaline free-base nicotine is bitter and a respiratory irritant. High-nicotine electronic cigarette (e-cigarette) …
Effects of nicotine on pupil size and performance during multiple-object tracking in non-nicotine users.
Wardhani IK, Mathôt S, Boehler CN, Laeng B. Wardhani IK, et al. Int J Psychophysiol. 2020 Dec;158:45-55. doi: 10.1016/j.ijpsycho.2020.09.005. Epub 2020 Oct 17. Int J Psychophysiol. 2020. PMID: 33080291 Clinical Trial.
Nicotine and placebo were administered through nicotine and nicotine-free taste-matched chewing gum, respectively. ...We speculate that nicotine might enhance performance only for certain cognitive functions, and only for specific populations, such as
Nicotine and placebo were administered through nicotine and nicotine-free taste-matched chewing gum, respectively. ...W
Reduced nicotine content cigarettes and use of alternative nicotine products: exploratory trial.
Hatsukami DK, Luo X, Dick L, Kangkum M, Allen SS, Murphy SE, Hecht SS, Shields PG, al'Absi M. Hatsukami DK, et al. Addiction. 2017 Jan;112(1):156-167. doi: 10.1111/add.13603. Epub 2016 Nov 2. Addiction. 2017. PMID: 27614097 Free PMC article. Clinical Trial.
AIMS: To compare the use of alternative nicotine products, smoking behavior and tobacco biomarker exposure in smokers unwilling to quit who were assigned randomly to normal nicotine content (NNC) cigarettes or very low nicotine content (VLNC) cigarettes. ...C …
AIMS: To compare the use of alternative nicotine products, smoking behavior and tobacco biomarker exposure in smokers unwilling to qu …
A Multicenter, Randomized, Double-blind, Parallel, Placebo-controlled Clinical Study to Evaluate the Efficacy and Safety of a Nicotine Mint Lozenge (2 and 4 mg) in Smoking Cessation.
Xiao D, Kotler M, Kang J, Wang C. Xiao D, et al. J Addict Med. 2020 Jan/Feb;14(1):69-77. doi: 10.1097/ADM.0000000000000547. J Addict Med. 2020. PMID: 31658113 Free PMC article. Clinical Trial.
CONCLUSIONS: The 4 mg nicotine lozenge provided a directionally significant improvement in smoking cessation rates compared with placebo in Chinese adult smokers with high nicotine dependence for the primary endpoint. ...Both nicotine lozenges were generally …
CONCLUSIONS: The 4 mg nicotine lozenge provided a directionally significant improvement in smoking cessation rates compared with plac …
Attention-enhancing effects of propranolol and synergistic effects with nicotine.
Hahn B, Olmstead CK, Yuille MB, Chiappelli JJ, Wells AK. Hahn B, et al. Cogn Affect Behav Neurosci. 2020 Jun;20(3):658-668. doi: 10.3758/s13415-020-00794-5. Cogn Affect Behav Neurosci. 2020. PMID: 32405757 Free PMC article. Clinical Trial.
Nicotine increases the output of every major neurotransmitter. In previous studies designed to identify the secondary neurotransmitter systems mediating nicotine's attention-enhancing effects in a rat model, the beta-adrenoceptor antagonist propranolol blocke
Nicotine increases the output of every major neurotransmitter. In previous studies designed to identify the secondary neurotransmitte
[Pharmacology of nicotine].
Bourlaud I, Underner M, Perault MC, Patte F. Bourlaud I, et al. Rev Mal Respir. 1992;9(4):367-74. Rev Mal Respir. 1992. PMID: 1509183 Review. French.
The phenomenon of autotitration explains how a dependent smoker can unconsciously change his method of smoking to maintain a steady nicotine level. Nicotine leads to a liberation of catecholamines by acting on the nervous system through the intermediary of nicoti
The phenomenon of autotitration explains how a dependent smoker can unconsciously change his method of smoking to maintain a steady nicot
e-Cigarettes for smoking cessation: Do they deliver?
Kitzen JM, McConaha JL, Bookser ML, Pergolizzi JV Jr, Taylor R Jr, Raffa RB. Kitzen JM, et al. J Clin Pharm Ther. 2019 Aug;44(4):650-655. doi: 10.1111/jcpt.12833. Epub 2019 Apr 4. J Clin Pharm Ther. 2019. PMID: 30950094 Clinical Trial.
WHAT IS KNOWN AND OBJECTIVE: Electronic nicotine delivery systems (ENDS) are battery-powered devices that allow nicotine and/or other substances to be inhaled in aerosolized form. e-Cigarettes (electronic cigarettes), the most commonly used ENDS, have been proposed …
WHAT IS KNOWN AND OBJECTIVE: Electronic nicotine delivery systems (ENDS) are battery-powered devices that allow nicotine and/o …
Association between nicotine withdrawal and reward responsiveness in humans and rats.
Pergadia ML, Der-Avakian A, D'Souza MS, Madden PAF, Heath AC, Shiffman S, Markou A, Pizzagalli DA. Pergadia ML, et al. JAMA Psychiatry. 2014 Nov;71(11):1238-1245. doi: 10.1001/jamapsychiatry.2014.1016. JAMA Psychiatry. 2014. PMID: 25208057 Free PMC article. Clinical Trial.
DESIGN, SETTING, PARTICIPANTS: Experimental studies used analogous reward responsiveness tasks in both humans and rats to examine whether reward responsiveness varied in (1) an ad libitum smoking condition compared with a 24-hour acute nicotine abstinence condition in 31 h …
DESIGN, SETTING, PARTICIPANTS: Experimental studies used analogous reward responsiveness tasks in both humans and rats to examine whether re …
An Exploratory Trial of Transdermal Nicotine for Aggression and Irritability in Adults with Autism Spectrum Disorder.
Lewis AS, van Schalkwyk GI, Lopez MO, Volkmar FR, Picciotto MR, Sukhodolsky DG. Lewis AS, et al. J Autism Dev Disord. 2018 Aug;48(8):2748-2757. doi: 10.1007/s10803-018-3536-7. J Autism Dev Disord. 2018. PMID: 29536216 Free PMC article. Clinical Trial.
We explored the feasibility, tolerability, and preliminary efficacy of targeting nAChRs using transdermal nicotine to reduce aggressive symptoms in adults with ASD. Eight subjects were randomized in a double-blind crossover trial of 7 mg transdermal nicotine or plac …
We explored the feasibility, tolerability, and preliminary efficacy of targeting nAChRs using transdermal nicotine to reduce aggressi …
4,017 results