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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1966 4
1967 8
1968 7
1969 7
1970 7
1971 8
1972 2
1973 6
1974 3
1975 8
1976 7
1977 9
1978 8
1979 10
1980 13
1981 12
1982 17
1983 11
1984 19
1985 12
1986 12
1987 12
1988 18
1989 35
1990 31
1991 26
1992 15
1993 25
1994 21
1995 29
1996 25
1997 26
1998 25
1999 45
2000 55
2001 50
2002 44
2003 37
2004 41
2005 39
2006 45
2007 40
2008 28
2009 21
2010 20
2011 15
2012 17
2013 15
2014 15
2015 15
2016 15
2017 8
2018 5
2019 4
2020 10
2021 5
2022 8
2023 8
2024 10
2025 9
2026 1

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1,047 results

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Page 1
Linzagolix therapy versus a placebo in patients with endometriosis-associated pain: a prospective, randomized, double-blind, Phase 3 study (EDELWEISS 3).
Donnez J, Becker C, Taylor H, Carmona Herrera F, Donnez O, Horne A, Paszkowski M, Petraglia F, Renner SP, Patel A, Boolell M, Bestel E, Dolmans MM. Donnez J, et al. Hum Reprod. 2024 Jun 3;39(6):1208-1221. doi: 10.1093/humrep/deae076. Hum Reprod. 2024. PMID: 38648863 Free PMC article. Clinical Trial.
STUDY QUESTION: Does linzagolix administered orally once daily for up to 3 months at a dose of 75 mg alone or 200 mg in combination with add-back therapy (ABT) (1.0 mg estradiol; 0.5 mg norethindrone acetate, also known as norethisterone acetate [NETA]) demonstrate …
STUDY QUESTION: Does linzagolix administered orally once daily for up to 3 months at a dose of 75 mg alone or 200 mg in combination with add …
Impact of relugolix combination therapy on functioning and quality of life in women with endometriosis-associated pain.
As-Sanie S, Abrao MS, Reznichenko G, Wilk K, Zhong Y, Perry J, Hunsche E, Soulban G, Becker CM. As-Sanie S, et al. Fertil Steril. 2024 Oct;122(4):687-695. doi: 10.1016/j.fertnstert.2024.06.009. Epub 2024 Jun 19. Fertil Steril. 2024. PMID: 38906210 Free article. Clinical Trial.
OBJECTIVE: To evaluate the effect of relugolix combination therapy (relugolix CT; 40 mg relugolix, 1 mg estradiol, and 0.5 mg norethisterone acetate) for up to 2 years in the SPIRIT long-term extension study on functioning and health-related quality of life (QoL), using th …
OBJECTIVE: To evaluate the effect of relugolix combination therapy (relugolix CT; 40 mg relugolix, 1 mg estradiol, and 0.5 mg norethister …
Intramuscular testosterone undecanoate and norethisterone enanthate in a clinical trial for male contraception.
Kamischke A, Venherm S, Plöger D, von Eckardstein S, Nieschlag E. Kamischke A, et al. J Clin Endocrinol Metab. 2001 Jan;86(1):303-9. doi: 10.1210/jcem.86.1.7057. J Clin Endocrinol Metab. 2001. PMID: 11232016 Clinical Trial.
However, the efficacy of most trials remained disappointing. Norethisterone enanthate (NETE) has been used as a long-acting injectable female contraceptive and has shown sustained suppression of spermatogenesis in male monkeys and prolonged suppression of gonadotropins in …
However, the efficacy of most trials remained disappointing. Norethisterone enanthate (NETE) has been used as a long-acting injectabl …
Phase I clinical trial of two contraceptive preparations. Norethisterone enanthate (NEN) and norethisterone acetate (NET).
Andino N. Andino N. Contraception. 1981 Feb;23(2):141-55. doi: 10.1016/0010-7824(81)90100-1. Contraception. 1981. PMID: 6786825 Clinical Trial.
A Phase I Clinical Trial was conducted in 20 fertile Cuban women using for contraception: Norethisterone Enanthate injectable (NEN) and Norethisterone Acetate minipill (NET). Women had daily blood sampling during a control cycle and during the second month of treatm …
A Phase I Clinical Trial was conducted in 20 fertile Cuban women using for contraception: Norethisterone Enanthate injectable (NEN) a …
The injectable contraceptives depot medroxyprogesterone acetate and norethisterone enanthate substantially and differentially decrease testosterone and sex hormone binding globulin levels: A secondary study from the WHICH randomized clinical trial.
Avenant C, Singata-Madliki M, Bick AJ, Africander D, Balakrishna Y, Storbeck KH, Moliki JM, Dlamini S, Skosana S, Smit J, Beksinska M, Beesham I, Seocharan I, Batting J, Hofmeyr GJ, Hapgood JP. Avenant C, et al. PLoS One. 2024 Aug 23;19(8):e0307736. doi: 10.1371/journal.pone.0307736. eCollection 2024. PLoS One. 2024. PMID: 39178280 Free PMC article. Clinical Trial.
HIV acquisition risk with norethisterone (NET) enanthate (NET-EN) is reportedly less than for depo-medroxyprogesterone acetate intramuscular (DMPA-IM). ...
HIV acquisition risk with norethisterone (NET) enanthate (NET-EN) is reportedly less than for depo-medroxyprogesterone acetate intram …
Norethindrone acetate and estradiol-induced endometrial hyperplasia.
Kurman RJ, Félix JC, Archer DF, Nanavati N, Arce J, Moyer DL. Kurman RJ, et al. Obstet Gynecol. 2000 Sep;96(3):373-9. doi: 10.1016/s0029-7844(00)00944-3. Obstet Gynecol. 2000. PMID: 10960628 Free article. Clinical Trial.
OBJECTIVE: To identify the lowest effective continuous dose of norethindrone acetate that significantly reduces 12-month incidence of endometrial hyperplasia associated with unopposed 17beta-estradiol (E2), 1 mg. ...RESULTS: Continuous-combined E2-norethindrone acet …
OBJECTIVE: To identify the lowest effective continuous dose of norethindrone acetate that significantly reduces 12-month incidence of …
Linzagolix with and without hormonal add-back therapy for symptomatic uterine fibroids: PRIMROSE 1 & 2 long-term extension and withdrawal study.
Donnez J, Petraglia F, Taylor H, Becker CM, Becker S, Herrera FC, Bestel E, Hori S, Dolmans MM. Donnez J, et al. Fertil Steril. 2025 Oct;124(4):737-748. doi: 10.1016/j.fertnstert.2025.06.016. Epub 2025 Jun 19. Fertil Steril. 2025. PMID: 40543832 Free article. Clinical Trial.
OBJECTIVE: To evaluate whether oral linzagolix administered once daily for up to 52 weeks (extension study) at a dose of 100 mg or 200 mg with or without hormonal add-back therapy (ABT) (1.0 mg estradiol; 0.5 mg norethisterone acetate) can maintain the efficacy and tolerab …
OBJECTIVE: To evaluate whether oral linzagolix administered once daily for up to 52 weeks (extension study) at a dose of 100 mg or 200 mg wi …
The effect of isotretinoin on the pharmacokinetics and pharmacodynamics of ethinyl estradiol and norethindrone.
Hendrix CW, Jackson KA, Whitmore E, Guidos A, Kretzer R, Liss CM, Shah LP, Khoo KC, McLane J, Trapnell CB. Hendrix CW, et al. Clin Pharmacol Ther. 2004 May;75(5):464-75. doi: 10.1016/j.clpt.2004.01.003. Clin Pharmacol Ther. 2004. PMID: 15116059 Clinical Trial.
The pharmacokinetics of ethinyl estradiol and norethindrone (INN, norethisterone) (the components of Ortho Novum 7/7/7; Ortho-McNeil Pharmaceutical, Inc, Raritan, NJ) and pharmacodynamic assessments of oral contraceptive effectiveness (concentrations of serum proges …
The pharmacokinetics of ethinyl estradiol and norethindrone (INN, norethisterone) (the components of Ortho Novum 7/7/7; Ortho- …
Linzagolix rapidly reduces heavy menstrual bleeding in women with uterine fibroids: an analysis of the PRIMROSE 1 and 2 trials.
Donnez J, Becker CM, Mangler M, Paszkowski M, Paszkowski T, St-Pierre J, Ionescu-Ittu R, Boolell M, Bestel E, Hori S, Petraglia F. Donnez J, et al. Fertil Steril. 2025 Jun;123(6):1093-1100. doi: 10.1016/j.fertnstert.2024.12.031. Epub 2025 Jan 3. Fertil Steril. 2025. PMID: 39755138 Free article. Clinical Trial.
Eligible participants were randomized equally across four treatment arms (linzagolix 100 mg and 200 mg, with and without concomitant hormonal add-back therapy [ABT] consisting of 1-mg estradiol and 0.5-mg norethisterone acetate) and one placebo arm. The cumulative incidenc …
Eligible participants were randomized equally across four treatment arms (linzagolix 100 mg and 200 mg, with and without concomitant hormona …
Misreporting contraceptive use and the association of peak study progestin levels with weight and BMI among women randomized to the progestin-only injectable contraceptives DMPA-IM and NET-EN.
Avenant C, Bick AJ, Skosana SB, Dlamini S, Balakrishna Y, Moliki JM, Singata-Madliki M, Hofmeyr GJ, Smit J, Beksinska M, Beesham I, Seocharan I, Batting J, Chen PL, Storbeck KH, Africander D, Hapgood JP. Avenant C, et al. PLoS One. 2023 Dec 22;18(12):e0295959. doi: 10.1371/journal.pone.0295959. eCollection 2023. PLoS One. 2023. PMID: 38134043 Free PMC article. Clinical Trial.
The WHICH clinical trial randomized HIV-negative women to DMPA-IM (n = 262) or norethisterone enanthate (NET-EN) (n = 259) at two South African sites between 2018-2019. We measured serum concentrations of study and non-study progestins at initiation (D0) and peak serum lev …
The WHICH clinical trial randomized HIV-negative women to DMPA-IM (n = 262) or norethisterone enanthate (NET-EN) (n = 259) at two Sou …
1,047 results