Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

Filters

My Custom Filters

Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1965 3
1966 5
1967 4
1968 10
1969 6
1970 4
1971 2
1972 6
1973 6
1974 8
1975 7
1976 9
1977 10
1978 16
1979 7
1980 8
1981 11
1982 10
1983 6
1984 8
1985 10
1986 12
1987 14
1988 7
1989 15
1990 9
1991 8
1992 11
1993 13
1994 10
1995 12
1996 16
1997 19
1998 20
1999 16
2000 16
2001 27
2002 16
2003 27
2004 11
2005 9
2006 15
2007 15
2008 10
2009 30
2010 14
2011 15
2012 9
2013 11
2014 10
2015 10
2016 4
2017 4
2018 4
2019 3
2020 3
2021 3
2022 5
2023 4
2024 2
2025 0

Publication date

Text availability

Article attribute

Article type

Additional filters

Article Language

Species

Sex

Age

Other

Search Results

585 results

Results by year

Filters applied: . Clear all
Page 1
Antidepressant Augmentation versus Switch in Treatment-Resistant Geriatric Depression.
Lenze EJ, Mulsant BH, Roose SP, Lavretsky H, Reynolds CF 3rd, Blumberger DM, Brown PJ, Cristancho P, Flint AJ, Gebara MA, Gettinger TR, Lenard E, Miller JP, Nicol GE, Oughli HA, Pham VT, Rollman BL, Yang L, Karp JF. Lenze EJ, et al. N Engl J Med. 2023 Mar 23;388(12):1067-1079. doi: 10.1056/NEJMoa2204462. Epub 2023 Mar 3. N Engl J Med. 2023. PMID: 36867173 Free PMC article. Clinical Trial.
In step 2, a total of 248 patients were enrolled; 127 were assigned to lithium augmentation and 121 to a switch to nortriptyline. Well-being scores improved by 3.17 points and 2.18 points, respectively (difference, 0.99; 95% CI, -1.92 to 3.91). ...Among patients in whom au …
In step 2, a total of 248 patients were enrolled; 127 were assigned to lithium augmentation and 121 to a switch to nortriptyline. Wel …
Effectiveness of Genotype-Specific Tricyclic Antidepressant Dosing in Patients With Major Depressive Disorder: A Randomized Clinical Trial.
Vos CF, Ter Hark SE, Schellekens AFA, Spijker J, van der Meij A, Grotenhuis AJ, Mihaescu R, Kievit W, Donders R, Aarnoutse RE, Coenen MJH, Janzing JGE. Vos CF, et al. JAMA Netw Open. 2023 May 1;6(5):e2312443. doi: 10.1001/jamanetworkopen.2023.12443. JAMA Netw Open. 2023. PMID: 37155164 Free PMC article. Clinical Trial.
Patients were treated with the TCAs nortriptyline, clomipramine, or imipramine, with clinical follow-up of 7 weeks. Patients were enrolled from June 1, 2018, to January 1, 2022. ...
Patients were treated with the TCAs nortriptyline, clomipramine, or imipramine, with clinical follow-up of 7 weeks. Patients were enr …
Efficacy and safety of venlafaxine versus nortriptyline for the preventive treatment of migraine: A double-blind randomized clinical trial.
Roghani M, Ghaedi G, Iranzadeh S, Golezar MH, Afshinmajd S. Roghani M, et al. Clin Neurol Neurosurg. 2024 Aug;243:108400. doi: 10.1016/j.clineuro.2024.108400. Epub 2024 Jun 17. Clin Neurol Neurosurg. 2024. PMID: 38901375 Clinical Trial.
CONCLUSIONS: Venlafaxine and nortriptyline demonstrate clinically significant and comparable therapeutic efficacy for migraine patients in reducing the intensity, frequency, and duration of headache attacks. Venlafaxine may be preferred to nortriptyline in the conte …
CONCLUSIONS: Venlafaxine and nortriptyline demonstrate clinically significant and comparable therapeutic efficacy for migraine patien …
Influence of adjuvant nortriptyline on the efficacy of electroconvulsive therapy: A randomized controlled trial and 1-year follow-up.
Pluijms EM, Kamperman AM, Hoogendijk WJG, van den Broek WW, Birkenhäger TK. Pluijms EM, et al. Acta Psychiatr Scand. 2022 May;145(5):517-528. doi: 10.1111/acps.13408. Epub 2022 Feb 18. Acta Psychiatr Scand. 2022. PMID: 35152416 Free PMC article. Clinical Trial.
In the nortriptyline group, 83% showed response, 74% attained remission, and the mean decrease in HRSD score was 21.6 points. ...In both study phases, no statistically significant differences between the nortriptyline and the placebo group were found. CONCLUSION: In …
In the nortriptyline group, 83% showed response, 74% attained remission, and the mean decrease in HRSD score was 21.6 points. ...In b …
Efficacy and safety of nortriptyline in functional dyspepsia in Asians: A randomized double-blind placebo-controlled trial.
Kaosombatwattana U, Pongprasobchai S, Limsrivilai J, Maneerattanaporn M, Leelakusolvong S, Tanwandee T. Kaosombatwattana U, et al. J Gastroenterol Hepatol. 2018 Feb;33(2):411-417. doi: 10.1111/jgh.13914. J Gastroenterol Hepatol. 2018. PMID: 28768370 Clinical Trial.
Eight and seven patients in nortriptyline and placebo groups were lost to follow up. Seven patients withdrew due to mild adverse events (nortriptyline 1 and placebo 6). Overall, 19 with nortriptyline and 20 with placebo completed the study. Patients receiving …
Eight and seven patients in nortriptyline and placebo groups were lost to follow up. Seven patients withdrew due to mild adverse even …
Clinical response and plasma concentrations of amitriptyline and its metabolite-nortriptyline in depressive patients.
Miljković B, Pokrajac M, Timotijević I, Varagić V. Miljković B, et al. Eur J Drug Metab Pharmacokinet. 1996 Jul-Sep;21(3):251-5. doi: 10.1007/BF03189722. Eur J Drug Metab Pharmacokinet. 1996. PMID: 8980924 Clinical Trial.
Although many attempts have been made, to date no convincing evidence exists of a relationship between plasma concentrations of amitriptyline (AT), its active metabolite nortriptyline (NT) and clinical response. Fifteen patients with primary depression (according to DSM-IV …
Although many attempts have been made, to date no convincing evidence exists of a relationship between plasma concentrations of amitriptylin …
Nortriptyline and gabapentin, alone and in combination for neuropathic pain: a double-blind, randomised controlled crossover trial.
Gilron I, Bailey JM, Tu D, Holden RR, Jackson AC, Houlden RL. Gilron I, et al. Lancet. 2009 Oct 10;374(9697):1252-61. doi: 10.1016/S0140-6736(09)61081-3. Epub 2009 Sep 30. Lancet. 2009. PMID: 19796802 Clinical Trial.
We assessed the efficacy and tolerability of combined nortriptyline and gabapentin compared with each drug given alone. METHODS: In this double-blind, double-dummy, crossover trial, patients with diabetic polyneuropathy or postherpetic neuralgia, and who had a daily pain s …
We assessed the efficacy and tolerability of combined nortriptyline and gabapentin compared with each drug given alone. METHODS: In t …
Nortriptyline for treating enuresis in ADHD--a randomized double-blind controlled clinical trial.
Ghanizadeh A, Haghighat R. Ghanizadeh A, et al. Pediatr Nephrol. 2012 Nov;27(11):2091-2097. doi: 10.1007/s00467-012-2211-z. Epub 2012 Jun 15. Pediatr Nephrol. 2012. PMID: 22700161 Clinical Trial.
In addition, enuresis was not different from the baseline frequency of enuresis after stopping nortriptyline or placebo administration. Both nortriptyline and placebo were tolerated well. CONCLUSIONS: Administration of nortriptyline for treating enuresis in A …
In addition, enuresis was not different from the baseline frequency of enuresis after stopping nortriptyline or placebo administratio …
A controlled trial of nortriptyline, sustained-release bupropion and placebo for smoking cessation: preliminary results.
Haggsträm FM, Chatkin JM, Sussenbach-Vaz E, Cesari DH, Fam CF, Fritscher CC. Haggsträm FM, et al. Pulm Pharmacol Ther. 2006;19(3):205-9. doi: 10.1016/j.pupt.2005.05.003. Epub 2006 Mar 6. Pulm Pharmacol Ther. 2006. PMID: 16517193 Clinical Trial.
The most common adverse events were dry mouth and drowsiness in the nortriptyline group and dry mouth and insomnia in the bupropion group. CONCLUSIONS: Treatment with CBT + bupropion resulted in a better 6-month rate of smoking cessation compared to CBT+nortriptyline
The most common adverse events were dry mouth and drowsiness in the nortriptyline group and dry mouth and insomnia in the bupropion g …
A placebo-controlled randomized clinical trial of nortriptyline for chronic low back pain.
Atkinson HJ, Slater MA, Williams RA, Zisook S, Patterson TL, Grant I, Wahlgren DR, Abramson I, Garfin SR. Atkinson HJ, et al. Pain. 1998 Jun;76(3):287-296. doi: 10.1016/S0304-3959(98)00064-5. Pain. 1998. PMID: 9718247 Clinical Trial.

The intervention consisted of inert placebo or nortriptyline titrated to within the therapeutic range for treating major depression (50-150 ng/ml). ...Also, completers with radicular pain on nortriptyline (n = 5) had significantly (P < 0.05) better analgesia and

The intervention consisted of inert placebo or nortriptyline titrated to within the therapeutic range for treating major depression ( …
585 results