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Page 1
Oseltamivir.
Tullu MS. Tullu MS. J Postgrad Med. 2009 Jul-Sep;55(3):225-30. doi: 10.4103/0022-3859.57411. J Postgrad Med. 2009. PMID: 19884755 Review.
Oseltamivir is readily absorbed from the gastrointestinal tract and is converted to the active metabolite- oseltamivir carboxylate, which has a wider distribution in the body. Oseltamivir carboxylate is eliminated in the urine with a half-life of 6-10 …
Oseltamivir is readily absorbed from the gastrointestinal tract and is converted to the active metabolite- oseltamivir carboxylate …
[Hypothermic Action of Oseltamivir Not Dependent on Its Anti-influenza Virus Action].
Ono H. Ono H. Yakugaku Zasshi. 2019;139(5):767-781. doi: 10.1248/yakushi.18-00191. Yakugaku Zasshi. 2019. PMID: 31061347 Free article. Review. Japanese.
Oseltamivir was found to target the ion channels of nicotinic acetylcholine receptors, as demonstrated by patch clamp experiments with cells expressing the human alpha3beta4 nicotinic receptor. Metabolized oseltamivir carboxylate, which inhibits the influenza virus …
Oseltamivir was found to target the ion channels of nicotinic acetylcholine receptors, as demonstrated by patch clamp experiments with cells …
Oseltamivir in seasonal, pandemic, and avian influenza: a comprehensive review of 10-years clinical experience.
Smith JR, Rayner CR, Donner B, Wollenhaupt M, Klumpp K, Dutkowski R. Smith JR, et al. Adv Ther. 2011 Nov;28(11):927-59. doi: 10.1007/s12325-011-0072-7. Epub 2011 Nov 1. Adv Ther. 2011. PMID: 22057727 Free PMC article. Review.
The article reviews the pharmacokinetics of oseltamivir and its active metabolite, oseltamivir carboxylate, including information on special populations such as children and elderly adults, and the co-administration of oseltamivir with other agents. ...The fourth ma …
The article reviews the pharmacokinetics of oseltamivir and its active metabolite, oseltamivir carboxylate, including informat …
Oseltamivir: a clinical and pharmacological perspective.
Doucette KE, Aoki FY. Doucette KE, et al. Expert Opin Pharmacother. 2001 Oct;2(10):1671-83. doi: 10.1517/14656566.2.10.1671. Expert Opin Pharmacother. 2001. PMID: 11825310 Review.
Oseltamivir is the ethyl ester prodrug of the antiviral molecule, oseltamivir carboxylate, a potent and selective inhibitor of influenza A and B neuraminidase (NA) (sialidase). It is highly bioavailable in capsule and suspension formulations and, after conversion to …
Oseltamivir is the ethyl ester prodrug of the antiviral molecule, oseltamivir carboxylate, a potent and selective inhibitor of …
Mixture toxicity of the antiviral drug Tamiflu((R)) (oseltamivir ethylester) and its active metabolite oseltamivir acid.
Escher BI, Bramaz N, Lienert J, Neuwoehner J, Straub JO. Escher BI, et al. Aquat Toxicol. 2010 Feb 18;96(3):194-202. doi: 10.1016/j.aquatox.2009.10.020. Epub 2009 Nov 1. Aquat Toxicol. 2010. PMID: 19939473
The pro-drug Tamiflu is converted in the human body to the pharmacologically active metabolite, oseltamivir acid, with a yield of 75%. Oseltamivir acid is indirectly photodegradable and slowly biodegradable in sewage works and sediment/water systems. . …
The pro-drug Tamiflu is converted in the human body to the pharmacologically active metabolite, oseltamivir acid, with a yield …
Assessment of neuropsychiatric adverse events in influenza patients treated with oseltamivir: a comprehensive review.
Toovey S, Rayner C, Prinssen E, Chu T, Donner B, Thakrar B, Dutkowski R, Hoffmann G, Breidenbach A, Lindemann L, Carey E, Boak L, Gieschke R, Sacks S, Solsky J, Small I, Reddy D. Toovey S, et al. Drug Saf. 2008;31(12):1097-114. doi: 10.2165/0002018-200831120-00006. Drug Saf. 2008. PMID: 19026027 Review.
No clinically relevant differences in plasma pharmacokinetics of oseltamivir and its active metabolite oseltamivir carboxylate were noted between Japanese and Caucasian adults or children. Penetration into the CNS of both oseltamivir and oseltamivir carbox …
No clinically relevant differences in plasma pharmacokinetics of oseltamivir and its active metabolite oseltamivir carboxylate …
Oseltamivir pharmacology in young children: a commentary.
Kamal MA. Kamal MA. Infect Disord Drug Targets. 2013 Feb;13(1):2-5. doi: 10.2174/18715265112129990002. Infect Disord Drug Targets. 2013. PMID: 23675921
The two review articles in this volume discuss the complex pharmacokinetics of oseltamivir and its active metabolite oseltamivir carboxylate from different perspectives while attempting to contrast and critique different literature views of the optimal dose in neona …
The two review articles in this volume discuss the complex pharmacokinetics of oseltamivir and its active metabolite oseltamivir c …
A part-randomized study of intravenous oseltamivir in adolescents and adults.
Várkonyi I, Chappey C, Giraudon M, Burleigh L. Várkonyi I, et al. Eur J Clin Microbiol Infect Dis. 2015 Jun;34(6):1181-8. doi: 10.1007/s10096-015-2338-5. Epub 2015 Feb 13. Eur J Clin Microbiol Infect Dis. 2015. PMID: 25678009 Clinical Trial.
Five patients died. Adequate systemic exposure to oseltamivir carboxylate (OC) was achieved at the intravenous doses tested. Oseltamivir-resistant viruses (H275Y) were detected in two patients. In seriously ill, hospitalized patients with/without renal impairment, i …
Five patients died. Adequate systemic exposure to oseltamivir carboxylate (OC) was achieved at the intravenous doses tested. O …
Effect of adenosine system in the action of oseltamivir on behavior in mice.
Uchiyama H, Hiromura M, Shiratani T, Kuroki H, Honda S, Kosako K, Soeda S, Inoue K, Toda A. Uchiyama H, et al. Neurosci Lett. 2015 Jul 10;599:7-11. doi: 10.1016/j.neulet.2015.05.014. Epub 2015 May 14. Neurosci Lett. 2015. PMID: 25980995
We have previously reported that the mechanisms underlying the effects of caffeine, a non-selective adenosine A1/A2 receptor antagonist, combined with oseltamivir. Oseltamivir is rapidly hydrolyzed to its active form (oseltamivir carboxylate, OCB). In this st …
We have previously reported that the mechanisms underlying the effects of caffeine, a non-selective adenosine A1/A2 receptor antagoni …
Oseltamivir pharmacokinetics in morbid obesity (OPTIMO trial).
Thorne-Humphrey LM, Goralski KB, Slayter KL, Hatchette TF, Johnston BL, McNeil SA; 2009 OPTIMO Study Group. Thorne-Humphrey LM, et al. J Antimicrob Chemother. 2011 Sep;66(9):2083-91. doi: 10.1093/jac/dkr257. Epub 2011 Jun 23. J Antimicrob Chemother. 2011. PMID: 21700623 Clinical Trial.
In the morbidly obese versus control subjects, respectively, the single-dose median oseltamivir carboxylate CL/F [22 (17-40) L/h versus 23 (12-33) L/h], AUC(0-) [3100 (1700-4100) ng.h/mL versus 3000 (2100-5900) ng.h/mL] and V/F [200 (130-370) L versus 260 (150-430) …
In the morbidly obese versus control subjects, respectively, the single-dose median oseltamivir carboxylate CL/F [22 (17-40) L …
48 results