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Platform for determining the inhibition profile of neuraminidase inhibitors in an influenza virus N1 background.
Hoffmann A, Schade D, Kirchmair J, Clement B, Sauerbrei A, Schmidtke M. Hoffmann A, et al. J Virol Methods. 2016 Nov;237:192-199. doi: 10.1016/j.jviromet.2016.09.014. Epub 2016 Sep 19. J Virol Methods. 2016. PMID: 27659246
Employing reverse genetics, a set of influenza virus variants containing an amino acid substitution associated with oseltamivir resistance in N1 isolates (H274Y, N294S, Y155H or Q136L) was generated. ...The profiling platform was validated with both oseltamivir …
Employing reverse genetics, a set of influenza virus variants containing an amino acid substitution associated with oseltamivir …
Impact of R152K and R368K neuraminidase catalytic substitutions on in vitro properties and virulence of recombinant A(H1N1)pdm09 viruses.
Tu V, Abed Y, Fage C, Baz M, Boivin G. Tu V, et al. Antiviral Res. 2018 Jun;154:110-115. doi: 10.1016/j.antiviral.2018.04.009. Epub 2018 Apr 16. Antiviral Res. 2018. PMID: 29674164
In NA inhibition assays, the R152K and R368K substitutions resulted in reduced inhibition [10- to 100-fold increases in IC(50) vs the wild-type (WT)] or highly reduced inhibition (>100-fold increases in IC(50)) to at least 3 approved NAIs (oseltamivir, zanamivir, perami …
In NA inhibition assays, the R152K and R368K substitutions resulted in reduced inhibition [10- to 100-fold increases in IC(50) vs the wild-t …
The I427T neuraminidase (NA) substitution, located outside the NA active site of an influenza A(H1N1)pdm09 variant with reduced susceptibility to NA inhibitors, alters NA properties and impairs viral fitness.
Tu V, Abed Y, Barbeau X, Carbonneau J, Fage C, Lagüe P, Boivin G. Tu V, et al. Antiviral Res. 2017 Jan;137:6-13. doi: 10.1016/j.antiviral.2016.11.007. Epub 2016 Nov 9. Antiviral Res. 2017. PMID: 27838351
The I427T substitution, which was responsible for the resistance phenotype observed in the double (I427T/Q313R) mutant, induced 17-, 56-, 7-, and 14-fold increases in IC(50) values against oseltamivir, zanamivir, peramivir and laninamivir, respectively. The I427T substitut …
The I427T substitution, which was responsible for the resistance phenotype observed in the double (I427T/Q313R) mutant, induced 17-, 56-, 7- …
Sequence analysis of haemagglutinin and neuraminidase of H1N1 strain from a patient coinfected with Mycobacterium tuberculosis.
Alghamdi AN, Mahfouz ME, Hamdi FA, Al Aboud D, Al-Laylah TZ, Alotaibi MI, Al-Thomali KWA, Abdel-Moneim AS. Alghamdi AN, et al. Mol Cell Probes. 2017 Aug;34:59-63. doi: 10.1016/j.mcp.2017.05.002. Epub 2017 May 9. Mol Cell Probes. 2017. PMID: 28499541
Molecular modelling and in-silico docking of the virus, and other selected strains with the drug oseltamivir were conducted and compared. Sequence analysis of the viral haemagglutinin revealed it to be closely related to the 6B.1 clade, with high identity to the circulatin …
Molecular modelling and in-silico docking of the virus, and other selected strains with the drug oseltamivir were conducted and compa …