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366 results

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Page 1
Oseltamivir.
Tullu MS. Tullu MS. J Postgrad Med. 2009 Jul-Sep;55(3):225-30. doi: 10.4103/0022-3859.57411. J Postgrad Med. 2009. PMID: 19884755 Review.
Oseltamivir is readily absorbed from the gastrointestinal tract and is converted to the active metabolite- oseltamivir carboxylate, which has a wider distribution in the body. Oseltamivir carboxylate is eliminated in the urine with a half-life of 6-10 …
Oseltamivir is readily absorbed from the gastrointestinal tract and is converted to the active metabolite- oseltamivir carboxylate …
Considerations when treating influenza infections with oseltamivir.
Gu C, Chen Y, Li H, Wang J, Liu S. Gu C, et al. Expert Opin Pharmacother. 2024 Jul;25(10):1301-1316. doi: 10.1080/14656566.2024.2376660. Epub 2024 Jul 15. Expert Opin Pharmacother. 2024. PMID: 38995220 Review.
EXPERT OPINION: Oseltamivir is an oral prodrug of oseltamivir carboxylate, an influenza A and B neuraminidase inhibitor. Recently, the therapeutic efficacy of oseltamivir has been demonstrated in several trials. ...
EXPERT OPINION: Oseltamivir is an oral prodrug of oseltamivir carboxylate, an influenza A and B neuraminidase inhibitor. Recen …
Pharmacokinetic properties of anti-influenza neuraminidase inhibitors.
Chairat K, Tarning J, White NJ, Lindegardh N. Chairat K, et al. J Clin Pharmacol. 2013 Feb;53(2):119-39. doi: 10.1177/0091270012440280. Epub 2013 Jan 24. J Clin Pharmacol. 2013. PMID: 23436258 Review.
Oseltamivir shows dose linear kinetics, and oseltamivir carboxylate has an elimination half-life (t(1/2) beta) after oral administration in healthy individuals of approximately 7.7 hours. Oseltamivir carboxylate is eliminated primarily by tubular secre …
Oseltamivir shows dose linear kinetics, and oseltamivir carboxylate has an elimination half-life (t(1/2) beta) after oral admi …
Oseltamivir: a first line defense against swine flu.
Agrawal R, Rewatkar PV, Kokil GR, Verma A, Kalra A. Agrawal R, et al. Med Chem. 2010 Jul;6(4):247-51. doi: 10.2174/1573406411006040247. Med Chem. 2010. PMID: 20843284 Review.
Oseltamivir (has known by its brand name 'Tamiflu') is a prodrug, requiring ester hydrolysis for conversion to the active form, Oseltamivir carboxylate. Oseltamivir was the first orally active neuraminidase inhibitor commercially developed by US based Gilead Science …
Oseltamivir (has known by its brand name 'Tamiflu') is a prodrug, requiring ester hydrolysis for conversion to the active form, Oseltamiv …
Antivirals for the treatment and prevention of epidemic and pandemic influenza.
Oxford JS. Oxford JS. Influenza Other Respir Viruses. 2007 Jan;1(1):27-34. doi: 10.1111/j.1750-2659.2006.00006.x. Influenza Other Respir Viruses. 2007. PMID: 19453477 Free PMC article. Review.
Oseltamivir, the most widely used NI, is administered orally as a prodrug (oseltamivir carboxylate) and systemically distributed to all potential infection sites. Zanamivir, a second NI, is administered by inhalation via a disk inhaler and deposited primarily in the …
Oseltamivir, the most widely used NI, is administered orally as a prodrug (oseltamivir carboxylate) and systemically distribut …
[Hypothermic Action of Oseltamivir Not Dependent on Its Anti-influenza Virus Action].
Ono H. Ono H. Yakugaku Zasshi. 2019;139(5):767-781. doi: 10.1248/yakushi.18-00191. Yakugaku Zasshi. 2019. PMID: 31061347 Free article. Review. Japanese.
Oseltamivir was found to target the ion channels of nicotinic acetylcholine receptors, as demonstrated by patch clamp experiments with cells expressing the human alpha3beta4 nicotinic receptor. Metabolized oseltamivir carboxylate, which inhibits the influenza virus …
Oseltamivir was found to target the ion channels of nicotinic acetylcholine receptors, as demonstrated by patch clamp experiments with cells …
Oseltamivir: a review of its use in influenza.
McClellan K, Perry CM. McClellan K, et al. Drugs. 2001;61(2):263-83. doi: 10.2165/00003495-200161020-00011. Drugs. 2001. PMID: 11270942 Review.
Oseltamivir is a prodrug of oseltamivir carboxylate (Ro 64-0802, GS4071), a potent and selective inhibitor of the neuraminidase glycoprotein essential for replication of influenza A and B viruses. ...
Oseltamivir is a prodrug of oseltamivir carboxylate (Ro 64-0802, GS4071), a potent and selective inhibitor of the neuraminidas …
Oseltamivir: a clinical and pharmacological perspective.
Doucette KE, Aoki FY. Doucette KE, et al. Expert Opin Pharmacother. 2001 Oct;2(10):1671-83. doi: 10.1517/14656566.2.10.1671. Expert Opin Pharmacother. 2001. PMID: 11825310 Review.
Oseltamivir is the ethyl ester prodrug of the antiviral molecule, oseltamivir carboxylate, a potent and selective inhibitor of influenza A and B neuraminidase (NA) (sialidase). It is highly bioavailable in capsule and suspension formulations and, after conversion to …
Oseltamivir is the ethyl ester prodrug of the antiviral molecule, oseltamivir carboxylate, a potent and selective inhibitor of …
Edible bird's nest: N- and O-glycan analysis and synergistic anti-avian influenza virus activity with neuraminidase inhibitors.
Sriwilaijaroen N, Hanamatsu H, Yokota I, Nishikaze T, Ijichi T, Takahashi T, Sakoda Y, Furukawa JI, Suzuki Y. Sriwilaijaroen N, et al. Antiviral Res. 2024 Dec;232:106040. doi: 10.1016/j.antiviral.2024.106040. Epub 2024 Nov 20. Antiviral Res. 2024. PMID: 39577572
Isobologram analysis revealed that the treated EBN had a strong synergistic effect with either oseltamivir carboxylate or zanamivir, a competitive inhibitor of receptor-destroying neuraminidases (NAs), against the avian H5N1 virus. ...
Isobologram analysis revealed that the treated EBN had a strong synergistic effect with either oseltamivir carboxylate or zana …
A phase I, single-center, randomized, open-label, three-period crossover study to evaluate the drug-drug interaction between ZSP1273 and oseltamivir in healthy Chinese subjects.
Pang Y, Li H, Chen X, Cao Y, Jiang H, Huang J, Liu Y. Pang Y, et al. Antimicrob Agents Chemother. 2025 Apr 2;69(4):e0172924. doi: 10.1128/aac.01729-24. Epub 2025 Feb 24. Antimicrob Agents Chemother. 2025. PMID: 39992105 Free PMC article. Clinical Trial.
The pharmacokinetic parameters above of oseltamivir carboxylate remained within 80%-125%, except only the lower bound of the 90% CI for C(max,ss) slightly below 80% (77.0%). Considering the rapid metabolism of oseltamivir into the active metabolite oseltamivir …
The pharmacokinetic parameters above of oseltamivir carboxylate remained within 80%-125%, except only the lower bound of the 9 …
366 results