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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1965 4
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1972 21
1973 21
1974 16
1975 25
1976 18
1977 20
1978 20
1979 11
1980 13
1981 16
1982 15
1983 17
1984 13
1985 10
1986 23
1987 12
1988 21
1989 14
1990 9
1991 16
1992 8
1993 19
1994 14
1995 15
1996 27
1997 14
1998 18
1999 20
2000 15
2001 5
2002 14
2003 14
2004 12
2005 15
2006 13
2007 11
2008 9
2009 7
2010 11
2011 10
2012 10
2013 14
2014 5
2015 13
2016 14
2017 7
2018 5
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788 results

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Page 1
Levetiracetam Versus Phenobarbital for Neonatal Seizures: A Randomized Controlled Trial.
Sharpe C, Reiner GE, Davis SL, Nespeca M, Gold JJ, Rasmussen M, Kuperman R, Harbert MJ, Michelson D, Joe P, Wang S, Rismanchi N, Le NM, Mower A, Kim J, Battin MR, Lane B, Honold J, Knodel E, Arnell K, Bridge R, Lee L, Ernstrom K, Raman R, Haas RH; NEOLEV2 INVESTIGATORS. Sharpe C, et al. Pediatrics. 2020 Jun;145(6):e20193182. doi: 10.1542/peds.2019-3182. Epub 2020 May 8. Pediatrics. 2020. PMID: 32385134 Free PMC article. Clinical Trial.
Our objectives were to study the efficacy and safety of levetiracetam compared with phenobarbital as a first-line treatment of neonatal seizures. METHODS: The study was a multicenter, randomized, blinded, controlled, phase IIb trial investigating the efficacy and safety of …
Our objectives were to study the efficacy and safety of levetiracetam compared with phenobarbital as a first-line treatment of neonat …
Phenobarbital for acute alcohol withdrawal: a prospective randomized double-blind placebo-controlled study.
Rosenson J, Clements C, Simon B, Vieaux J, Graffman S, Vahidnia F, Cisse B, Lam J, Alter H. Rosenson J, et al. J Emerg Med. 2013 Mar;44(3):592-598.e2. doi: 10.1016/j.jemermed.2012.07.056. Epub 2012 Sep 19. J Emerg Med. 2013. PMID: 22999778 Clinical Trial.
Patients that received phenobarbital had fewer ICU admissions (8% vs. 25%, 95% confidence interval 4-32). There were no differences in adverse events. CONCLUSIONS: A single dose of i.v. phenobarbital combined with a symptom-guided lorazepam-based alcohol withdrawal …
Patients that received phenobarbital had fewer ICU admissions (8% vs. 25%, 95% confidence interval 4-32). There were no differences i …
A prospective, randomized, trial of phenobarbital versus benzodiazepines for acute alcohol withdrawal.
Hendey GW, Dery RA, Barnes RL, Snowden B, Mentler P. Hendey GW, et al. Am J Emerg Med. 2011 May;29(4):382-5. doi: 10.1016/j.ajem.2009.10.010. Epub 2010 Mar 25. Am J Emerg Med. 2011. PMID: 20825805 Clinical Trial.
OBJECTIVE: The aim of this study was to compare phenobarbital (PB) versus lorazepam (LZ) in the treatment of alcohol withdrawal in the emergency department (ED) and at 48 hours. ...There were no differences between PB and LZ in baseline CIWA scores (P = .3), discharge scor …
OBJECTIVE: The aim of this study was to compare phenobarbital (PB) versus lorazepam (LZ) in the treatment of alcohol withdrawal in th …
A comparison of four treatments for generalized convulsive status epilepticus. Veterans Affairs Status Epilepticus Cooperative Study Group.
Treiman DM, Meyers PD, Walton NY, Collins JF, Colling C, Rowan AJ, Handforth A, Faught E, Calabrese VP, Uthman BM, Ramsay RE, Mamdani MB. Treiman DM, et al. N Engl J Med. 1998 Sep 17;339(12):792-8. doi: 10.1056/NEJM199809173391202. N Engl J Med. 1998. PMID: 9738086 Free article. Clinical Trial.
In this group, lorazepam was successful in 64.9 percent of those assigned to receive it, phenobarbital in 58.2 percent, diazepam plus phenytoin in 55.8 percent, and phenytoin in 43.6 percent (P=0.02 for the overall comparison among the four groups). ...Although lorazepam i …
In this group, lorazepam was successful in 64.9 percent of those assigned to receive it, phenobarbital in 58.2 percent, diazepam plus …
Phenobarbital--valporic acid interaction.
Patel IH, Levy RH, Cutler RE. Patel IH, et al. Clin Pharmacol Ther. 1980 Apr;27(4):515-21. doi: 10.1038/clpt.1980.72. Clin Pharmacol Ther. 1980. PMID: 6766833 Clinical Trial.
In one treatment subjects received a 60-mg dose of phenobarbital orally. In the other, subjects received 250 mg valproic acid orally twice daily for 14 consecutive days and a 60-mg dose of phenobarbital orally on day 4. ...The findings indicate that valproic acid in …
In one treatment subjects received a 60-mg dose of phenobarbital orally. In the other, subjects received 250 mg valproic acid orally …
Phenobarbital and propranolol in essential tremor: a double-blind controlled clinical trial.
Baruzzi A, Procaccianti G, Martinelli P, Riva R, Denoth F, Montanaro N, Lugaresi E. Baruzzi A, et al. Neurology. 1983 Mar;33(3):296-300. doi: 10.1212/wnl.33.3.296. Neurology. 1983. PMID: 6338416 Clinical Trial.
In a double-blind study with Latin square design, phenobarbital (about 1.3 mg per kilogram), propranolol (about 1.7 mg per kilogram), and placebo were given orally for 1 month to 12 patients with essential tremor. ...Patients' subjective evaluation and tremor amplitude mea …
In a double-blind study with Latin square design, phenobarbital (about 1.3 mg per kilogram), propranolol (about 1.7 mg per kilogram), …
A Randomized Controlled Trial of Phenobarbital and Levetiracetam in Childhood Epilepsy.
Akter N, Rahman MM, Akhter S, Fatema K. Akter N, et al. Mymensingh Med J. 2018 Oct;27(4):776-784. Mymensingh Med J. 2018. PMID: 30487494 Clinical Trial.
The children were followed up for 12 months at 3 months interval to compare the seizure remission and side effects of Levetiracetam and Phenobarbital. The children in levetiracetam group was about 10 months older along with older age of onset of seizure (p=0.02) than those …
The children were followed up for 12 months at 3 months interval to compare the seizure remission and side effects of Levetiracetam and P …
Clinical efficacy of phenobarbital combined with ursodeoxycholic acid in the treatment of neonatal patients with cholestasis.
Jiang L, Jiang Q, Yang C. Jiang L, et al. Arab J Gastroenterol. 2025 May;26(2):195-200. doi: 10.1016/j.ajg.2024.12.005. Epub 2025 May 15. Arab J Gastroenterol. 2025. PMID: 40374485 Free article. Clinical Trial.
BACKGROUND AND STUDY AIMS: The aim of this study was to explore and evaluate the clinical effect of phenobarbital combined with ursodeoxycholic acid in the treatment of neonatal cholestasis. ...The PB group was given routine treatment and phenobarbital, and the comb …
BACKGROUND AND STUDY AIMS: The aim of this study was to explore and evaluate the clinical effect of phenobarbital combined with ursod …
Long-term follow-up of phenobarbital versus valproate for generalized convulsive status epilepticus in adults: A randomized clinical trial.
Liu G, Wang Y, Tian F, Jiang M, Huang H, Chen W, Zhang Y, Su Y. Liu G, et al. Epilepsy Res. 2023 Sep;195:107187. doi: 10.1016/j.eplepsyres.2023.107187. Epub 2023 Jul 8. Epilepsy Res. 2023. PMID: 37467704 Free article. Clinical Trial.
Mild cognitive impairment was found in 7.14% of phenobarbital group and 50.0% in valproate group (P = 0.026). In addition, there were no significant differences with respect to anxiety (36.36% vs. 38.10%) and depression (31.82% vs. 47.62%) between the phenobarbital …
Mild cognitive impairment was found in 7.14% of phenobarbital group and 50.0% in valproate group (P = 0.026). In addition, there were …
Pharmacokinetics and clinical effect of phenobarbital in children with severe falciparum malaria and convulsions.
Kokwaro GO, Ogutu BR, Muchohi SN, Otieno GO, Newton CR. Kokwaro GO, et al. Br J Clin Pharmacol. 2003 Oct;56(4):453-7. doi: 10.1046/j.1365-2125.2003.01951.x. Br J Clin Pharmacol. 2003. PMID: 12968992 Free PMC article. Clinical Trial.
We evaluated a 15-mg kg(-1) intravenous (i.v.) dose of phenobarbital to determine its pharmacokinetics and clinical effects in children with severe falciparum malaria and status epilepticus. METHODS: Twelve children (M/F: 11/1), aged 7-62 months, received a loading dose of …
We evaluated a 15-mg kg(-1) intravenous (i.v.) dose of phenobarbital to determine its pharmacokinetics and clinical effects in childr …
788 results