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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1947 1
1953 1
1954 1
1955 1
1956 3
1957 2
1958 8
1959 1
1960 1
1964 2
1966 1
1968 1
1970 1
1972 1
1975 4
1977 1
1979 2
1980 3
1981 6
1982 5
1983 7
1984 4
1985 7
1986 10
1987 6
1988 9
1989 7
1990 6
1991 12
1992 8
1993 6
1994 8
1995 7
1996 9
1997 8
1998 17
1999 11
2000 10
2001 17
2002 12
2003 21
2004 28
2005 20
2006 35
2007 46
2008 23
2009 48
2010 39
2011 56
2012 56
2013 74
2014 77
2015 102
2016 110
2017 108
2018 91
2019 121
2020 115
2021 98
2022 115
2023 114
2024 96
2025 119
2026 78

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1,807 results

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Page 1
Alpha-1 antitrypsin deficiency.
Primhak RA, Tanner MS. Primhak RA, et al. Arch Dis Child. 2001 Jul;85(1):2-5. doi: 10.1136/adc.85.1.2. Arch Dis Child. 2001. PMID: 11420185 Free PMC article. Review. No abstract available.
Impact of tauroursodeoxycholic acid and 4-phenylbutyric acid on mitochondrial functions and morphology of SH-SY5Y cells.
Liskova M, Evinova A, Guzikova J, Hudak L, Pokusa M, Kotulova L, Racay P. Liskova M, et al. Gen Physiol Biophys. 2025 Jul;44(4):275-287. doi: 10.4149/gpb_2025017. Gen Physiol Biophys. 2025. PMID: 40567071
The aim of our work was to study impact of tauroursodeoxycholic acid (TUDCA), 4-phenylbutyric acid (PBA) and their combination on mitochondrial functions and morphology. ...
The aim of our work was to study impact of tauroursodeoxycholic acid (TUDCA), 4-phenylbutyric acid (PBA) and their comb …
The therapeutic effects of 4-phenylbutyric acid in maintaining proteostasis.
Kolb PS, Ayaub EA, Zhou W, Yum V, Dickhout JG, Ask K. Kolb PS, et al. Int J Biochem Cell Biol. 2015 Apr;61:45-52. doi: 10.1016/j.biocel.2015.01.015. Epub 2015 Feb 7. Int J Biochem Cell Biol. 2015. PMID: 25660369 Review.
Recently, there has been an increasing amount of literature published on the effects of 4-phenylbutyric acid (4-PBA) in various biological systems. 4-PBA is currently used clinically to treat urea cycle disorders under the trade name Buphenyl. ...
Recently, there has been an increasing amount of literature published on the effects of 4-phenylbutyric acid (4- …
Monocytes Reprogrammed by 4-PBA Potently Contribute to the Resolution of Inflammation and Atherosclerosis.
Geng S, Lu R, Zhang Y, Wu Y, Xie L, Caldwell BA, Pradhan K, Yi Z, Hou J, Xu F, Chen X, Li L. Geng S, et al. Circ Res. 2024 Sep 27;135(8):856-872. doi: 10.1161/CIRCRESAHA.124.325023. Epub 2024 Sep 3. Circ Res. 2024. PMID: 39224974 Free PMC article.
However, approaches that can effectively resolve chronic low-grade inflammation targeting monocytes are not readily available. The small chemical compound 4-phenylbutyric acid (4-PBA) exhibits broad anti-inflammatory effects in reducing atherosclerosis …
However, approaches that can effectively resolve chronic low-grade inflammation targeting monocytes are not readily available. The small che …
Lipid-regulating properties of butyric acid and 4-phenylbutyric acid: Molecular mechanisms and therapeutic applications.
He B, Moreau R. He B, et al. Pharmacol Res. 2019 Jun;144:116-131. doi: 10.1016/j.phrs.2019.04.002. Epub 2019 Apr 5. Pharmacol Res. 2019. PMID: 30954630 Review.
In particular, butyric acid (BA) and its derivative, 4-phenylbutyric acid (PBA), which afford health benefits against lipid disorders while being generally well tolerated by animals and humans have been assessed clinically. ...
In particular, butyric acid (BA) and its derivative, 4-phenylbutyric acid (PBA), which afford health benefits against l …
4-Phenylbutyric Acid Improves Gait Ability of UBAP1-Related Spastic Paraplegia Mouse Model: Therapeutic Potential for SPG80.
Shimozono K, Kim YJ, Hata T, Nan H, Saito K, Mori Y, Ueno Y, Isono F, Iwasaki M, Koizumi S, Ohtsuka T, Takiyama Y. Shimozono K, et al. Int J Mol Sci. 2025 Oct 8;26(19):9779. doi: 10.3390/ijms26199779. Int J Mol Sci. 2025. PMID: 41097044 Free PMC article.
In the present study, we evaluated the therapeutic potential of 4-phenylbutyric acid (4-PBA), a chemical chaperone and histone deacetylase inhibitor, in Ubap1 knock-in (KI) mice expressing a disease-associated truncated UBAP1 variant. ...
In the present study, we evaluated the therapeutic potential of 4-phenylbutyric acid (4-PBA), a chemical chapero …
Effects of Tauroursodeoxycholic Acid and 4-Phenylbutyric Acid on Selenium Distribution in Mice Model with Type 1 Diabetes.
Xing D, Zhou Q, Wang Y, Xu J. Xing D, et al. Biol Trace Elem Res. 2023 Mar;201(3):1205-1213. doi: 10.1007/s12011-022-03193-8. Epub 2022 Mar 18. Biol Trace Elem Res. 2023. PMID: 35303254 Free PMC article.
As pharmaceutical chaperones, tauroursodeoxycholic acid (TUDCA) and 4-phenylbutyric acid (4-PBA) can effectively improve the oxidative stress of the endoplasmic reticulum. ...
As pharmaceutical chaperones, tauroursodeoxycholic acid (TUDCA) and 4-phenylbutyric acid (4-PBA) can effectively …
Sodium Phenylbutyrate and Taurursodiol.
[No authors listed] [No authors listed] Am J Health Syst Pharm. 2023 Mar 7;80(6):316-318. doi: 10.1093/ajhp/zxac363. Am J Health Syst Pharm. 2023. PMID: 36645072 No abstract available.
1,807 results