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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1966 7
1967 12
1968 11
1969 16
1970 8
1971 11
1972 15
1973 16
1974 19
1975 22
1976 15
1977 13
1978 17
1979 12
1980 11
1981 13
1982 9
1983 19
1984 18
1985 12
1986 12
1987 17
1988 10
1989 25
1990 13
1991 33
1992 21
1993 24
1994 31
1995 33
1996 36
1997 29
1998 28
1999 44
2000 25
2001 19
2002 30
2003 19
2004 19
2005 20
2006 18
2007 13
2008 14
2009 11
2010 11
2011 12
2012 13
2013 21
2014 6
2015 15
2016 14
2017 10
2018 12
2019 12
2020 12
2021 6
2022 3
2023 4
2024 5
2025 3
2026 2

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951 results

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Page 1
Phenytoin revisited.
Finkel MJ. Finkel MJ. Clin Ther. 1984;6(5):577-91. Clin Ther. 1984. PMID: 6383610 Review.
Phenytoin has a wide range of pharmacologic effects other than its anticonvulsant activity. ...Based on phenytoin's pharmacologic effects in animals, controlled trials of the drug appear to be warranted in cerebral ischemia and stroke, spinal cord injury, ang …
Phenytoin has a wide range of pharmacologic effects other than its anticonvulsant activity. ...Based on phenytoin's pha …
Levetiracetam as an alternative to phenytoin for second-line emergency treatment of children with convulsive status epilepticus: the EcLiPSE RCT.
Appleton RE, Rainford NE, Gamble C, Messahel S, Humphreys A, Hickey H, Woolfall K, Roper L, Noblet J, Lee E, Potter S, Tate P, Al Najjar N, Iyer A, Evans V, Lyttle MD. Appleton RE, et al. Health Technol Assess. 2020 Nov;24(58):1-96. doi: 10.3310/hta24580. Health Technol Assess. 2020. PMID: 33190679 Free PMC article. Clinical Trial.
It seems to have less serious side effects than phenytoin. However, there is no good scientific evidence as to whether phenytoin or levetiracetam is better. ...The Emergency treatment with Levetiracetam or Phenytoin in Status Epilepticus in children (EcLiPSE) …
It seems to have less serious side effects than phenytoin. However, there is no good scientific evidence as to whether phenytoin …
Efficacy and safety of phenytoin and levetiracetam for acute symptomatic seizures in children with acute encephalitis syndrome: an open label, randomised controlled trial.
Sharawat IK DM, Murugan VK MD, Bhardwaj S MD, Tomar A DM, Tiwari L MD, Dhamija P DM, Panda PK DM. Sharawat IK DM, et al. Seizure. 2024 May;118:110-116. doi: 10.1016/j.seizure.2024.04.015. Epub 2024 Apr 18. Seizure. 2024. PMID: 38678766 Free article. Clinical Trial.
Within the first week, 5 and 3 children in the phenytoin and levetiracetam groups expired. Up to 1 week or death (whichever occurred earliest), 46 (92 %) and 44 (88 %) children remained seizure-free. ...However, the incidence of treatment-emergent adverse events (TEAEs) ca …
Within the first week, 5 and 3 children in the phenytoin and levetiracetam groups expired. Up to 1 week or death (whichever occurred …
Phenytoin auto-induction.
Chetty M, Miller R, Seymour MA. Chetty M, et al. Ther Drug Monit. 1998 Feb;20(1):60-2. doi: 10.1097/00007691-199802000-00011. Ther Drug Monit. 1998. PMID: 9485556 Clinical Trial.
Information regarding phenytoin auto-induction is sparse and conflicting. However, confirmation of the presence or absence of auto-induction by phenytoin could have important implications in phenytoin therapy and research. ...This decrease in AUC after the th …
Information regarding phenytoin auto-induction is sparse and conflicting. However, confirmation of the presence or absence of auto-in …
Evaluation and comparison of the efficacy and safety of the combination of topical phenytoin and microneedling with microneedling alone in the treatment of atrophic acne scars: A controlled blinded randomized clinical trial.
Sadeghzadeh-Bazargan A, Pashaei A, Ghassemi M, Dehghani A, Shafiei M, Goodarzi A. Sadeghzadeh-Bazargan A, et al. Skin Res Technol. 2024 Jun;30(6):e13766. doi: 10.1111/srt.13766. Skin Res Technol. 2024. Retraction in: Skin Res Technol. 2025 Sep;31(9):e70225. doi: 10.1111/srt.70225. PMID: 38807440 Free PMC article. Retracted. Clinical Trial.
On the other side, a 1% phenytoin cream was administered three times daily for 1 week following the microneedling procedure. ...On the other hand, when it comes to acne scar grade and patients' satisfaction, the phenytoin group outperformed the control group in all …
On the other side, a 1% phenytoin cream was administered three times daily for 1 week following the microneedling procedure. ...On th …
Phenytoin prodrug: preclinical and clinical studies.
Leppik IE, Boucher R, Wilder BJ, Murthy VS, Rask CA, Watridge C, Graves NM, Rangel RJ, Turlapaty P. Leppik IE, et al. Epilepsia. 1989;30 Suppl 2:S22-6. doi: 10.1111/j.1528-1157.1989.tb05821.x. Epilepsia. 1989. PMID: 2670535 Clinical Trial.
The currently available phenytoin (PHT) solution has many disadvantages stemming from poor aqueous solubility of PHT. ...
The currently available phenytoin (PHT) solution has many disadvantages stemming from poor aqueous solubility of PHT. ...
Carbamazepine vs phenytoin. A controlled clinical trial in focal motor and generalized epilepsy.
Kosteljanetz M, Christiansen J, Dam AM, Hansen BS, Lyon BB, Pedersen H, Dam M. Kosteljanetz M, et al. Arch Neurol. 1979 Jan;36(1):22-4. doi: 10.1001/archneur.1979.00500370052010. Arch Neurol. 1979. PMID: 105689 Clinical Trial.
The antiepileptic effects of carbamazepine and phenytoin were compared in a double-blind crossover trial studying patients with primary and secondary generalized seizures and partial seizures with motor symptoms. ...No statistically significant differences were found betwe …
The antiepileptic effects of carbamazepine and phenytoin were compared in a double-blind crossover trial studying patients with prima …
Comparison of Phenytoin, Valproate and Levetiracetam in Pediatric Convulsive Status Epilepticus: A Randomized Double-blind Controlled Clinical Trial.
Vignesh V, Rameshkumar R, Mahadevan S. Vignesh V, et al. Indian Pediatr. 2020 Mar 15;57(3):222-227. Indian Pediatr. 2020. PMID: 32198861 Free article. Clinical Trial.
OBJECTIVE: To compare the efficacy of phenytoin, valproate, and levetiracetam in the management of pediatric convulsive status epilepticus. ...CONCLUSIONS: Phenytoin, valproate, and levetiracetam were equally effective in controlling pediatric convulsive status epil …
OBJECTIVE: To compare the efficacy of phenytoin, valproate, and levetiracetam in the management of pediatric convulsive status epilep …
Fosphenytoin. Pharmacoeconomic implications of therapy.
Holliday SM, Benfield P, Plosker GL. Holliday SM, et al. Pharmacoeconomics. 1998 Dec;14(6):685-90. doi: 10.2165/00019053-199814060-00008. Pharmacoeconomics. 1998. PMID: 10346419 Review.
Lower potential for local tissue and cardiac toxicity than phenytoin. Associated with less pain and phlebitis at the injection site, fewer reductions in infusion rate and fewer changes of administration site because of injection site complications than phenytoin. .. …
Lower potential for local tissue and cardiac toxicity than phenytoin. Associated with less pain and phlebitis at the injection site, …
Comparative double blind clinical trial of phenytoin and sodium valproate as anticonvulsant prophylaxis after craniotomy: efficacy, tolerability, and cognitive effects.
Beenen LF, Lindeboom J, Kasteleijn-Nolst Trenité DG, Heimans JJ, Snoek FJ, Touw DJ, Adèr HJ, van Alphen HA. Beenen LF, et al. J Neurol Neurosurg Psychiatry. 1999 Oct;67(4):474-80. doi: 10.1136/jnnp.67.4.474. J Neurol Neurosurg Psychiatry. 1999. PMID: 10486394 Free PMC article. Clinical Trial.
OBJECTIVE: To determine the efficacy, tolerability, and impact on quality of life and cognitive functioning of anticonvulsant prophylaxis with phenytoin or sodium valproate in patients after craniotomy. METHODS: A prospective, stratified, randomised, double blind single ce …
OBJECTIVE: To determine the efficacy, tolerability, and impact on quality of life and cognitive functioning of anticonvulsant prophylaxis wi …
951 results