Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

Filters

My Custom Filters

Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1966 7
1967 12
1968 11
1969 16
1970 8
1971 11
1972 15
1973 16
1974 19
1975 22
1976 15
1977 13
1978 17
1979 12
1980 11
1981 13
1982 9
1983 19
1984 18
1985 12
1986 12
1987 17
1988 10
1989 25
1990 13
1991 33
1992 21
1993 24
1994 31
1995 33
1996 36
1997 29
1998 28
1999 44
2000 25
2001 19
2002 30
2003 19
2004 19
2005 20
2006 18
2007 13
2008 14
2009 11
2010 11
2011 12
2012 13
2013 21
2014 6
2015 15
2016 14
2017 10
2018 12
2019 13
2020 12
2021 7
2022 3
2023 4
2024 5
2025 1

Publication date

Text availability

Article attribute

Article type

Additional filters

Article Language

Species

Sex

Age

Other

Search Results

948 results

Results by year

Filters applied: . Clear all
Page 1
Randomized Trial of Three Anticonvulsant Medications for Status Epilepticus.
Kapur J, Elm J, Chamberlain JM, Barsan W, Cloyd J, Lowenstein D, Shinnar S, Conwit R, Meinzer C, Cock H, Fountain N, Connor JT, Silbergleit R; NETT and PECARN Investigators. Kapur J, et al. N Engl J Med. 2019 Nov 28;381(22):2103-2113. doi: 10.1056/NEJMoa1905795. N Engl J Med. 2019. PMID: 31774955 Free PMC article. Clinical Trial.
Efficacy of levetiracetam, fosphenytoin, and valproate for established status epilepticus by age group (ESETT): a double-blind, responsive-adaptive, randomised controlled trial.
Chamberlain JM, Kapur J, Shinnar S, Elm J, Holsti M, Babcock L, Rogers A, Barsan W, Cloyd J, Lowenstein D, Bleck TP, Conwit R, Meinzer C, Cock H, Fountain NB, Underwood E, Connor JT, Silbergleit R; Neurological Emergencies Treatment Trials; Pediatric Emergency Care Applied Research Network investigators. Chamberlain JM, et al. Lancet. 2020 Apr 11;395(10231):1217-1224. doi: 10.1016/S0140-6736(20)30611-5. Epub 2020 Mar 20. Lancet. 2020. PMID: 32203691 Free PMC article. Clinical Trial.
Evaluation and comparison of the efficacy and safety of the combination of topical phenytoin and microneedling with microneedling alone in the treatment of atrophic acne scars: A controlled blinded randomized clinical trial.
Sadeghzadeh-Bazargan A, Pashaei A, Ghassemi M, Dehghani A, Shafiei M, Goodarzi A. Sadeghzadeh-Bazargan A, et al. Skin Res Technol. 2024 Jun;30(6):e13766. doi: 10.1111/srt.13766. Skin Res Technol. 2024. PMID: 38807440 Free PMC article. Clinical Trial.
On the other side, a 1% phenytoin cream was administered three times daily for 1 week following the microneedling procedure. ...On the other hand, when it comes to acne scar grade and patients' satisfaction, the phenytoin group outperformed the control group in all …
On the other side, a 1% phenytoin cream was administered three times daily for 1 week following the microneedling procedure. ...On th …
A comparison of four treatments for generalized convulsive status epilepticus. Veterans Affairs Status Epilepticus Cooperative Study Group.
Treiman DM, Meyers PD, Walton NY, Collins JF, Colling C, Rowan AJ, Handforth A, Faught E, Calabrese VP, Uthman BM, Ramsay RE, Mamdani MB. Treiman DM, et al. N Engl J Med. 1998 Sep 17;339(12):792-8. doi: 10.1056/NEJM199809173391202. N Engl J Med. 1998. PMID: 9738086 Free article. Clinical Trial.
In this group, lorazepam was successful in 64.9 percent of those assigned to receive it, phenobarbital in 58.2 percent, diazepam plus phenytoin in 55.8 percent, and phenytoin in 43.6 percent (P=0.02 for the overall comparison among the four groups). ...CONCLUSIONS: …
In this group, lorazepam was successful in 64.9 percent of those assigned to receive it, phenobarbital in 58.2 percent, diazepam plus phe …
Levetiracetam versus phenytoin for second-line treatment of paediatric convulsive status epilepticus (EcLiPSE): a multicentre, open-label, randomised trial.
Lyttle MD, Rainford NEA, Gamble C, Messahel S, Humphreys A, Hickey H, Woolfall K, Roper L, Noblet J, Lee ED, Potter S, Tate P, Iyer A, Evans V, Appleton RE; Paediatric Emergency Research in the United Kingdom & Ireland (PERUKI) collaborative. Lyttle MD, et al. Lancet. 2019 May 25;393(10186):2125-2134. doi: 10.1016/S0140-6736(19)30724-X. Epub 2019 Apr 17. Lancet. 2019. PMID: 31005385 Free PMC article. Clinical Trial.
This trial compared the efficacy and safety of phenytoin and levetiracetam for second-line management of paediatric convulsive status epilepticus. ...After exclusion of those who did not require second-line treatment and those who did not consent, 286 randomised participan …
This trial compared the efficacy and safety of phenytoin and levetiracetam for second-line management of paediatric convulsive status …
Phenytoin revisited.
Finkel MJ. Finkel MJ. Clin Ther. 1984;6(5):577-91. Clin Ther. 1984. PMID: 6383610 Review.
Phenytoin has a wide range of pharmacologic effects other than its anticonvulsant activity. ...Based on phenytoin's pharmacologic effects in animals, controlled trials of the drug appear to be warranted in cerebral ischemia and stroke, spinal cord injury, ang …
Phenytoin has a wide range of pharmacologic effects other than its anticonvulsant activity. ...Based on phenytoin's pha …
Phenytoin auto-induction.
Chetty M, Miller R, Seymour MA. Chetty M, et al. Ther Drug Monit. 1998 Feb;20(1):60-2. doi: 10.1097/00007691-199802000-00011. Ther Drug Monit. 1998. PMID: 9485556 Clinical Trial.
Information regarding phenytoin auto-induction is sparse and conflicting. However, confirmation of the presence or absence of auto-induction by phenytoin could have important implications in phenytoin therapy and research. ...This decrease in AUC after the th …
Information regarding phenytoin auto-induction is sparse and conflicting. However, confirmation of the presence or absence of auto-in …
Levetiracetam as an alternative to phenytoin for second-line emergency treatment of children with convulsive status epilepticus: the EcLiPSE RCT.
Appleton RE, Rainford NE, Gamble C, Messahel S, Humphreys A, Hickey H, Woolfall K, Roper L, Noblet J, Lee E, Potter S, Tate P, Al Najjar N, Iyer A, Evans V, Lyttle MD. Appleton RE, et al. Health Technol Assess. 2020 Nov;24(58):1-96. doi: 10.3310/hta24580. Health Technol Assess. 2020. PMID: 33190679 Free PMC article. Clinical Trial.
It seems to have less serious side effects than phenytoin. However, there is no good scientific evidence as to whether phenytoin or levetiracetam is better. ...The Emergency treatment with Levetiracetam or Phenytoin in Status Epilepticus in children (EcLiPSE) …
It seems to have less serious side effects than phenytoin. However, there is no good scientific evidence as to whether phenytoin …
Efficacy and safety of phenytoin and levetiracetam for acute symptomatic seizures in children with acute encephalitis syndrome: an open label, randomised controlled trial.
Sharawat IK DM, Murugan VK MD, Bhardwaj S MD, Tomar A DM, Tiwari L MD, Dhamija P DM, Panda PK DM. Sharawat IK DM, et al. Seizure. 2024 May;118:110-116. doi: 10.1016/j.seizure.2024.04.015. Epub 2024 Apr 18. Seizure. 2024. PMID: 38678766 Free article. Clinical Trial.
Within the first week, 5 and 3 children in the phenytoin and levetiracetam groups expired. Up to 1 week or death (whichever occurred earliest), 46 (92 %) and 44 (88 %) children remained seizure-free. ...However, the incidence of treatment-emergent adverse events (TEAEs) ca …
Within the first week, 5 and 3 children in the phenytoin and levetiracetam groups expired. Up to 1 week or death (whichever occurred …
Levetiracetam versus fosphenytoin as a second-line treatment after diazepam for adult convulsive status epilepticus: a multicentre non-inferiority randomised control trial.
Nakamura K, Marushima A, Takahashi Y, Mochizuki M, Kimura A, Fukuda Y, Asami M, Nakamoto H, Egawa S, Kaneko J, Unemoto K, Kondo Y, Yonekawa C, Uchida M, Hoshiyama E, Yamada T, Maruo K, Ishikawa E, Matsumaru Y, Inoue Y; IENE ECT with the LIFE study group. Nakamura K, et al. J Neurol Neurosurg Psychiatry. 2023 Jan;94(1):42-48. doi: 10.1136/jnnp-2022-329485. Epub 2022 Oct 7. J Neurol Neurosurg Psychiatry. 2023. PMID: 36207063 Free PMC article. Clinical Trial.
LEV may be recommended as a second-line treatment for SE along with phenytoin/FPHT. TRIAL REGISTRATION NUMBER: jRCTs031190160....
LEV may be recommended as a second-line treatment for SE along with phenytoin/FPHT. TRIAL REGISTRATION NUMBER: jRCTs031190160....
948 results