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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1989 1
1990 4
1991 3
1992 6
1993 9
1994 14
1995 15
1996 18
1997 28
1998 21
1999 31
2000 72
2001 103
2002 132
2003 149
2004 201
2005 257
2006 319
2007 386
2008 367
2009 365
2010 369
2011 401
2012 431
2013 373
2014 383
2015 387
2016 380
2017 423
2018 336
2019 348
2020 343
2021 322
2022 306
2023 294
2024 214

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6,950 results

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Page 1
Thiazolidinediones: the Forgotten Diabetes Medications.
Lebovitz HE. Lebovitz HE. Curr Diab Rep. 2019 Nov 27;19(12):151. doi: 10.1007/s11892-019-1270-y. Curr Diab Rep. 2019. PMID: 31776781 Free PMC article. Review.
RECENT FINDINGS: Recent studies indicate that cardiovascular toxicity with rosiglitazone and increase in bladder cancer with pioglitazone are no longer significant issues. There are new data which show that pioglitazone treatment reduces myocardial infarctions and i …
RECENT FINDINGS: Recent studies indicate that cardiovascular toxicity with rosiglitazone and increase in bladder cancer with pioglitazone …
Pioglitazone: The forgotten, cost-effective cardioprotective drug for type 2 diabetes.
DeFronzo RA, Inzucchi S, Abdul-Ghani M, Nissen SE. DeFronzo RA, et al. Diab Vasc Dis Res. 2019 Mar;16(2):133-143. doi: 10.1177/1479164118825376. Epub 2019 Feb 1. Diab Vasc Dis Res. 2019. PMID: 30706731 Free article. Review.
However, there is strong evidence that an older and now generically available medication, the thiazolidinedione, pioglitazone, can retard the atherosclerotic process (PERISCOPE and Chicago) and reduce cardiovascular events in large randomized prospective cardiovascular out …
However, there is strong evidence that an older and now generically available medication, the thiazolidinedione, pioglitazone, can re …
Bacteria-Derived Outer-Membrane Vesicles Hitchhike Neutrophils to Enhance Ischemic Stroke Therapy.
Pan J, Wang Z, Huang X, Xue J, Zhang S, Guo X, Zhou S. Pan J, et al. Adv Mater. 2023 Sep;35(38):e2301779. doi: 10.1002/adma.202301779. Epub 2023 Jul 27. Adv Mater. 2023. PMID: 37358255
Here, a strategy is proposed based on bacteria-derived outer-membrane vesicle (OMV) hitchhiking on the neutrophils for enhanced brain delivery of pioglitazone (PGZ) to treat ischemic stroke. By encapsulating PGZ into OMV, the resulting OMV@PGZ nanoparticles inherit the fun …
Here, a strategy is proposed based on bacteria-derived outer-membrane vesicle (OMV) hitchhiking on the neutrophils for enhanced brain delive …
Exosomes derived from pioglitazone-pretreated MSCs accelerate diabetic wound healing through enhancing angiogenesis.
Hu Y, Tao R, Chen L, Xiong Y, Xue H, Hu L, Yan C, Xie X, Lin Z, Panayi AC, Mi B, Liu G. Hu Y, et al. J Nanobiotechnology. 2021 May 21;19(1):150. doi: 10.1186/s12951-021-00894-5. J Nanobiotechnology. 2021. PMID: 34020670 Free PMC article.
The present study aimed to investigate the effect of exosomes derived from MSCs pretreated with pioglitazone (PGZ-Exos) on diabetic wound healing. RESULTS: We isolated PGZ-Exos from the supernatants of pioglitazone-treated BMSCs and found that PGZ-Exos significantly …
The present study aimed to investigate the effect of exosomes derived from MSCs pretreated with pioglitazone (PGZ-Exos) on diabetic w …
A gut microbial metabolite of linoleic acid ameliorates liver fibrosis by inhibiting TGF-β signaling in hepatic stellate cells.
Kasahara N, Imi Y, Amano R, Shinohara M, Okada K, Hosokawa Y, Imamori M, Tomimoto C, Kunisawa J, Kishino S, Ogawa J, Ogawa W, Hosooka T. Kasahara N, et al. Sci Rep. 2023 Nov 3;13(1):18983. doi: 10.1038/s41598-023-46404-5. Sci Rep. 2023. PMID: 37923895 Free PMC article.
The antidiabetic drug pioglitazone ameliorates insulin resistance by activating the transcription factor PPARgamma. ...The mechanism by which pioglitazone achieves this latter effect has remained unclear, however. We here show that pioglitazone administration …
The antidiabetic drug pioglitazone ameliorates insulin resistance by activating the transcription factor PPARgamma. ...The mechanism …
[Rediscovery of pioglitazone].
Pokoly B, Somogyi A. Pokoly B, et al. Orv Hetil. 2023 Jul 2;164(26):1012-1019. doi: 10.1556/650.2023.32783. Print 2023 Jul 2. Orv Hetil. 2023. PMID: 37393546 Hungarian.
In this paper, we summarize the most important evidence that accumulated with pioglitazone over the past years. We briefly overview the molecular, cellular and pathophysiological changes it causes, and then, in addition to discussing the cardiovascular, metabolic and other …
In this paper, we summarize the most important evidence that accumulated with pioglitazone over the past years. We briefly overview t …
Pioglitazone and nephrolithiasis.
Niu SW, He JS, You-Hsien Lin H. Niu SW, et al. Kidney Int. 2019 Aug;96(2):518-519. doi: 10.1016/j.kint.2019.04.015. Kidney Int. 2019. PMID: 31331471 Free article. No abstract available.
The authors reply.
Sakhaee K, Maalouf N. Sakhaee K, et al. Kidney Int. 2019 Aug;96(2):519. doi: 10.1016/j.kint.2019.04.016. Kidney Int. 2019. PMID: 31331472 Free article. No abstract available.
Pioglitazone-Loaded Cartilage-Targeted Nanomicelles (Pio@C-HA-DOs) for Osteoarthritis Treatment.
Chen J, Xu W, Dai T, Jiao S, Xue X, Jiang J, Li S, Meng Q. Chen J, et al. Int J Nanomedicine. 2023 Oct 18;18:5871-5890. doi: 10.2147/IJN.S428938. eCollection 2023. Int J Nanomedicine. 2023. PMID: 37873552 Free PMC article.
BACKGROUND: Hyaluronic acid (HA) is a popular biological material for osteoarthritis (OA) treatment. Pioglitazone, a PPAR-gamma agonist, has been found to inhibit OA, but its use is limited because achieving the desired local drug concentration after administration is chal …
BACKGROUND: Hyaluronic acid (HA) is a popular biological material for osteoarthritis (OA) treatment. Pioglitazone, a PPAR-gamma agoni …
Effects of pioglitazone on cardiovascular events and all-cause mortality in patients with type 2 diabetes: A meta-analysis of randomized controlled trials.
Mannucci E, Giaccari A, Gallo M, Targher G, Pintaudi B, Candido R, Monami M; SID-AMD joint panel for Italian Guidelines on Treatment of Type 2 Diabetes. Mannucci E, et al. Nutr Metab Cardiovasc Dis. 2022 Mar;32(3):529-536. doi: 10.1016/j.numecd.2021.12.006. Epub 2021 Dec 10. Nutr Metab Cardiovasc Dis. 2022. PMID: 35144855 Free article.
Pioglitazone was associated with a significant reduction of MACE in patients with prior cardiovascular events (MH-OR 0.84, 95% CI 0.72-0.99). CONCLUSIONS: This meta-analysis showed no significant effects of pioglitazone on incident MACE, all-cause mortality, and HHF …
Pioglitazone was associated with a significant reduction of MACE in patients with prior cardiovascular events (MH-OR 0.84, 95% CI 0.7 …
6,950 results