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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1894 2
1945 1
1947 10
1948 18
1949 20
1950 40
1951 24
1952 32
1953 36
1954 59
1955 76
1956 75
1957 89
1958 84
1959 82
1960 92
1961 69
1962 126
1963 195
1964 199
1965 162
1966 171
1967 221
1968 279
1969 287
1970 295
1971 322
1972 353
1973 365
1974 465
1975 403
1976 354
1977 380
1978 369
1979 401
1980 493
1981 511
1982 600
1983 750
1984 789
1985 899
1986 974
1987 1012
1988 1061
1989 1191
1990 1517
1991 1275
1992 1354
1993 1338
1994 1360
1995 1302
1996 1390
1997 1440
1998 1559
1999 1625
2000 1670
2001 1838
2002 1952
2003 2335
2004 2499
2005 2706
2006 2966
2007 3141
2008 3135
2009 3224
2010 3350
2011 3521
2012 3583
2013 3557
2014 3464
2015 3348
2016 3267
2017 3228
2018 3248
2019 3228
2020 3042
2021 1823
2022 18
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85,403 results
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An Overview of Piperazine Scaffold as Promising Nucleus for Different Therapeutic Targets.
Sharma A, Wakode S, Fayaz F, Khasimbi S, Pottoo FH, Kaur A. Sharma A, et al. Curr Pharm Des. 2020;26(35):4373-4385. doi: 10.2174/1381612826666200417154810. Curr Pharm Des. 2020. PMID: 32303168 Review.
Piperazine has a flexible core structure for the design and synthesis of new bioactive compounds. ...In the past few years, researchers focused on the therapeutic profile of piperazine synthons for different biological targets. The present review highlights the deve
Piperazine has a flexible core structure for the design and synthesis of new bioactive compounds. ...In the past few years, researche
Synthesis and evaluation of sulfonyl piperazine LpxH inhibitors.
Kwak SH, Cochrane CS, Ennis AF, Lim WY, Webster CG, Cho J, Fenton BA, Zhou P, Hong J. Kwak SH, et al. Bioorg Chem. 2020 Sep;102:104055. doi: 10.1016/j.bioorg.2020.104055. Epub 2020 Jun 30. Bioorg Chem. 2020. PMID: 32663666 Free PMC article.
Recently, we reported the crystal structure of Klebsiella pneumoniae LpxH in complex with 1 (AZ1), a sulfonyl piperazine LpxH inhibitor. The analysis of the LpxH-AZ1 co-crystal structure and ligand dynamics led to the design of 2 (JH-LPH-28) and 3 (JH-LPH-33) with enhanced …
Recently, we reported the crystal structure of Klebsiella pneumoniae LpxH in complex with 1 (AZ1), a sulfonyl piperazine LpxH inhibit …
Piperazine: A Promising Scaffold with Analgesic and Anti-inflammatory Potential.
Jain A, Chaudhary J, Khaira H, Chopra B, Dhingra A. Jain A, et al. Drug Res (Stuttg). 2021 Feb;71(2):62-72. doi: 10.1055/a-1323-2813. Epub 2020 Dec 17. Drug Res (Stuttg). 2021. PMID: 33336346 Review.
Piperazine, a nitrogen-containing heterocyclic has acquired an inimitable position in medicinal chemistry because of its versatile structure, which has fascinated researchers to design novel piperazine based molecules having various biological actions. ...Moreover,
Piperazine, a nitrogen-containing heterocyclic has acquired an inimitable position in medicinal chemistry because of its versatile st
Benchtop NMR analysis of piperazine-based drugs hyperpolarised by SABRE.
Tennant T, Hulme MC, Robertson TBR, Sutcliffe OB, Mewis RE. Tennant T, et al. Magn Reson Chem. 2020 Dec;58(12):1151-1159. doi: 10.1002/mrc.4999. Epub 2020 Jan 28. Magn Reson Chem. 2020. PMID: 31945193
Piperazine-based drugs, such as N-benzylpiperazine (BZP), became attractive in the 2000s due to possessing effects similar to amphetamines. Herein, BZP, in addition to its pyridyl analogues, 2-, 3-, and 4-pyridylmethylpiperidine (2-PMP, 3-PMP, and 4-PMP respectively) was s
Piperazine-based drugs, such as N-benzylpiperazine (BZP), became attractive in the 2000s due to possessing effects similar to ampheta
Recent advances in the synthesis of piperazine based ligands and metal complexes and their applications.
Kant R , Maji S . Kant R , et al. Dalton Trans. 2021 Jan 21;50(3):785-800. doi: 10.1039/d0dt03569f. Epub 2021 Jan 8. Dalton Trans. 2021. PMID: 33416816 Review.
The piperazine scaffold is a privileged structure frequently found in biologically active compounds. ...This is one of the reasons why piperazine based compounds are gaining prominence in today's research. ...
The piperazine scaffold is a privileged structure frequently found in biologically active compounds. ...This is one of the reasons wh …
Novel piperazine-2,5-dione analogs bearing 1H-indole: Synthesis and biological effects.
Huang Z, Yin L, Guan L, Li Z, Tan C. Huang Z, et al. Bioorg Med Chem Lett. 2020 Dec 15;30(24):127654. doi: 10.1016/j.bmcl.2020.127654. Epub 2020 Nov 2. Bioorg Med Chem Lett. 2020. PMID: 33144244
In this work, a series of novel piperazine-2,5-dione derivatives bearing indole analogs (2a-2q) was designed and synthesized. ...
In this work, a series of novel piperazine-2,5-dione derivatives bearing indole analogs (2a-2q) was designed and synthesized. ...
Newly Synthesized Fluorinated Cinnamylpiperazines Possessing Low In Vitro MAO-B Binding.
I Jevtić I, Lai TH, Z Penjišević J, Dukić-Stefanović S, B Andrić D, Brust P, Kostić-Rajačić SV, Teodoro R. I Jevtić I, et al. Molecules. 2020 Oct 26;25(21):4941. doi: 10.3390/molecules25214941. Molecules. 2020. PMID: 33114548 Free PMC article.
The three-step synthesis starting from commercially available piperazine afforded the final products in overall yields between 9% and 29%. ...
The three-step synthesis starting from commercially available piperazine afforded the final products in overall yields between 9% and …
Design and synthesis of purine connected piperazine derivatives as novel inhibitors of Mycobacterium tuberculosis.
Konduri S, Prashanth J, Krishna VS, Sriram D, Behera JN, Siegel D, Rao KP. Konduri S, et al. Bioorg Med Chem Lett. 2020 Nov 15;30(22):127512. doi: 10.1016/j.bmcl.2020.127512. Epub 2020 Aug 29. Bioorg Med Chem Lett. 2020. PMID: 32871269
A series of novel purine linked piperazine derivatives were synthesized to identify new, potent inhibitors of Mycobacterium tuberculosis. ...Following this piperazine linked derivatives were also synthesized from 6 using diverse isocyanate partners. ...
A series of novel purine linked piperazine derivatives were synthesized to identify new, potent inhibitors of Mycobacterium tuberculo …
Design, synthesis, anti-tobacco mosaic viral and molecule docking simulations of urea/thiourea derivatives of 2-(piperazine-1-yl)-pyrimidine and 1-(4-Fluoro/4-Chloro phenyl)-piperazine and 1-(4-Chloro phenyl)-piperazine - A study.
Nagalakshmamma V, Venkataswamy M, Pasala C, Umamaheswari A, Thyagaraju K, Nagaraju C, Chalapathi PV. Nagalakshmamma V, et al. Bioorg Chem. 2020 Sep;102:104084. doi: 10.1016/j.bioorg.2020.104084. Epub 2020 Jul 10. Bioorg Chem. 2020. PMID: 32693309
The objectives of the present work are to design, syhthesize and introduce novel urea/thiourea derivatives of 2-(piperazine-1-yl)-pyrimidine and 1-(4-Fluoro/4-Chloro phenyl)-piperazine molecules as tobacco mosaic virus (TMV) inhibitors. A series of urea/thiourea der …
The objectives of the present work are to design, syhthesize and introduce novel urea/thiourea derivatives of 2-(piperazine-1-yl)-pyr …
85,403 results
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