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Combining Pirfenidone With Mycophenolate Mofetil for Systemic Sclerosis-Related Interstitial Lung Disease (Scleroderma Lung Study III): An Investigator-Initiated, Multicenter, Randomized, Double-Blind, Placebo-Controlled Phase 2 Trial.
Khanna D, Spino C, Tashkin DP, Bernstein EJ, Goldin J, Kleerup EC, Harui A, Ibrahim G, Kim GHJ, Huang S, McLain R, Tu YH, Nagaraja V, Silver RM, Steen VD, Weigt SS, Lee JS, Fischer A, Scholand MB, Gordon JK, Dellaripa PF, Rosas IO, Hunninghake GM, Trojanowski MA, Simms RW, Dematte JE, Hsu VM, Domsic RT, Raghu G, Mayes MD, Boente RD, Roth MD; Scleroderma Lung Study III Investigators. Khanna D, et al. ACR Open Rheumatol. 2025 Dec;7(12):e70126. doi: 10.1002/acr2.70126. ACR Open Rheumatol. 2025. PMID: 41294296 Free PMC article.
We hypothesized that combining MMF with pirfenidone (PFD) would produce a significantly more rapid and/or greater improvement in lung function. ...
We hypothesized that combining MMF with pirfenidone (PFD) would produce a significantly more rapid and/or greater improvement in lung …
Pirfenidone and its derivative: novel bronchodilators and leukocyte airway inflammation inhibitors.
Xie Y, Abel PW, Xing T, Zhong N, Jiang H, An SS, Panettieri RA Jr, Casale TB, Tu Y. Xie Y, et al. Am J Respir Cell Mol Biol. 2026 Sep 1;74(9):1189-1203. doi: 10.1093/ajrcmb/aanag047. Am J Respir Cell Mol Biol. 2026. PMID: 42089319
To identify novel bronchodilators, we screened the Sigma LOPAC1280 compound library using beta2-agonist-desensitized precision-cut lung slices (PCLS) as an ex vivo model and identified pirfenidone (PFD), an FDA-approved drug for idiopathic pulmonary fibrosis, as a novel br …
To identify novel bronchodilators, we screened the Sigma LOPAC1280 compound library using beta2-agonist-desensitized precision-cut lung slic …
Pirfenidone Elevates GLIS1 by Disrupting the USP7/DNMT1 Complex and Alleviates Renal Fibrosis in Diabetic Kidney Disease Through ROS Reduction and TGF-beta1/Smad Signaling Inhibition.
Tu W, Hu L, Wu L, Zhou H, Yang R, Chen Y. Tu W, et al. FASEB J. 2026 May 31;40(10):e71860. doi: 10.1096/fj.202600235R. FASEB J. 2026. PMID: 42159303
Renal fibrosis is a pathological feature of advanced-stage diabetic kidney disease (DKD). Here, we investigated the effect of Pirfenidone (PFD) on renal fibrosis under diabetic conditions and its molecular mechanism. ...
Renal fibrosis is a pathological feature of advanced-stage diabetic kidney disease (DKD). Here, we investigated the effect of Pirfenidone …
Impact of Pirfenidone on Patient-Reported Outcomes in Patients With Idiopathic Pulmonary Fibrosis From the Pulmonary Fibrosis Foundation Patient Registry.
Kang M, Gupta S, Tu YH, Raimundo K, Patel AM, Flaherty KR. Kang M, et al. CHEST Pulm. 2024 Jul 6;2(4):100082. doi: 10.1016/j.chpulm.2024.100082. eCollection 2024 Dec. CHEST Pulm. 2024. PMID: 42548421 Free PMC article.
RESEARCH QUESTION: What is the impact of pirfenidone vs no treatment on health-related quality of life and IPF-related symptoms of cough, dyspnea, and fatigue? ...RESULTS: In the Leicester Cough Questionnaire population (n = 237; pirfenidone, n = 155; no treatment, …
RESEARCH QUESTION: What is the impact of pirfenidone vs no treatment on health-related quality of life and IPF-related symptoms of co …
Upregulation of RGS2: a new mechanism for pirfenidone amelioration of pulmonary fibrosis.
Xie Y, Jiang H, Zhang Q, Mehrotra S, Abel PW, Toews ML, Wolff DW, Rennard S, Panettieri RA Jr, Casale TB, Tu Y. Xie Y, et al. Respir Res. 2016 Aug 22;17(1):103. doi: 10.1186/s12931-016-0418-4. Respir Res. 2016. PMID: 27549302 Free PMC article.
BACKGROUND: Pirfenidone was recently approved for treatment of idiopathic pulmonary fibrosis. However, the therapeutic dose of pirfenidone is very high, causing side effects that limit its doses and therapeutic effectiveness. ...Upregulated RGS2 contributes signific …
BACKGROUND: Pirfenidone was recently approved for treatment of idiopathic pulmonary fibrosis. However, the therapeutic dose of pir …
Therapeutic effect of pirfenidone in the sugen/hypoxia rat model of severe pulmonary hypertension.
Poble PB, Phan C, Quatremare T, Bordenave J, Thuillet R, Cumont A, Huertas A, Tu L, Dorfmüller P, Humbert M, Ghigna MR, Savale L, Guignabert C. Poble PB, et al. FASEB J. 2019 Mar;33(3):3670-3679. doi: 10.1096/fj.201801659R. Epub 2018 Nov 27. FASEB J. 2019. PMID: 30481487 Free article.
Heightened pulmonary artery smooth muscle cell (PA-SMC) proliferation and migration and dynamic remodeling of the extracellular matrix are hallmark pathogenic features of pulmonary arterial hypertension (PAH). Pirfenidone (PFD) is an orally bioavailable pyridone derivative …
Heightened pulmonary artery smooth muscle cell (PA-SMC) proliferation and migration and dynamic remodeling of the extracellular matrix are h …
Real-World Experience in the Clinical Use of Pirfenidone in Patients with Idiopathic Pulmonary Fibrosis in Taiwan: A Post-Marketing Surveillance Study.
Kuo PH, Tu CY, Chen CH, Kao KC, Hsu JY, Lin MC, Chong IW, Sheu CC. Kuo PH, et al. Biomedicines. 2024 Oct 15;12(10):2348. doi: 10.3390/biomedicines12102348. Biomedicines. 2024. PMID: 39457660 Free PMC article.
BACKGROUND: Idiopathic pulmonary fibrosis (IPF) is a serious, progressive lung disease for which treatments are scarce. Pirfenidone has been approved for the treatment of IPF in Taiwan since 2016. This study aimed to gain a better insight into pirfenidone's real-wor …
BACKGROUND: Idiopathic pulmonary fibrosis (IPF) is a serious, progressive lung disease for which treatments are scarce. Pirfenidone h …
Effect of pirfenidone on pulmonary fibrosis in acute lung injury via the regulation of the miR-34a-5p/TGF-beta1/SMAD pathway.
Yu C, Li Y, Tu Y, Dai M, Fei L. Yu C, et al. J Thorac Dis. 2025 Jun 30;17(6):4238-4248. doi: 10.21037/jtd-2025-829. Epub 2025 Jun 18. J Thorac Dis. 2025. PMID: 40688289 Free PMC article.
This study aims to investigate the molecular regulatory mechanisms of miR-34a-5p and pirfenidone (PFD) in the pathological process of PF, providing novel experimental data to elucidate the molecular mechanisms underlying the therapeutic effects of miR-34a-5p and PFD in the …
This study aims to investigate the molecular regulatory mechanisms of miR-34a-5p and pirfenidone (PFD) in the pathological process of …
Prophylactic adjuvant therapy for postoperative recurrence of urethral stricture: a narrative review.
Chen H, Yin F, Zhong H, Mo Y, Tu H, Lai Z, Huang R, Zou J, Xiao R. Chen H, et al. Transl Androl Urol. 2025 Oct 31;14(10):3413-3427. doi: 10.21037/tau-2025-471. Epub 2025 Oct 28. Transl Androl Urol. 2025. PMID: 41230148 Free PMC article. Review.
METHODS: For the period from 2004 to 2025, we searched the terms "urethral stricture", "postoperative recurrence", "mitomycin C", "paclitaxel", "steroids", "pirfenidone", "hydrogel", and "biodegradable stents" in the PubMed, Embase, and Web of Science databases and conduct …
METHODS: For the period from 2004 to 2025, we searched the terms "urethral stricture", "postoperative recurrence", "mitomycin C", "paclitaxe …
15 results