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13 results

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Page 1
Solvent-based formulations for intravenous mouse pharmacokinetic studies: tolerability and recommended solvent dose limits.
Thackaberry EA, Wang X, Schweiger M, Messick K, Valle N, Dean B, Sambrone A, Bowman T, Xie M. Thackaberry EA, et al. Xenobiotica. 2014 Mar;44(3):235-41. doi: 10.3109/00498254.2013.845706. Epub 2013 Oct 18. Xenobiotica. 2014. PMID: 24138296
The purpose of this investigation is to establish recommended no-observed-effect level (NOEL) and maximum tolerated dose (MTD) for several commonly used intravenous solvents in the CD-1 mouse. 2. The acute tolerability of polyethylene glycol 400, N-methylpyrr …
The purpose of this investigation is to establish recommended no-observed-effect level (NOEL) and maximum tolerated dose (MTD) for several c …
Efficacy of a fixed combination of 0.09 % xanthan gum/0.1 % chondroitin sulfate preservative free vs polyethylene glycol/propylene glycol in subjects with dry eye disease: a multicenter randomized controlled trial.
Pérez-Balbuena AL, Ochoa-Tabares JC, Belalcazar-Rey S, Urzúa-Salinas C, Saucedo-Rodríguez LR, Velasco-Ramos R, Suárez-Sánchez RG, Rodríguez-Carrizalez AD, Oregón-Miranda AA. Pérez-Balbuena AL, et al. BMC Ophthalmol. 2016 Sep 20;16(1):164. doi: 10.1186/s12886-016-0343-9. BMC Ophthalmol. 2016. PMID: 27645318 Free PMC article. Clinical Trial.
METHODS: A phase III, double-blind, masked, controlled, multicenter, clinical trial of 148 subjects, randomized to either a fixed combination of xanthan gum 0.09 % and chondroitin sulfate 0.1 % (XG/CS) ophthalmic solution (n = 76) or a fixed combination of polyethylene …
METHODS: A phase III, double-blind, masked, controlled, multicenter, clinical trial of 148 subjects, randomized to either a fixed combinatio …
Optimization of granular formulations of Metarhizium humberi microsclerotia with humectants.
Catão AML, Rodrigues J, Marreto RN, Mascarin GM, Fernandes ÉKK, Humber RA, Luz C. Catão AML, et al. J Basic Microbiol. 2021 Sep;61(9):808-813. doi: 10.1002/jobm.202100171. Epub 2021 Jul 26. J Basic Microbiol. 2021. PMID: 34309880
Because high ambient moisture is a crucial condition to induce fungal development and conidiogenesis on granules, we tested the impacts of the additions of three humectants-glycerin, propylene glycol, and polyethylene glycol 400-on water absorption by pellets …
Because high ambient moisture is a crucial condition to induce fungal development and conidiogenesis on granules, we tested the impacts of t …
Novel ocular lubricant containing an intelligent delivery system: details of its mechanism of action.
Springs C. Springs C. Dev Ophthalmol. 2010;45:139-147. doi: 10.1159/000315027. Epub 2010 May 18. Dev Ophthalmol. 2010. PMID: 20502034 Review.
OBJECTIVE: The purpose of this review is to outline the mechanism of action of a novel ocular lubricant incorporating hydroxypropyl-guar (HPG) and the demulcents polyethylene glycol 400 and propylene glycol. METHODS: The literature relating to the mechanism o …
OBJECTIVE: The purpose of this review is to outline the mechanism of action of a novel ocular lubricant incorporating hydroxypropyl-guar (HP …
Impact of formulation excipients on human intestinal transit.
Schulze JD, Ashiru DA, Khela MK, Evans DF, Patel R, Parsons GE, Coffin MD, Basit AW. Schulze JD, et al. J Pharm Pharmacol. 2006 Jun;58(6):821-5. doi: 10.1211/jpp.58.6.0012. J Pharm Pharmacol. 2006. PMID: 16734983
The accelerating effect of polyethylene glycol 400 on small intestinal transit has been previously reported. The aim of this study was to investigate the influence of other solubility-enhancing excipient, propylene glycol, D-alpha-tocopheryl-polyethylene glyc …
The accelerating effect of polyethylene glycol 400 on small intestinal transit has been previously reported. The aim of …
Excipient effects on gastrointestinal transit and drug absorption in beagle dogs.
Schulze JD, Peters EE, Vickers AW, Staton JS, Coffin MD, Parsons GE, Basit AW. Schulze JD, et al. Int J Pharm. 2005 Aug 26;300(1-2):67-75. doi: 10.1016/j.ijpharm.2005.05.004. Int J Pharm. 2005. PMID: 15979264
Previous work has shown that polyethylene glycol 400 (PEG 400) has an accelerating effect on gastrointestinal transit and a modulating influence on drug absorption in humans. ...
Previous work has shown that polyethylene glycol 400 (PEG 400) has an accelerating effect on gastrointestinal transit a …
Rational design and development of a stable liquid formulation of riluzole and its pharmacokinetic evaluation after oral and IV administrations in rats.
Sarkar M, Grossman RG, Toups EG, Chow DS. Sarkar M, et al. Eur J Pharm Sci. 2018 Dec 1;125:1-10. doi: 10.1016/j.ejps.2018.09.004. Epub 2018 Sep 8. Eur J Pharm Sci. 2018. PMID: 30201516
Riluzole was solubilized using water miscible organic solvents, namely, polyethylene glycol 400, propylene glycol and glycerin. A Central Composite Design (CCD) approach was used to develop an optimum co-solvent composition that can solubilize the entire 50 m …
Riluzole was solubilized using water miscible organic solvents, namely, polyethylene glycol 400, propylene glycol and g …
Common solubilizers to estimate the Caco-2 transport of poorly water-soluble drugs.
Takahashi Y, Kondo H, Yasuda T, Watanabe T, Kobayashi S, Yokohama S. Takahashi Y, et al. Int J Pharm. 2002 Oct 10;246(1-2):85-94. doi: 10.1016/s0378-5173(02)00347-2. Int J Pharm. 2002. PMID: 12270611
First, the effects of propylene glycol (PG), hydroxypropyl-beta-cyclodextrin (HP-beta-CD), polyethylene glycol 400 (PEG 400), and Tween 80 on the viability (transepithelial electrical resistance, TEER) of 3-day cultured Caco-2 monolayers were evaluated. ...
First, the effects of propylene glycol (PG), hydroxypropyl-beta-cyclodextrin (HP-beta-CD), polyethylene glycol 400 (PEG …
Protecting the ocular surface and improving the quality of life of dry eye patients: a study of the efficacy of an HP-guar containing ocular lubricant in a population of dry eye patients.
Rolando M, Autori S, Badino F, Barabino S. Rolando M, et al. J Ocul Pharmacol Ther. 2009 Jun;25(3):271-8. doi: 10.1089/jop.2008.0026. J Ocul Pharmacol Ther. 2009. PMID: 19366323 Clinical Trial.
PURPOSE: The aim of this study was to evaluate the efficacy of a non-Newtonian tear substitute containing 0.4% polyethylene glycol 400 (PEG 400) and 0.3% propylene glycol in an 0.18% hydroxypropyl-guar (HPG) containing vehicle (Systane Lubricant Eye Drops; Al …
PURPOSE: The aim of this study was to evaluate the efficacy of a non-Newtonian tear substitute containing 0.4% polyethylene glycol …
13 results