Cryogel-supported stem cell factory for customized sustained release of bispecific antibodies for cancer immunotherapy.
Aliperta R, Welzel PB, Bergmann R, Freudenberg U, Berndt N, Feldmann A, Arndt C, Koristka S, Stanzione M, Cartellieri M, Ehninger A, Ehninger G, Werner C, Pietzsch J, Steinbach J, Bornhäuser M, Bachmann MP.
Aliperta R, et al.
Sci Rep. 2017 Feb 16;7:42855. doi: 10.1038/srep42855.
Sci Rep. 2017.
PMID: 28205621
Free PMC article.
Here we propose an innovative immunotherapeutic organoid by housing human mesenchymal stromal cells (MSCs), gene-modified for the secretion of an anti-CD33-anti-CD3 bispecific antibody (bsAb), in a small biocompatible star-shaped poly(ethylene glycol)-heparin cryogel scaff …
Here we propose an innovative immunotherapeutic organoid by housing human mesenchymal stromal cells (MSCs), gene-modified for the secretion …