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160 results

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Page 1
Solvent-based formulations for intravenous mouse pharmacokinetic studies: tolerability and recommended solvent dose limits.
Thackaberry EA, Wang X, Schweiger M, Messick K, Valle N, Dean B, Sambrone A, Bowman T, Xie M. Thackaberry EA, et al. Xenobiotica. 2014 Mar;44(3):235-41. doi: 10.3109/00498254.2013.845706. Epub 2013 Oct 18. Xenobiotica. 2014. PMID: 24138296
The purpose of this investigation is to establish recommended no-observed-effect level (NOEL) and maximum tolerated dose (MTD) for several commonly used intravenous solvents in the CD-1 mouse. 2. The acute tolerability of polyethylene glycol 400, N-methylpyrr …
The purpose of this investigation is to establish recommended no-observed-effect level (NOEL) and maximum tolerated dose (MTD) for several c …
Impact of polyethylene glycol 400/propylene glycol/hydroxypropyl-guar and 0.1% sodium hyaluronate on postoperative discomfort following cataract extraction surgery: a comparative study.
Labiris G, Ntonti P, Sideroudi H, Kozobolis V. Labiris G, et al. Eye Vis (Lond). 2017 May 10;4:13. doi: 10.1186/s40662-017-0079-5. eCollection 2017. Eye Vis (Lond). 2017. PMID: 28497070 Free PMC article.
METHODS: A total of 180 patients that underwent cataract extraction surgery were randomly divided into three groups according to their postoperative regime: a) Study group 1 (SG1) received a fixed combination of tobramycin and dexamethasone (FCTD) quid for 3 weeks and, additional …
METHODS: A total of 180 patients that underwent cataract extraction surgery were randomly divided into three groups according to their posto …
Bactericidal activity of propylene glycol, glycerine, polyethylene glycol 400, and polyethylene glycol 1000 against selected microorganisms.
Nalawade TM, Bhat K, Sogi SH. Nalawade TM, et al. J Int Soc Prev Community Dent. 2015 Mar-Apr;5(2):114-9. doi: 10.4103/2231-0762.155736. J Int Soc Prev Community Dent. 2015. PMID: 25992336 Free PMC article.
AIM: The aim of the present study was to evaluate the bactericidal activity of propylene glycol, glycerine, polyethylene glycol 400 (PEG 400), and polyethylene glycol 1000 (PEG 1000) against selected microorganisms in vitro. MATERIALS AND …
AIM: The aim of the present study was to evaluate the bactericidal activity of propylene glycol, glycerine, polyethylene …
Assessment of toxicity and tolerability of a combination vehicle; 5% Pharmasolve, 45% Propylene glycol and 50% Polyethylene glycol 400 in rats following repeated intravenous administration.
Pandey SK, Goyal VK, Nalge P, Are P, Vincent S, Nirogi R. Pandey SK, et al. Regul Toxicol Pharmacol. 2017 Dec;91:103-108. doi: 10.1016/j.yrtph.2017.10.016. Epub 2017 Oct 21. Regul Toxicol Pharmacol. 2017. PMID: 29066335
Vehicle toxicity and tolerability data are not readily available for a number of combination vehicles therefore, an i.v. tolerability studies was planned in rats with 5% v/v Pharmasolve (NMP), 45% v/v Propylene glycol (PG) and 50% v/v Polyethylene glycol (PEG …
Vehicle toxicity and tolerability data are not readily available for a number of combination vehicles therefore, an i.v. tolerability studie …
Comparison of the Efficacy of Carboxymethylcellulose 0.5%, Hydroxypropyl-guar Containing Polyethylene Glycol 400/Propylene Glycol, and Hydroxypropyl Methyl Cellulose 0.3% Tear Substitutes in Improving Ocular Surface Disease Index in Cases of Dry Eye.
Maharana PK, Raghuwanshi S, Chauhan AK, Rai VG, Pattebahadur R. Maharana PK, et al. Middle East Afr J Ophthalmol. 2017 Oct-Dec;24(4):202-206. doi: 10.4103/meajo.MEAJO_165_15. Middle East Afr J Ophthalmol. 2017. PMID: 29422755 Free PMC article.
PURPOSE: To compare the efficacy of carboxymethylcellulose 0.5% (CMC), hydroxypropyl-guar containing polyethylene glycol 400/propylene glycol (PEG/PG), and hydroxypropyl methylcellulose 0.3% (HPMC) as tear substitutes in patients with dry eye. . …
PURPOSE: To compare the efficacy of carboxymethylcellulose 0.5% (CMC), hydroxypropyl-guar containing polyethylene glycol 40 …
The effect of glycerol, propylene glycol and polyethylene glycol 400 on the partition coefficient of benzophenone-3 (oxybenzone).
Mbah CJ. Mbah CJ. Pharmazie. 2007 Jan;62(1):38-40. Pharmazie. 2007. PMID: 17294811
The objective of the study was to investigate the potential effect of glycerol, propylene glycol and polyethylene glycol 400 on dermal absorption of oxybenzone by studying their effects on its partition coefficient. ...The findings suggest that …
The objective of the study was to investigate the potential effect of glycerol, propylene glycol and polyethylene gl …
Ototoxicity of antimycotics.
Marsh RR, Tom LW. Marsh RR, et al. Otolaryngol Head Neck Surg. 1989 Feb;100(2):134-6. doi: 10.1177/019459988910000209. Otolaryngol Head Neck Surg. 1989. PMID: 2495509
Five antimycotic preparations were tested for acute ototoxic potential in guinea pigs. Those containing acetic acid or propylene glycol caused appreciable elevation of brainstem response thresholds, while little or no impairment resulted from tolnaftate or clotrimaz …
Five antimycotic preparations were tested for acute ototoxic potential in guinea pigs. Those containing acetic acid or propylene g …
Insights into the formulation properties, biocompatibility, and permeability of poorly water-soluble methoxyflavones with PEG400 and propylene glycol.
Eze FN, Jansakul C, Srichana T. Eze FN, et al. Acta Pharm. 2023 Sep 14;73(3):385-404. doi: 10.2478/acph-2023-0030. Print 2023 Sep 1. Acta Pharm. 2023. PMID: 37708958 Free article.
Data from differential scanning calorimetry, Fourier-transform infrared (FTIR), and proton nuclear magnetic resonance ((1)H NMR) spectroscopic analysis revealed physico-chemical compatibility between the three methoxyflavones and PEG400/propylene glycol. Furthermore …
Data from differential scanning calorimetry, Fourier-transform infrared (FTIR), and proton nuclear magnetic resonance ((1)H NMR) spectroscop …
Drug-plasticizer interactions causing solid state transitions of rifaximin.
Höfler K, Littringer E, Pichler A, Scheler S. Höfler K, et al. Int J Pharm. 2022 Sep 25;625:122128. doi: 10.1016/j.ijpharm.2022.122128. Epub 2022 Aug 19. Int J Pharm. 2022. PMID: 35995318
For a detailed study, rifaximin was incubated with five plasticizers of different solubility and miscibility as well as different molecular geometry (linear vs branched), (dibutyl sebacate, tributyl citrate, triacetin, polyethylene glycol 400, and propylen …
For a detailed study, rifaximin was incubated with five plasticizers of different solubility and miscibility as well as different molecular …
Solubility and Thermodynamic Data of Febuxostat in Various Mono Solvents at Different Temperatures.
Haq N, Alghaith AF, Alshehri S, Shakeel F. Haq N, et al. Molecules. 2022 Jun 23;27(13):4043. doi: 10.3390/molecules27134043. Molecules. 2022. PMID: 35807294 Free PMC article.
This study examines the solubility and thermodynamics of febuxostat (FBX) in a variety of mono solvents, including "water, methanol (MeOH), ethanol (EtOH), isopropanol (IPA), 1-butanol (1-BuOH), 2-butanol (2-BuOH), ethylene glycol (EG), propylene glycol (PG), …
This study examines the solubility and thermodynamics of febuxostat (FBX) in a variety of mono solvents, including "water, methanol (MeOH), …
160 results