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Safety of triazole antifungals: a pharmacovigilance study from 2004 to 2021 based on FAERS.
Chai S, Zhan JL, Zhao LM, Liu XD. Chai S, et al. Ther Adv Drug Saf. 2022 Dec 16;13:20420986221143266. doi: 10.1177/20420986221143266. eCollection 2022. Ther Adv Drug Saf. 2022. PMID: 36545565 Free PMC article.
PLAIN LANGUAGE SUMMARY: A study on the adverse effects of triazole antifungals Introduction: The triazole antifungals we studied include fluconazole, itraconazole, voriconazole, posaconazole, and isavuconazole. Triazole antifungals are widely used as broad-spectrum antifun …
PLAIN LANGUAGE SUMMARY: A study on the adverse effects of triazole antifungals Introduction: The triazole antifungals we studied include flu …
Attention to the interactions between vincristine and triazole antifungals: perspectives from real-world retrospective analysis and pharmacovigilance assessment.
Huang D, Zhang Y, Liu L, Yang M, Zeng T, Wang S. Huang D, et al. Expert Opin Drug Saf. 2025 Apr 20:1-12. doi: 10.1080/14740338.2025.2496432. Online ahead of print. Expert Opin Drug Saf. 2025. PMID: 40249035
RESULTS: The FAERS database indicated that neurological and gastrointestinal systems were most commonly involved systems when combined use triazole antifungals and vincristine, with ileus being the most frequently reported AE. The highest signal strengths for ileus were wi …
RESULTS: The FAERS database indicated that neurological and gastrointestinal systems were most commonly involved systems when combined use t …
High-dose posaconazole for azole-resistant aspergillosis and other difficult-to-treat mould infections.
Schauwvlieghe AFAD, Buil JB, Verweij PE, Hoek RAS, Cornelissen JJ, Blijlevens NMA, Henriet SSV, Rijnders BJA, Brüggemann RJM. Schauwvlieghe AFAD, et al. Mycoses. 2020 Feb;63(2):122-130. doi: 10.1111/myc.13028. Epub 2019 Dec 15. Mycoses. 2020. PMID: 31660650 Free PMC article.
In addition, we describe the adverse events (AE) observed in 25 patients with POS concentrations at the higher end of the population distribution during treatment with the licensed dose. ...Grade 3-4 AEs were observed in 5 of the 25 patients with spontaneous high POS serum …
In addition, we describe the adverse events (AE) observed in 25 patients with POS concentrations at the higher end of the population …
Factors Influencing the Safety and Efficiency of Antifungal Prophylaxis with Posaconazole in Children with Hematological Diseases: From Genetics to Polypharmacotherapy.
Sienkiewicz-Oleszkiewicz B, Urbańczyk K, Stachowiak M, Rodziewicz A, Zięba A, Kałwak K, Wiela-Hojeńska A. Sienkiewicz-Oleszkiewicz B, et al. Indian J Hematol Blood Transfus. 2019 Oct;35(4):699-706. doi: 10.1007/s12288-019-01134-5. Epub 2019 May 14. Indian J Hematol Blood Transfus. 2019. PMID: 31741622 Free PMC article.
A protocol with data on the health condition, treatment and adverse events (AE), as well as a survey on treatment tolerance for the legal guardians was evaluated. ...Sixty-five legal guardians completed the survey, most of them reported the treatment to be well tolerated. …
A protocol with data on the health condition, treatment and adverse events (AE), as well as a survey on treatment tolerance for the l …
Therapeutic drug monitoring and adverse events of delayed-release posaconazole tablets in patients with chronic pulmonary aspergillosis.
Kosmidis C, Rodriguez-Goncer I, Rautemaa-Richardson R, Richardson MD, Moore CB, Denning DW. Kosmidis C, et al. J Antimicrob Chemother. 2019 Apr 1;74(4):1056-1061. doi: 10.1093/jac/dky539. J Antimicrob Chemother. 2019. PMID: 30590533
OBJECTIVES: To explore the pharmacokinetics and adverse event (AE) profile of posaconazole tablets in patients with CPA. METHODS: Patients started on posaconazole tablets at the National Aspergillosis Centre (NAC), Manchester, UK between February 2014 and Oct …
OBJECTIVES: To explore the pharmacokinetics and adverse event (AE) profile of posaconazole tablets in patients with CPA. METHO …
Anidulafungin: a new echinocandin with a novel profile.
Vazquez JA. Vazquez JA. Clin Ther. 2005 Jun;27(6):657-73. doi: 10.1016/j.clinthera.2005.06.010. Clin Ther. 2005. PMID: 16117974 Review.
METHODS: Data were identified using MEDLINE and National Library of Medicine Gateway searches for English-language literature (key words: anidulafungin, esophageal candidiasis, echinocandin, caspofungin, ravuconazole, voriconazole, posaconazole, micafungin, and fluconazole …
METHODS: Data were identified using MEDLINE and National Library of Medicine Gateway searches for English-language literature (key words: an …
Gateways to clinical trials.
Tomillero A, Moral MA. Tomillero A, et al. Methods Find Exp Clin Pharmacol. 2010 Jan-Feb;32(1):47-86. Methods Find Exp Clin Pharmacol. 2010. PMID: 20383346
(-)-Epigallocatechin gallate, Abafungin, ACE-031, Adapalene/benzoyl peroxide, AE-37, Aflibercept, AGS-003, Albiglutide, Alemtuzumab, Aliskiren fumarate, ALT-801, AN-2728, Anacetrapib, API, Aprepitant, ARQ-197, Ascorbic acid, Atazanavir sulfate, ATN-224, AVI-4658, Azacitidi …
(-)-Epigallocatechin gallate, Abafungin, ACE-031, Adapalene/benzoyl peroxide, AE-37, Aflibercept, AGS-003, Albiglutide, Alemtuzumab, …
Pharmacovigilance insights: safety profiles of antifungal agents for invasive aspergillosis.
Jia W, Wang T, Wang J. Jia W, et al. Front Pharmacol. 2026 Jan 7;16:1718019. doi: 10.3389/fphar.2025.1718019. eCollection 2025. Front Pharmacol. 2026. PMID: 41573736 Free PMC article.
Caspofungin demonstrated marked hepatotoxicity (cholestasis: ROR = 23.79), whereas Posaconazole and Isavuconazole showed lower mortality rates (19.56% and 22.70%, respectively). ...Amphotericin B and Caspofungin are associated with severe renal/hepatic toxicities and highe …
Caspofungin demonstrated marked hepatotoxicity (cholestasis: ROR = 23.79), whereas Posaconazole and Isavuconazole showed lower mortal …
Anti-Candida albicans Activity of Ononin and Other Secondary Metabolites from Platonia Insignis MART.
Silva AFD, Farias JR, Franco DCG, Galiza AA, Motta EP, Oliveira ADS, Vasconcelos CC, Cartágenes MDSS, Rocha CQD, Silva MCPD, Lopes AJO, Nascimento FRFD, Monteiro CA, Guerra RNM. Silva AFD, et al. Metabolites. 2022 Oct 24;12(11):1014. doi: 10.3390/metabo12111014. Metabolites. 2022. PMID: 36355097 Free PMC article.
According in silico evaluation, ononin showed the best electron affinity in molecular docking with CaCYP51, with a binding free energy of -10.89 kcal/mol, superior to that of the antifungal drugs fluconazole and posaconazole. The ononin + CaCYP51 complex formed hydrogen bo …
According in silico evaluation, ononin showed the best electron affinity in molecular docking with CaCYP51, with a binding free energy of -1 …
Relative impact of traditional vs. newer oral antifungals for dermatophyte toenail onychomycosis: a network meta-analysis study.
Gupta AK, Venkataraman M, Bamimore MA. Gupta AK, et al. Br J Dermatol. 2023 Jul 7;189(1):12-22. doi: 10.1093/bjd/ljad070. Br J Dermatol. 2023. PMID: 37253047
Our two efficacy-related endpoints were: (i) mycological and (ii) complete cure at 1 year; safety--related endpoints were: (i) 1-year count of any adverse event (AE), (ii) 1-year odds of discontinuation due to any AE, (iii) 1-year odds of discontinuation due to live …
Our two efficacy-related endpoints were: (i) mycological and (ii) complete cure at 1 year; safety--related endpoints were: (i) 1-year count …
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