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Page 1
What We Know About TMEM175 in Parkinson's Disease.
Wang J, Sun X, Cheng L, Qu M, Zhang C, Li X, Zhou L. Wang J, et al. CNS Neurosci Ther. 2025 Jan;31(1):e70195. doi: 10.1111/cns.70195. CNS Neurosci Ther. 2025. PMID: 39834146 Free PMC article. Review.
Studies have found that lysosomal dysfunction disrupts cellular homeostasis and is associated with Parkinson's disease (PD). Transmembrane protein 175 (TMEM175) is a lysosomal cation channel whose activity is essential for lysosomal homeostasis. ...In this paper, th …
Studies have found that lysosomal dysfunction disrupts cellular homeostasis and is associated with Parkinson's disease (PD). Transmem …
Unraveling pH Regulation of TMEM175, an Endolysosomal Cation Channel With a Role in Parkinson's Disease.
Schulze T, Rauh O, Thiel G, Fertig N, Bazzone A, Grimm C. Schulze T, et al. J Cell Physiol. 2025 Feb;240(2):e70008. doi: 10.1002/jcp.70008. J Cell Physiol. 2025. PMID: 39902728 Free PMC article. Review.
Transmembrane protein 175 (TMEM175) is an endolysosomal cation channel, which has attracted much attention recently from academics and the pharmaceutical industry alike since human mutations in TMEM175 were found to be associated with the development of Parkinson's disease …
Transmembrane protein 175 (TMEM175) is an endolysosomal cation channel, which has attracted much attention recently from academics an …
Hyponatremia and hypokalemia in patients on peritoneal dialysis.
Zanger R. Zanger R. Semin Dial. 2010 Nov-Dec;23(6):575-80. doi: 10.1111/j.1525-139X.2010.00789.x. Epub 2010 Dec 2. Semin Dial. 2010. PMID: 21121953 Review.
Hypokalemia occurs in up to 60% of patients on peritoneal dialysis (PD) for end-stage renal disease. It can be associated with poor clinical outcomes, including malnutrition and death. ...Hyponatremia may be caused by excessive thirst, a particular problem in patients on …
Hypokalemia occurs in up to 60% of patients on peritoneal dialysis (PD) for end-stage renal disease. It can be associated with poor c …
SF6 Negative Ion Formation in Charge Transfer Experiments.
Kumar S, Hoshino M, Kerkeni B, García G, Ouerfelli G, Al-Mogren MM, Limão-Vieira P. Kumar S, et al. Molecules. 2024 Aug 30;29(17):4118. doi: 10.3390/molecules29174118. Molecules. 2024. PMID: 39274966 Free PMC article.
Other less intense anions amounting to <20% are assigned to SF(3)(-) and F(2)(-), while a trace contribution at 32u is tentatively assigned to S(-) formation, although the rather complex intramolecular energy redistribution within the temporary negative ion is formed during th …
Other less intense anions amounting to <20% are assigned to SF(3)(-) and F(2)(-), while a trace contribution at 32u is tentatively assign …
Pathophysiological Roles of Two Intracellular P-Type ATPases: The Cancer-Associated Na+,K+-ATPase α3 Isoform and the Parkinson's Disease-Related ATP13A2.
Fujii T, Shimizu T, Sakai H. Fujii T, et al. Int J Mol Sci. 2026 Feb 13;27(4):1800. doi: 10.3390/ijms27041800. Int J Mol Sci. 2026. PMID: 41751935 Free PMC article. Review.
In this review, we highlight new insights into the pathological roles of the Na(+),K(+)-ATPase alpha3 isoform (alpha3NaK) in malignant cells and ATP13A2 in Parkinson's disease (PD). Cancer tissues frequently overexpress alpha3NaK which is aberrantly localized to intracellu …
In this review, we highlight new insights into the pathological roles of the Na(+),K(+)-ATPase alpha3 isoform (alpha3NaK) in malignant cells …
Low-lying Negative Ion States Probed in Potassium - Ethanol Collisions.
Lozano AI, Kumar S, Pereira PJS, Kerkeni B, García G, Limão-Vieira P. Lozano AI, et al. Chemphyschem. 2024 Jul 15;25(14):e202400314. doi: 10.1002/cphc.202400314. Epub 2024 May 22. Chemphyschem. 2024. PMID: 38630012
Dissociative electron transfer in collisions between neutral potassium atoms and neutral ethanol molecules yields mainly OH(-), followed by C(2)H(5)O(-), O(-), CH(3) (-) and CH(2) (-). ...The electronic state spectroscopy of such negative ions, was obtained from potassi …
Dissociative electron transfer in collisions between neutral potassium atoms and neutral ethanol molecules yields mainly OH(-), follo …
Body sodium, potassium and water in peritoneal dialysis-associated hyponatremia.
Sun Y, Mills D, Ing TS, Shapiro JI, Tzamaloukas AH. Sun Y, et al. Perit Dial Int. 2014 May;34(3):253-9. doi: 10.3747/pdi.2012.00201. Perit Dial Int. 2014. PMID: 24863873 Free PMC article.
OBJECTIVE: This report presents a method quantitatively analyzing abnormalities of body water and monovalent cations (sodium plus potassium) in patients on peritoneal dialysis (PD) with true hyponatremia. METHODS: It is well known that in the face of euglycemia seru …
OBJECTIVE: This report presents a method quantitatively analyzing abnormalities of body water and monovalent cations (sodium plus potassi …
Mechanistic Studies of the Palladium-Catalyzed Desulfinative Cross-Coupling of Aryl Bromides and (Hetero)Aryl Sulfinate Salts.
de Gombert A, McKay AI, Davis CJ, Wheelhouse KM, Willis MC. de Gombert A, et al. J Am Chem Soc. 2020 Feb 19;142(7):3564-3576. doi: 10.1021/jacs.9b13260. Epub 2020 Feb 7. J Am Chem Soc. 2020. PMID: 32031375 Free PMC article.
We also investigated the role of the basic additive potassium carbonate, the use of which is crucial for efficient reactions, and deduced a dual function in which carbonate is responsible for the removal of free sulfur dioxide from the reaction medium, and the potassium …
We also investigated the role of the basic additive potassium carbonate, the use of which is crucial for efficient reactions, and ded …
Hysteresis of KcsA potassium channel's activation- deactivation gating is caused by structural changes at the channel's selectivity filter.
Tilegenova C, Cortes DM, Cuello LG. Tilegenova C, et al. Proc Natl Acad Sci U S A. 2017 Mar 21;114(12):3234-3239. doi: 10.1073/pnas.1618101114. Epub 2017 Mar 6. Proc Natl Acad Sci U S A. 2017. PMID: 28265056 Free PMC article.
However, uncoupling the Shaker K(+) channel's pore domain (PD) from the VSD prevented the mode-shift of the gating currents. Consequently, it was proposed that an open-state stabilization of the PD imposes a mechanical load on the VSD, which causes its mode-shift. F …
However, uncoupling the Shaker K(+) channel's pore domain (PD) from the VSD prevented the mode-shift of the gating currents. Conseque …
The site-selectivity and mechanism of Pd-catalyzed C(sp(2))-H arylation of simple arenes.
Kim D, Choi G, Kim W, Kim D, Kang YK, Hong SH. Kim D, et al. Chem Sci. 2020 Oct 27;12(1):363-373. doi: 10.1039/d0sc05414c. Chem Sci. 2020. PMID: 34163602 Free PMC article.
Control over site-selectivity is a critical challenge for practical application of catalytic C-H functionalization reactions in organic synthesis. Despite the seminal breakthrough of the Pd-catalyzed C(sp(2))-H arylation of simple arenes via a concerted metalation-deproton …
Control over site-selectivity is a critical challenge for practical application of catalytic C-H functionalization reactions in organic synt …
51 results