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Year Number of Results
1986 4
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1988 11
1989 17
1990 44
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1993 100
1994 105
1995 131
1996 157
1997 134
1998 152
1999 154
2000 175
2001 237
2002 237
2003 236
2004 255
2005 304
2006 268
2007 226
2008 261
2009 190
2010 208
2011 194
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2013 178
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2015 151
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2024 97
2025 19

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5,274 results

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Page 1
Statin therapy increases lipoprotein(a) levels.
Tsimikas S, Gordts PLSM, Nora C, Yeang C, Witztum JL. Tsimikas S, et al. Eur Heart J. 2020 Jun 21;41(24):2275-2284. doi: 10.1093/eurheartj/ehz310. Eur Heart J. 2020. PMID: 31111151
Statins included atorvastatin 10 mg/day and 80 mg/day, pravastatin 40 mg/day, rosuvastatin 40 mg/day, and pitavastatin 2 mg/day. Lipoprotein(a) levels were measured with the same validated assay. ...-statin pooled analysis, the ratio of geometric means (95% CI) for atorvas …
Statins included atorvastatin 10 mg/day and 80 mg/day, pravastatin 40 mg/day, rosuvastatin 40 mg/day, and pitavastatin 2 mg/day. Lipo …
Pravastatin sodium.
Al-Badr AA, Mostafa GA. Al-Badr AA, et al. Profiles Drug Subst Excip Relat Methodol. 2014;39:433-513. doi: 10.1016/B978-0-12-800173-8.00008-8. Profiles Drug Subst Excip Relat Methodol. 2014. PMID: 24794911 Review.
Pravastatin sodium is an [HMG-CoA] reductase inhibitor and is a lipid-regulating drug. This monograph includes the description of the drug: nomenclature, formulae, elemental composition, solubility, appearance, and partition coefficient. ...The chapter also contains the ph …
Pravastatin sodium is an [HMG-CoA] reductase inhibitor and is a lipid-regulating drug. This monograph includes the description of the …
Pravastatin to treat and prevent preeclampsia. Preclinical and clinical studies.
Girardi G. Girardi G. J Reprod Immunol. 2017 Nov;124:15-20. doi: 10.1016/j.jri.2017.09.009. Epub 2017 Sep 29. J Reprod Immunol. 2017. PMID: 29028516 Review.
Numerous epidemiological studies provided robust evidence demonstrating that pravastatin exposure during pregnancy does not affect fetal development. In addition, pravastatin is hydrophilic and has a limited passage through the placenta, diminishing any safety conce …
Numerous epidemiological studies provided robust evidence demonstrating that pravastatin exposure during pregnancy does not affect fe …
Pravastatin: an evidence-based statin?
del Sol AI, Nanayakkara PW. del Sol AI, et al. Expert Opin Drug Metab Toxicol. 2008 Jun;4(6):821-5. doi: 10.1517/17425255.4.6.821. Expert Opin Drug Metab Toxicol. 2008. PMID: 18611121 Review.
One of the first and best studied statins is pravastatin, which has been studied in both primary and secondary prevention trials. With 40 mg pravastatin daily, total cholesterol can be reduced by 25-34% with a very consistent risk reduction of 24% of death from card …
One of the first and best studied statins is pravastatin, which has been studied in both primary and secondary prevention trials. Wit …
Pravastatin for the prevention of preeclampsia in high-risk pregnant women.
Costantine MM, Cleary K; Eunice Kennedy Shriver National Institute of Child Health and Human Development Obstetric--Fetal Pharmacology Research Units Network*. Costantine MM, et al. Obstet Gynecol. 2013 Feb;121(2 Pt 1):349-353. doi: 10.1097/AOG.0b013e31827d8ad5. Obstet Gynecol. 2013. PMID: 23344286 Free PMC article.
These beneficial effects are likely to contribute substantially to preventing preeclampsia and provide biological plausibility for the use of pravastatin in this setting. Pravastatin has favorable safety and pharmacokinetic profiles. In addition, animal studies and …
These beneficial effects are likely to contribute substantially to preventing preeclampsia and provide biological plausibility for the use o …
A randomized pilot clinical trial of pravastatin versus placebo in pregnant patients at high risk of preeclampsia.
Costantine MM, West H, Wisner KL, Caritis S, Clark S, Venkataramanan R, Stika CS, Rytting E, Wang X, Ahmed MS; Eunice Kennedy Shriver National Institute of Child Health and Human Development Obstetric-Fetal Pharmacology Research Centers (OPRC) Network, Bethesda, MD. Costantine MM, et al. Am J Obstet Gynecol. 2021 Dec;225(6):666.e1-666.e15. doi: 10.1016/j.ajog.2021.05.018. Epub 2021 May 24. Am J Obstet Gynecol. 2021. PMID: 34033812 Free PMC article. Clinical Trial.
In the majority of the umbilical cord and maternal samples at the time of delivery, pravastatin concentrations were below the limit of quantification of the assay. The pregnancy and neonatal outcomes were more favorable in the pravastatin group. ...Until then, pr …
In the majority of the umbilical cord and maternal samples at the time of delivery, pravastatin concentrations were below the limit o …
Challenges in Conducting Clinical Trials for Preeclampsia.
Bank TC, Kline D, Costantine MM. Bank TC, et al. Curr Hypertens Rep. 2024 Feb;26(2):59-68. doi: 10.1007/s11906-023-01276-y. Epub 2023 Nov 16. Curr Hypertens Rep. 2024. PMID: 37971596 Review.
Several medications, including aspirin, pravastatin, metformin, and esomeprazole, which are commonly used in non-pregnant populations, are now being investigated for preeclampsia prevention. ...While complex, and laden with challenges, there is great ongoing need for thera …
Several medications, including aspirin, pravastatin, metformin, and esomeprazole, which are commonly used in non-pregnant populations …
Aspirin and Pravastatin for Preeclampsia Prevention in High-Risk Pregnancy.
Eid J, Rood KM, Costantine MM. Eid J, et al. Obstet Gynecol Clin North Am. 2023 Mar;50(1):79-88. doi: 10.1016/j.ogc.2022.10.005. Obstet Gynecol Clin North Am. 2023. PMID: 36822711 Review.
In this review, we summarize the evidence behind the use of low-dose aspirin and pravastatin in pregnant individuals at high risk of preeclampsia....
In this review, we summarize the evidence behind the use of low-dose aspirin and pravastatin in pregnant individuals at high risk of …
5,274 results