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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1970 1
1974 5
1975 21
1976 10
1977 14
1978 7
1979 13
1980 20
1981 21
1982 13
1983 22
1984 24
1985 26
1986 55
1987 45
1988 40
1989 45
1990 35
1991 60
1992 24
1993 39
1994 35
1995 38
1996 38
1997 31
1998 40
1999 28
2000 34
2001 24
2002 23
2003 29
2004 16
2005 26
2006 32
2007 26
2008 28
2009 21
2010 18
2011 16
2012 16
2013 19
2014 16
2015 13
2016 19
2017 13
2018 15
2019 7
2020 6
2021 7
2022 6
2023 4
2024 4

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1,144 results

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Page 1
Trial of Prazosin for Post-Traumatic Stress Disorder in Military Veterans.
Raskind MA, Peskind ER, Chow B, Harris C, Davis-Karim A, Holmes HA, Hart KL, McFall M, Mellman TA, Reist C, Romesser J, Rosenheck R, Shih MC, Stein MB, Swift R, Gleason T, Lu Y, Huang GD. Raskind MA, et al. N Engl J Med. 2018 Feb 8;378(6):507-517. doi: 10.1056/NEJMoa1507598. N Engl J Med. 2018. PMID: 29414272 Free article. Clinical Trial.
After week 10, participants continued to receive prazosin or placebo in a double-blind fashion for an additional 16 weeks. ...The adverse event of new or worsening suicidal ideation occurred in 8% of the participants assigned to prazosin versus 15% of those assigned …
After week 10, participants continued to receive prazosin or placebo in a double-blind fashion for an additional 16 weeks. ...The adv …
Effect of vasodilator therapy on mortality in chronic congestive heart failure. Results of a Veterans Administration Cooperative Study.
Cohn JN, Archibald DG, Ziesche S, Franciosa JA, Harston WE, Tristani FE, Dunkman WB, Jacobs W, Francis GS, Flohr KH, et al. Cohn JN, et al. N Engl J Med. 1986 Jun 12;314(24):1547-52. doi: 10.1056/NEJM198606123142404. N Engl J Med. 1986. PMID: 3520315 Clinical Trial.
To evaluate the effects of vasodilator therapy on mortality among patients with chronic congestive heart failure, we randomly assigned 642 men with impaired cardiac function and reduced exercise tolerance who were taking digoxin and a diuretic to receive additional double-blind t …
To evaluate the effects of vasodilator therapy on mortality among patients with chronic congestive heart failure, we randomly assigned 642 m …
Clinical pharmacokinetics of prazosin.
Jaillon P. Jaillon P. Clin Pharmacokinet. 1980 Jul-Aug;5(4):365-76. doi: 10.2165/00003088-198005040-00004. Clin Pharmacokinet. 1980. PMID: 6994981 Review.
Preliminary studies in humans indicate that pathways for biotransformation of prazosin are similar to those observed in the rat and dog. Only 6% of prazosin is excreted unchanged, mainly in the urine. ...In both cases, the plasma free fraction of prazosin is …
Preliminary studies in humans indicate that pathways for biotransformation of prazosin are similar to those observed in the rat and d …
Double-Blind Randomized Clinical Trial of Prazosin for Alcohol Use Disorder.
Simpson TL, Saxon AJ, Stappenbeck C, Malte CA, Lyons R, Tell D, Millard SP, Raskind M. Simpson TL, et al. Am J Psychiatry. 2018 Dec 1;175(12):1216-1224. doi: 10.1176/appi.ajp.2018.17080913. Epub 2018 Aug 29. Am J Psychiatry. 2018. PMID: 30153753 Free PMC article. Clinical Trial.
After a positive pilot study, the authors tested the alpha-1 adrenergic receptor antagonist prazosin to treat alcohol use disorder in a larger sample. METHOD: Ninety-two participants with alcohol use disorder but without posttraumatic stress disorder were randomly assigned …
After a positive pilot study, the authors tested the alpha-1 adrenergic receptor antagonist prazosin to treat alcohol use disorder in …
A randomized controlled clinical trial of prazosin for alcohol use disorder in active duty soldiers: Predictive effects of elevated cardiovascular parameters.
Raskind MA, Williams T, Holmes H, Hart K, Crews L, Poupore EL, Thomas RG, Darnell J, Daniels C, Goke K, Hendrickson R, Terry G, Mayer C, Simpson T, Saxon A, Rasmussen D, Peskind ER. Raskind MA, et al. Alcohol Clin Exp Res (Hoboken). 2023 Feb;47(2):348-360. doi: 10.1111/acer.14989. Epub 2023 Feb 21. Alcohol Clin Exp Res (Hoboken). 2023. PMID: 36809662 Clinical Trial.

RESULTS: PACS declines did not differ significantly between the prazosin and placebo groups in the overall sample. In the subgroup with comorbid PTSD (n = 48), PACS declines were significantly greater in the prazosin than in the placebo condition (p < 0.05). ...D

…
RESULTS: PACS declines did not differ significantly between the prazosin and placebo groups in the overall sample. In the subgroup wi …
Randomized controlled pilot trial of prazosin for prophylaxis of posttraumatic headaches in active-duty service members and veterans.
Mayer CL, Savage PJ, Engle CK, Groh SS, Shofer JB, Hargrove AM, Williams TJ, Poupore EL, Hart KL, Riechers RG 2nd, Ruff RL, Peskind ER, Raskind MA. Mayer CL, et al. Headache. 2023 Jun;63(6):751-762. doi: 10.1111/head.14529. Epub 2023 Jun 14. Headache. 2023. PMID: 37313689 Clinical Trial.
RESULTS: Intent-to-treat analysis of randomized study participants (prazosin N = 32; placebo N = 16) demonstrated greater benefit over time in the prazosin group for all three outcome measures. ...The trial completion rate of 94% in the prazosin group (30/32) …
RESULTS: Intent-to-treat analysis of randomized study participants (prazosin N = 32; placebo N = 16) demonstrated greater benefit ove …
Cerebral endothelium-dependent function and reactivity to hypercapnia: the role of α1-adrenoreceptors.
Carr JMJR, Howe CA, Gibbons TD, Tymko MM, Steele AR, Vizcardo-Galindo GA, Tremblay JC, Ainslie PN. Carr JMJR, et al. J Appl Physiol (1985). 2022 Dec 1;133(6):1356-1367. doi: 10.1152/japplphysiol.00400.2022. Epub 2022 Nov 3. J Appl Physiol (1985). 2022. PMID: 36326471 Free article. Clinical Trial.
We assessed hypercapnic cerebrovascular reactivity (CVR) and endothelium-dependent function [cerebral shear-mediated dilation (cSMD)] in the internal carotid artery (ICA) with and without systemic alpha(1)-adrenoreceptor blockade via Prazosin. We hypothesized that CVR woul …
We assessed hypercapnic cerebrovascular reactivity (CVR) and endothelium-dependent function [cerebral shear-mediated dilation (cSMD)] in the …
Moderation of Prazosin's Efficacy by Alcohol Withdrawal Symptoms.
Sinha R, Wemm S, Fogelman N, Milivojevic V, Morgan PM, Angarita GA, Hermes G, Fox HC. Sinha R, et al. Am J Psychiatry. 2021 May 1;178(5):447-458. doi: 10.1176/appi.ajp.2020.20050609. Epub 2020 Nov 19. Am J Psychiatry. 2021. PMID: 33207935 Free PMC article. Clinical Trial.
No such benefit of prazosin was observed in those reporting low or no alcohol withdrawal symptoms. ...These data support further evaluation of alcohol withdrawal symptoms as a prognostic indicator of prazosin's efficacy in the treatment of AUD....
No such benefit of prazosin was observed in those reporting low or no alcohol withdrawal symptoms. ...These data support further eval …
A Randomized, Placebo-controlled, Clinical Trial of Prazosin for the Treatment of Alcohol Use Disorder.
Wilcox CE, Tonigan JS, Bogenschutz MP, Clifford J, Bigelow R, Simpson T. Wilcox CE, et al. J Addict Med. 2018 Sep/Oct;12(5):339-345. doi: 10.1097/ADM.0000000000000413. J Addict Med. 2018. PMID: 29664896 Free PMC article. Clinical Trial.
METHODS: Thirty-six individuals with AUD were randomized to treatment with prazosin, an alpha-1 noradrenergic antagonist, or placebo, for 6 weeks (target daily dose 16 mg). ...CONCLUSIONS: Our findings do not support the clinical utility of prazosin for all treatmen …
METHODS: Thirty-six individuals with AUD were randomized to treatment with prazosin, an alpha-1 noradrenergic antagonist, or placebo, …
A pilot trial of prazosin, an alpha-1 adrenergic antagonist, for comorbid alcohol dependence and posttraumatic stress disorder.
Simpson TL, Malte CA, Dietel B, Tell D, Pocock I, Lyons R, Varon D, Raskind M, Saxon AJ. Simpson TL, et al. Alcohol Clin Exp Res. 2015 May;39(5):808-17. doi: 10.1111/acer.12703. Epub 2015 Apr 1. Alcohol Clin Exp Res. 2015. PMID: 25827659 Free PMC article. Clinical Trial.
METHODS: Prazosin and matched placebo were compared in the context of an outpatient 6-week double-blind randomized controlled pilot trial involving 30 individuals with comorbid PTSD/AD. ...CONCLUSIONS: Consistent with the extant research evaluating medications for comorbid …
METHODS: Prazosin and matched placebo were compared in the context of an outpatient 6-week double-blind randomized controlled pilot t …
1,144 results