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Year Number of Results
1980 3
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1988 31
1989 34
1990 76
1991 79
1992 92
1993 129
1994 138
1995 177
1996 181
1997 187
1998 223
1999 243
2000 226
2001 246
2002 248
2003 253
2004 279
2005 260
2006 242
2007 288
2008 244
2009 268
2010 277
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2025 3

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7,124 results

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Page 1
Effects of Remimazolam and Propofol on Emergence Agitation in Elderly Patients Undergoing Hip Replacement: A Clinical, Randomized, Controlled Study.
Duan J, Ju X, Wang X, Liu N, Xu S, Wang S. Duan J, et al. Drug Des Devel Ther. 2023 Sep 1;17:2669-2678. doi: 10.2147/DDDT.S419146. eCollection 2023. Drug Des Devel Ther. 2023. PMID: 37680862 Free PMC article. Clinical Trial.
They were randomly assigned to two groups: the remimazolam group (group R) and the propofol group (group P). In group R, remimazolam was administered intravenously during the induction and maintenance of anesthesia, In group P, propofol was used during the induction …
They were randomly assigned to two groups: the remimazolam group (group R) and the propofol group (group P). In group R, remimazolam …
Safety and efficacy of ciprofol vs. propofol for sedation in intensive care unit patients with mechanical ventilation: a multi-center, open label, randomized, phase 2 trial.
Liu Y, Yu X, Zhu D, Zeng J, Lin Q, Zang B, Chen C, Liu N, Liu X, Gao W, Guan X. Liu Y, et al. Chin Med J (Engl). 2022 May 5;135(9):1043-1051. doi: 10.1097/CM9.0000000000001912. Chin Med J (Engl). 2022. PMID: 34924506 Free PMC article. Clinical Trial.
METHODS: In this multicenter, open label, randomized, propofol positive-controlled, phase 2 trial, 39 Chinese intensive care unit patients receiving mechanical ventilation were enrolled and randomly assigned to a ciprofol or propofol group in a 2:1 ratio. ...Drug- a …
METHODS: In this multicenter, open label, randomized, propofol positive-controlled, phase 2 trial, 39 Chinese intensive care unit pat …
Remimazolam besylate versus propofol for deep sedation in critically ill patients: a randomized pilot study.
Tang Y, Gao X, Xu J, Ren L, Qi H, Li R, Shu H, Zou X, Yuan S, Yang X, Shang Y. Tang Y, et al. Crit Care. 2023 Dec 4;27(1):474. doi: 10.1186/s13054-023-04760-8. Crit Care. 2023. PMID: 38049909 Free PMC article. Clinical Trial.
OBJECTIVE: To compare the efficacy and safety of remimazolam besylate and propofol for deep sedation in critically ill patients. METHODS: In this single-center, prospective, randomized, controlled pilot study, patients in the intensive care unit (ICU) requiring deep sedati …
OBJECTIVE: To compare the efficacy and safety of remimazolam besylate and propofol for deep sedation in critically ill patients. METH …
Effects of ciprofol for the induction of general anesthesia in patients scheduled for elective surgery compared to propofol: a phase 3, multicenter, randomized, double-blind, comparative study.
Wang X, Wang X, Liu J, Zuo YX, Zhu QM, Wei XC, Zou XH, Luo AL, Zhang FX, Li YL, Zheng H, Li H, Wang S, Wang DX, Guo QL, Liu CM, Wang YT, Zhu ZQ, Wang GY, Ai YQ, Xu MJ. Wang X, et al. Eur Rev Med Pharmacol Sci. 2022 Mar;26(5):1607-1617. doi: 10.26355/eurrev_202203_28228. Eur Rev Med Pharmacol Sci. 2022. PMID: 35302207 Free article. Clinical Trial.
RESULTS: The anesthesia induction success rates for both ciprofol 0.4 mg/kg and propofol 2 mg/kg groups were 100.0%, with a 95% CI lower success limit of -4.18% difference between the two groups, indicating that ciprofol was non-inferior to propofol. ...Safety was c …
RESULTS: The anesthesia induction success rates for both ciprofol 0.4 mg/kg and propofol 2 mg/kg groups were 100.0%, with a 95% CI lo …
Efficacy and safety of ciprofol versus propofol for the induction of anesthesia in adult patients: a multicenter phase 2a clinical trial.
Zhu Q, Luo Z, Wang X, Wang D, Li J, Wei X, Tang J, Yao S, Ouyang W, Zhang W, Zuo Y, Wang X, Liu J. Zhu Q, et al. Int J Clin Pharm. 2023 Apr;45(2):473-482. doi: 10.1007/s11096-022-01529-x. Epub 2023 Jan 21. Int J Clin Pharm. 2023. PMID: 36680620 Free PMC article. Clinical Trial.
Ten patients per group were assigned to ciprofol-0.3, 0.4 and 0.5 mg/kg, and propofol-2.0 or 2.5 mg/kg groups, respectively to receive an intravenous bolus dose. An additional 20 patients were enrolled in the ciprofol-0.3, 0.5 or propofol-2.0 mg/kg groups. ...There …
Ten patients per group were assigned to ciprofol-0.3, 0.4 and 0.5 mg/kg, and propofol-2.0 or 2.5 mg/kg groups, respectively to receiv …
Efficacy and safety of remimazolam besylate versus propofol during hysteroscopy: single-centre randomized controlled trial.
Zhang X, Li S, Liu J. Zhang X, et al. BMC Anesthesiol. 2021 May 20;21(1):156. doi: 10.1186/s12871-021-01373-y. BMC Anesthesiol. 2021. PMID: 34016045 Free PMC article. Clinical Trial.
This trial was conducted to confirm the efficacy and safety of remimazolam besylate versus propofol during hysteroscopy. METHODS: Patients undergoing hysteroscopy were randomly assigned to either the remimazolam (Group R) or the propofol group (Group P). Group R was …
This trial was conducted to confirm the efficacy and safety of remimazolam besylate versus propofol during hysteroscopy. METHODS: Pat …
True patient-controlled sedation.
Cook LB, Lockwood GG, Moore CM, Whitwam JG. Cook LB, et al. Anaesthesia. 1993 Dec;48(12):1039-44. doi: 10.1111/j.1365-2044.1993.tb07521.x. Anaesthesia. 1993. PMID: 8285322 Free article. Clinical Trial.
Onset of sedation with propofol or midazolam took 70.6 (SD 22.4) and 106.3 (50.7) s respectively. Mean doses over the first 5 min were midazolam 2.7 (1.2) mg, and propofol 54 (18) mg. ...After 30 min the p-deletion and critical flicker fusion scores were still impai …
Onset of sedation with propofol or midazolam took 70.6 (SD 22.4) and 106.3 (50.7) s respectively. Mean doses over the first 5 min wer …
Supraglottic jet oxygenation and ventilation reduces desaturation during bronchoscopy under moderate to deep sedation with propofol and remifentanil: A randomised controlled clinical trial.
Zha B, Wu Z, Xie P, Xiong H, Xu L, Wei H. Zha B, et al. Eur J Anaesthesiol. 2021 Mar 1;38(3):294-301. doi: 10.1097/EJA.0000000000001401. Eur J Anaesthesiol. 2021. PMID: 33234777 Free PMC article. Clinical Trial.
BACKGROUND: Hypoxaemia is frequently seen during flexible bronchoscopies that are done with a nasal approach under the traditional sedation with propofol. This study investigated the potential benefits of supraglottic jet oxygenation and ventilation (SJOV) using the Wei na …
BACKGROUND: Hypoxaemia is frequently seen during flexible bronchoscopies that are done with a nasal approach under the traditional sedation …
Effect of remifentanil and midazolam on ED95 of propofol for loss of consciousness in elderly patients: A randomized, clinical trial.
You AH, Kim JY, Kim DH, Suh J, Han DW. You AH, et al. Medicine (Baltimore). 2019 Apr;98(16):e15132. doi: 10.1097/MD.0000000000015132. Medicine (Baltimore). 2019. PMID: 31008935 Free PMC article. Clinical Trial.
BACKGROUND: Older people are more vulnerable to hemodynamic instability caused by propofol due to their decreased initial distribution volume and increased sensitivity to propofol. ...The patients were randomized into 3 groups using a computer-generated randomizatio …
BACKGROUND: Older people are more vulnerable to hemodynamic instability caused by propofol due to their decreased initial distributio …
Changes in information integration and brain networks during propofol-, dexmedetomidine-, and ketamine-induced unresponsiveness.
Liang Z, Chang Y, Liu X, Cao S, Chen Y, Wang T, Xu J, Li D, Zhang J. Liang Z, et al. Br J Anaesth. 2024 Mar;132(3):528-540. doi: 10.1016/j.bja.2023.11.033. Epub 2023 Dec 16. Br J Anaesth. 2024. PMID: 38105166 Clinical Trial.
METHODS: A total of 72 participants were randomised to receive i.v. infusion of propofol, dexmedetomidine, or ketamine at a constant infusion rate until loss of responsiveness. ...
METHODS: A total of 72 participants were randomised to receive i.v. infusion of propofol, dexmedetomidine, or ketamine at a constant …
7,124 results