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Quinaprilat: a review of its pharmacokinetics, pharmacodynamics, toxicological data and clinical application.
Kieback AG, Felix SB, Reffelmann T. Kieback AG, et al. Expert Opin Drug Metab Toxicol. 2009 Oct;5(10):1337-47. doi: 10.1517/17425250903282773. Expert Opin Drug Metab Toxicol. 2009. PMID: 19761414 Review.
Quinaprilat is excreted mainly in urine. In long-term animal studies, quinaprilat was not teratogenic, mutagenic or carcinogenic. However, due to the risk of fetal and neonatal morbidity and death, it should not be administrated in pregnancy. Quinaprilat is c …
Quinaprilat is excreted mainly in urine. In long-term animal studies, quinaprilat was not teratogenic, mutagenic or carcinogen …
Effects of quinapril on angiotensin converting enzyme and plasma renin activity as well as pharmacokinetic parameters of quinapril and its active metabolite, quinaprilat, after intravenous and oral administration to mature horses.
Davis JL, Kruger K, LaFevers DH, Barlow BM, Schirmer JM, Breuhaus BA. Davis JL, et al. Equine Vet J. 2014 Nov;46(6):729-33. doi: 10.1111/evj.12206. Epub 2014 Jan 7. Equine Vet J. 2014. PMID: 24175935 Clinical Trial.
There is limited information regarding their effects in horses. OBJECTIVES: The purpose of this study was to determine the pharmacokinetics of quinapril and its effects on ACE and renin in horses. ...Noncompartmental pharmacokinetic modelling and statistical analyse …
There is limited information regarding their effects in horses. OBJECTIVES: The purpose of this study was to determine the pharmacoki …
Protective effects of quinaprilat and trandolaprilat, active metabolites of quinapril and trandolapril, on hemolysis induced by lysophosphatidylcholine in human erythrocytes.
Hayase N, Satomi M, Hara A, Awaya T, Shimizu K, Matsubara K. Hayase N, et al. Biol Pharm Bull. 2003 May;26(5):712-6. doi: 10.1248/bpb.26.712. Biol Pharm Bull. 2003. PMID: 12736518 Free article.
We examined the effects of the angiotensin converting enzyme (ACE) inhibitors captopril, enalaprilat, quinapril, and trandolapril, and their active metabolites quinaprilat and trandolaprilat, on hemolysis induced by lysophosphatidylcholine (LPC) in human erythrocyte …
We examined the effects of the angiotensin converting enzyme (ACE) inhibitors captopril, enalaprilat, quinapril, and trandolapril, an …
Quinapril--a preclinical review of the pharmacology, pharmacokinetics, and toxicology.
Kaplan HR, Taylor DG, Olson SC, Andrews LK. Kaplan HR, et al. Angiology. 1989 Apr;40(4 Pt 2):335-50. doi: 10.1177/000331978904000403. Angiology. 1989. PMID: 2539761 Review.
Hemodynamic studies in dogs indicate that quinapril decreases total peripheral and renal vascular resistance. Quinaprilat produces natriuresis and mild diuresis at doses that do not alter mean arterial blood pressure. ...Plasma radiolabel concentration-time profiles exhibi …
Hemodynamic studies in dogs indicate that quinapril decreases total peripheral and renal vascular resistance. Quinaprilat produces na …
Quinapril: a new second-generation ACE inhibitor.
Cetnarowski-Cropp AB. Cetnarowski-Cropp AB. DICP. 1991 May;25(5):499-504. doi: 10.1177/106002809102500510. DICP. 1991. PMID: 2068835 Review.
The drug undergoes hepatic hydrolysis into its major active diacid metabolite, quinaprilat, and two minor inactive metabolites. On a weight basis quinaprilat is three times as potent an ACE inhibitor as quinapril. ...Peak serum concentrations of quinapril and qui …
The drug undergoes hepatic hydrolysis into its major active diacid metabolite, quinaprilat, and two minor inactive metabolites. On a …
Quinaprilat-eluting stents do not attenuate intimal thickening following stenting in porcine coronary arteries.
van Beusekom HM, Ferrero V, Ribichini F, van der Giessen WJ. van Beusekom HM, et al. Atherosclerosis. 2009 Jul;205(1):120-5. doi: 10.1016/j.atherosclerosis.2008.11.029. Epub 2008 Dec 6. Atherosclerosis. 2009. PMID: 19135197
The aim of this study was to evaluate the angiographic and histomorphologic effects of quinaprilat-eluting stents in normal porcine coronary arteries. METHODS: Ten pigs received phosphorylcholine-coated stents in each of the three major coronary arteries: one loaded …
The aim of this study was to evaluate the angiographic and histomorphologic effects of quinaprilat-eluting stents in normal po …
Hemodynamic and hormonal effects of quinaprilat in patients with congestive heart failure.
Mitrovic V, Mudra H, Bonzel T, Schmidt W, Strand JC, Bakovic-Alt R, Posvar EL. Mitrovic V, et al. Clin Pharmacol Ther. 1996 Jun;59(6):686-98. doi: 10.1016/S0009-9236(96)90009-0. Clin Pharmacol Ther. 1996. PMID: 8681494 Clinical Trial.
METHODS: Patients were randomly assigned to three treatment groups to receive low (0.5 to 1.0 mg), medium (1.0 and 2.5 mg), or high (5.0 and 10.0 mg) single intravenous doses of quinaprilat or placebo on day 1. On the basis of responses observed on day 1, the three treatme …
METHODS: Patients were randomly assigned to three treatment groups to receive low (0.5 to 1.0 mg), medium (1.0 and 2.5 mg), or high (5.0 and …
Pharmacokinetics of quinapril and its active metabolite quinaprilat during continuous ambulatory peritoneal dialysis.
Swartz RD, Starmann B, Horvath AM, Olson SC, Posvar EL. Swartz RD, et al. J Clin Pharmacol. 1990 Dec;30(12):1136-41. doi: 10.1002/j.1552-4604.1990.tb01857.x. J Clin Pharmacol. 1990. PMID: 2273086 Free article.
Overall, quinapril was well tolerated by these CAPD patients, with mild and transient side effects, not unexpected in this clinical setting, which included pruritus, headache, nausea, and cough. ...The elimination half-life of quinaprilat was markedly prolonged when …
Overall, quinapril was well tolerated by these CAPD patients, with mild and transient side effects, not unexpected in this clinical s …
Electrophysiologic effects of quinaprilat in dogs during acute myocardial ischemia and following reperfusion.
Fujinaga H, Wakatsuki T, Nishikado A, Oki T, Ito S. Fujinaga H, et al. Coron Artery Dis. 1998;9(10):697-701. Coron Artery Dis. 1998. PMID: 9894622
BACKGROUND: There have been few studies concerning the electrophysiologic changes associated with the use of angiotensin-converting enzyme inhibitors in patients with acute myocardial infarction. We examined the electrophysiologic effects of quinaprilat in dogs duri …
BACKGROUND: There have been few studies concerning the electrophysiologic changes associated with the use of angiotensin-converting enzyme i …
Multiple-dose propranolol administration does not influence the single dose pharmacokinetics of quinapril and its active metabolite (quinaprilat).
Horvath AM, Pilon D, Caillé G, Colburn WA, Ferry JJ, Frank GJ, Lacasse Y, Olson SC. Horvath AM, et al. Biopharm Drug Dispos. 1990 Apr;11(3):191-6. doi: 10.1002/bdd.2510110303. Biopharm Drug Dispos. 1990. PMID: 2328305
To evaluate the influence of multiple dose propranolol administration on the single dose pharmacokinetics of quinapril and its active metabolite, quinaprilat, a drug-drug interaction study was performed in ten healthy volunteers. Each subject received a single 20 mg quinap …
To evaluate the influence of multiple dose propranolol administration on the single dose pharmacokinetics of quinapril and its active metabo …
27 results