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2004 1
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Page 1
Preventive effects of ramelteon on delirium: a randomized placebo-controlled trial.
Hatta K, Kishi Y, Wada K, Takeuchi T, Odawara T, Usui C, Nakamura H; DELIRIA-J Group. Hatta K, et al. JAMA Psychiatry. 2014 Apr;71(4):397-403. doi: 10.1001/jamapsychiatry.2013.3320. JAMA Psychiatry. 2014. PMID: 24554232 Clinical Trial.
The Kaplan-Meier estimates of time to development of delirium were 6.94 (95% CI, 6.82-7.06) days for ramelteon and 5.74 (5.05-6.42) days for placebo. Comparison by log-rank test showed that the frequency of delirium was significantly lower in patients taking ramelteon …
The Kaplan-Meier estimates of time to development of delirium were 6.94 (95% CI, 6.82-7.06) days for ramelteon and 5.74 (5.05-6.42) d …
Real-World Effectiveness of Ramelteon and Suvorexant for Delirium Prevention in 948 Patients With Delirium Risk Factors.
Hatta K, Kishi Y, Wada K, Takeuchi T, Hashimoto N, Suda K, Taira T, Tsuchida K, Ohmori T, Akizuki N, Nishio Y, Nakanishi Y, Usui C, Kurata A, Horikawa N, Eguchi H, Ito S, Muto H, Nakamura H, Uchimura N. Hatta K, et al. J Clin Psychiatry. 2019 Dec 17;81(1):19m12865. doi: 10.4088/JCP.19m12865. J Clin Psychiatry. 2019. PMID: 31851436 Free article. Clinical Trial.
OBJECTIVE: The aim of this study was to examine the effectiveness of ramelteon and suvorexant for delirium prevention in real-world practice. It explored whether ramelteon and/or suvorexant would affect delirium prevention among both patients at risk for but without …
OBJECTIVE: The aim of this study was to examine the effectiveness of ramelteon and suvorexant for delirium prevention in real-world p …
Lemborexant for the Treatment of Insomnia: Direct and Indirect Comparisons With Other Hypnotics Using Number Needed to Treat, Number Needed to Harm, and Likelihood to Be Helped or Harmed.
Citrome L, Juday T, Frech F, Atkins N Jr. Citrome L, et al. J Clin Psychiatry. 2021 Jun 1;82:20m13795. doi: 10.4088/JCP.20m13795. J Clin Psychiatry. 2021. PMID: 34077032 Free article. Clinical Trial.
Direct comparisons were made with zolpidem extended release (ER), and indirect comparisons were made with other hypnotic agents, including suvorexant, doxepin, ramelteon, zolpidem immediate release, eszopiclone, zaleplon, and selected benzodiazepines, using data from publi …
Direct comparisons were made with zolpidem extended release (ER), and indirect comparisons were made with other hypnotic agents, including s …
Effects of Ramelteon on the Prevention of Postoperative Delirium in Older Patients Undergoing Orthopedic Surgery: The RECOVER Randomized Controlled Trial.
Oh ES, Leoutsakos JM, Rosenberg PB, Pletnikova AM, Khanuja HS, Sterling RS, Oni JK, Sieber FE, Fedarko NS, Akhlaghi N, Neufeld KJ. Oh ES, et al. Am J Geriatr Psychiatry. 2021 Jan;29(1):90-100. doi: 10.1016/j.jagp.2020.05.006. Epub 2020 May 16. Am J Geriatr Psychiatry. 2021. PMID: 32532654 Free PMC article. Clinical Trial.
PARTICIPANTS: Patients aged 65 years or older, undergoing elective primary or revision hip or knee replacement. INTERVENTION: Ramelteon (8 mg) or placebo MEASUREMENTS: Eighty participants were randomized to an oral gel cap of ramelteon or placebo for 3 consecutive n …
PARTICIPANTS: Patients aged 65 years or older, undergoing elective primary or revision hip or knee replacement. INTERVENTION: Ramelteon …
Effect of Administration of Ramelteon, a Melatonin Receptor Agonist, on the Duration of Stay in the ICU: A Single-Center Randomized Placebo-Controlled Trial.
Nishikimi M, Numaguchi A, Takahashi K, Miyagawa Y, Matsui K, Higashi M, Makishi G, Matsui S, Matsuda N. Nishikimi M, et al. Crit Care Med. 2018 Jul;46(7):1099-1105. doi: 10.1097/CCM.0000000000003132. Crit Care Med. 2018. PMID: 29595562 Free PMC article. Clinical Trial.
MEASUREMENTS AND MAIN RESULTS: A total of 88 subjects were randomized to the ramelteon group (45 subjects) or the placebo group (43 subjects). As the primary endpoint, there was a trend toward decrease in the duration of ICU stay (4.56 d) in the ramelteon group comp …
MEASUREMENTS AND MAIN RESULTS: A total of 88 subjects were randomized to the ramelteon group (45 subjects) or the placebo group (43 s …
Efficacy and safety of sublingual ramelteon as an adjunctive therapy in the maintenance treatment of bipolar I disorder in adults: A phase 3, randomized controlled trial.
Mahableshwarkar AR, Calabrese JR, Macek TA, Budur K, Adefuye A, Dong X, Hanson E, Sachs GS. Mahableshwarkar AR, et al. J Affect Disord. 2017 Oct 15;221:275-282. doi: 10.1016/j.jad.2017.06.044. Epub 2017 Jun 20. J Affect Disord. 2017. PMID: 28662460 Free article. Clinical Trial.
This study evaluated the efficacy and safety of a new sublingual formulation of the melatonin receptor agonist ramelteon (ramelteon SL) as adjunctive therapy in the maintenance treatment of bipolar I patients. ...Ramelteon SL was well tolerated, with a safety …
This study evaluated the efficacy and safety of a new sublingual formulation of the melatonin receptor agonist ramelteon (ramelteo …
Effect of add-on ramelteon therapy on sleep and circadian rhythm disruption in patients with schizophrenia: A randomized controlled trial.
Mishra A, Maiti R, Mishra BR, Jena M, Nath S, Sahu P. Mishra A, et al. Eur Neuropsychopharmacol. 2020 Feb;31:109-118. doi: 10.1016/j.euroneuro.2019.11.008. Epub 2019 Dec 9. Eur Neuropsychopharmacol. 2020. PMID: 31831203 Clinical Trial.
The sleep and circadian rhythm disruptions in schizophrenia are attributed to a decrease in nocturnal melatonin level which may worsen if treated with conventional sedative drugs. This study was planned to evaluate the effects of add-on ramelteon on sleep and circadian rhy …
The sleep and circadian rhythm disruptions in schizophrenia are attributed to a decrease in nocturnal melatonin level which may worsen if tr …
Preventative effects of ramelteon against postoperative delirium after elective liver resection.
Hokuto D, Nomi T, Yoshikawa T, Matsuo Y, Kamitani N, Sho M. Hokuto D, et al. PLoS One. 2020 Nov 2;15(11):e0241673. doi: 10.1371/journal.pone.0241673. eCollection 2020. PLoS One. 2020. PMID: 33137161 Free PMC article. Clinical Trial.
The aim of this study was to examine whether ramelteon is effective at preventing delirium after elective liver resection. ...CONCLUSION: The administration of ramelteon might reduce the risk of postoperative delirium after elective liver resection....
The aim of this study was to examine whether ramelteon is effective at preventing delirium after elective liver resection. ...CONCLUS …
Residual effects of low dose of suvorexant, zolpidem, and ramelteon in healthy elderly subjects: A randomized double-blind study.
Uemura SI, Imanishi A, Terui Y, Park I, Satake M, Han G, Shioya T, Kanbayashi T, Nishino S. Uemura SI, et al. Neuropsychopharmacol Rep. 2022 Sep;42(3):288-298. doi: 10.1002/npr2.12262. Epub 2022 Jun 24. Neuropsychopharmacol Rep. 2022. PMID: 35748642 Free PMC article. Clinical Trial.
During the second sleep period, suvorexant had shorter sleep latency and longer stage2 sleep time than ramelteon and zolpidem, respectively. During the whole entire sleep, the REM sleep time with suvorexant was longer than zolpidem and placebo. For the body sway test with …
During the second sleep period, suvorexant had shorter sleep latency and longer stage2 sleep time than ramelteon and zolpidem, respec …
Safety and subjective sleep effects of ramelteon administration in adults and older adults with chronic primary insomnia: a 1-year, open-label study.
Richardson GS, Zammit G, Wang-Weigand S, Zhang J. Richardson GS, et al. J Clin Psychiatry. 2009 Apr;70(4):467-76. doi: 10.4088/jcp.07m03834. Epub 2009 Mar 10. J Clin Psychiatry. 2009. PMID: 19284927 Clinical Trial.
OBJECTIVE: To evaluate the long-term safety and subjective sleep effects of ramelteon in adults with chronic insomnia. METHOD: Subjects with primary insomnia (DSM-IV-TR criteria) for >or= 3 months received ramelteon nightly for 1 year; a 3-day placebo run out fol …
OBJECTIVE: To evaluate the long-term safety and subjective sleep effects of ramelteon in adults with chronic insomnia. METHOD: Subjec …
61 results