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93 results

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Page 1
Expressional profile of cardiac uncoupling protein-2 following myocardial ischemia reperfusion in losartan- and ramiprilat-treated rats.
Safari F, Bayat G, Shekarforoush S, Hekmatimoghaddam S, Anvari Z, Moghadam MF, Hajizadeh S. Safari F, et al. J Renin Angiotensin Aldosterone Syst. 2014 Sep;15(3):209-17. doi: 10.1177/1470320312474050. Epub 2013 Jan 31. J Renin Angiotensin Aldosterone Syst. 2014. PMID: 23372044 Free article.
BACKGROUND AND AIMS: The aim of this study was to investigate the early changes of cardiac uncoupling protein-2 (UCP2) expression following myocardial ischemia reperfusion in rats chronically treated with ramiprilat and losartan. METHODS: Male Wistar rats were assigned int …
BACKGROUND AND AIMS: The aim of this study was to investigate the early changes of cardiac uncoupling protein-2 (UCP2) expression following …
Clinical pharmacokinetics of ramipril.
Meisel S, Shamiss A, Rosenthal T. Meisel S, et al. Clin Pharmacokinet. 1994 Jan;26(1):7-15. doi: 10.2165/00003088-199426010-00002. Clin Pharmacokinet. 1994. PMID: 8137599 Review.
After absorption from the gastrointestinal tract, rapid hydrolysis of ramipril occurs in the liver. In the therapeutic concentration range, protein binding of ramipril and ramiprilat is 73 and 56%, respectively. Ramiprilat binds to ACE with high affinity at c …
After absorption from the gastrointestinal tract, rapid hydrolysis of ramipril occurs in the liver. In the therapeutic concentration …
Aliskiren versus ramipril in hypertension.
Verdecchia P, Angeli F, Mazzotta G, Martire P, Garofoli M, Gentile G, Reboldi G. Verdecchia P, et al. Ther Adv Cardiovasc Dis. 2010 Jun;4(3):193-200. doi: 10.1177/1753944710369682. Epub 2010 Apr 23. Ther Adv Cardiovasc Dis. 2010. PMID: 20418269 Free article. Review.
Another potential explanation may be the longer terminal elimination halflife of aliskiren (about 40 hours) compared with ramiprilat (13-17 hours). These data provide further evidence that aliskiren monotherapy provides a sustained BP reduction over the 24 hours....
Another potential explanation may be the longer terminal elimination halflife of aliskiren (about 40 hours) compared with ramiprilat …
The analysis of ramipril/ramiprilat concentration in human serum with liquid chromatography-tandem mass spectrometry - interpretation of high concentrations for the purposes of forensic toxicology.
Dziadosz M, Rosenberger W, Klintschar M, Teske J. Dziadosz M, et al. Forensic Sci Med Pathol. 2024 Mar;20(1):100-105. doi: 10.1007/s12024-023-00621-6. Epub 2023 Apr 15. Forensic Sci Med Pathol. 2024. PMID: 37060536 Free PMC article.
Ramipril is a popular angiotensin-converting enzyme inhibitor applied in the treatment of hypertension. Its therapeutic effect is oriented on the concentration of the active metabolite ramiprilat. ...Most real samples targeted for ramipril/ramiprilat were ass …
Ramipril is a popular angiotensin-converting enzyme inhibitor applied in the treatment of hypertension. Its therapeutic effect is ori …
Pharmacokinetic and pharmacodynamic parameters of ramipril and ramiprilat in healthy dogs and dogs with reduced glomerular filtration rate.
Lefebvre HP, Jeunesse E, Laroute V, Toutain PL. Lefebvre HP, et al. J Vet Intern Med. 2006 May-Jun;20(3):499-507. doi: 10.1892/0891-6640(2006)20[499:pappor]2.0.co;2. J Vet Intern Med. 2006. PMID: 16734081 Free article. Clinical Trial.
Ramipril, an angiotensin-converting enzyme (ACE) inhibitor for use in dogs, is converted in vivo to its active form, ramiprilat, which is eliminated in the bile and urine in the dog. The objective of this study was to assess the effect of renal impairment on the pharmacoki …
Ramipril, an angiotensin-converting enzyme (ACE) inhibitor for use in dogs, is converted in vivo to its active form, ramiprilat, whic …
Human physiologically based pharmacokinetic model for ACE inhibitors: ramipril and ramiprilat.
Levitt DG, Schoemaker RC. Levitt DG, et al. BMC Clin Pharmacol. 2006 Jan 6;6:1. doi: 10.1186/1472-6904-6-1. BMC Clin Pharmacol. 2006. PMID: 16398929 Free PMC article.
The model includes: 1) two independent ACE binding sites; 2) non-equilibrium time dependent binding; 3) liver and kidney ramipril intracellular uptake, conversion to ramiprilat and extrusion from the cell; 4) intestinal ramipril absorption. The experimental in vitro ram …
The model includes: 1) two independent ACE binding sites; 2) non-equilibrium time dependent binding; 3) liver and kidney ramipril intracellu …
Impact of methylation of acyl glucuronide metabolites on incurred sample reanalysis evaluation: ramiprilat case study.
Côté C, Lahaie M, Latour S, Bergeron M, Dicaire C, Savoie N, Furtado M, Garofolo F. Côté C, et al. Bioanalysis. 2011 May;3(9):951-65. doi: 10.4155/bio.11.59. Bioanalysis. 2011. PMID: 21545343
BACKGROUND: Reanalysis of incurred samples showed that the bioanalytical method for the quantification of ramipril and ramiprilat was generating irreproducible results for ramiprilat. RESULTS: An additional peak interfering with ramiprilat was observed in the …
BACKGROUND: Reanalysis of incurred samples showed that the bioanalytical method for the quantification of ramipril and ramiprilat was …
Ramipril: a review of its use in the prevention of cardiovascular outcomes.
Warner GT, Perry CM. Warner GT, et al. Drugs. 2002;62(9):1381-405. doi: 10.2165/00003495-200262090-00016. Drugs. 2002. PMID: 12076194 Review.
Ramipril, an angiotensin-converting enzyme (ACE) inhibitor, is a prodrug which is rapidly hydrolysed after absorption to the active metabolite ramiprilat. Earlier trials have shown that ACE inhibitors, when given to patients with low ejection fractions, have reduced the re …
Ramipril, an angiotensin-converting enzyme (ACE) inhibitor, is a prodrug which is rapidly hydrolysed after absorption to the active metaboli …
Ramipril. A review of its pharmacological properties and therapeutic efficacy in cardiovascular disorders.
Todd PA, Benfield P. Todd PA, et al. Drugs. 1990 Jan;39(1):110-35. doi: 10.2165/00003495-199039010-00009. Drugs. 1990. PMID: 2138076 Review.
Like enalapril it is a prodrug, which is hydrolysed after absorption to form the active metabolite ramiprilat which has a long elimination half-life, permitting once daily administration. ...Ramipril 5 to 10 mg once daily shows comparable antihypertensive efficacy to usual …
Like enalapril it is a prodrug, which is hydrolysed after absorption to form the active metabolite ramiprilat which has a long elimin …
Spotlight on ramipril in the prevention of cardiovascular outcomes.
Warner GT, Perry CM. Warner GT, et al. Am J Cardiovasc Drugs. 2003;3(2):113-6. doi: 10.2165/00129784-200303020-00005. Am J Cardiovasc Drugs. 2003. PMID: 14727938 Review.
Ramipril (Altace)Use of tradenames is for product identification purposes only and does not imply endorsement.), an angiotensin-converting enzyme (ACE) inhibitor, is a prodrug which is rapidly hydrolyzed after absorption to the active metabolite ramiprilat. Earlier trials …
Ramipril (Altace)Use of tradenames is for product identification purposes only and does not imply endorsement.), an angiotensin-converting e …
93 results