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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1986 1
1987 1
1996 2
1998 1
1999 2
2000 1
2001 5
2002 6
2003 3
2004 16
2005 25
2006 28
2007 19
2008 21
2009 24
2010 42
2011 37
2012 27
2013 28
2014 36
2015 39
2016 34
2017 25
2018 27
2019 20
2020 21
2021 18
2022 19
2023 20
2024 24
2025 5

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517 results

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Page 1
Freezing of gait in Parkinson's disease: pathophysiology, risk factors and treatments.
Gao C, Liu J, Tan Y, Chen S. Gao C, et al. Transl Neurodegener. 2020 Apr 15;9:12. doi: 10.1186/s40035-020-00191-5. eCollection 2020. Transl Neurodegener. 2020. PMID: 32322387 Free PMC article. Review.
Several novel therapeutic strategies seem to be effective, such as rTMS over supplementary motor area (SMA), dual-site DBS, spinal cord stimulation (SCS) and VNS. ...Although firm conclusions cannot be drawn on therapeutic efficacy, the literature suggested that som …
Several novel therapeutic strategies seem to be effective, such as rTMS over supplementary motor area (SMA), dual-site DBS, spinal co …
Parkinson's Disease: From Pathogenesis to Pharmacogenomics.
Cacabelos R. Cacabelos R. Int J Mol Sci. 2017 Mar 4;18(3):551. doi: 10.3390/ijms18030551. Int J Mol Sci. 2017. PMID: 28273839 Free PMC article. Review.
Conventional pharmacological treatments for PD are dopamine precursors (levodopa, l-DOPA, l-3,4 dihidroxifenilalanina), and other symptomatic treatments including dopamine agonists (amantadine, apomorphine, bromocriptine, cabergoline, lisuride, pergolide, pramipexole, ropinirole, …
Conventional pharmacological treatments for PD are dopamine precursors (levodopa, l-DOPA, l-3,4 dihidroxifenilalanina), and other symptomati …
Rasagiline.
Siddiqui MA, Plosker GL. Siddiqui MA, et al. Drugs Aging. 2005;22(1):83-91; discussion 93-4. doi: 10.2165/00002512-200522010-00006. Drugs Aging. 2005. PMID: 15663351 Review.
Rasagiline also possesses neuroprotective properties that are independent of its MAO inhibitory activity. ...Rasagiline has shown significant beneficial effects as monotherapy in the treatment of early Parkinson's disease. ...
Rasagiline also possesses neuroprotective properties that are independent of its MAO inhibitory activity. ...Rasagiline has sh …
Rasagiline.
Schapira A, Bate G, Kirkpatrick P. Schapira A, et al. Nat Rev Drug Discov. 2005 Aug;4(8):625-6. doi: 10.1038/nrd1803. Nat Rev Drug Discov. 2005. PMID: 16106586 No abstract available.
Clinical benefit of MAO-B and COMT inhibition in Parkinson's disease: practical considerations.
Regensburger M, Ip CW, Kohl Z, Schrader C, Urban PP, Kassubek J, Jost WH. Regensburger M, et al. J Neural Transm (Vienna). 2023 Jun;130(6):847-861. doi: 10.1007/s00702-023-02623-8. Epub 2023 Mar 24. J Neural Transm (Vienna). 2023. PMID: 36964457 Free PMC article. Review.
Inhibitors of monoamine oxidase B (MAO-B) and catechol-O-methyltransferase (COMT) are major strategies to reduce levodopa degradation and thus to increase and prolong its effect in striatal dopaminergic neurotransmission in Parkinson's disease patients. While selegiline/rasagi …
Inhibitors of monoamine oxidase B (MAO-B) and catechol-O-methyltransferase (COMT) are major strategies to reduce levodopa degradation and th …
Monoamine Oxidases.
Edmondson DE, Binda C. Edmondson DE, et al. Subcell Biochem. 2018;87:117-139. doi: 10.1007/978-981-10-7757-9_5. Subcell Biochem. 2018. PMID: 29464559 Review.
Currently, the treatment of Parkinson's disease involves the use of selective MAO B inhibitors such as rasagiline and safinamide. MAO inhibition was shown to exert a general neuroprotective effect as a result of the reduction of oxidative stress produced by these enzymes, …
Currently, the treatment of Parkinson's disease involves the use of selective MAO B inhibitors such as rasagiline and safinamide. MAO …
Pharmacokinetic/pharmacodynamic evaluation of rasagiline mesylate for Parkinson's disease.
Müller T. Müller T. Expert Opin Drug Metab Toxicol. 2014 Oct;10(10):1423-32. doi: 10.1517/17425255.2014.943182. Epub 2014 Sep 6. Expert Opin Drug Metab Toxicol. 2014. PMID: 25196265 Review.
Rasagiline moderately improves motor symptoms and therefore reduces the predominant levodopa-associated wearing-off phenomena. AREAS COVERED: Following a PubMed database search with the terms rasagiline and selegiline, this review describes the role of rasagiline …
Rasagiline moderately improves motor symptoms and therefore reduces the predominant levodopa-associated wearing-off phenomena. AREAS …
Rasagiline in neurodegeneration.
Schapira AH. Schapira AH. Exp Neurol. 2008 Aug;212(2):255-7. doi: 10.1016/j.expneurol.2008.05.002. Epub 2008 May 16. Exp Neurol. 2008. PMID: 18571162 Review. No abstract available.
Targeting SIRT3 sensitizes glioblastoma to ferroptosis by promoting mitophagy and inhibiting SLC7A11.
Li X, Zhang W, Xing Z, Hu S, Zhang G, Wang T, Wang T, Fan Q, Chen G, Cheng J, Jiang X, Cai R. Li X, et al. Cell Death Dis. 2024 Feb 23;15(2):168. doi: 10.1038/s41419-024-06558-0. Cell Death Dis. 2024. PMID: 38395990 Free PMC article.
This study aimed to characterize SIRT3 expression and activity in GBM and investigate the potential therapeutic effects of targeting SIRT3 while also inducing ferroptosis in these cells. We first found that SIRT3 expression was higher in GBM tissues than in normal brain ti …
This study aimed to characterize SIRT3 expression and activity in GBM and investigate the potential therapeutic effects of targeting …
517 results