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1,054 results

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Page 1
Phase III clinical trial comparing the efficacy and safety of adamgammadex with sugammadex for reversal of rocuronium-induced neuromuscular block.
Zhang Y, Jiang Y, Lei Q, Li C, Jin S, Wang Q, Huang Y, Li Y, Hong Y, Wang S, Lin H, Li H, Ou Y, Zou X, Sun Q, Guo Q, Chen Z, Min S, Qi Y, Jie Q, Liu J, Liu B, Zhang W. Zhang Y, et al. Br J Anaesth. 2024 Jan;132(1):45-52. doi: 10.1016/j.bja.2023.10.022. Epub 2023 Nov 25. Br J Anaesth. 2024. PMID: 38007377 Free article. Clinical Trial.
BACKGROUND: Preliminary clinical trials of adamgammadex, a new cyclodextrin-based selective reversal agent, have demonstrated its efficacy in reversing neuromuscular block by rocuronium. METHODS: This multicentre, randomised, double-blind, positive-controlled, non-inferior …
BACKGROUND: Preliminary clinical trials of adamgammadex, a new cyclodextrin-based selective reversal agent, have demonstrated its efficacy i …
Fentanyl versus placebo with ketamine and rocuronium for patients undergoing rapid sequence intubation in the emergency department: The FAKT study-A randomized clinical trial.
Ferguson I, Buttfield A, Burns B, Reid C, Shepherd S, Milligan J, Harris IA, Aneman A; Australasian College for Emergency Medicine Clinical Trials Network. Ferguson I, et al. Acad Emerg Med. 2022 Jun;29(6):719-728. doi: 10.1111/acem.14446. Epub 2022 Mar 15. Acad Emerg Med. 2022. PMID: 35064992 Free PMC article. Clinical Trial.
A total of 290 participants were randomized to receive either fentanyl or 0.9% saline (placebo) in combination with ketamine and rocuronium, according to a weight-based dosing schedule. The primary outcome was the proportion of patients in each group with at least one SBP …
A total of 290 participants were randomized to receive either fentanyl or 0.9% saline (placebo) in combination with ketamine and rocuroni
Effect of Rocuronium vs Succinylcholine on Endotracheal Intubation Success Rate Among Patients Undergoing Out-of-Hospital Rapid Sequence Intubation: A Randomized Clinical Trial.
Guihard B, Chollet-Xémard C, Lakhnati P, Vivien B, Broche C, Savary D, Ricard-Hibon A, Marianne Dit Cassou PJ, Adnet F, Wiel E, Deutsch J, Tissier C, Loeb T, Bounes V, Rousseau E, Jabre P, Huiart L, Ferdynus C, Combes X. Guihard B, et al. JAMA. 2019 Dec 17;322(23):2303-2312. doi: 10.1001/jama.2019.18254. JAMA. 2019. PMID: 31846014 Free PMC article. Clinical Trial.
IMPORTANCE: Rocuronium and succinylcholine are often used for rapid sequence intubation, although the comparative efficacy of these paralytic agents for achieving successful intubation in an emergency setting has not been evaluated in clinical trials. Succinylcholine use h …
IMPORTANCE: Rocuronium and succinylcholine are often used for rapid sequence intubation, although the comparative efficacy of these p …
Comparation Among Opioid-Based, Low Opioid and Opioid Free Anesthesia in Colorectal Oncologic Surgery.
Toleska M, Dimitrovski A, Dimitrovska NT. Toleska M, et al. Pril (Makedon Akad Nauk Umet Odd Med Nauki). 2023 Mar 29;44(1):117-126. doi: 10.2478/prilozi-2023-0013. Print 2023 Mar 1. Pril (Makedon Akad Nauk Umet Odd Med Nauki). 2023. PMID: 36987755 Free article. Clinical Trial.
The first group of patients, or Opioid-based anesthesia group (OBAG), received the following for induction to anesthesia: lidocaine at 1 mg/kg, fentanyl 100 at gr, propofol at 2mg/kg and rocuronium bromide at 0.6 mg/kg. They intermittently received 50-100 gr fentanyl intra …
The first group of patients, or Opioid-based anesthesia group (OBAG), received the following for induction to anesthesia: lidocaine at 1 mg/ …
The efficacy and safety of using a combination of rocuronium and sugammadex for awake craniotomy anesthesia: A randomized clinical trial.
Chen Y, Yang R, Sun M, He H, Lin Y, Bai H, Xiong M, Xu B. Chen Y, et al. Medicine (Baltimore). 2024 Mar 22;103(12):e37436. doi: 10.1097/MD.0000000000037436. Medicine (Baltimore). 2024. PMID: 38518023 Free PMC article. Clinical Trial.
This study compared the arousal time and quality after AC achieved by 2 different drug combinations: rocuronium with sugammadex and propofol with remifentanil. METHODS: This prospective, randomized, controlled trial included 42 adult patients undergoing AC with a laryngeal …
This study compared the arousal time and quality after AC achieved by 2 different drug combinations: rocuronium with sugammadex and p …
A Dose-finding Study of Sugammadex for Reversal of Rocuronium in Cardiac Surgery Patients and Postoperative Monitoring for Recurrent Paralysis.
Bowdle TA, Haththotuwegama KJ, Jelacic S, Nguyen ST, Togashi K, Michaelsen KE. Bowdle TA, et al. Anesthesiology. 2023 Jul 1;139(1):6-15. doi: 10.1097/ALN.0000000000004578. Anesthesiology. 2023. PMID: 37027807 Clinical Trial.
BACKGROUND: The dose of sugammadex recommended by the manufacturer for reversal of rocuronium is 2 mg/kg when the train-of-four count is 2 or more and 4 mg/kg when it is less than 2 but there is a posttetanic count of at least 1. ...METHODS: Neuromuscular blockade was moni …
BACKGROUND: The dose of sugammadex recommended by the manufacturer for reversal of rocuronium is 2 mg/kg when the train-of-four count …
Sugammadex Versus Neostigmine for Reversal of Neuromuscular Blockade in Patients With Severe Renal Impairment: A Randomized, Double-Blinded Study.
Oh MW, Mohapatra SG, Pak T, Hermawan A, Chen CA, Thota B, Chen J, Siu E, Park J, Moon TS. Oh MW, et al. Anesth Analg. 2024 May 1;138(5):1043-1051. doi: 10.1213/ANE.0000000000006807. Epub 2024 Jan 8. Anesth Analg. 2024. PMID: 38190344 Clinical Trial.
The objective of this study was to determine if reversal of rocuronium-induced neuromuscular blockade with sugammadex versus reversal of cisatracurium-induced neuromuscular blockade with neostigmine results in a faster return to a train-of-four ratio (TOFR) 90% in patients …
The objective of this study was to determine if reversal of rocuronium-induced neuromuscular blockade with sugammadex versus reversal …
Optimal dose of combined rocuronium and cisatracurium during minor surgery: A randomized trial.
Park WY, Choi JC, Yun HJ, Jeon YG, Park G, Choi JB. Park WY, et al. Medicine (Baltimore). 2018 Mar;97(10):e9779. doi: 10.1097/MD.0000000000009779. Medicine (Baltimore). 2018. PMID: 29517695 Free PMC article. Clinical Trial.
BACKGROUND: Combined rocuronium and cisatracurium have synergistic effects. We investigated whether reduced doses are effective during coadministration, by monitoring neuromuscular relaxation during surgery. ...CONCLUSION: Our findings contribute to determining clinically …
BACKGROUND: Combined rocuronium and cisatracurium have synergistic effects. We investigated whether reduced doses are effective durin …
The effect of rocuronium on ventilatory leak and sealing pressure using a supraglottic airway device: A randomized clinical trial.
Fujimoto M, Kubota F, Yamamoto T. Fujimoto M, et al. Acta Anaesthesiol Scand. 2020 Sep;64(8):1120-1127. doi: 10.1111/aas.13608. Epub 2020 May 5. Acta Anaesthesiol Scand. 2020. PMID: 32319087 Clinical Trial.
We hypothesized that ventilatory leak would decrease due to the increase in sealing pressure after administration of 0.15 and 0.30 mg/kg rocuronium iv. METHODS: Forty patients were randomly assigned to a control group or one of two rocuronium groups. ...Then, 0.15 m …
We hypothesized that ventilatory leak would decrease due to the increase in sealing pressure after administration of 0.15 and 0.30 mg/kg …
1,054 results