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Year Number of Results
1986 2
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1995 22
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2000 56
2001 48
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2008 39
2009 42
2010 44
2011 49
2012 45
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1,210 results

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Page 1
Brexpiprazole and Sertraline Combination Treatment in Posttraumatic Stress Disorder: A Phase 3 Randomized Clinical Trial.
Davis LL, Behl S, Lee D, Zeng H, Skubiak T, Weaver S, Hefting N, Larsen KG, Hobart M. Davis LL, et al. JAMA Psychiatry. 2025 Mar 1;82(3):218-227. doi: 10.1001/jamapsychiatry.2024.3996. JAMA Psychiatry. 2025. PMID: 39693081 Free PMC article. Clinical Trial.
OBJECTIVE: To investigate the efficacy, safety, and tolerability of brexpiprazole and sertraline combination treatment (brexpiprazole + sertraline) compared with sertraline + placebo for PTSD. ...INTERVENTIONS: Oral brexpiprazole 2 to 3 mg per day (flexible d …
OBJECTIVE: To investigate the efficacy, safety, and tolerability of brexpiprazole and sertraline combination treatment (brexpiprazole …
The clinical effectiveness of sertraline in primary care and the role of depression severity and duration (PANDA): a pragmatic, double-blind, placebo-controlled randomised trial.
Lewis G, Duffy L, Ades A, Amos R, Araya R, Brabyn S, Button KS, Churchill R, Derrick C, Dowrick C, Gilbody S, Fawsitt C, Hollingworth W, Jones V, Kendrick T, Kessler D, Kounali D, Khan N, Lanham P, Pervin J, Peters TJ, Riozzie D, Salaminios G, Thomas L, Welton NJ, Wiles N, Woodhouse R, Lewis G. Lewis G, et al. Lancet Psychiatry. 2019 Nov;6(11):903-914. doi: 10.1016/S2215-0366(19)30366-9. Epub 2019 Sep 19. Lancet Psychiatry. 2019. PMID: 31543474 Free PMC article. Clinical Trial.
We observed weak evidence that depressive symptoms were reduced by sertraline at 12 weeks. We recorded seven adverse events-four for sertraline and three for placebo, and adverse events did not differ by treatment allocation. Three adverse events were classified as …
We observed weak evidence that depressive symptoms were reduced by sertraline at 12 weeks. We recorded seven adverse events-four for …
Cognitive behavioral therapy, sertraline, or a combination in childhood anxiety.
Walkup JT, Albano AM, Piacentini J, Birmaher B, Compton SN, Sherrill JT, Ginsburg GS, Rynn MA, McCracken J, Waslick B, Iyengar S, March JS, Kendall PC. Walkup JT, et al. N Engl J Med. 2008 Dec 25;359(26):2753-66. doi: 10.1056/NEJMoa0804633. Epub 2008 Oct 30. N Engl J Med. 2008. PMID: 18974308 Free PMC article. Clinical Trial.
Results on the Pediatric Anxiety Rating Scale documented a similar magnitude and pattern of response; combination therapy had a greater response than cognitive behavioral therapy, which was equivalent to sertraline, and all therapies were superior to placebo. Adverse event …
Results on the Pediatric Anxiety Rating Scale documented a similar magnitude and pattern of response; combination therapy had a greater resp …
Cognitive-behavior therapy, sertraline, and their combination for children and adolescents with obsessive-compulsive disorder: the Pediatric OCD Treatment Study (POTS) randomized controlled trial.
Pediatric OCD Treatment Study (POTS) Team. Pediatric OCD Treatment Study (POTS) Team. JAMA. 2004 Oct 27;292(16):1969-76. doi: 10.1001/jama.292.16.1969. JAMA. 2004. PMID: 15507582 Clinical Trial.
OBJECTIVE: To evaluate the efficacy of CBT alone and medical management with the selective serotonin reuptake inhibitor sertraline alone, or CBT and sertraline combined, as initial treatment for children and adolescents with OCD. ...CBT alone did not differ from …
OBJECTIVE: To evaluate the efficacy of CBT alone and medical management with the selective serotonin reuptake inhibitor sertraline al …
Treatment Response Prediction in Major Depressive Disorder Using Multimodal MRI and Clinical Data: Secondary Analysis of a Randomized Clinical Trial.
Poirot MG, Ruhe HG, Mutsaerts HMM, Maximov II, Groote IR, Bjørnerud A, Marquering HA, Reneman L, Caan MWA. Poirot MG, et al. Am J Psychiatry. 2024 Mar 1;181(3):223-233. doi: 10.1176/appi.ajp.20230206. Epub 2024 Feb 7. Am J Psychiatry. 2024. PMID: 38321916 Clinical Trial.
External cross-validation on data from placebo nonresponders (bAcc=62%, AUROC=0.66) and placebo nonresponders who were switched to sertraline (bAcc=65%, AUROC=0.68) resulted in differences that suggest specificity for sertraline treatment compared with placebo treat …
External cross-validation on data from placebo nonresponders (bAcc=62%, AUROC=0.66) and placebo nonresponders who were switched to sertra …
Rhodiola rosea versus sertraline for major depressive disorder: A randomized placebo-controlled trial.
Mao JJ, Xie SX, Zee J, Soeller I, Li QS, Rockwell K, Amsterdam JD. Mao JJ, et al. Phytomedicine. 2015 Mar 15;22(3):394-9. doi: 10.1016/j.phymed.2015.01.010. Epub 2015 Feb 23. Phytomedicine. 2015. PMID: 25837277 Free PMC article. Clinical Trial.
BACKGROUND: We performed a proof of concept trial to evaluate relative safety and efficacy of Rhodiola rosea (R. rosea) versus sertraline for mild to moderate major depressive disorder. HYPOTHESIS: We hypothesize that R. rosea would have similar therapeutic effects as s …
BACKGROUND: We performed a proof of concept trial to evaluate relative safety and efficacy of Rhodiola rosea (R. rosea) versus sertraline …
Brexpiprazole in Combination With Sertraline and as Monotherapy in Posttraumatic Stress Disorder: A Full-Factorial Randomized Clinical Trial.
Hobart M, Chang D, Hefting N, Davis LL. Hobart M, et al. J Clin Psychiatry. 2025 Feb 19;86(1):24m15577. doi: 10.4088/JCP.24m15577. J Clin Psychiatry. 2025. PMID: 40009045 Clinical Trial.
Adult outpatients with PTSD (DSM-5) were randomized (1:1:1:1) to oral brexpiprazole + sertraline, brexpiprazole + placebo, sertraline + placebo, or placebo + placebo. Doses were flexible (brexpiprazole 1-3 mg/d; sertraline 100-200 mg/d). ...Brexpiprazole + pl …
Adult outpatients with PTSD (DSM-5) were randomized (1:1:1:1) to oral brexpiprazole + sertraline, brexpiprazole + placebo, sertral …
A placebo-controlled, randomized clinical trial comparing sertraline and imipramine for the treatment of dysthymia.
Thase ME, Fava M, Halbreich U, Kocsis JH, Koran L, Davidson J, Rosenbaum J, Harrison W. Thase ME, et al. Arch Gen Psychiatry. 1996 Sep;53(9):777-84. doi: 10.1001/archpsyc.1996.01830090023004. Arch Gen Psychiatry. 1996. PMID: 8792754 Clinical Trial.

With the use of a Clinical Global impressions improvement score of 1 or 2 (very much or much improved) to define response, response rates were 59% for sertraline, 64% for imipramine, and 44% for placebo (P = .02 for sertraline vs placebo and P < .001 for imiprami

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With the use of a Clinical Global impressions improvement score of 1 or 2 (very much or much improved) to define response, response rates we …
Adjunctive sertraline for asymptomatic cryptococcal antigenemia: A randomized clinical trial.
Boulware DR, Nalintya E, Rajasingham R, Kirumira P, Naluyima R, Turya F, Namanda S, Rutakingirwa MK, Skipper CP, Nikweri Y, Hullsiek KH, Bangdiwala AS, Meya DB. Boulware DR, et al. Med Mycol. 2020 Nov 10;58(8):1037-1043. doi: 10.1093/mmy/myaa033. Med Mycol. 2020. PMID: 32415846 Free PMC article. Clinical Trial.
Three SAEs in the sertraline group presented with psychosis and aggressive behavioral changes with one meeting Hunter's criteria for serotonin syndrome while receiving 200 mg/day sertraline. Two transient psychoses were associated with antecedent fluconazole and …
Three SAEs in the sertraline group presented with psychosis and aggressive behavioral changes with one meeting Hunter's criteria for …
Sertraline vs. ELectrical Current Therapy for Treating Depression Clinical Trial--SELECT TDCS: design, rationale and objectives.
Brunoni AR, Valiengo L, Baccaro A, Zanao TA, de Oliveira JF, Vieira GP, Bueno VF, Goulart AC, Boggio PS, Lotufo PA, Bensenor IM, Fregni F. Brunoni AR, et al. Contemp Clin Trials. 2011 Jan;32(1):90-8. doi: 10.1016/j.cct.2010.09.007. Epub 2010 Sep 18. Contemp Clin Trials. 2011. PMID: 20854930 Clinical Trial.
METHODS AND DESIGN: The SELECT TDCS trial aims to compare sertraline vs. tDCS in a double-blinded, randomized, factorial trial enrolling 120 participants to be allocated to four groups to receive sertraline+tDCS, sertraline, tDCS or placebo. ...DISCUSSION: Wi …
METHODS AND DESIGN: The SELECT TDCS trial aims to compare sertraline vs. tDCS in a double-blinded, randomized, factorial trial enroll …
1,210 results