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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1996 2
1997 1
1998 7
1999 38
2000 25
2001 46
2002 54
2003 48
2004 75
2005 62
2006 74
2007 74
2008 69
2009 50
2010 66
2011 61
2012 50
2013 47
2014 46
2015 40
2016 38
2017 40
2018 38
2019 26
2020 29
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1,055 results

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Page 1
Sildenafil improves clinical signs and radiographic features in dogs with congenital idiopathic megaoesophagus: a randomised controlled trial.
Quintavalla F, Menozzi A, Pozzoli C, Poli E, Donati P, Wyler DK, Serventi P, Bertini S. Quintavalla F, et al. Vet Rec. 2017 Apr 22;180(16):404. doi: 10.1136/vr.103832. Epub 2017 Feb 10. Vet Rec. 2017. PMID: 28188161 Clinical Trial.
We evaluated the efficacy of oral sildenafil citrate in dogs with congenital idiopathic megaoesophagus (CIM). Twenty-one puppies were randomly assigned to two groups (treatment and control). ...These results suggest that sildenafil citrate helps amelio …
We evaluated the efficacy of oral sildenafil citrate in dogs with congenital idiopathic megaoesophagus (CIM). Twenty-one puppi …
Endophenotype-based in silico network medicine discovery combined with insurance record data mining identifies sildenafil as a candidate drug for Alzheimer's disease.
Fang J, Zhang P, Zhou Y, Chiang CW, Tan J, Hou Y, Stauffer S, Li L, Pieper AA, Cummings J, Cheng F. Fang J, et al. Nat Aging. 2021 Dec;1(12):1175-1188. doi: 10.1038/s43587-021-00138-z. Epub 2021 Dec 6. Nat Aging. 2021. PMID: 35572351 Free PMC article. Clinical Trial.
We developed an endophenotype disease module-based methodology for Alzheimer's disease (AD) drug repurposing and identified sildenafil as a potential disease risk modifier. Based on retrospective case-control pharmacoepidemiologic analyses of insurance claims data for 7.23 …
We developed an endophenotype disease module-based methodology for Alzheimer's disease (AD) drug repurposing and identified sildenafil …
Oral sildenafil versus bosentan for treatment of persistent pulmonary hypertension of the newborn: a randomized controlled trial.
Kallimath A, Deshpande S, Singh P, Garegrat R, Lakshminrusimha S, Maheshwari R, Suryawanshi P. Kallimath A, et al. BMC Pediatr. 2024 Nov 1;24(1):698. doi: 10.1186/s12887-024-05107-0. BMC Pediatr. 2024. PMID: 39487423 Free PMC article. Clinical Trial.
The median (IQR) time for the primary outcome (PASP to reduce by 25% within 48 h) was 36 (24-48) h and 96 (48-120) h in sildenafil and bosentan groups respectively (p = 0.008). There was also a higher need to add other pulmonary vasodilators in bosentan group as compared t …
The median (IQR) time for the primary outcome (PASP to reduce by 25% within 48 h) was 36 (24-48) h and 96 (48-120) h in sildenafil an …
More potential for sildenafil than potency.
Mahler F, Baumgartner I. Mahler F, et al. Circulation. 2005 Nov 8;112(19):2894-5. doi: 10.1161/CIRCULATIONAHA.105.577643. Circulation. 2005. PMID: 16275879 Clinical Trial. No abstract available.
Sildenafil inhibits gastroduodenal motility.
Bortolotti M, Mari C, Lopilato C, La Rovere L, Miglioli M. Bortolotti M, et al. Aliment Pharmacol Ther. 2001 Feb;15(2):157-61. doi: 10.1046/j.1365-2036.2001.00917.x. Aliment Pharmacol Ther. 2001. PMID: 11148432 Clinical Trial.
RESULTS: Antral and duodenal wave frequency and amplitude were significantly lower during the first 60 min after sildenafil administration. Both antral and duodenal phases I were significantly longer after sildenafil than after placebo, and the number of phases III …
RESULTS: Antral and duodenal wave frequency and amplitude were significantly lower during the first 60 min after sildenafil administr …
Intrapartum Sildenafil to Improve Perinatal Outcomes: A Randomized Clinical Trial.
Kumar S, Tarnow-Mordi W, Mol BW, Flenady V, Liley HG, Badawi N, Walker S, Hyett J, Seidler AL, Callander E, Simes J, O'Connell RL; iSEARCH Investigators. Kumar S, et al. JAMA. 2025 Jul 8;334(2):149-159. doi: 10.1001/jama.2025.7710. JAMA. 2025. PMID: 40489090 Free PMC article. Clinical Trial.
IMPORTANCE: Sildenafil citrate may increase uteroplacental blood flow. Its ability to reduce perinatal complications related to fetal hypoxia during labor is uncertain. ...Induction of labor occurred in 1353 of 1621 women (83.5%) in the sildenafil citrate …
IMPORTANCE: Sildenafil citrate may increase uteroplacental blood flow. Its ability to reduce perinatal complications related t …
Effects of sildenafil on Doppler parameters, maternal and neonatal outcomes in the active labor phase of low-risk pregnancies: a randomized clinical trial.
Marsosi V, Haghighi L, Nasimi PH, Ghaemi M, Navaee S. Marsosi V, et al. J Perinat Med. 2023 Nov 7;52(2):210-214. doi: 10.1515/jpm-2023-0210. Print 2024 Feb 26. J Perinat Med. 2023. PMID: 37931599 Clinical Trial.
OBJECTIVES: The benefits of sildenafil by increasing blood flow in the improvement of Doppler parameters of umbilical (UA), uterine (UtA), and fetal middle cerebral arteries (MCA) remain uncertain. ...The patients were randomly assigned into two groups receiving sildena …
OBJECTIVES: The benefits of sildenafil by increasing blood flow in the improvement of Doppler parameters of umbilical (UA), uterine ( …
Sildenafil in the treatment of pressure ulcer: a randomised clinical trial.
Farsaei S, Khalili H, Farboud ES, Khazaeipour Z. Farsaei S, et al. Int Wound J. 2015 Feb;12(1):111-7. doi: 10.1111/iwj.12104. Epub 2013 Jun 4. Int Wound J. 2015. PMID: 23731453 Free PMC article. Clinical Trial.
Although animal studies have suggested the beneficial effects of sildenafil on wound healing, related clinical data are lacking. This is the first clinical study that has evaluated the effects of topical sildenafil on PrU healing in human subjects. ...Decreases in g …
Although animal studies have suggested the beneficial effects of sildenafil on wound healing, related clinical data are lacking. This …
A randomized clinical trial investigating treatment choice in Chinese men receiving sildenafil citrate and tadalafil for treating erectile dysfunction.
Bai WJ, Li HJ, Jin JJ, Xu WP, Sebastian S, Wang XF. Bai WJ, et al. Asian J Androl. 2017 Jul-Aug;19(4):500-504. doi: 10.4103/1008-682X.175782. Asian J Androl. 2017. PMID: 27101805 Free PMC article. Clinical Trial.
Sildenafil and tadalafil are efficacious and well tolerated in Chinese men with erectile dysfunction (ED). ...This open-label, randomized, crossover study compared psychosocial outcomes and drug attribute choices between tadalafil and sildenafil in Chinese men with …
Sildenafil and tadalafil are efficacious and well tolerated in Chinese men with erectile dysfunction (ED). ...This open-label, random …
A population pharmacokinetic analysis of sildenafil citrate in patients with erectile dysfunction.
Milligan PA, Marshall SF, Karlsson MO. Milligan PA, et al. Br J Clin Pharmacol. 2002;53 Suppl 1(Suppl 1):45S-52S. doi: 10.1046/j.0306-5251.2001.00032.x. Br J Clin Pharmacol. 2002. PMID: 11879259 Free PMC article. Clinical Trial.
AIMS: To analyse the pharmacokinetics of sildenafil citrate in patients with erectile dysfunction in order to characterize covariate relationships and assist in the development of rational dosage strategies. ...Overall, 2077 patients, 1335 of whom received silden …
AIMS: To analyse the pharmacokinetics of sildenafil citrate in patients with erectile dysfunction in order to characterize cov …
1,055 results