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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1986 2
1987 2
1988 7
1989 14
1990 23
1991 20
1992 25
1993 26
1994 28
1995 55
1996 27
1997 46
1998 45
1999 52
2000 57
2001 75
2002 69
2003 95
2004 93
2005 102
2006 87
2007 92
2008 103
2009 102
2010 104
2011 106
2012 91
2013 100
2014 91
2015 81
2016 62
2017 66
2018 42
2019 37
2020 26
2021 30
2022 35
2023 18
2024 14
2025 11
2026 2

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1,977 results

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Page 1
Simvastatin and oxidative stress in humans: A randomized, double-blinded, placebo-controlled clinical trial.
Rasmussen ST, Andersen JT, Nielsen TK, Cejvanovic V, Petersen KM, Henriksen T, Weimann A, Lykkesfeldt J, Poulsen HE. Rasmussen ST, et al. Redox Biol. 2016 Oct;9:32-38. doi: 10.1016/j.redox.2016.05.007. Epub 2016 May 30. Redox Biol. 2016. PMID: 27281490 Free PMC article. Clinical Trial.
Therefore, we hypothesized that simvastatin may reduce oxidative stress in humans in vivo. We conducted a randomized, double-blinded, placebo-controlled study in which subjects were treated with either 40mg of simvastatin or placebo for 14 days. ...A total of 40 par …
Therefore, we hypothesized that simvastatin may reduce oxidative stress in humans in vivo. We conducted a randomized, double-blinded, …
Safety and efficacy of topical simvastatin plus cholesterol cream versus topical simvastatin cream alone for porokeratosis ptychotropica: A randomized, single-blind, split-body, placebo-controlled, investigator-initiated trial.
Chen Z, Liu Y, Yu H, Li J, Huang X, Xiang R, Mo R, Chen H, Yang Y. Chen Z, et al. J Am Acad Dermatol. 2025 Oct;93(4):980-987. doi: 10.1016/j.jaad.2025.04.082. Epub 2025 May 20. J Am Acad Dermatol. 2025. PMID: 40403974 Clinical Trial.
OBJECTIVE: To evaluate the efficacy and safety of topical simvastatin and simvastatin/cholesterol in treating PP. METHODS: In this single-blind, split-body, placebo-controlled trial, PP patients were 1:1 randomized to apply either 2% simvastatin or 2% simv …
OBJECTIVE: To evaluate the efficacy and safety of topical simvastatin and simvastatin/cholesterol in treating PP. METHODS: In …
A phase II clinical trial of the Safety Of Simvastatin (SOS) in patients with pulmonary lymphangioleiomyomatosis and with tuberous sclerosis complex.
Krymskaya VP, Courtwright AM, Fleck V, Dorgan D, Kotloff R, McCormack FX, Kreider M. Krymskaya VP, et al. Respir Med. 2020 Mar;163:105898. doi: 10.1016/j.rmed.2020.105898. Epub 2020 Feb 8. Respir Med. 2020. PMID: 32125970 Free article. Clinical Trial.
No patients withdrew or had a reduction in simvastatin dose because of adverse events. Two patients required sirolumus dose reduction for supratherapeutic trough levels following simvastatin initiation. ...The addition of simvastatin, however, was associated …
No patients withdrew or had a reduction in simvastatin dose because of adverse events. Two patients required sirolumus dose reduction …
CYP3A4*22 and CYP3A5*3 are associated with increased levels of plasma simvastatin concentrations in the cholesterol and pharmacogenetics study cohort.
Kitzmiller JP, Luzum JA, Baldassarre D, Krauss RM, Medina MW. Kitzmiller JP, et al. Pharmacogenet Genomics. 2014 Oct;24(10):486-91. doi: 10.1097/FPC.0000000000000079. Pharmacogenet Genomics. 2014. PMID: 25051018 Free PMC article. Clinical Trial.
We aim to determine whether CYP3A4*22 and CYP3A5*3 alleles are associated with increased plasma concentrations of simvastatin lactone (SV) and simvastatin acid (SVA). This is the first report evaluating associations between in-vivo simvastatin concentrations …
We aim to determine whether CYP3A4*22 and CYP3A5*3 alleles are associated with increased plasma concentrations of simvastatin lactone …
Evaluating the Effects of Oral and Topical Simvastatin in the Treatment of Acne Vulgaris: A Double-blind, Randomized, Placebo-controlled Clinical Trial.
Ahmadvand A, Yazdanfar A, Yasrebifar F, Mohammadi Y, Mahjub R, Mehrpooya M. Ahmadvand A, et al. Curr Clin Pharmacol. 2018;13(4):279-283. doi: 10.2174/1574884713666180821143545. Curr Clin Pharmacol. 2018. PMID: 30129417 Clinical Trial.
Moreover, the oral simvastatin appeared to be more efficacious as compared with placebo group (P value<0.001). ...However, further studies with larger sample size, using improved formulations of topical simvastatin are needed to confirm these results....
Moreover, the oral simvastatin appeared to be more efficacious as compared with placebo group (P value<0.001). ...However, further …
A comparison of simvastatin and atorvastatin up to maximal recommended doses in a large multicenter randomized clinical trial.
Illingworth DR, Crouse JR 3rd, Hunninghake DB, Davidson MH, Escobar ID, Stalenhoef AF, Paragh G, Ma PT, Liu M, Melino MR, O'Grady L, Mercuri M, Mitchel YB; Simvastatin Atorvastatin HDL Study Group. Illingworth DR, et al. Curr Med Res Opin. 2001;17(1):43-50. Curr Med Res Opin. 2001. PMID: 11464446 Clinical Trial.
PRIMARY HYPOTHESIS: Simvastatin, across a range of doses, will be more effective than atorvastatin at raising HDL cholesterol and apo A-I levels. ...At the maximal dose comparison, simvastatin 80 mg and atorvastatin 80 mg, the HDL cholesterol and apo A-I differences …
PRIMARY HYPOTHESIS: Simvastatin, across a range of doses, will be more effective than atorvastatin at raising HDL cholesterol and apo …
High-dose simvastatin for aneurysmal subarachnoid hemorrhage: multicenter randomized controlled double-blinded clinical trial.
Wong GK, Chan DY, Siu DY, Zee BC, Poon WS, Chan MT, Gin T, Leung M; HDS-SAH Investigators. Wong GK, et al. Stroke. 2015 Feb;46(2):382-8. doi: 10.1161/STROKEAHA.114.007006. Epub 2014 Dec 16. Stroke. 2015. PMID: 25516195 Clinical Trial.
BACKGROUND AND PURPOSE: Experimental evidence has indicated the benefits of simvastatin for the treatment of subarachnoid hemorrhage. Two randomized placebo-controlled pilot trials that used the highest clinically approved dose of simvastatin (80 mg daily) gave posi …
BACKGROUND AND PURPOSE: Experimental evidence has indicated the benefits of simvastatin for the treatment of subarachnoid hemorrhage. …
Comparison of simvastatin and metformin in treatment of polycystic ovary syndrome: prospective randomized trial.
Banaszewska B, Pawelczyk L, Spaczynski RZ, Duleba AJ. Banaszewska B, et al. J Clin Endocrinol Metab. 2009 Dec;94(12):4938-45. doi: 10.1210/jc.2009-1674. Epub 2009 Nov 4. J Clin Endocrinol Metab. 2009. PMID: 19890022 Free PMC article. Clinical Trial.
OBJECTIVE: The aim of the study was to compare effects of simvastatin and metformin on PCOS. DESIGN: In a prospective trial, women with PCOS (n = 136) were randomized to simvastatin (S), metformin (M), or simvastatin plus metformin (SM) groups. ...Tota …
OBJECTIVE: The aim of the study was to compare effects of simvastatin and metformin on PCOS. DESIGN: In a prospective trial, women wi …
Effect of ezetimibe and/or simvastatin on coenzyme Q10 levels in plasma: a randomised trial.
Berthold HK, Naini A, Di Mauro S, Hallikainen M, Gylling H, Krone W, Gouni-Berthold I. Berthold HK, et al. Drug Saf. 2006;29(8):703-12. doi: 10.2165/00002018-200629080-00007. Drug Saf. 2006. PMID: 16872244 Clinical Trial.
Subjects received ezetimibe 10 mg/day, simvastatin 40 mg/day or the combination of ezetimibe 10 mg/day plus simvastatin 40 mg/day for 14 days. ...CoQ10 level was independent of cholesterol synthesis or absorption markers. CONCLUSIONS: Simvastatin and the comb …
Subjects received ezetimibe 10 mg/day, simvastatin 40 mg/day or the combination of ezetimibe 10 mg/day plus simvastatin 40 mg/ …
Safety of two different doses of simvastatin plus rifaximin in decompensated cirrhosis (LIVERHOPE-SAFETY): a randomised, double-blind, placebo-controlled, phase 2 trial.
Pose E, Napoleone L, Amin A, Campion D, Jimenez C, Piano S, Roux O, Uschner FE, de Wit K, Zaccherini G, Alessandria C, Angeli P, Bernardi M, Beuers U, Caraceni P, Durand F, Mookerjee RP, Trebicka J, Vargas V, Andrade RJ, Carol M, Pich J, Ferrero J, Domenech G, Llopis M, Torres F, Kamath PS, Abraldes JG, Solà E, Ginès P. Pose E, et al. Lancet Gastroenterol Hepatol. 2020 Jan;5(1):31-41. doi: 10.1016/S2468-1253(19)30320-6. Epub 2019 Oct 10. Lancet Gastroenterol Hepatol. 2020. PMID: 31607677 Free article. Clinical Trial.
We randomly assigned patients (1:1:1) to receive either simvastatin 40 mg/day plus rifaximin 1200 mg/day, simvastatin 20 mg/day plus rifaximin 1200 mg/day, or placebo of both medications for 12 weeks. ...We observed no significant differences in alkaline phosphatase …
We randomly assigned patients (1:1:1) to receive either simvastatin 40 mg/day plus rifaximin 1200 mg/day, simvastatin 20 mg/da …
1,977 results