Potassium/sodium cation carriers robustly upregulate CD20 antigen by targeting MYC, and synergize with anti- CD20 immunotherapies to eliminate malignant B cells.
Torun A, Zdanowicz A, Miazek-Zapala N, Zapala P, Pradhan B, Jedrzejczyk M, Ciechanowicz A, Pilch Z, Skorzynski M, Słabicki M, Rymkiewicz G, Barankiewicz J, Martines C, Laurenti L, Struga M, Winiarska M, Golab J, Kucia M, Ratajczak MZ, Huczynski A, Calado DP, Efremov DG, Zerrouqi A, Pyrzynska B.
Torun A, et al.
Haematologica. 2025 Jul 1;110(7):1555-1572. doi: 10.3324/haematol.2024.285826. Epub 2024 Dec 19.
Haematologica. 2025.
PMID: 39704178
Free PMC article.
Our investigation uncovers that nanomolar concentrations of salinomycin, monensin, nigericin, and narasin (a group of potassium/ sodium cation carriers) robustly enhance surface expression of CD20 antigen in B-cell-derived tumor cells, including primary malignant ce …
Our investigation uncovers that nanomolar concentrations of salinomycin, monensin, nigericin, and narasin (a group of potassium/ sodium …