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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1968 1
1971 1
1972 2
1973 5
1974 2
1975 3
1976 3
1977 3
1978 4
1979 12
1980 13
1981 11
1982 8
1983 12
1984 8
1985 18
1986 16
1987 25
1988 30
1989 22
1990 25
1991 22
1992 25
1993 18
1994 14
1995 23
1996 24
1997 11
1998 8
1999 20
2000 17
2001 13
2002 22
2003 15
2004 16
2005 15
2006 24
2007 25
2008 14
2009 18
2010 21
2011 17
2012 20
2013 29
2014 29
2015 17
2016 20
2017 19
2018 11
2019 12
2020 6
2021 7
2022 9
2023 4
2024 8
2025 2
2026 1

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745 results

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Page 1
Phase 1 dose-escalation trial combining sulfasalazine and stereotactic radiosurgery in patients with recurrent glioblastoma.
Skeie BS, Craig-Craven AR, Grüner ER, Biermann M, Riemer F, Bragstad S, Sarowar S, Behbahani M, Sleire L, Schwarzlmüller T, Goplen D, Heggdal JI, Knisely JPS, Schulder M, Eide GE, Filippi CG, Enger PØ. Skeie BS, et al. Redox Biol. 2026 Sep;95:104241. doi: 10.1016/j.redox.2026.104241. Epub 2026 May 30. Redox Biol. 2026. PMID: 42229231 Free PMC article. Clinical Trial.
Glioblastoma radioresistance is linked to glutathione, a key antioxidant protecting against oxidative stress. Sulfasalazine inhibits the xCT antiporter mediating cystine uptake required for glutathione synthesis in glioma, potentiating radiotherapy in preclinical studies. …
Glioblastoma radioresistance is linked to glutathione, a key antioxidant protecting against oxidative stress. Sulfasalazine inhibits …
Evolution of olsalazine.
Truelove SC. Truelove SC. Scand J Gastroenterol Suppl. 1988;148:3-6. doi: 10.3109/00365528809101538. Scand J Gastroenterol Suppl. 1988. PMID: 2906475 Review.
Sulphasalazine was first produced nearly 50 years ago through the inspiration of a Swedish doctor, Dr Nanna Svartz. ...Olsalazine was developed to retain the property of sulphasalazine of reaching the colon intact, but also to liberate two molecules of 5-ASA with no …
Sulphasalazine was first produced nearly 50 years ago through the inspiration of a Swedish doctor, Dr Nanna Svartz. ...Olsalazine was …
Sulfasalazine. Pharmacology, clinical use, toxicity, and related new drug development.
Peppercorn MA. Peppercorn MA. Ann Intern Med. 1984 Sep;101(3):377-86. doi: 10.7326/0003-4819-101-3-377. Ann Intern Med. 1984. PMID: 6147110 Review.
Sulfasalazine is metabolized by intestinal bacteria, resulting in the release of sulfapyridine and 5-aminosalicylate. ...The drug's mechanism of action may relate to its effects on prostaglandin synthesis or interference with arachidonic acid metabolism by the lipoxygenase …
Sulfasalazine is metabolized by intestinal bacteria, resulting in the release of sulfapyridine and 5-aminosalicylate. ...The drug's m …
Clinical efficacy and safety of etanercept versus sulfasalazine in patients with ankylosing spondylitis: a randomized, double-blind trial.
Braun J, van der Horst-Bruinsma IE, Huang F, Burgos-Vargas R, Vlahos B, Koenig AS, Freundlich B. Braun J, et al. Arthritis Rheum. 2011 Jun;63(6):1543-51. doi: 10.1002/art.30223. Arthritis Rheum. 2011. PMID: 21630245 Clinical Trial.
Until now, no clinical trial has compared the efficacy and safety of a TNF blocker with that of sulfasalazine. This study was undertaken to compare the efficacy and safety of etanercept with that of sulfasalazine after 16 weeks of treatment in patients with axial an …
Until now, no clinical trial has compared the efficacy and safety of a TNF blocker with that of sulfasalazine. This study was underta …
A controlled comparative study of the effects of methotrexate and pharmacogenetic factors on arterial blood pressure and arterial stiffness in patients with rheumatoid arthritis.
Mangoni AA, Wiese MD, Woodman RJ, Sotgia S, Zinellu A, Carru C, Hulin JA, Shanahan EM, Tommasi S. Mangoni AA, et al. Ann Med. 2025 Dec;57(1):2539311. doi: 10.1080/07853890.2025.2539311. Epub 2025 Jul 31. Ann Med. 2025. PMID: 40742006 Free PMC article. Clinical Trial.
PATIENTS AND METHODS: We conducted a controlled comparative study of treatment-naive newly diagnosed RA patients commenced on subcutaneous methotrexate (Group 1, n = 31, age 57 15 years, 65% females, Disease Activity Score-28 - C-reactive protein, DAS28-CRP = 4.7 1.2) or the …
PATIENTS AND METHODS: We conducted a controlled comparative study of treatment-naive newly diagnosed RA patients commenced on subcutaneous m …
Comparisons of sulfasalazine to gold and placebo in the treatment of rheumatoid arthritis.
Williams HJ. Williams HJ. J Rheumatol Suppl. 1988 Sep;16:9-13. J Rheumatol Suppl. 1988. PMID: 2903928 Review.
Studies comparing sulfasalazine to gold or placebo are few in number. Two controlled trials have been conducted comparing sulfasalazine and placebo, and 2 uncontrolled trials have compared sulfasalazine and gold sodium thiomalate. A controlled trial conducted …
Studies comparing sulfasalazine to gold or placebo are few in number. Two controlled trials have been conducted comparing sulfasal …
Meta-analysis of sulfasalazine in ankylosing spondylitis.
Ferraz MB, Tugwell P, Goldsmith CH, Atra E. Ferraz MB, et al. J Rheumatol. 1990 Nov;17(11):1482-6. J Rheumatol. 1990. PMID: 1980310 Clinical Trial.
Adverse effects, mostly mild, were more frequently observed in the sulfasalazine group (odds ratio [OR] = 1.5746, p = 0.1082). The occurrence of dropouts (OR = 1.1554, p = 0.6119) was similar in both groups. Sulfasalazine is a safe and effective drug in the short te …
Adverse effects, mostly mild, were more frequently observed in the sulfasalazine group (odds ratio [OR] = 1.5746, p = 0.1082). The oc …
Drug therapy of inflammatory bowel disease.
Sack DM, Peppercorn MA. Sack DM, et al. Pharmacotherapy. 1983 May-Jun;3(3):158-76. doi: 10.1002/j.1875-9114.1983.tb03245.x. Pharmacotherapy. 1983. PMID: 6136027 Review.
Although the etiology of inflammatory bowel disease is unknown and specific therapy is unavailable, enough information on existing empiric agents is available to allow rational therapy. These agents include sulfasalazine, steroids, immunosuppressive drugs, metronidazole an …
Although the etiology of inflammatory bowel disease is unknown and specific therapy is unavailable, enough information on existing empiric a …
Comparison between leflunomide and sulfasalazine based triple therapy in methotrexate refractory rheumatoid arthritis: an open-label, non-inferiority randomized controlled trial.
Belani PJ, Kavadichanda CG, Negi VS. Belani PJ, et al. Rheumatol Int. 2022 May;42(5):771-782. doi: 10.1007/s00296-021-04994-1. Epub 2021 Sep 29. Rheumatol Int. 2022. PMID: 34586472 Clinical Trial.
Secondary endpoints were improvement in DAS28, functional outcome and adverse events at 24 weeks. 136 eligible patients were randomized to either Leflunomide or Sulfasalazine group (68 in each group).63 and 59 patients in Leflunomide and 66 and 61 patients in Sulfasalaz …
Secondary endpoints were improvement in DAS28, functional outcome and adverse events at 24 weeks. 136 eligible patients were randomized to e …
The comparative efficacy and toxicity of second-line drugs in rheumatoid arthritis. Results of two metaanalyses.
Felson DT, Anderson JJ, Meenan RF. Felson DT, et al. Arthritis Rheum. 1990 Oct;33(10):1449-61. doi: 10.1002/art.1780331001. Arthritis Rheum. 1990. PMID: 1977391 Clinical Trial.
We performed 2 metaanalyses of placebo-controlled and comparative clinical trials to examine the relative efficacy and toxicity of methotrexate (MTX), injectable gold, D-penicillamine (DP), sulfasalazine (SSZ), auranofin (AUR), and antimalarial drugs, the second-line drugs …
We performed 2 metaanalyses of placebo-controlled and comparative clinical trials to examine the relative efficacy and toxicity of methotrex …
745 results