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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1981 1
1983 1
1984 2
1985 6
1986 22
1987 11
1988 12
1989 14
1990 12
1991 19
1992 25
1993 16
1994 17
1995 24
1996 20
1997 26
1998 25
1999 21
2000 18
2001 17
2002 24
2003 17
2004 25
2005 17
2006 19
2007 34
2008 22
2009 20
2010 11
2011 14
2012 12
2013 13
2014 12
2015 11
2016 10
2017 10
2018 12
2019 9
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2021 16
2022 14
2023 6

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612 results

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Page 1
Drugs for hypertension.
[No authors listed] [No authors listed] Med Lett Drugs Ther. 2020 May 18;62(1598):73-80. Med Lett Drugs Ther. 2020. PMID: 32555118 No abstract available.
Enhancing glycolysis attenuates Parkinson's disease progression in models and clinical databases.
Cai R, Zhang Y, Simmering JE, Schultz JL, Li Y, Fernandez-Carasa I, Consiglio A, Raya A, Polgreen PM, Narayanan NS, Yuan Y, Chen Z, Su W, Han Y, Zhao C, Gao L, Ji X, Welsh MJ, Liu L. Cai R, et al. J Clin Invest. 2019 Oct 1;129(10):4539-4549. doi: 10.1172/JCI129987. J Clin Invest. 2019. PMID: 31524631 Free PMC article.
Impaired energy metabolism and reduced ATP levels are common features of PD. Previous studies revealed that terazosin (TZ) enhances the activity of phosphoglycerate kinase 1 (PGK1), thereby stimulating glycolysis and increasing cellular ATP levels. ...Because TZ is …
Impaired energy metabolism and reduced ATP levels are common features of PD. Previous studies revealed that terazosin (TZ) enh …
[Terazosin].
Schäfers RF, Michel MC. Schäfers RF, et al. Dtsch Med Wochenschr. 1998 Apr 9;123(15):459-60. doi: 10.1055/s-0029-1233226. Dtsch Med Wochenschr. 1998. PMID: 9581161 Review. German. No abstract available.
Terazosin Stimulates Pgk1 to Remedy Gastrointestinal Disorders.
Liu J, Zhao W, Li C, Wu T, Han L, Hu Z, Li X, Zhou J, Chen X. Liu J, et al. Int J Mol Sci. 2021 Dec 30;23(1):416. doi: 10.3390/ijms23010416. Int J Mol Sci. 2021. PMID: 35008842 Free PMC article.
Meanwhile, we also find terazosin ameliorates ethanol-induced gastric mucosal damage in mice. Collectively, as a clinical drug, terazosin should be translated into therapeutics for gastrointestinal disease soon....
Meanwhile, we also find terazosin ameliorates ethanol-induced gastric mucosal damage in mice. Collectively, as a clinical drug, te …
Pharmacology of terazosin.
Kyncl JJ. Kyncl JJ. Am J Med. 1986 May 23;80(5B):12-9. doi: 10.1016/0002-9343(86)90846-6. Am J Med. 1986. PMID: 2872801
Terazosin is a quinazoline antihypertensive agent that is chemically similar to prazosin. ...The absorption of terazosin appeared to be slower than that of prazosin in rats. However, from eight to 16 hours after dosing, terazosin concentrations in plasma exce …
Terazosin is a quinazoline antihypertensive agent that is chemically similar to prazosin. ...The absorption of terazosin appea …
Terazosin Analogs Targeting Pgk1 as Neuroprotective Agents: Design, Synthesis, and Evaluation.
Wang Y, Qian S, Zhao F, Wang Y, Li J. Wang Y, et al. Front Chem. 2022 Jul 26;10:906974. doi: 10.3389/fchem.2022.906974. eCollection 2022. Front Chem. 2022. PMID: 35958233 Free PMC article.
These findings indicated that terazosin analogs have bright prospects for the development of PD therapeutics. In this study, a series of terazosin analogs were designed and synthesized for neuroprotective effects by targeting Pgk1. ...
These findings indicated that terazosin analogs have bright prospects for the development of PD therapeutics. In this study, a …
Pharmacokinetics of terazosin.
Sonders RC. Sonders RC. Am J Med. 1986 May 23;80(5B):20-4. doi: 10.1016/0002-9343(86)90847-8. Am J Med. 1986. PMID: 2872802
Terazosin was administered intravenously and orally in doses ranging up to 7.5 mg. ...Orally administered terazosin is rapidly, consistently, and almost completely absorbed into the bloodstream. ...
Terazosin was administered intravenously and orally in doses ranging up to 7.5 mg. ...Orally administered terazosin is rapidly …
Parkinson disease among patients treated for benign prostatic hyperplasia with α1 adrenergic receptor antagonists.
Sasane R, Bartels A, Field M, Sierra MI, Duvvuri S, Gray DL, Pin SS, Renger JJ, Stone DJ. Sasane R, et al. J Clin Invest. 2021 Jun 1;131(11):e145112. doi: 10.1172/JCI145112. J Clin Invest. 2021. PMID: 33822767 Free PMC article. Clinical Trial.
An epidemiological study of terazosin users showed a lower incidence of Parkinson disease when compared with users of tamsulosin, an alpha1 adrenergic receptor antagonist of a different class that does not activate PGK1. ...Patients were classified as tamsulosin users (n = …
An epidemiological study of terazosin users showed a lower incidence of Parkinson disease when compared with users of tamsulosin, an …
A pilot to assess target engagement of terazosin in Parkinson's disease.
Schultz JL, Brinker AN, Xu J, Ernst SE, Tayyari F, Rauckhorst AJ, Liu L, Uc EY, Taylor EB, Simmering JE, Magnotta VA, Welsh MJ, Narayanan NS. Schultz JL, et al. Parkinsonism Relat Disord. 2022 Jan;94:79-83. doi: 10.1016/j.parkreldis.2021.11.022. Epub 2021 Nov 27. Parkinsonism Relat Disord. 2022. PMID: 34894470 Free PMC article. Clinical Trial.
BACKGROUND: Impaired brain energy metabolism is a key feature of Parkinson's disease (PD). Terazosin (TZ) binds phosphoglycerate kinase 1 and stimulates its activity, which enhances glycolysis and increases ATP levels. Preclinical and epidemiologic data suggest that …
BACKGROUND: Impaired brain energy metabolism is a key feature of Parkinson's disease (PD). Terazosin (TZ) binds phosphoglycera …
612 results