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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1965 10
1966 6
1967 13
1968 6
1969 13
1970 14
1971 19
1972 16
1973 29
1974 13
1975 17
1976 27
1977 26
1978 37
1979 51
1980 45
1981 56
1982 53
1983 70
1984 63
1985 76
1986 94
1987 91
1988 94
1989 105
1990 66
1991 76
1992 69
1993 72
1994 74
1995 81
1996 66
1997 63
1998 66
1999 60
2000 53
2001 40
2002 31
2003 34
2004 34
2005 34
2006 43
2007 33
2008 31
2009 21
2010 24
2011 16
2012 23
2013 23
2014 15
2015 13
2016 21
2017 15
2018 8
2019 9
2020 7
2021 13
2022 13
2023 0
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Search Results

2,234 results
Results by year
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Page 1
The effect of low-dose corticosteroids and theophylline on the risk of acute exacerbations of COPD: the TASCS randomised controlled trial.
Jenkins CR, Wen FQ, Martin A, Barnes PJ, Celli B, Zhong NS, Zheng JP, Scaria A, Di Tanna GL, Bradbury T, Berend N; TASCS study investigators. Jenkins CR, et al. Eur Respir J. 2021 Jun 10;57(6):2003338. doi: 10.1183/13993003.03338-2020. Print 2021 Jun. Eur Respir J. 2021. PMID: 33334939 Free article. Clinical Trial.
There were negligible differences between annualised exacerbation rates across the three treatments: 0.89 (95% CI 0.78-1.02) on theophylline plus prednisone, 0.86 (95% CI 0.75-0.99) on theophylline plus placebo and 1.00 (95% CI 0.87-1.14) on placebo. The rate ratio …
There were negligible differences between annualised exacerbation rates across the three treatments: 0.89 (95% CI 0.78-1.02) on theophyll
A long-term clinical trial on the efficacy and safety profile of doxofylline in Asthma: The LESDA study.
Calzetta L, Matera MG, Goldstein MF, Fairweather WR, Howard WW, Cazzola M, Rogliani P. Calzetta L, et al. Pulm Pharmacol Ther. 2020 Feb;60:101883. doi: 10.1016/j.pupt.2019.101883. Epub 2019 Dec 26. Pulm Pharmacol Ther. 2020. PMID: 31884206 Free article. Clinical Trial.
Doxofylline, an oral methylxanthine with bronchodilator and anti-inflammatory activities, offers a promising alternative to theophylline due to its superior efficacy/safety profile. No long-term studies on the efficacy and safety of doxofylline are currently available in a …
Doxofylline, an oral methylxanthine with bronchodilator and anti-inflammatory activities, offers a promising alternative to theophylline
[Combination of theophylline and beta-adrenergic agonists in the treatment of asthma: efficacy and tolerance. Review of the literature].
Iung B, Laaban JP, Rochemaure J. Iung B, et al. Rev Pneumol Clin. 1989;45(4):152-60. Rev Pneumol Clin. 1989. PMID: 2576327 Review. French.
Theophylline and beta 2-mimetic agents have long been used concomitantly in the treatment of asthma, but divergent opinions are lingering on concerning the safety and effectiveness of this combination in both chronic and acute asthma. ...In clinical studies the incidence o
Theophylline and beta 2-mimetic agents have long been used concomitantly in the treatment of asthma, but divergent opinions are linge
Salivary theophylline monitoring: reassessment and clinical considerations.
Kirk JK, Dupuis RE, Miles MV, Gaddy GD, Miranda-Massari JR, Williams DM. Kirk JK, et al. Ther Drug Monit. 1994 Feb;16(1):58-66. doi: 10.1097/00007691-199402000-00010. Ther Drug Monit. 1994. PMID: 8160257 Clinical Trial.
To assess the reliability of salivary theophylline concentrations for patient monitoring, concentrations of theophylline in sera and saliva of 50 patients (ages 6-81 years) receiving oral or parenteral theophylline were determined by two methods: a rapid dry- …
To assess the reliability of salivary theophylline concentrations for patient monitoring, concentrations of theophylline in se …
Methylxanthine drug therapy in chronic heart failure associated with hypoxaemia: double-blind placebo-controlled clinical trial of doxofylline versus theophylline and bamifylline.
Dini FL, Pasini G, Cortellini G, Cani E, Bettini R, Garagnani A, Gobbi G, Greco A, Onorato G, Pasini P, et al. Dini FL, et al. Int J Clin Pharmacol Res. 1993;13(6):305-16. Int J Clin Pharmacol Res. 1993. PMID: 8088931 Clinical Trial.
The effects of the methylxanthine drugs doxofylline, theophylline and bamifylline were investigated on the basis of clinical and gasometric parameters in hypoxic patients with chronic heart failure. ...After 10 days' treatment, the NYHA class was found to be diminished in …
The effects of the methylxanthine drugs doxofylline, theophylline and bamifylline were investigated on the basis of clinical and gaso …
A randomized controlled clinical trial of pharmacokinetic theophylline dosing.
Hurley SF, Dziukas LJ, McNeil JJ, Brignell MJ. Hurley SF, et al. Am Rev Respir Dis. 1986 Dec;134(6):1219-24. doi: 10.1164/arrd.1986.134.5.1219. Am Rev Respir Dis. 1986. PMID: 3538957 Clinical Trial.
Intravenously administered and subsequent orally administered theophylline dosages for patients in the monitored group were adjusted daily on the basis of each patients's estimated theophylline clearance; dosages for control patients were determined by attending phy …
Intravenously administered and subsequent orally administered theophylline dosages for patients in the monitored group were adjusted …
Clinical and pharmacokinetic evaluation of a sustained-release liquid theophylline preparation.
Guill MF, Pruitt AW, Altman RE, Lawless TE, Brown DA, DuRant RH, Bottini PB. Guill MF, et al. J Allergy Clin Immunol. 1988 Aug;82(2):281-6. doi: 10.1016/0091-6749(88)91012-3. J Allergy Clin Immunol. 1988. PMID: 3403868 Clinical Trial.
Indexes of theophylline fluctuation during the dosing interval indicated equivalent or reduced variability for the suspension. Relative bioavailability of theophylline suspension was 89% of that for the solution.(ABSTRACT TRUNCATED AT 250 WORDS)...
Indexes of theophylline fluctuation during the dosing interval indicated equivalent or reduced variability for the suspension. Relati …
A blinded, randomized, placebo-controlled trial to compare theophylline and doxapram for the treatment of apnea of prematurity.
Peliowski A, Finer NN. Peliowski A, et al. J Pediatr. 1990 Apr;116(4):648-53. doi: 10.1016/s0022-3476(05)81620-8. J Pediatr. 1990. PMID: 2181103 Clinical Trial.
Of 10 infants, two had a short-term response to placebo, 8 of 10 infants to theophylline, and 7 of 11 infants to doxapram (placebo vs treatment with theophylline or doxapram: p = 0.01). ...Of the 15 infants randomly assigned to receive theophylline, seven res …
Of 10 infants, two had a short-term response to placebo, 8 of 10 infants to theophylline, and 7 of 11 infants to doxapram (placebo vs …
Theophylline Acetaldehyde as the Initial Product in Doxophylline Metabolism in Human Liver.
Zhao X, Ma H, Pan Q, Wang H, Qian X, Song P, Zou L, Mao M, Xia S, Ge G, Yang L. Zhao X, et al. Drug Metab Dispos. 2020 May;48(5):345-352. doi: 10.1124/dmd.119.089565. Epub 2020 Feb 21. Drug Metab Dispos. 2020. PMID: 32086296 Clinical Trial.
Doxophylline (DOXO) and theophylline are widely used as bronchodilators for treating asthma and chronic obstructive pulmonary disease, and DOXO has a better safety profile than theophylline. ...Among them, six metabolites were reported for the first time. The top th …
Doxophylline (DOXO) and theophylline are widely used as bronchodilators for treating asthma and chronic obstructive pulmonary disease …
Intranasal theophylline treatment of hyposmia and hypogeusia: a pilot study.
Henkin RI, Schultz M, Minnick-Poppe L. Henkin RI, et al. Arch Otolaryngol Head Neck Surg. 2012 Nov;138(11):1064-70. doi: 10.1001/2013.jamaoto.342. Arch Otolaryngol Head Neck Surg. 2012. PMID: 23165381 Clinical Trial.
DESIGN: We performed an open-label pilot study in patients with hyposmia and hypogeusia under the following 3 conditions: (1) before treatment, (2) after oral theophylline anhydrous treatment, and (3) after intranasal theophylline treatment. ...Body weight in …
DESIGN: We performed an open-label pilot study in patients with hyposmia and hypogeusia under the following 3 conditions: (1) before treatme …
2,234 results