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42 results

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Page 1
A phase I clinical trial of tiopronin, a putative neuroprotective agent, in aneurysmal subarachnoid hemorrhage.
Kim GH, Kellner CP, Hickman ZL, Zacharia BE, Starke RM, Hwang BY, Ducruet AF, Fernandez L, Mayer SA, Tracey KJ, Connolly ES Jr. Kim GH, et al. Neurosurgery. 2010 Jul;67(1):182-5; discussion 186. doi: 10.1227/01.NEU.0000370919.93259.3C. Neurosurgery. 2010. PMID: 20559104 Free PMC article. Clinical Trial.
METHODS: This Phase I dose-escalation trial enrolled three-patient cohorts using a conventional "3+3" study design. Tiopronin dose began at 1 g/d until aSAH Day 14. Each subsequent cohort received a dose of tiopronin based on predetermined guidelines. ...Plans for a …
METHODS: This Phase I dose-escalation trial enrolled three-patient cohorts using a conventional "3+3" study design. Tiopronin dose be …
Influence of Tiopronin on the Metabolism of Alcohol in Healthy Subjects.
Nass F, Schneider B, Wilm S, Kardel B, Gabor E, Merges F, Kroll M. Nass F, et al. Drug Res (Stuttg). 2017 Apr;67(4):204-210. doi: 10.1055/s-0042-123826. Epub 2017 Jan 31. Drug Res (Stuttg). 2017. PMID: 28142160 Clinical Trial.
Drug safety- and drug-alcohol interaction studies have mainly been conducted for frequently prescribed drugs with high financial interests. Orphan drugs such as tiopronin (ORPHA25073) are often neglected in terms of clinical research. Tiopronin is a drug that is mai …
Drug safety- and drug-alcohol interaction studies have mainly been conducted for frequently prescribed drugs with high financial interests. …
Clinical course and cystine stone formation during tiopronin treatment.
Lindell A, Denneberg T, Hellgren E, Jeppsson JO, Tiselius HG. Lindell A, et al. Urol Res. 1995;23(2):111-7. doi: 10.1007/BF00307941. Urol Res. 1995. PMID: 7676533 Clinical Trial.
Thirty-one patients with homozygous cystinuria and treated with tiopronin (2-mercaptopropionylglycine) were followed for between 0.4 and 12 years (median 8.8). ...It is concluded that the formation of cystine stones can be efficiently counteracted during treatment with …
Thirty-one patients with homozygous cystinuria and treated with tiopronin (2-mercaptopropionylglycine) were followed for between 0.4 …
Urinary excretion of free cystine and the tiopronin-cysteine-mixed disulfide during long term tiopronin treatment of cystinuria.
Lindell A, Denneberg T, Jeppsson JO. Lindell A, et al. Nephron. 1995;71(3):328-42. doi: 10.1159/000188740. Nephron. 1995. PMID: 8569983 Clinical Trial.
We report the results of a biochemical evaluation of long-term treatment of cystinuria with the SH compound tiopronin (2-mercaptopropionylglycine). The effects of tiopronin were studied by monitoring the urinary excretion of free cysteine and the mixed disulfide bet …
We report the results of a biochemical evaluation of long-term treatment of cystinuria with the SH compound tiopronin (2-mercaptoprop …
Inhibition of puerperal lactation with 2-mercaptopropionyl-glycine.
Akrivis C, Vezyraki P, Kiortsis DN, Fotopoulos A, Evangelou A. Akrivis C, et al. Eur J Clin Pharmacol. 2000 Dec;56(9-10):621-3. doi: 10.1007/s002280000228. Eur J Clin Pharmacol. 2000. PMID: 11214766 Clinical Trial.
In group I, no medication was administered but only conservative measures were taken (restriction of fluid intake, ice-bags applied on the breasts, tight breast binders). Subjects in group II received tiopronin (200 mg/day) for 14 days. In group III, tiopronin (500 …
In group I, no medication was administered but only conservative measures were taken (restriction of fluid intake, ice-bags applied on the b …
Prospective analysis of tiopronin in prevention of sorafenib and antiviral therapy inducing liver toxicity in advanced hepatitis B virus-related hepatocellular carcinoma.
Li J, Qiu X, Guo W, Yan B, Zhang S. Li J, et al. Med Oncol. 2015 Oct;32(10):238. doi: 10.1007/s12032-015-0684-x. Epub 2015 Sep 2. Med Oncol. 2015. PMID: 26330362 Clinical Trial.
This prospective study determined the efficacy of tiopronin in hepatotoxicity prevention of HBV-related HCC treatment. Eighty-two patients (median age, 50 years; 71 % male) of advanced HCC treated with sorafenib and antiviral therapy were included, of whom 40 were given th …
This prospective study determined the efficacy of tiopronin in hepatotoxicity prevention of HBV-related HCC treatment. Eighty-two pat …
Pharmacokinetics of 2-(alpha-thenoylthio)-propionylglycine (TTPG) in healthy volunteers--an oral dose-proportionality investigation.
Marzo A, Bruno G, Nava D, Giubilei C, Arrigoni Martelli E, Douin MJ, Chassard D, Mignot A, Thebault JJ. Marzo A, et al. J Pharm Biomed Anal. 1992 Sep;10(9):623-9. doi: 10.1016/0731-7085(92)80089-6. J Pharm Biomed Anal. 1992. PMID: 1286128 Clinical Trial.
Plasma concentration and urinary excretion of TTPG and its two systemic metabolites, namely propionylglycine (tiopronin) and thiophenecarboxylic acid (TCA) were assayed by a previously well validated HPLC method. Due to differences in the physical and chemical properties o …
Plasma concentration and urinary excretion of TTPG and its two systemic metabolites, namely propionylglycine (tiopronin) and thiophen …
Studies on renal function in patients with cystinuria.
Lindell A, Denneberg T, Granerus G. Lindell A, et al. Nephron. 1997;77(1):76-85. doi: 10.1159/000190250. Nephron. 1997. PMID: 9380242 Clinical Trial.
The patients had been subjected to a stone-preventing regimen composed of increased fluid intake, urinary alkalinization and treatment with a sulphydryl compound, tiopronin or D-penicillamine, for an average of 11.7 years (range 1-24). Urinary cystine concentration was det …
The patients had been subjected to a stone-preventing regimen composed of increased fluid intake, urinary alkalinization and treatment with …
The effect of sodium intake on cystinuria with and without tiopronin treatment.
Lindell A, Denneberg T, Edholm E, Jeppsson JO. Lindell A, et al. Nephron. 1995;71(4):407-15. doi: 10.1159/000188760. Nephron. 1995. PMID: 8587620 Clinical Trial.
We have studied the effect of a sodium-restricted diet on the urinary excretion of cystine in 13 patients with cystinuria, 7 of whom were treated with the SH compound tiopronin (2-mercaptopropionylglycine). Five of the patients with tiopronin and 5 without were also …
We have studied the effect of a sodium-restricted diet on the urinary excretion of cystine in 13 patients with cystinuria, 7 of whom were tr …
42 results