Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

Filters

My NCBI Filters

Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1980 2
1981 1
1982 2
1983 3
1984 7
1985 4
1986 8
1987 7
1988 9
1989 10
1990 9
1991 5
1992 11
1993 5
1994 15
1995 11
1996 7
1997 9
1998 11
1999 8
2000 11
2001 9
2002 7
2003 8
2004 14
2005 8
2006 11
2007 6
2008 18
2009 15
2010 15
2011 12
2012 11
2013 13
2014 10
2015 9
2016 8
2017 10
2018 19
2019 8
2020 17
2021 8
2022 16
2023 7
2024 7

Text availability

Article attribute

Article type

Publication date

Search Results

386 results

Results by year

Filters applied: . Clear all
Page 1
New directions in the treatment of opioid withdrawal.
Srivastava AB, Mariani JJ, Levin FR. Srivastava AB, et al. Lancet. 2020 Jun 20;395(10241):1938-1948. doi: 10.1016/S0140-6736(20)30852-7. Lancet. 2020. PMID: 32563380 Free PMC article. Review.
Newer agents likewise exploit these pharmacological mechanisms, including tramadol (mu-opioid receptor agonism) and tizanidine (alpha2 agonism). Areas for future research include managing withdrawal in the context of stabilising patients with opioid use disorder to extende …
Newer agents likewise exploit these pharmacological mechanisms, including tramadol (mu-opioid receptor agonism) and tizanidine (alpha …
Review of multiple sclerosis: Epidemiology, etiology, pathophysiology, and treatment.
Haki M, Al-Biati HA, Al-Tameemi ZS, Ali IS, Al-Hussaniy HA. Haki M, et al. Medicine (Baltimore). 2024 Feb 23;103(8):e37297. doi: 10.1097/MD.0000000000037297. Medicine (Baltimore). 2024. PMID: 38394496 Free PMC article. Review.
Management of spasticity requires physiotherapy, prescription of initial drugs such as baclofen or gabapentin, secondary drug options such as tizanidine or dantrolene, and third-line treatment such as benzodiazepines. ...
Management of spasticity requires physiotherapy, prescription of initial drugs such as baclofen or gabapentin, secondary drug options such a …
Choosing a skeletal muscle relaxant.
See S, Ginzburg R. See S, et al. Am Fam Physician. 2008 Aug 1;78(3):365-70. Am Fam Physician. 2008. PMID: 18711953 Free article. Review.
Cyclobenzaprine is the most heavily studied and has been shown to be effective for various musculoskeletal conditions. The sedative properties of tizanidine and cyclobenzaprine may benefit patients with insomnia caused by severe muscle spasms. ...
Cyclobenzaprine is the most heavily studied and has been shown to be effective for various musculoskeletal conditions. The sedative properti …
Pharmacotherapy for Spine-Related Pain in Older Adults.
Fu JL, Perloff MD. Fu JL, et al. Drugs Aging. 2022 Jul;39(7):523-550. doi: 10.1007/s40266-022-00946-x. Epub 2022 Jun 27. Drugs Aging. 2022. PMID: 35754070 Review.
Some muscle relaxants (carisoprodol, chlorzoxazone, cyclobenzaprine, metaxalone, methocarbamol, and orphenadrine) are avoided in older adults due to risk for sedation and falls. Others (tizanidine, baclofen, dantrolene) may be helpful for neck and back pain, with the most …
Some muscle relaxants (carisoprodol, chlorzoxazone, cyclobenzaprine, metaxalone, methocarbamol, and orphenadrine) are avoided in older adult …
Phenytoin-tizanidine interaction.
Ueno K, Miyai K, Mitsuzane K. Ueno K, et al. DICP. 1991 Nov;25(11):1273. doi: 10.1177/106002809102501124. DICP. 1991. PMID: 1722371 No abstract available.
Comparative effectiveness and safety of analgesic medicines for adults with acute non-specific low back pain: systematic review and network meta-analysis.
Wewege MA, Bagg MK, Jones MD, Ferraro MC, Cashin AG, Rizzo RR, Leake HB, Hagstrom AD, Sharma S, McLachlan AJ, Maher CG, Day R, Wand BM, O'Connell NE, Nikolakopolou A, Schabrun S, Gustin SM, McAuley JH. Wewege MA, et al. BMJ. 2023 Mar 22;380:e072962. doi: 10.1136/bmj-2022-072962. BMJ. 2023. PMID: 36948512 Free PMC article.
Low or very low confidence was noted in evidence for reduced pain intensity after treatment with tolperisone (mean difference -26.1 (95% confidence intervals -34.0 to -18.2)), aceclofenac plus tizanidine (-26.1 (-38.5 to -13.6)), pregabalin (-24.7 (-34.6 to -14.7)), and 14 …
Low or very low confidence was noted in evidence for reduced pain intensity after treatment with tolperisone (mean difference -26.1 (95% con …
Tizanidine: neuropharmacology and mechanism of action.
Coward DM. Coward DM. Neurology. 1994 Nov;44(11 Suppl 9):S6-10; discussion S10-1. Neurology. 1994. PMID: 7970012 Review.
Pharmacologic and electrophysiologic studies over the past 20 years have shown tizanidine to be a potent, central-acting myotonolytic agent that principally affects spinal polysynaptic reflexes. ...Similar alpha 2-receptor-mediated inhibition of interneuronal activity appe …
Pharmacologic and electrophysiologic studies over the past 20 years have shown tizanidine to be a potent, central-acting myotonolytic …
Microneedle-Mediated Transdermal Delivery of Tizanidine Hydrochloride.
Thakkar H, Pandya K, Patel B. Thakkar H, et al. Methods Mol Biol. 2020;2059:239-258. doi: 10.1007/978-1-4939-9798-5_13. Methods Mol Biol. 2020. PMID: 31435926
Tizanidine hydrochloride is a skeletal muscle relaxant used for the treatment of spasm, a sudden involuntary muscle contraction leading to pain. ...Thus, in the present investigation, preparation and evaluation of a transdermal delivery system for tizanidine hydroch
Tizanidine hydrochloride is a skeletal muscle relaxant used for the treatment of spasm, a sudden involuntary muscle contraction leadi
[Tizanidine-induced toxic hepatitis].
Afonso Pérez E, Pego Reigosa R, Lancho Seco A, Brañas Fernández F. Afonso Pérez E, et al. Med Clin (Barc). 1999 Apr 10;112(12):478-9. Med Clin (Barc). 1999. PMID: 10320966 Review. Spanish. No abstract available.
Tizanidine: Advances in Pharmacology & Therapeutics and Drug Formulations.
Zhu LL, Wang YH, Zhou Q. Zhu LL, et al. J Pain Res. 2024 Mar 21;17:1257-1271. doi: 10.2147/JPR.S461032. eCollection 2024. J Pain Res. 2024. PMID: 38529017 Free PMC article. Review.
In our geriatric practice, off-label use of tizanidine as preemptive analgesia drove us to find recent advances in its pharmacology and therapeutics. ...CONCLUSION: Tizanidine is an SMR with unique features and may be an optimal initial choice for older adult …
In our geriatric practice, off-label use of tizanidine as preemptive analgesia drove us to find recent advances in its pharmacolog
386 results