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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1977 1
1981 4
1982 2
1984 1
1986 1
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1988 6
1989 2
1991 1
1992 2
1993 1
1994 6
1995 3
1996 3
1997 3
1999 4
2000 1
2001 3
2002 4
2004 5
2005 3
2006 5
2007 6
2008 8
2009 4
2010 3
2011 2
2012 5
2013 4
2014 10
2015 2
2016 2
2017 1
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2019 1
2020 1
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113 results

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Page 1
Comparison of diclofenac with tramadol, tizanidine or placebo in the treatment of acute low back pain and sciatica: multi-center randomized controlled trial.
Hung KKC, Lam RPK, Lee HKH, Choi YF, Tenney J, Zuo Z, Chong MKC, Hui TSI, Wong TK, Yiu TY, Chan SY, Mok CPY, Leung LY, Mak WK, Sun DTF, Cheng CH, Graham CA. Hung KKC, et al. Postgrad Med J. 2024 Sep 22;100(1188):741-750. doi: 10.1093/postmj/qgae052. Postgrad Med J. 2024. PMID: 38679808 Free article. Clinical Trial.
Patients were randomized to the receive tramadol 50 mg, tizanidine 2 mg, or placebo every 6 hours for 2 weeks in a 1:1:1 ratio. The RMDQ and other secondary outcomes were measured at baseline, Day 2, 7, 14, 21, and 28. ...Complier Average Causal Effect analysis also showed …
Patients were randomized to the receive tramadol 50 mg, tizanidine 2 mg, or placebo every 6 hours for 2 weeks in a 1:1:1 ratio. The R …
A randomized, double-blind, placebo-controlled trial to evaluate the effect of nabiximols oromucosal spray on clinical measures of spasticity in patients with multiple sclerosis.
Bethoux FA, Farrell R, Checketts D, Sahr N, Berwaerts J, Alexander JK, Skobieranda F. Bethoux FA, et al. Mult Scler Relat Disord. 2024 Sep;89:105740. doi: 10.1016/j.msard.2024.105740. Epub 2024 Jun 20. Mult Scler Relat Disord. 2024. PMID: 39106541 Free article. Clinical Trial.
Patients had a diagnosis of MS and an untransformed MAS score of at least 2 in 2 of 6 LLMT-6 muscle groups despite current treatment with 1 of the following oral antispasticity agents: baclofen, tizanidine, or dantrolene. Eligible participants were randomly assigned to 1 …
Patients had a diagnosis of MS and an untransformed MAS score of at least 2 in 2 of 6 LLMT-6 muscle groups despite current treatment with …
Spasmodic torticollis: treatment with Tizanidine.
ten Houten R, Lakke JP, de Jong P, van Weerden TW, van den Burg W, Wesseling H. ten Houten R, et al. Acta Neurol Scand. 1984 Nov;70(5):373-6. doi: 10.1111/j.1600-0404.1984.tb00839.x. Acta Neurol Scand. 1984. PMID: 6391067 Clinical Trial.
A randomized double-blind cross-over study was performed to compare the efficacy of Tizanidine to that of placebo in the treatment of spasmodic torticollis. No evidence was found that Tizanidine was effective in 10 patients with spasmodic torticollis who received …
A randomized double-blind cross-over study was performed to compare the efficacy of Tizanidine to that of placebo in the treatment of …
Effect of cold application and tizanidine on clonus: clinical and electrophysiological assessment.
Boyraz I, Oktay F, Celik C, Akyuz M, Uysal H. Boyraz I, et al. J Spinal Cord Med. 2009;32(2):132-9. doi: 10.1080/10790268.2009.11760764. J Spinal Cord Med. 2009. PMID: 19569460 Free PMC article. Clinical Trial.
METHODS: The 38 patients were divided into 3 groups: cold group (n=19), tizanidine group (n=13), and patient control group (n=6). A separate group of 21 able-bodied volunteers served as controls for the cold group. ...Tizanidine had no significant effect on clonus. …
METHODS: The 38 patients were divided into 3 groups: cold group (n=19), tizanidine group (n=13), and patient control group (n=6). A s …
Correlations between dose, plasma concentrations, and antispastic action of tizanidine (Sirdalud).
Emre M, Leslie GC, Muir C, Part NJ, Pokorny R, Roberts RC. Emre M, et al. J Neurol Neurosurg Psychiatry. 1994 Nov;57(11):1355-9. doi: 10.1136/jnnp.57.11.1355. J Neurol Neurosurg Psychiatry. 1994. PMID: 7964811 Free PMC article. Clinical Trial.
In a double blind, placebo controlled, cross over study the correlations between single doses (2, 4, and 8 mg), plasma concentrations, and antispastic action of tizanidine were investigated in 16 patients with extensor spasticity of the legs due to multiple sclerosis. ...I …
In a double blind, placebo controlled, cross over study the correlations between single doses (2, 4, and 8 mg), plasma concentrations, and a …
Patient education and self-care for the management of jaw pain upon awakening: a randomized controlled clinical trial comparing the effectiveness of adding pharmacologic treatment with cyclobenzaprine or tizanidine.
Alencar FG Jr, Viana PG, Zamperini C, Becker A. Alencar FG Jr, et al. J Oral Facial Pain Headache. 2014 Spring;28(2):119-27. doi: 10.11607/ofph.963. J Oral Facial Pain Headache. 2014. PMID: 24822235 Clinical Trial.
AIMS: To compare the effectiveness of adding cyclobenzaprine, tizanidine, or placebo to patient education and a self-care management program for patients with myofascial pain and specifically presenting with jaw pain upon awakening. ...However, no significant differences a …
AIMS: To compare the effectiveness of adding cyclobenzaprine, tizanidine, or placebo to patient education and a self-care management …
Nightly sublingual tizanidine HCl in multiple sclerosis: clinical efficacy and safety.
Vakhapova V, Auriel E, Karni A. Vakhapova V, et al. Clin Neuropharmacol. 2010 May;33(3):151-4. doi: 10.1097/WNF.0b013e3181daad7d. Clin Neuropharmacol. 2010. PMID: 20502134 Clinical Trial.
Enrolled patients received placebo once nightly and were then randomized to receive oral tizanidine HCl following sublingual tizanidine HCl or sublingual tizanidine HCl following oral tizanidine HCl, each arm for 7 days. ...There were significant reduc …
Enrolled patients received placebo once nightly and were then randomized to receive oral tizanidine HCl following sublingual tizan …
Relative bioavailability of tizanidine 4-mg capsule and tablet formulations after a standardized high-fat meal: a single-dose, randomized, open-label, crossover study in healthy subjects.
Henney HR 3rd, Shah J. Henney HR 3rd, et al. Clin Ther. 2007 Apr;29(4):661-9. doi: 10.1016/j.clinthera.2007.04.012. Clin Ther. 2007. PMID: 17617289 Clinical Trial.
BACKGROUND: An immediate-release, multiparticulate capsule formulation of tizanidine has been developed to modify tizanidine pharmacokinetic characteristics in an attempt to decrease adverse events (AEs) while maintaining effectiveness in the management of spasticit …
BACKGROUND: An immediate-release, multiparticulate capsule formulation of tizanidine has been developed to modify tizanidine p …
A clinical and experimental investigation of the effects of tizanidine in trigeminal neuralgia.
Fromm GH, Aumentado D, Terrence CF. Fromm GH, et al. Pain. 1993 Jun;53(3):265-271. doi: 10.1016/0304-3959(93)90222-B. Pain. 1993. PMID: 8351156 Clinical Trial.
Experiments in cats anesthetized with alpha-chloralose showed that tizanidine (TZD: 5-chloro-4-(2-imidazolin-2-yl-amino)-2,1,3-benzothiodiazole) partly resembled carbamazepine (CBZ) and baclofen (BCF) in that it depressed excitatory transmission and facilitated segmental i …
Experiments in cats anesthetized with alpha-chloralose showed that tizanidine (TZD: 5-chloro-4-(2-imidazolin-2-yl-amino)-2,1,3-benzot …
113 results