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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1996 7
1997 8
1998 3
1999 12
2000 12
2001 15
2002 19
2003 36
2004 32
2005 48
2006 40
2007 71
2008 36
2009 32
2010 35
2011 39
2012 27
2013 32
2014 34
2015 11
2016 24
2017 21
2018 15
2019 14
2020 15
2021 7
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580 results
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Page 1
Trial of Amitriptyline, Topiramate, and Placebo for Pediatric Migraine.
Powers SW, Coffey CS, Chamberlin LA, Ecklund DJ, Klingner EA, Yankey JW, Korbee LL, Porter LL, Hershey AD; CHAMP Investigators. Powers SW, et al. N Engl J Med. 2017 Jan 12;376(2):115-124. doi: 10.1056/NEJMoa1610384. Epub 2016 Oct 27. N Engl J Med. 2017. PMID: 27788026 Free PMC article. Clinical Trial.
There were no significant between-group differences in the primary outcome, which occurred in 52% of the patients in the amitriptyline group, 55% of those in the topiramate group, and 61% of those in the placebo group (amitriptyline vs. placebo, P=0.26; topiramate v …
There were no significant between-group differences in the primary outcome, which occurred in 52% of the patients in the amitriptyline group …
The SANAD study of effectiveness of valproate, lamotrigine, or topiramate for generalised and unclassifiable epilepsy: an unblinded randomised controlled trial.
Marson AG, Al-Kharusi AM, Alwaidh M, Appleton R, Baker GA, Chadwick DW, Cramp C, Cockerell OC, Cooper PN, Doughty J, Eaton B, Gamble C, Goulding PJ, Howell SJ, Hughes A, Jackson M, Jacoby A, Kellett M, Lawson GR, Leach JP, Nicolaides P, Roberts R, Shackley P, Shen J, Smith DF, Smith PE, Smith CT, Vanoli A, Williamson PR; SANAD Study group. Marson AG, et al. Lancet. 2007 Mar 24;369(9566):1016-26. doi: 10.1016/S0140-6736(07)60461-9. Lancet. 2007. PMID: 17382828 Free PMC article. Clinical Trial.
Patients were randomly assigned to valproate, lamotrigine, or topiramate between Jan 12, 1999, and Aug 31, 2004, and follow-up data were obtained up to Jan 13, 2006. ...But there was no significant difference between valproate and topiramate in either the analysis o …
Patients were randomly assigned to valproate, lamotrigine, or topiramate between Jan 12, 1999, and Aug 31, 2004, and follow-up data w …
Effects of low-dose, controlled-release, phentermine plus topiramate combination on weight and associated comorbidities in overweight and obese adults (CONQUER): a randomised, placebo-controlled, phase 3 trial.
Gadde KM, Allison DB, Ryan DH, Peterson CA, Troupin B, Schwiers ML, Day WW. Gadde KM, et al. Lancet. 2011 Apr 16;377(9774):1341-52. doi: 10.1016/S0140-6736(11)60205-5. Epub 2011 Apr 8. Lancet. 2011. PMID: 21481449 Clinical Trial.
FINDINGS: Of 2487 patients, 994 were assigned to placebo, 498 to phentermine 75 mg plus topiramate 460 mg, and 995 to phentermine 150 mg plus topiramate 920 mg; 979, 488, and 981 patients, respectively, were analysed. At 56 weeks, change in bodyweight was -14 kg (le …
FINDINGS: Of 2487 patients, 994 were assigned to placebo, 498 to phentermine 75 mg plus topiramate 460 mg, and 995 to phentermine 150 …
FORWARD Study: Evaluating the Comparative Effectiveness of OnabotulinumtoxinA and Topiramate for Headache Prevention in Adults With Chronic Migraine.
Rothrock JF, Adams AM, Lipton RB, Silberstein SD, Jo E, Zhao X, Blumenfeld AM; FORWARD Study investigative group. Rothrock JF, et al. Headache. 2019 Nov;59(10):1700-1713. doi: 10.1111/head.13653. Epub 2019 Sep 26. Headache. 2019. PMID: 31559634 Free PMC article. Clinical Trial.
RESULTS: We enrolled 282 patients (onabotulinumtoxinA, n = 140; topiramate, n = 142) and 148 patients completed randomized treatment (onabotulinumtoxinA, n = 120 [86%]; topiramate, n = 28 [20%]). Primary reasons for withdrawal were ineffective treatment (onabotulinu …
RESULTS: We enrolled 282 patients (onabotulinumtoxinA, n = 140; topiramate, n = 142) and 148 patients completed randomized treatment …
Extended release mixed amphetamine salts and topiramate for cocaine dependence: A randomized clinical replication trial with frequent users.
Levin FR, Mariani JJ, Pavlicova M, Choi CJ, Mahony AL, Brooks DJ, Bisaga A, Dakwar E, Carpenter KM, Naqvi N, Nunes EV, Kampman K. Levin FR, et al. Drug Alcohol Depend. 2020 Jan 1;206:107700. doi: 10.1016/j.drugalcdep.2019.107700. Epub 2019 Nov 1. Drug Alcohol Depend. 2020. PMID: 31753736 Free PMC article. Clinical Trial.
BACKGROUND: Cocaine use disorder (CUD) remains a substantial public health problem with no clearly effective pharmacotherapy available. In a prior trial, combined amphetamine and topiramate treatment significantly reduced cocaine use among individuals demonstrating the mos …
BACKGROUND: Cocaine use disorder (CUD) remains a substantial public health problem with no clearly effective pharmacotherapy available. In a …
A randomized, placebo-controlled crossover trial of phentermine-topiramate ER in patients with binge-eating disorder and bulimia nervosa.
Safer DL, Adler S, Dalai SS, Bentley JP, Toyama H, Pajarito S, Najarian T. Safer DL, et al. Int J Eat Disord. 2020 Feb;53(2):266-277. doi: 10.1002/eat.23192. Epub 2019 Nov 13. Int J Eat Disord. 2020. PMID: 31721257 Clinical Trial.
OBJECTIVE: Open trials suggest phentermine/topiramate ER (PHEN/TPM-ER), food and drug administration (FDA) approved for obesity, has utility for binge eating. ...
OBJECTIVE: Open trials suggest phentermine/topiramate ER (PHEN/TPM-ER), food and drug administration (FDA) approved for obesity, has …
Exercise as migraine prophylaxis: a randomized study using relaxation and topiramate as controls.
Varkey E, Cider A, Carlsson J, Linde M. Varkey E, et al. Cephalalgia. 2011 Oct;31(14):1428-38. doi: 10.1177/0333102411419681. Epub 2011 Sep 2. Cephalalgia. 2011. PMID: 21890526 Free PMC article. Clinical Trial.
METHODS: In a randomized, controlled trial of adults with migraine, exercising for 40 minutes three times a week was compared to relaxation according to a recorded programme or daily topiramate use, which was slowly increased to the individual's highest tolerable do …
METHODS: In a randomized, controlled trial of adults with migraine, exercising for 40 minutes three times a week was compared to relaxation …
Comparison of topiramate and risperidone for the treatment of behavioral disturbances of patients with Alzheimer disease: a double-blind, randomized clinical trial.
Mowla A, Pani A. Mowla A, et al. J Clin Psychopharmacol. 2010 Feb;30(1):40-3. doi: 10.1097/JCP.0b013e3181ca0c59. J Clin Psychopharmacol. 2010. PMID: 20075646 Clinical Trial.
RESULT: Forty-eight patients were randomized to treatment with either topiramate or risperidone, and 41 patients (21 of 25 in topiramate group and 20 of 23 in risperidone group) completed the trial. ...There were no significant changes in the cognitive status of pat …
RESULT: Forty-eight patients were randomized to treatment with either topiramate or risperidone, and 41 patients (21 of 25 in topi
Comparative pre-emptive analgesic efficacy study of novel antiepileptic agents gabapentin, lamotrigine and topiramate in patients undergoing major surgeries at a tertiary care hospital: a randomized double blind clinical trial.
Bhosale UA, Yegnanarayan R, Gupta A, Shah P, Sardesai S. Bhosale UA, et al. J Basic Clin Physiol Pharmacol. 2017 Jan 1;28(1):59-66. doi: 10.1515/jbcpp-2016-0013. J Basic Clin Physiol Pharmacol. 2017. PMID: 27487492 Clinical Trial.
The present study is designed to study and compare the pre-emptive analgesic efficacy of lamotrigine, topiramate and gabapentin (as control) in postoperative pain control. ...RESULTS: Significantly higher pain scores were observed in the topiramate group postoperati …
The present study is designed to study and compare the pre-emptive analgesic efficacy of lamotrigine, topiramate and gabapentin (as c …
A randomized, one-year clinical trial comparing the efficacy of topiramate, flunarizine, and a combination of flunarizine and topiramate in migraine prophylaxis.
Luo N, Di W, Zhang A, Wang Y, Ding M, Qi W, Zhu Y, Massing MW, Fang Y. Luo N, et al. Pain Med. 2012 Jan;13(1):80-6. doi: 10.1111/j.1526-4637.2011.01295.x. Pain Med. 2012. PMID: 22233396 Clinical Trial.
In the flunarizine group, the average weight change was 0.6kg. Topiramate was associated with a mean weight loss was of -0.9kg in the topiramate group and -0.2kg in the flunarizine plus topiramate group. ...Adding topiramate to flunarizine may reduce t …
In the flunarizine group, the average weight change was 0.6kg. Topiramate was associated with a mean weight loss was of -0.9kg in the …
580 results