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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1978 16
1979 3
1980 4
1981 8
1982 8
1983 1
1984 9
1985 6
1986 10
1987 6
1988 9
1989 8
1990 12
1991 12
1992 34
1993 25
1994 37
1995 28
1996 46
1997 69
1998 77
1999 94
2000 100
2001 89
2002 108
2003 149
2004 144
2005 192
2006 199
2007 216
2008 234
2009 251
2010 259
2011 299
2012 345
2013 331
2014 362
2015 380
2016 361
2017 395
2018 423
2019 473
2020 508
2021 380
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6,054 results
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Page 1
Tramadol, Pharmacology, Side Effects, and Serotonin Syndrome: A Review.
Beakley BD, Kaye AM, Kaye AD. Beakley BD, et al. Pain Physician. 2015 Jul-Aug;18(4):395-400. Pain Physician. 2015. PMID: 26218943 Free article. Review.
While serotonin syndrome is often associated with the use of selective serotonin inhibitors (SSRI), an increasing number of reports are being presented involving the use of tramadol. METHODS: This review article contains an overview of serotonin syndrome while specifically …
While serotonin syndrome is often associated with the use of selective serotonin inhibitors (SSRI), an increasing number of reports are bein …
Clinical pharmacology of tramadol.
Grond S, Sablotzki A. Grond S, et al. Clin Pharmacokinet. 2004;43(13):879-923. doi: 10.2165/00003088-200443130-00004. Clin Pharmacokinet. 2004. PMID: 15509185 Review.
Tramadol, a centrally acting analgesic structurally related to codeine and morphine, consists of two enantiomers, both of which contribute to analgesic activity via different mechanisms. (+)-Tramadol and the metabolite (+)-O-desmethyl-tramadol (M1) are agonis
Tramadol, a centrally acting analgesic structurally related to codeine and morphine, consists of two enantiomers, both of which contr
Discovery and development of tramadol for the treatment of pain.
Bravo L, Mico JA, Berrocoso E. Bravo L, et al. Expert Opin Drug Discov. 2017 Dec;12(12):1281-1291. doi: 10.1080/17460441.2017.1377697. Epub 2017 Sep 17. Expert Opin Drug Discov. 2017. PMID: 28920461 Review.
For this reason, tramadol is considered an atypical opioid. These special pharmacological characteristics have made tramadol one of the most commonly prescribed analgesic drugs to treat moderate to severe pain. ...Given its 'mild effect' on opioid receptors, tram
For this reason, tramadol is considered an atypical opioid. These special pharmacological characteristics have made tramadol o …
Tramadol: Understanding the Risk of Serotonin Syndrome and Seizures.
Hassamal S, Miotto K, Dale W, Danovitch I. Hassamal S, et al. Am J Med. 2018 Nov;131(11):1382.e1-1382.e6. doi: 10.1016/j.amjmed.2018.04.025. Epub 2018 May 10. Am J Med. 2018. PMID: 29752906 Review.
Tramadol is commonly prescribed for pain control because it presents a lower risk for addiction and respiratory depression compared to other opioids. However, tramadol's serotonin and norepinephrine reuptake inhibitory effects result in a unique adverse effec
Tramadol is commonly prescribed for pain control because it presents a lower risk for addiction and respiratory depression compared t
Revisiting Tramadol: A Multi-Modal Agent for Pain Management.
Barakat A. Barakat A. CNS Drugs. 2019 May;33(5):481-501. doi: 10.1007/s40263-019-00623-5. CNS Drugs. 2019. PMID: 31004280 Review.
Tramadol also modifies the crosstalk between neuronal and non-neuronal cells in peripheral and central sites. Through these molecular effects, tramadol could modulate peripheral and central neuronal hyperexcitability. ...
Tramadol also modifies the crosstalk between neuronal and non-neuronal cells in peripheral and central sites. Through these molecular
Comparative pharmacology and toxicology of tramadol and tapentadol.
Faria J, Barbosa J, Moreira R, Queirós O, Carvalho F, Dinis-Oliveira RJ. Faria J, et al. Eur J Pain. 2018 May;22(5):827-844. doi: 10.1002/ejp.1196. Epub 2018 Feb 19. Eur J Pain. 2018. PMID: 29369473 Review.
Tramadol is a prodrug that acts through noradrenaline and serotonin reuptake inhibition, with a weak opioid component added by its metabolite O-desmethyltramadol. ...In addition, it leads to less side effects and lower abuse liability. However, in vivo and in vitro studies
Tramadol is a prodrug that acts through noradrenaline and serotonin reuptake inhibition, with a weak opioid component added by its me
Serotonin syndrome: is it a reason to avoid the use of tramadol with antidepressants?
Park SH, Wackernah RC, Stimmel GL. Park SH, et al. J Pharm Pract. 2014 Feb;27(1):71-8. doi: 10.1177/0897190013504957. Epub 2013 Oct 23. J Pharm Pract. 2014. PMID: 24153222 Review.
The prescribing of antidepressants with tramadol may be unnecessarily restricted due to fear of causing this syndrome. ...Tramadol is only contraindicated in combination with MAOIs but not other antidepressants in common use today. ...
The prescribing of antidepressants with tramadol may be unnecessarily restricted due to fear of causing this syndrome. ...Tramadol
[Pharmacology of tramadol].
Dayer P, Desmeules J, Collart L. Dayer P, et al. Drugs. 1997;53 Suppl 2:18-24. doi: 10.2165/00003495-199700532-00006. Drugs. 1997. PMID: 9190321 Review. French.
This explains the approximately 2-fold accumulation of the parent drug and its M1 derivative that is observed during multiple dose treatment with tramadol. The recommended daily dose of tramadol is between 50 and 100mg every 4 to 6 hours, with a maximum dose of 400 …
This explains the approximately 2-fold accumulation of the parent drug and its M1 derivative that is observed during multiple dose treatment …
Tramadol.
Young JW, Juurlink DN. Young JW, et al. CMAJ. 2013 May 14;185(8):E352. doi: 10.1503/cmaj.121592. Epub 2013 Mar 18. CMAJ. 2013. PMID: 23509136 Free PMC article. No abstract available.
Tramadol.
Pasero C, McCaffery M. Pasero C, et al. Am J Nurs. 2003 Feb;103(2):71, 73. doi: 10.1097/00000446-200302000-00032. Am J Nurs. 2003. PMID: 12582344 Review. No abstract available.
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