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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1971 2
1973 8
1974 2
1975 7
1976 12
1977 6
1979 5
1980 8
1981 4
1982 9
1983 5
1984 19
1985 4
1986 12
1987 9
1988 16
1989 16
1990 9
1991 8
1992 5
1993 5
1994 15
1995 3
1996 7
1997 7
1998 2
1999 13
2000 7
2001 3
2002 3
2003 7
2004 7
2005 5
2006 2
2007 8
2008 4
2009 6
2010 4
2011 6
2012 4
2013 6
2014 8
2015 7
2016 4
2017 5
2018 3
2019 4
2020 8
2021 4
2022 3
2023 5
2024 5
2025 4

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340 results

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Page 1
Effectiveness of Existing Insomnia Therapies for Patients Undergoing Hemodialysis : A Randomized Clinical Trial.
Mehrotra R, Cukor D, McCurry SM, Rue T, Roumelioti ME, Heagerty PJ, Unruh M. Mehrotra R, et al. Ann Intern Med. 2024 Feb;177(2):177-188. doi: 10.7326/M23-1794. Epub 2024 Jan 16. Ann Intern Med. 2024. PMID: 38224591 Clinical Trial.
RESULTS: A total of 923 patients were prescreened, and of the 411 patients with chronic insomnia, 126 were randomly assigned to CBT-I (n = 43), trazodone (n = 42), or placebo (n = 41). The change in ISI scores from baseline to 7 weeks with CBT-I or trazodone was no …
RESULTS: A total of 923 patients were prescreened, and of the 411 patients with chronic insomnia, 126 were randomly assigned to CBT-I (n = 4 …
Effect of Psychological and Medication Therapies for Insomnia on Daytime Functions: A Randomized Clinical Trial.
Morin CM, Chen SJ, Ivers H, Beaulieu-Bonneau S, Krystal AD, Guay B, Bélanger L, Cartwright A, Simmons B, Lamy M, Busby M, Edinger JD. Morin CM, et al. JAMA Netw Open. 2023 Dec 1;6(12):e2349638. doi: 10.1001/jamanetworkopen.2023.49638. JAMA Netw Open. 2023. PMID: 38153735 Free PMC article. Clinical Trial.
INTERVENTIONS: Participants were randomly assigned to either BT or zolpidem as first-stage therapy, and those whose insomnia had not remitted received a second-stage psychological therapy (BT or cognitive therapy) or medication therapy (zolpidem or trazodone). MAIN OUTCOME …
INTERVENTIONS: Participants were randomly assigned to either BT or zolpidem as first-stage therapy, and those whose insomnia had not remitte …
The effects of atomoxetine and trazodone combination on obstructive sleep apnea and sleep microstructure: A double-blind randomized clinical trial study.
Shahbazi M, Heidari R, Tafakhori A, Samadi S, Nikeghbalian Z, Amirifard H, Najafi A. Shahbazi M, et al. Sleep Med. 2024 Jan;113:13-18. doi: 10.1016/j.sleep.2023.11.006. Epub 2023 Nov 7. Sleep Med. 2024. PMID: 37979502 Clinical Trial.
STUDY OBJECTIVES: we aimed to compare the effects of atomoxetine and trazodone (A-T) in combination with placebo in patients with obstructive sleep apnea (OSA). ...Patients were studied on two separate nights with one-week intervals, once treated with trazodone (50 …
STUDY OBJECTIVES: we aimed to compare the effects of atomoxetine and trazodone (A-T) in combination with placebo in patients with obs …
Safety and efficacy of melatonin, clonazepam, and trazodone in patients with Parkinson's disease and sleep disorders: a randomized, double-blind trial.
Hadi F, Agah E, Tavanbakhsh S, Mirsepassi Z, Mousavi SV, Talachi N, Tafakhori A, Aghamollaii V. Hadi F, et al. Neurol Sci. 2022 Oct;43(10):6141-6148. doi: 10.1007/s10072-022-06188-4. Epub 2022 Jun 6. Neurol Sci. 2022. PMID: 35660990 Clinical Trial.
Melatonin intake was associated with a higher decrease in RBDSQ score compared to trazodone (P = 0.011) and clonazepam (P = 0.004). Trazodone intake was associated with a higher decrease in ESS score compared to clonazepam (P = 0.010). Mild adverse events were repor …
Melatonin intake was associated with a higher decrease in RBDSQ score compared to trazodone (P = 0.011) and clonazepam (P = 0.004). …
Safety and efficacy of memantine and trazodone versus placebo for motor neuron disease (MND SMART): stage two interim analysis from the first cycle of a phase 3, multiarm, multistage, randomised, adaptive platform trial.
Pal S, Chataway J, Swingler R, Macleod MR, Carragher NO, Hardingham G, Selvaraj BT, Smith C, Wong C, Newton J, Lyle D, Stenson A, Dakin RS, Ihenacho A, Colville S, Mehta AR, Stallard N, Carpenter JR, Parker RA, Keerie C, Weir CJ, Virgo B, Morris S, Waters N, Gray B, MacDonald D, MacDonald E, Parmar MKB, Chandran S; MND SMART Investigators. Pal S, et al. Lancet Neurol. 2024 Nov;23(11):1097-1107. doi: 10.1016/S1474-4422(24)00326-0. Epub 2024 Sep 19. Lancet Neurol. 2024. PMID: 39307154 Free article. Clinical Trial.
The one-sided p values were both above the significance threshold of 10%, indicating that neither memantine nor trazodone groups met the criteria for continuation. There were 483 participants with at least one adverse event (145 [77%] on placebo, 170 [91%] on memantine, an …
The one-sided p values were both above the significance threshold of 10%, indicating that neither memantine nor trazodone groups met …
Effect of trazodone versus cognitive-behavioural treatment on high- and slow-frequency activity during non-rapid eye movement sleep in chronic insomnia: A pilot, randomized clinical trial.
Li Y, Vgontzas AN, Fernandez-Mendoza J, Fang J, Puzino K, Bixler EO. Li Y, et al. J Sleep Res. 2021 Oct;30(5):e13324. doi: 10.1111/jsr.13324. Epub 2021 Mar 5. J Sleep Res. 2021. PMID: 33675113 Clinical Trial.
Trazodone and cognitive-behavioural treatment for insomnia (CBT-I) are widely used to treat patients with chronic insomnia. ...In conclusion, trazodone, but not CBT-I, decreased fast-frequency EEG activity during NREM sleep. Compared to CBT-I, trazodone appea …
Trazodone and cognitive-behavioural treatment for insomnia (CBT-I) are widely used to treat patients with chronic insomnia. ...In con …
Effects of atomoxetine plus a hypnotic on obstructive sleep apnea severity in patients with a moderately collapsible pharyngeal airway.
Corser B, Eves E, Warren-McCormick J, Rucosky G. Corser B, et al. J Clin Sleep Med. 2023 Jun 1;19(6):1035-1042. doi: 10.5664/jcsm.10464. J Clin Sleep Med. 2023. PMID: 36734173 Free PMC article. Clinical Trial.
As a result, we tested the combination of atomoxetine plus 2 hypnotics in patients with OSA. The effects of atomoxetine plus: (1) trazodone (Ato-Trazo) and (2) lemborexant vs placebo on apnea-hypopnea index, hypoxic burden, arousal threshold, and total sleep time were asse …
As a result, we tested the combination of atomoxetine plus 2 hypnotics in patients with OSA. The effects of atomoxetine plus: (1) trazodo …
Pharmacokinetics, pharmacodynamics and clinical use of trazodone and its active metabolite m-chlorophenylpiperazine in the horse.
Davis JL, Schirmer J, Medlin E. Davis JL, et al. J Vet Pharmacol Ther. 2018 Jun;41(3):393-401. doi: 10.1111/jvp.12477. Epub 2018 Jan 14. J Vet Pharmacol Ther. 2018. PMID: 29333613 Free PMC article. Clinical Trial.
The aims of this study were to determine the pharmacokinetics of oral trazodone in experimental horses and to evaluate the effect of oral trazodone in clinical horses. Six experimental horses were administered trazodone at 7.5 or 10 mg/kg. Plasma concentratio …
The aims of this study were to determine the pharmacokinetics of oral trazodone in experimental horses and to evaluate the effect of …
Motor Neuron Disease Systematic Multi-Arm Adaptive Randomised Trial (MND-SMART): a multi-arm, multi-stage, adaptive, platform, phase III randomised, double-blind, placebo-controlled trial of repurposed drugs in motor neuron disease.
Wong C, Dakin RS, Williamson J, Newton J, Steven M, Colville S, Stavrou M, Gregory JM, Elliott E, Mehta AR, Chataway J, Swingler RJ, Parker RA, Weir CJ, Stallard N, Parmar MKB, Macleod MR, Pal S, Chandran S. Wong C, et al. BMJ Open. 2022 Jul 7;12(7):e064173. doi: 10.1136/bmjopen-2022-064173. BMJ Open. 2022. PMID: 35798516 Free PMC article. Clinical Trial.
The first two drugs selected for evaluation in MND-SMART are trazodone and memantine. METHODS AND ANALYSIS: Initially, up to 531 participants (177/arm) will be randomised 1:1:1 to oral liquid trazodone, memantine and placebo. ...
The first two drugs selected for evaluation in MND-SMART are trazodone and memantine. METHODS AND ANALYSIS: Initially, up to 531 part …
Effect of viloxazine and trazodone in obstructive sleep apnoea: a randomised, placebo-controlled, cross-over study.
Aishah A, Kim M, Gell L, Vena D, Azarbarzin A, Pho H, Norman D, Ojile J, Esmaeili N, Taranto-Montemurro L, Wellman A, Sands S, Messineo L. Aishah A, et al. Thorax. 2025 Aug 15;80(9):641-649. doi: 10.1136/thorax-2024-222513. Thorax. 2025. PMID: 40360261 Clinical Trial.
We investigated the effect of a potentially more manageable noradrenergic, viloxazine, with and without trazodone, on OSA severity. METHODS: In this double-blind, placebo-controlled, cross-over study, 24 patients with OSA (18-75 years) were analysed and randomised to 500 m …
We investigated the effect of a potentially more manageable noradrenergic, viloxazine, with and without trazodone, on OSA severity. M …
340 results