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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1971 1
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1974 2
1975 4
1976 7
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1978 14
1979 11
1980 12
1981 10
1982 24
1983 23
1984 12
1985 12
1986 22
1987 19
1988 24
1989 20
1990 25
1991 23
1992 17
1993 27
1994 40
1995 34
1996 37
1997 49
1998 40
1999 40
2000 35
2001 35
2002 24
2003 28
2004 31
2005 29
2006 26
2007 28
2008 21
2009 32
2010 32
2011 40
2012 38
2013 26
2014 28
2015 25
2016 26
2017 18
2018 19
2019 23
2020 28
2021 17
2022 14
2023 14
2024 9
2025 11
2026 3

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1,151 results

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Page 1
Melasma.
Kauh YC, Zachian TF. Kauh YC, et al. Adv Exp Med Biol. 1999;455:491-9. doi: 10.1007/978-1-4615-4857-7_72. Adv Exp Med Biol. 1999. PMID: 10599387 Clinical Trial.
We have conducted a clinical trial utilizing all trans-retinoic acid (tretinoin, Retin-A) cream 0.1% q pm and hydroquinone lotion 3% (Melanex) applied every morning in Korean women with melasma. ...We reconfirmed that a synergistic mechanism between tretinoin and hy …
We have conducted a clinical trial utilizing all trans-retinoic acid (tretinoin, Retin-A) cream 0.1% q pm and hydroquinone lotion 3% …
Biomarkers of Tretinoin Precursors and Tretinoin Efficacy in Patients With Moderate to Severe Facial Photodamage: A Randomized Clinical Trial.
Chien AL, Kim DJ, Cheng N, Shin J, Leung SG, Nelson AM, Zang J, Suh H, Rainer B, Wallis L, Okoye GA, Loss M, Kang S. Chien AL, et al. JAMA Dermatol. 2022 Aug 1;158(8):879-886. doi: 10.1001/jamadermatol.2022.1891. JAMA Dermatol. 2022. PMID: 35675051 Free PMC article. Clinical Trial.
IMPORTANCE: Topical formulations of tretinoin precursors (retinol and its ester derivatives) are widely available over the counter and may offer similar clinical benefits to those of tretinoin for treatment of photoaging. However, which of the many purported molecul …
IMPORTANCE: Topical formulations of tretinoin precursors (retinol and its ester derivatives) are widely available over the counter an …
Isotretinoin (Accutane).
Scott B. Scott B. J Kans Med Soc. 1983 Jan;84(1):30, 36. J Kans Med Soc. 1983. PMID: 6219169 Clinical Trial. No abstract available.
Topical tretinoin therapy and all-cause mortality.
Weinstock MA, Bingham SF, Lew RA, Hall R, Eilers D, Kirsner R, Naylor M, Kalivas J, Cole G, Marcolivio K, Collins J, Digiovanna JJ, Vertrees JE; Veterans Affairs Topical Tretinoin Chemoprevention (VATTC) Trial Group. Weinstock MA, et al. Arch Dermatol. 2009 Jan;145(1):18-24. doi: 10.1001/archdermatol.2008.542. Arch Dermatol. 2009. PMID: 19153339 Clinical Trial.
OBJECTIVE: To evaluate the relation of topical tretinoin, a commonly used retinoid cream, with all-cause mortality in the Veterans Affairs Topical Tretinoin Chemoprevention Trial (VATTC). ...CONCLUSIONS: We observed an association of topical tretinoin therapy …
OBJECTIVE: To evaluate the relation of topical tretinoin, a commonly used retinoid cream, with all-cause mortality in the Veterans Af …
Efficacy and safety of tretinoin 0.05% cream to prevent hyperpigmentation during narrowband UV-B phototherapy in patients with facial vitiligo: a randomized clinical trial.
Ju HJ, Kim SH, Lee JH, Kim GM, Bae JM. Ju HJ, et al. J Dermatolog Treat. 2022 May;33(3):1738-1741. doi: 10.1080/09546634.2020.1817298. Epub 2020 Sep 10. J Dermatolog Treat. 2022. PMID: 32869680 Free article. Clinical Trial.
BACKGROUND: Narrowband UV-B (NBUVB) phototherapy is the mainstay of vitiligo treatment, but hyperpigmentation is one of the limitations. Meanwhile, topical tretinoin is effective against pigmentary disorders. OBJECTIVE: To determine whether tretinoin 0.05% cream wou …
BACKGROUND: Narrowband UV-B (NBUVB) phototherapy is the mainstay of vitiligo treatment, but hyperpigmentation is one of the limitations. Mea …
Efficacy and Safety of Generic Fluocinolone Acetonide, Hydroquinone, and Tretinoin Cream Compared With TRI-LUMA for the Treatment of Moderate-To-Severe Melasma in Chinese Patients: A Randomized, Single-Center, Placebo-Controlled Trial.
Hu H, Zhou P, Yao H, Zhu C, Shen B, Feng B, Yu X, Liu L. Hu H, et al. J Cosmet Dermatol. 2025 May;24(5):e70205. doi: 10.1111/jocd.70205. J Cosmet Dermatol. 2025. PMID: 40296512 Free PMC article. Clinical Trial.
BACKGROUND: Treatment with fluocinolone acetonide, hydroquinone, and tretinoin cream is the gold standard for melasma; however, the effects of this treatment in the Chinese population remain unclear. ...AIM: To evaluate the efficacy and safety of fluocinolone acetonide, hy …
BACKGROUND: Treatment with fluocinolone acetonide, hydroquinone, and tretinoin cream is the gold standard for melasma; however, the e …
Topical tretinoin in chronic rhinosinusitis with nasal polyps: a randomized clinical trial.
Antonio MA, Marson FAL, Toro MDC, Sampaio MH, Barreto IS, Dertkigil SSJ, Sakuma ETI, Guadagnini D, Sakano E. Antonio MA, et al. Int Forum Allergy Rhinol. 2021 Aug;11(8):1187-1196. doi: 10.1002/alr.22778. Epub 2021 Feb 14. Int Forum Allergy Rhinol. 2021. PMID: 33583149 Clinical Trial.
Unlike the nasal administration, the oral and ocular use of tretinoin, an immunoregulatory drug, is well established. Therefore, tretinoin was thought to act on nasal polyps, and possible adverse and/or therapeutic effects were investigated. ...The most interesting …
Unlike the nasal administration, the oral and ocular use of tretinoin, an immunoregulatory drug, is well established. Therefore, t …
Tretinoin (0.05% cream vs. 5% peel) for photoaging and field cancerization of the forearms: randomized, evaluator-blinded, clinical trial.
Sumita JM, Miot HA, Soares JLM, Raminelli ACP, Pereira SM, Ogawa MM, Picosse FR, Guadanhim LRS, Enokihara MMSS, Leonardi GR, Bagatin E. Sumita JM, et al. J Eur Acad Dermatol Venereol. 2018 Oct;32(10):1819-1826. doi: 10.1111/jdv.15020. Epub 2018 May 27. J Eur Acad Dermatol Venereol. 2018. PMID: 29704456 Clinical Trial.
BACKGROUND: Topical tretinoin cream is the gold standard treatment for skin ageing, particularly photoaging. ...OBJECTIVE: To compare efficacy and safety of tretinoin 0.05% cream and 5% as a peeling agent on photoaging and field cancerization of the forearms. ...
BACKGROUND: Topical tretinoin cream is the gold standard treatment for skin ageing, particularly photoaging. ...OBJECTIVE: To compare …
Clinical effects of long-term therapy with topical tretinoin and cellular mode of action.
Voorhees JJ. Voorhees JJ. J Int Med Res. 1990;18 Suppl 3:26C-28C. J Int Med Res. 1990. PMID: 2227085 Review.
Topical tretinoin induced epidermal hyperplasia, compaction of the stratum corneum and the deposition of ultrastructurally visible collagen fibrils in the papillary dermis. ...An Alcian Blue-positive glycosaminoglycan-like substance was detected in the stratum corneum of …
Topical tretinoin induced epidermal hyperplasia, compaction of the stratum corneum and the deposition of ultrastructurally visible co …
1,151 results