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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
2001 3
2002 19
2003 49
2004 94
2005 116
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2008 114
2009 141
2010 141
2011 125
2012 172
2013 187
2014 191
2015 184
2016 162
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3,198 results

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Page 1
Direct comparison of tadalafil with sildenafil for the treatment of erectile dysfunction: a systematic review and meta-analysis.
Gong B, Ma M, Xie W, Yang X, Huang Y, Sun T, Luo Y, Huang J. Gong B, et al. Int Urol Nephrol. 2017 Oct;49(10):1731-1740. doi: 10.1007/s11255-017-1644-5. Epub 2017 Jul 24. Int Urol Nephrol. 2017. PMID: 28741090 Free PMC article.
However, compared with sildenafil, tadalafil significantly improved psychological outcomes. Furthermore, the patients and their partners preferred tadalafil over sildenafil, and no significant difference was found in the adherence and persistence rates between ta …
However, compared with sildenafil, tadalafil significantly improved psychological outcomes. Furthermore, the patients and their partn …
Benefits of Tadalafil and Sildenafil on Mortality, Cardiovascular Disease, and Dementia.
Jehle DVK, Sunesra R, Uddin H, Paul KK, Joglar AA, Michler OD, Blackwell TA, Gaalema D, Hayek S, Jneid H. Jehle DVK, et al. Am J Med. 2025 Mar;138(3):441-448.e3. doi: 10.1016/j.amjmed.2024.10.039. Epub 2024 Nov 10. Am J Med. 2025. PMID: 39532245
Men at least 40 years of age prescribed tadalafil or sildenafil after an erectile dysfunction diagnosis, or tadalafil after lower urinary tract symptom diagnoses, from 2004 to 2021 were included. ...CONCLUSIONS: In conclusion, tadalafil and sildenafil use in …
Men at least 40 years of age prescribed tadalafil or sildenafil after an erectile dysfunction diagnosis, or tadalafil after lo …
Efficacy and safety of long-term tadalafil 5 mg once daily combined with sildenafil 50 mg as needed at the early stage of treatment for patients with erectile dysfunction.
Cui H, Liu B, Song Z, Fang J, Deng Y, Zhang S, Wang H, Wang Z. Cui H, et al. Andrologia. 2015 Feb;47(1):20-4. doi: 10.1111/and.12216. Epub 2014 Jan 6. Andrologia. 2015. PMID: 24387078 Clinical Trial.
We enrolled 180 patients with ED 1 : 1 to tadalafil 5 mg once daily or once-a-day tadalafil 5 mg combined with sildenafil 50 mg as needed. ...Total IIEF-5 scores of patients with severe ED in combined medication group were significantly higher than in tadalafil …
We enrolled 180 patients with ED 1 : 1 to tadalafil 5 mg once daily or once-a-day tadalafil 5 mg combined with sildenafil 50 m …
Tadalafil.
Curran M, Keating G. Curran M, et al. Drugs. 2003;63(20):2203-12; discussion 2213-4. doi: 10.2165/00003495-200363200-00004. Drugs. 2003. PMID: 14498756 Review.
Improvement in scores on other domains of the IIEF and the percentage of positive responses to a Global Assessment Question measuring erection improvement were also significantly greater with on-demand tadalafil than placebo. black triangle The adverse events associated wi …
Improvement in scores on other domains of the IIEF and the percentage of positive responses to a Global Assessment Question measuring erecti …
Cardiovascular effects of tadalafil.
Kloner RA, Mitchell M, Emmick JT. Kloner RA, et al. Am J Cardiol. 2003 Nov 6;92(9A):37M-46M. doi: 10.1016/s0002-9149(03)00074-2. Am J Cardiol. 2003. PMID: 14609622 Review.
To determine the effects of tadalafil on the cardiovascular system, safety assessments were performed on a database of >4000 subjects who received tadalafil in >60 clinical pharmacology, phase 2, phase 3, and open-label studies. ...The resulting mean maximal c …
To determine the effects of tadalafil on the cardiovascular system, safety assessments were performed on a database of >4000 subje …
Potential beneficial impacts of tadalafil on cardiovascular diseases.
Lan TY, Chiang CH, Chen JW, Chang TT. Lan TY, et al. J Chin Med Assoc. 2025 Apr 1;88(4):267-272. doi: 10.1097/JCMA.0000000000001205. Epub 2025 Jan 10. J Chin Med Assoc. 2025. PMID: 39789694 Free PMC article. Review.
Tadalafil is a selective phosphodiesterase type 5 (PDE5) inhibitor commonly used for the treatment of erectile dysfunction and benign prostatic hyperplasia. ...Although tadalafil shows potential efficacy in treating cardiovascular disease, further experimental studi …
Tadalafil is a selective phosphodiesterase type 5 (PDE5) inhibitor commonly used for the treatment of erectile dysfunction and benign …
Tadalafil: in pulmonary arterial hypertension.
Croxtall JD, Lyseng-Williamson KA. Croxtall JD, et al. Drugs. 2010 Mar 5;70(4):479-88. doi: 10.2165/11204580-000000000-00000. Drugs. 2010. PMID: 20205489 Review.
Both the time to the first occurrence of clinical worsening and the incidence of clinical worsening were significantly reduced in recipients of tadalafil 40 mg once daily compared with recipients of placebo. Furthermore, at week 16, tadalafil improved most HR-QOL ou …
Both the time to the first occurrence of clinical worsening and the incidence of clinical worsening were significantly reduced in recipients …
Nebivolol and Tadalafil Synergistically Ameliorate Insulin Resistance-Induced Retinopathy in Rats.
Seif HK, Mandour D, Ibrahim IAAE, Mahmoud MF, Elbatreek MH. Seif HK, et al. Arch Pharm (Weinheim). 2025 Aug;358(8):e70070. doi: 10.1002/ardp.70070. Arch Pharm (Weinheim). 2025. PMID: 40785220
We aimed to investigate the therapeutic effect of nebivolol and/or tadalafil on insulin resistance-induced retinopathy. Insulin resistance was induced in rats using a dietary model of a high-fructose, high-fat, high-salt diet (HFrFSD). ...In conclusion, nebivolol and ta …
We aimed to investigate the therapeutic effect of nebivolol and/or tadalafil on insulin resistance-induced retinopathy. Insulin resis …
Tadalafil for the treatment of benign prostatic hyperplasia.
Mónica FZ, De Nucci G. Mónica FZ, et al. Expert Opin Pharmacother. 2019 Jun;20(8):929-937. doi: 10.1080/14656566.2019.1589452. Epub 2019 Mar 22. Expert Opin Pharmacother. 2019. PMID: 30901259 Review.
Areas covered: This article reviews the major preclinical and clinical data on PDE5 inhibitors with a specific focus on tadalafil. It includes details of the role of the nitric oxide (NO)-cyclic guanosine monophosphate (cGMP) - PDE5 pathway in the LUT organs (bladder and p …
Areas covered: This article reviews the major preclinical and clinical data on PDE5 inhibitors with a specific focus on tadalafil. It …
Bioequivalence Study of Tadalafil Oral Soluble Film and Tadalafil Tablet in Healthy Chinese Volunteers Under Fasting Conditions.
Jiang X, Sun F, Shi P, Gu X, Zhao X, Zhang X, Xu Y, Gao X, Ma Y, Fu Y, Cao Y. Jiang X, et al. Clin Transl Sci. 2025 Dec;18(12):e70440. doi: 10.1111/cts.70440. Clin Transl Sci. 2025. PMID: 41340316 Free PMC article. Clinical Trial.
To investigate if a newly developed tadalafil oral soluble film (OSF) was bioequivalent to the approved tadalafil tablets, a clinical study was conducted in healthy Chinese male volunteers under fasting conditions. In this study, 36 volunteers were randomized into t …
To investigate if a newly developed tadalafil oral soluble film (OSF) was bioequivalent to the approved tadalafil tablets, a c …
3,198 results